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Index > Protein center > PDXP(Gene name) > Human
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  • PDXP (Gene name),
  • Pyridoxal phosphate phosphatase (Protein name ),  PLPP_HUMAN from NCBI database.
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  • General Annotation
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  • Antigen Annotation
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  • Gene name:
    PDXP(CIN;PLP;PLPP);
    Protein name:
    Pyridoxal phosphate phosphatase(PLP phosphatase);
    Alternative:
    Chronophin;
    Organism:
    Human (Homo sapiens). 
    General Annotation
    Sub Unit:
    Homodimer.
    Function:
    Protein serine phosphatase that dephosphorylates 'Ser-3' in cofilin and probably also dephosphorylates phospho-serine residues in DSTN. Regulates cofilin-dependent actin cytoskeleton reorganization. Required for normal progress through mitosis and normal cytokinesis. Does not dephosphorylate phospho-threonines in LIMK1. Does not dephosphorylate peptides containing phospho-tyrosine. Pyridoxal phosphate phosphatase. Has some activity towards pyridoxal 5'-phosphate (PLP), pyridoxine 5'-phosphate (PMP) and pyridoxine 5'-phosphate (PNP), with a highest activity with PLP followed by PNP.
    Subcellular Location:
    Cytoplasm cytosol Cytoplasm cytoskeleton Cell projection ruffle membrane Peripheral membrane protein Cytoplasmic side Cell projection lamellipodium membrane Peripheral membrane protein Cytoplasmic side Cell membrane Peripheral membrane protein Cytoplasmic side Colocalizes with the actin cytoskeleton in membrane ruffles and lamellipodia. Diffusely distributed throughout the cytosol during pro-metaphase and metaphase. Detected at the dynamic cell poles during telophase. Detected at the cleavage furrow and contractile ring during cytokinesis. Transiently detected at the plasma membrane in late stages of cytokinesis. Detected at the midbody.
    Protein Attributes:
    Sequence length:
    296
    Sequence:
    50:
    MARCERLRGA | ALRDVLGRAQ | GVLFDCDGVL | WNGERAVPGA | PELLERLARA | 
    100:
    GKAALFVSNN | SRRARPELAL | RFARLGFGGL | RAEQLFSSAL | CAARLLRQRL | 
    150:
    PGPPDAPGAV | FVLGGEGLRA | ELRAAGLRLA | GDPSAGDGAA | PRVRAVLVGY | 
    200:
    DEHFSFAKLR | EACAHLRDPE | CLLVATDRDP | WHPLSDGSRT | PGTGSLAAAV | 
    250:
    ETASGRQALV | VGKPSPYMFE | CITENFSIDP | ARTLMVGDRL | ETDILFGHRC | 
    296:
    GMTTVLTLTG | VSRLEEAQAY | LAAGQHDLVP | HYYVESIADL | TEGLED
    3D Structure:
    N/A
    Predicted Eptitope:
    Please Sign in.
    EIAab Sequence  Vaild Sequence:
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    Related Databases
    String:
    Pfam:
    SMR:
    UniGene:
    Pfam:
    MIM:
    KEGG:
    Uniprot:
     
    FOR
    ELISA Kit for Human PLP phosphatase
    Cat.:
    E1712h
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    Packing:
    96T
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    ELISA Kit for Human PLP phosphatase
    Cat.:
    E1712m
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    Packing:
    96T
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    ELISA Kit for Human PLP phosphatase
    Cat.:
    E1712b
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    MSDS:
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    Packing:
    96T
    ELISA Kit for Human PLP phosphatase
    Cat.:
    E1712r
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    MSDS:
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    Packing:
    96T
    CLIA Kit for Human PLP phosphatase
    Cat.:
    U1712m
    Price:
    Please sign in first.
    MSDS:
    Please sign in first.
    Packing:
    96T
    CLIA Kit for Human PLP phosphatase
    Cat.:
    U1712r
    Price:
    Please sign in first.
    MSDS:
    Please sign in first.
