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Index > Protein center > PLSCR1(Gene name) > Human
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  • PLSCR1 (Gene name),
  • Phospholipid scramblase 1 (Protein name ),  PLS1_HUMAN from NCBI database.
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  • General Annotation
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  • Antigen Annotation
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  • 3D
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  • Predicted Eptitope
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  • Vaild Sequence
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  • Gene name:
    PLSCR1;
    Protein name:
    Phospholipid scramblase 1(PL scramblase 1);
    Alternative:
    Erythrocyte phospholipid scramblase;Ca(2+)-dependent phospholipid scramblase 1;MmTRA1b;
    Organism:
    Human (Homo sapiens). 
    General Annotation
    Sub Unit:
    Interacts with ABL.
    Function:
    May play a role in the antiviral response of interferon (IFN) by amplifying and enhancing the IFN response through increased expression of select subset of potent antiviral genes. May contribute to cytokine-regulated cell proliferation and differentiation.
    Subcellular Location:
    Membrane Single-pass type II membrane protein
    Protein Attributes:
    Sequence length:
    318
    Sequence:
    50:
    MDKQNSQMNA | SHPETNLPVG | YPPQYPPTAF | QGPPGYSGYP | GPQVSYPPPP | 
    100:
    AGHSGPGPAG | FPVPNQPVYN | QPVYNQPVGA | AGVPWMPAPQ | PPLNCPPGLE | 
    150:
    YLSQIDQILI | HQQIELLEVL | TGFETNNKYE | IKNSFGQRVY | FAAEDTDCCT | 
    200:
    RNCCGPSRPF | TLRIIDNMGQ | EVITLERPLR | CSSCCCPCCL | QEIEIQAPPG | 
    250:
    VPIGYVIQTW | HPCLPKFTIQ | NEKREDVLKI | SGPCVVCSCC | GDVDFEIKSL | 
    300:
    DEQCVVGKIS | KHWTGILREA | FTDADNFGIQ | FPLDLDVKMK | AVMIGACFLI | 
    318:
    DFMFFESTGS | QEQKSGVW
    3D Structure:
    N/A
    Predicted Eptitope:
    Please Sign in.
    EIAab Sequence  Vaild Sequence:
    Please Sign in.
    Related Databases
    String:
    Pfam:
    MIM:
    UniGene:
    KEGG:
    Uniprot:
     
    FOR
    ELISA Kit for Human PL scramblase 1
    Cat.:
    E1781h
    Price:
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    MSDS:
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    Packing:
    96T
    Range:
    Please sign in first.
    ELISA Kit for Human PL scramblase 1
    Cat.:
    E1781r
    Price:
    Please sign in first.
    MSDS:
    Please sign in first.
    Packing:
    96T
    ELISA Kit for Human PL scramblase 1
    Cat.:
    E1781m
    Price:
    Please sign in first.
    MSDS:
    Please sign in first.
    Packing:
    96T
    CLIA Kit for Human PL scramblase 1
    Cat.:
    U1781r
    Price:
    Please sign in first.
    MSDS:
    Please sign in first.
    Packing:
    96T
    CLIA Kit for Human PL scramblase 1
    Cat.:
    U1781h
    Price:
    Please sign in first.
    MSDS:
    Please sign in first.
    Packing:
    96T
    Range:
    Please sign in first.
    CLIA Kit for Human PL scramblase 1
    Cat.:
    U1781m
    Price:
    Please sign in first.
    MSDS:
    Please sign in first.
    Packing:
    96T
    Polyclonal Antibody for Human PL scramblase 1
    Cat.:
    P1781Rb-m
    Price:
    Please sign in first.
    Packing:
    40ug/0.2ml
    Polyclonal Antibody for Human PL scramblase 1
    Cat.:
    P1781Rb-h
    Price:
    Please sign in first.
    Packing:
    40ug/0.2ml
    Polyclonal Antibody for Human PL scramblase 1
    Cat.:
    P1781Rb-r
    Price:
    Please sign in first.
    Packing:
    40ug/0.2ml
    Monoclonal Antibody for Human PL scramblase 1
    Monoclonal Antibody for Human PL scramblase 1
    Monoclonal Antibody for Human PL scramblase 1
    Protein for Human PL scramblase 1
    Protein for Human PL scramblase 1
    Protein for Human PL scramblase 1

    R&D Technical Data
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    Precision
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    Recovery
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    Linearity
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    References
    1. 1.
      "Molecular cloning of human plasma membrane phospholipid scramblase. A protein mediating transbilayer movement of plasma membrane phospholipids."
      Zhou Q. , Zhao J. , Stout J.G. , Luhm R.A. , Wiedmer T. , Sims P.J.
      J. Biol. Chem.272:18240-18244(1997) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1);PROTEIN SEQUENCE OF 87-118
      tissue: Erythrocyte.
    2. 2.
      "Identity of human normal counterpart (MmTRA1b) of mouse leukemogenesis-associated gene (MmTRA1a) product as plasma membrane phospholipid scramblase and chromosome mapping of the human MmTRA1b/phospholipid scramblase gene."
      Kasukabe T. , Kobayashi H. , Kaneko Y. , Okabe-Kado J. , Honma Y.
      Biochem. Biophys. Res. Commun.249:449-455(1998) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1)
      tissue: Monocytic leukemia.
    3. 3.
      "Identification of three new members of the phospholipid scramblase gene family."
