Gene name:
PDXP (CIN;PLP;PLPP) ;
Protein name:
Pyridoxal phosphate phosphatase (PLP phosphatase) ;
Alternative:
Chronophin ;
Organism:
Human (Homo sapiens).
General Annotation
Function:
Protein serine phosphatase that dephosphorylates 'Ser-3' in cofilin and probably also dephosphorylates phospho-serine residues in DSTN. Regulates cofilin-dependent actin cytoskeleton reorganization. Required for normal progress through mitosis and normal cytokinesis. Does not dephosphorylate phospho-threonines in LIMK1. Does not dephosphorylate peptides containing phospho-tyrosine. Pyridoxal phosphate phosphatase. Has some activity towards pyridoxal 5'-phosphate (PLP), pyridoxine 5'-phosphate (PMP) and pyridoxine 5'-phosphate (PNP), with a highest activity with PLP followed by PNP.
Subcellular Location:
Cytoplasm
cytosol
Cytoplasm
cytoskeleton
Cell projection
ruffle membrane
Peripheral membrane protein
Cytoplasmic side
Cell projection
lamellipodium membrane
Peripheral membrane protein
Cytoplasmic side
Cell membrane
Peripheral membrane protein
Cytoplasmic side
Colocalizes with the actin cytoskeleton in membrane ruffles and lamellipodia. Diffusely distributed throughout the cytosol during pro-metaphase and metaphase. Detected at the dynamic cell poles during telophase. Detected at the cleavage furrow and contractile ring during cytokinesis. Transiently detected at the plasma membrane in late stages of cytokinesis. Detected at the midbody.
Protein Attributes:
50:
MARCERLRGA | ALRDVLGRAQ | GVLFDCDGVL | WNGERAVPGA | PELLERLARA |
100:
GKAALFVSNN | SRRARPELAL | RFARLGFGGL | RAEQLFSSAL | CAARLLRQRL |
150:
PGPPDAPGAV | FVLGGEGLRA | ELRAAGLRLA | GDPSAGDGAA | PRVRAVLVGY |
200:
DEHFSFAKLR | EACAHLRDPE | CLLVATDRDP | WHPLSDGSRT | PGTGSLAAAV |
250:
ETASGRQALV | VGKPSPYMFE | CITENFSIDP | ARTLMVGDRL | ETDILFGHRC |
296:
GMTTVLTLTG | VSRLEEAQAY | LAAGQHDLVP | HYYVESIADL | TEGLED
Vaild Sequence:
Related Databases
Uniprot:
ELISA Kit
CLIA Kit
Polyclonal Antibody
Monoclonal Antibody
Protein
FOR
Human
Mouse
Bovine
Rat
ELISA Kit for Human PLP phosphatase
ELISA Kit for Human PLP phosphatase
ELISA Kit for Human PLP phosphatase
ELISA Kit for Human PLP phosphatase
CLIA Kit for Human PLP phosphatase
CLIA Kit for Human PLP phosphatase
CLIA Kit for Human PLP phosphatase
CLIA Kit for Human PLP phosphatase
Polyclonal Antibody for Human PLP phosphatase
Polyclonal Antibody for Human PLP phosphatase
Polyclonal Antibody for Human PLP phosphatase
Polyclonal Antibody for Human PLP phosphatase
Monoclonal Antibody for Human PLP phosphatase
Monoclonal Antibody for Human PLP phosphatase
Monoclonal Antibody for Human PLP phosphatase
Monoclonal Antibody for Human PLP phosphatase
Protein for Human PLP phosphatase
Protein for Human PLP phosphatase
Protein for Human PLP phosphatase
Protein for Human PLP phosphatase
R&D Technical Data
For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.
For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.
For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.
For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.
For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.
For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.
For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.
For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.
For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.
For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.
For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.
For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.
For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.
For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.
For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.
For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.
For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.
For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.
For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.
For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.
Precision
For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.
For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.
For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.
For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.
For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.
For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.
For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.
For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.
For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.
For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.
For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.
For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.
For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.
For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.
For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.
For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.
For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.
For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.
For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.
For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.
Recovery
For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.
For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.
For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.
For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.
For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.