    Packing:
    96T
    CLIA Kit for Human PLP phosphatase
    Cat.:
    U1712b
    Price:
    Please sign in first.
    MSDS:
    Please sign in first.
    Packing:
    96T
    CLIA Kit for Human PLP phosphatase
    Cat.:
    U1712h
    Price:
    Please sign in first.
    MSDS:
    Please sign in first.
    Packing:
    96T
    Polyclonal Antibody for Human PLP phosphatase
    Cat.:
    P1712Rb-h
    Price:
    Please sign in first.
    Packing:
    40ug/0.2ml
    Polyclonal Antibody for Human PLP phosphatase
    Cat.:
    P1712Rb-r
    Price:
    Please sign in first.
    Packing:
    40ug/0.2ml
    Polyclonal Antibody for Human PLP phosphatase
    Cat.:
    P1712Rb-m
    Price:
    Please sign in first.
    Packing:
    40ug/0.2ml
    Polyclonal Antibody for Human PLP phosphatase
    Monoclonal Antibody for Human PLP phosphatase
    Monoclonal Antibody for Human PLP phosphatase
    Monoclonal Antibody for Human PLP phosphatase
    Monoclonal Antibody for Human PLP phosphatase
    Protein for Human PLP phosphatase
    Protein for Human PLP phosphatase
    Protein for Human PLP phosphatase
    Protein for Human PLP phosphatase

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    References
    1. 1.
      "Human pyridoxal phosphatase. Molecular cloning, functional expression, and tissue distribution."
      Jang Y.M. , Kim D.W. , Kang T.-C. , Won M.H. , Baek N.-I. , Moon B.J. , Choi S.Y. , Kwon O.-S.
      J. Biol. Chem.278:50040-50046(2003) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [MRNA];FUNCTION;HOMODIMERIZATION;COFACTOR;SUBUNIT;TISSUE SPECIFICITY
      tissue: Brain.
    2. 2.
      "The DNA sequence of human chromosome 22."
      Dunham I. , Hunt A.R. , Collins J.E. , Bruskiewich R. , Beare D.M. , Clamp M. , Smink L.J. , Ainscough R. , Almeida J.P. , Babbage A.K. , Bagguley C. , Bailey J. , Barlow K.F. , Bates K.N. , Beasley O.P. , Bird C.P. , Blakey S.E. , Bridgeman A.M. , more...
      Nature402:489-495(1999) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]
    3. 3.
      "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
      The MGC Project Team
      Genome Res.14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA]
      tissue: Eye.
      tissue: Lung.
      tissue: Placenta.
    4. 4.
      Lubec G. , Afjehi-Sadat L. , Chen W.-Q. , Sun Y.
      Submitted (2008-12) to the UniProtKB
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: PROTEIN SEQUENCE OF 19-35; 100-119 AND 145-158;IDENTIFICATION BY MASS SPECTROMETRY
      tissue: Brain.
      tissue: Cajal-Retzius cell.
      tissue: Fetal brain cortex.
    5. 5.
      "Identification of an essential cysteine residue in pyridoxal phosphatase from human erythrocytes."
      Gao G.-J. , Fonda M.L.
      J. Biol. Chem.269:8234-8239(1994) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: PROTEIN SEQUENCE OF 19-30 AND 145-158;ENZYME ACTIVITY
    6. 6.
      "Chronophin, a novel HAD-type serine protein phosphatase, regulates cofilin-dependent actin dynamics."
      Gohla A. , Birkenfeld J. , Bokoch G.M.
      Nat. Cell Biol.7:21-29(2005) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: FUNCTION;CATALYTIC ACTIVITY;ENZYME REGULATION;COFACTOR;ACTIVE SITE;SUBCELLULAR LOCATION;MUTAGENESIS OF ASP-25;TISSUE SPECIFICITY
    7. 7.
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS]
    8. 8.
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: X-RAY CRYSTALLOGRAPHY (1.72 ANGSTROMS) OF 2-296 IN COMPLEXES WITH PYRODOXAL PHOSPHATE; CALCIUM AND MAGNESIUM IONS
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