      Wiedmer T. , Zhou Q. , Kwoh D.Y. , Sims P.J.
      Biochim. Biophys. Acta1467:244-253(2000) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA]
    4. 4.
      "Complete sequencing and characterization of 21,243 full-length human cDNAs."
      Ota T. , Suzuki Y. , Nishikawa T. , Otsuki T. , Sugiyama T. , Irie R. , Wakamatsu A. , Hayashi K. , Sato H. , Nagai K. , Kimura K. , Makita H. , Sekine M. , Obayashi M. , Nishi T. , Shibahara T. , Tanaka T. , Ishii S. , more...
      Nat. Genet.36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORMS 1 AND 2)
      tissue: Kidney.
      tissue: Placenta.
    5. 5.
      "The DNA sequence, annotation and analysis of human chromosome 3."
      Muzny D.M. , Scherer S.E. , Kaul R. , Wang J. , Yu J. , Sudbrak R. , Buhay C.J. , Chen R. , Cree A. , Ding Y. , Dugan-Rocha S. , Gill R. , Gunaratne P. , Harris R.A. , Hawes A.C. , Hernandez J. , Hodgson A.V. , Hume J. , more...
      Nature440:1194-1198(2006) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]
    6. 6.
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]
    7. 7.
      "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
      The MGC Project Team
      Genome Res.14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1)
      tissue: Colon.
      tissue: Uterus.
    8. 8.
      "Isolation of an erythrocyte membrane protein that mediates Ca2+-dependent transbilayer movement of phospholipid."
      Basse F. , Stout J.G. , Sims P.J. , Wiedmer T.
      J. Biol. Chem.271:17205-17210(1996) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: CHARACTERIZATION;FUNCTION
      tissue: Erythrocyte.
    9. 9.
      "Regulation of phospholipid scramblase activity during apoptosis and cell activation by protein kinase Cdelta."
      Frasch S.C. , Henson P.M. , Kailey J.M. , Richter D.A. , Janes M.S. , Fadok V.A. , Bratton D.L.
      J. Biol. Chem.275:23065-23073(2000) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: PHOSPHORYLATION AT THR-161;MUTAGENESIS
    10. 10.
      "c-Abl tyrosine kinase binds and phosphorylates phospholipid scramblase 1."
      Sun J. , Zhao J. , Schwartz M.A. , Wang J.Y. , Wiedmer T. , Sims P.J.
      J. Biol. Chem.276:28984-28990(2001) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: PHOSPHORYLATION AT TYR-69 AND TYR-74;MUTAGENESIS
    11. 11.
      "Palmitoylation of phospholipid scramblase is required for normal function in promoting Ca2+-activated transbilayer movement of membrane phospholipids."
      Zhao J. , Zhou Q. , Wiedmer T. , Sims P.J.
      Biochemistry37:6361-6366(1998) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: PALMITOYLATION
    12. 12.
      "Identity of a conserved motif in phospholipid scramblase that is required for Ca2+-accelerated transbilayer movement of membrane phospholipids."
      Zhou Q. , Sims P.J. , Wiedmer T.
      Biochemistry37:2356-2360(1998) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: MUTAGENESIS
    13. 13.
      "Palmitoylation of phospholipid scramblase 1 controls its distribution between nucleus and plasma membrane."
      Wiedmer T. , Zhao J. , Nanjundan M. , Sims P.J.
      Biochemistry42:1227-1233(2003) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: SUBCELLULAR LOCATION;PALMITOYLATION;MUTAGENESIS OF 184-CYS--CYS-189
    14. 14.
      "Phospholipid scramblase 1 potentiates the antiviral activity of interferon."
      Dong B. , Zhou Q. , Zhao J. , Zhou A. , Harty R.N. , Bose S. , Banerjee A. , Slee R. , Guenther J. , Williams B.R.G. , Wiedmer T. , Sims P.J. , Silverman R.H.
      J. Virol.78:8983-8993(2004) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: FUNCTION;INDUCTION
    15. 15.
      "Phospholipid scramblase 1 binds to the promoter region of the inositol 1,4,5-triphosphate receptor type 1 gene to enhance its expression."
      Zhou Q. , Ben-Efraim I. , Bigcas J.L. , Junqueira D. , Wiedmer T. , Sims P.J.
      J. Biol. Chem.280:35062-35068(2005) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: SUBCELLULAR LOCATION;DNA-BINDING
    16. 16.
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS]
    17. 17.
      "N-terminal proline-rich domain is required for scrambling activity of human phospholipid scramblases."
      Rayala S. , Francis V.G. , Sivagnanam U. , Gummadi S.N.
      J. Biol. Chem.289:13206-13218(2014) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: FUNCTION;PROLINE-RICH DOMAIN;SUBCELLULAR LOCATION
    18. 18.
      "Phospholipid scramblase 1 contains a nonclassical nuclear localization signal with unique binding site in importin alpha."
      Chen M.H. , Ben-Efraim I. , Mitrousis G. , Walker-Kopp N. , Sims P.J. , Cingolani G.
      J. Biol. Chem.280:10599-10606(2005) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: X-RAY CRYSTALLOGRAPHY (2.2 ANGSTROMS) OF 257-266 IN COMPLEX WITH MOUSE KPNA2;NUCLEAR LOCALIZATION SIGNAL;MUTAGENESIS OF 184-CYS--CYS-189
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