For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.
For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.
For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.
For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.
For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.
For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.
For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.
For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.
For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.
For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.
For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.
For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.
For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.
For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.
For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.
Linearity
For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.
For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.
For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.
For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.
For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.
For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.
For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.
For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.
For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.
For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.
For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.
For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.
For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.
For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.
For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.
For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.
For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.
For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.
For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.
For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.
References
1.
[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s)
Cited for : NUCLEOTIDE SEQUENCE [MRNA];FUNCTION;HOMODIMERIZATION;COFACTOR;SUBUNIT;TISSUE SPECIFICITY
tissue :
Brain .
2.
"The DNA sequence of human chromosome 22."
Dunham I.
,
Hunt A.R.
,
Collins J.E.
,
Bruskiewich R.
,
Beare D.M.
,
Clamp M.
,
Smink L.J.
,
Ainscough R.
,
Almeida J.P.
,
Babbage A.K.
,
Bagguley C.
,
Bailey J.
,
Barlow K.F.
,
Bates K.N.
,
Beasley O.P.
,
Bird C.P.
,
Blakey S.E.
,
Bridgeman A.M.
,
Buck D.
,
Burgess J.
,
Burrill W.D.
,
Burton J.
,
Carder C.
,
Carter N.P.
,
Chen Y.
,
Clark G.
,
Clegg S.M.
,
Cobley V.E.
,
Cole C.G.
,
Collier R.E.
,
Connor R.
,
Conroy D.
,
Corby N.R.
,
Coville G.J.
,
Cox A.V.
,
Davis J.
,
Dawson E.
,
Dhami P.D.
,
Dockree C.
,
Dodsworth S.J.
,
Durbin R.M.
,
Ellington A.G.
,
Evans K.L.
,
Fey J.M.
,
Fleming K.
,
French L.
,
Garner A.A.
,
Gilbert J.G.R.
,
Goward M.E.
,
Grafham D.V.
,
Griffiths M.N.D.
,
Hall C.
,
Hall R.E.
,
Hall-Tamlyn G.
,
Heathcott R.W.
,
Ho S.
,
Holmes S.
,
Hunt S.E.
,
Jones M.C.
,
Kershaw J.
,
Kimberley A.M.
,
King A.
,
Laird G.K.
,
Langford C.F.
,
Leversha M.A.
,
Lloyd C.
,
Lloyd D.M.
,
Martyn I.D.
,
Mashreghi-Mohammadi M.
,
Matthews L.H.
,
Mccann O.T.
,
Mcclay J.
,
Mclaren S.
,
McMurray A.A.
,
Milne S.A.
,
Mortimore B.J.
,
Odell C.N.
,
Pavitt R.
,
Pearce A.V.
,
Pearson D.
,
Phillimore B.J.C.T.
,
Phillips S.H.
,
Plumb R.W.
,
Ramsay H.
,
Ramsey Y.
,
Rogers L.
,
Ross M.T.
,
Scott C.E.
,
Sehra H.K.
,
Skuce C.D.
,
Smalley S.
,
Smith M.L.
,
Soderlund C.
,
Spragon L.
,
Steward C.A.
,
Sulston J.E.
,
Swann R.M.
,
Vaudin M.
,
Wall M.
,
Wallis J.M.
,
Whiteley M.N.
,
Willey D.L.
,
Williams L.
,
Williams S.A.
,
Williamson H.
,
Wilmer T.E.
,
Wilming L.
,
Wright C.L.
,
Hubbard T.
,
Bentley D.R.
,
Beck S.
,
Rogers J.
,
Shimizu N.
,
Minoshima S.
,
Kawasaki K.
,
Sasaki T.
,
Asakawa S.
,
Kudoh J.
,
Shintani A.
,
Shibuya K.
,
Yoshizaki Y.
,
Aoki N.
,
Mitsuyama S.
,
Roe B.A.
,
Chen F.
,
Chu L.
,
Crabtree J.
,
Deschamps S.
,
Do A.
,
Do T.
,
Dorman A.
,
Fang F.
,
Fu Y.
,
Hu P.
,
Hua A.
,
Kenton S.
,
Lai H.
,
Lao H.I.
,
Lewis J.
,
Lewis S.
,
Lin S.-P.
,
Loh P.
,
Malaj E.
,
Nguyen T.
,
Pan H.
,
Phan S.
,
Qi S.
,
Qian Y.
,
Ray L.
,
Ren Q.
,
Shaull S.
,
Sloan D.
,
Song L.
,
Wang Q.
,
Wang Y.
,
Wang Z.
,
White J.
,
Willingham D.
,
Wu H.
,
Yao Z.
,
Zhan M.
,
Zhang G.
,
Chissoe S.
,
Murray J.
,
Miller N.
,
Minx P.
,
Fulton R.
,
Johnson D.
,
Bemis G.
,
Bentley D.
,
Bradshaw H.
,
Bourne S.
,
Cordes M.
,
Du Z.
,
Fulton L.
,
Goela D.
,
Graves T.
,
Hawkins J.
,
Hinds K.
,
Kemp K.
,
Latreille P.
,
Layman D.
,
Ozersky P.
,
Rohlfing T.
,
Scheet P.
,
Walker C.
,
Wamsley A.
,
Wohldmann P.
,
Pepin K.
,
Nelson J.
,
Korf I.
,
Bedell J.A.
,
Hillier L.W.
,
Mardis E.
,
Waterston R.
,
Wilson R.
,
Emanuel B.S.
,
Shaikh T.
,
Kurahashi H.
,
Saitta S.
,
Budarf M.L.
,
McDermid H.E.
,
Johnson A.
,
Wong A.C.C.
,
Morrow B.E.
,
Edelmann L.
,
Kim U.J.
,
Shizuya H.
,
Simon M.I.
,
Dumanski J.P.
,
Peyrard M.
,
Kedra D.
,
Seroussi E.
,
Fransson I.
,
Tapia I.
,
Bruder C.E.
,
O'Brien K.P.
,
Wilkinson P.
,
Bodenteich A.
,
Hartman K.
,
Hu X.
,
Khan A.S.
,
Lane L.
,
Tilahun Y.
,
Wright H.
more...
Nature402:489-495(1999)
[
PubMed ]
[
Europe PMC ]
[
Abstract ]
[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s)
Cited for : NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]
3.
[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s)
Cited for : NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA]
tissue :
Eye .
tissue :
Lung .
tissue :
Placenta .
4.
[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s)
Cited for : PROTEIN SEQUENCE OF 19-35; 100-119 AND 145-158;IDENTIFICATION BY MASS SPECTROMETRY
tissue :
Brain .
tissue :
Cajal-Retzius cell .
tissue :
Fetal brain cortex .
5.
[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s)
Cited for : PROTEIN SEQUENCE OF 19-30 AND 145-158;ENZYME ACTIVITY
6.
[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s)
Cited for : FUNCTION;CATALYTIC ACTIVITY;ENZYME REGULATION;COFACTOR;ACTIVE SITE;SUBCELLULAR LOCATION;MUTAGENESIS OF ASP-25;TISSUE SPECIFICITY
7.
[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s)
Cited for : IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS]
8.
"Structural genomics of protein phosphatases."
Almo S.C.
,
Bonanno J.B.
,
Sauder J.M.
,
Emtage S.
,
Dilorenzo T.P.
,
Malashkevich V.
,
Wasserman S.R.
,
Swaminathan S.
,
Eswaramoorthy S.
,
Agarwal R.
,
Kumaran D.
,
Madegowda M.
,
Ragumani S.
,
Patskovsky Y.
,
Alvarado J.
,
Ramagopal U.A.
,
Faber-Barata J.
,
Chance M.R.
,
Sali A.
,
Fiser A.
,
Zhang Z.Y.
,
Lawrence D.S.
,
Burley S.K.
more...
J. Struct. Funct. Genomics8:121-140(2007)
[
PubMed ]
[
Europe PMC ]
[
Abstract ]
[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s)
Cited for : X-RAY CRYSTALLOGRAPHY (1.72 ANGSTROMS) OF 2-296 IN COMPLEXES WITH PYRODOXAL PHOSPHATE; CALCIUM AND MAGNESIUM IONS