Protein name:
Podocin ;
Alternative:
Organism:
Human (Homo sapiens).
General Annotation
Sub Unit:
Interacts with nephrin/NPHS1 and KIRREL. Interacts directly with CD2AP. Interacts with DDN.
Function:
Plays a role in the regulation of glomerular permeability, acting probably as a linker between the plasma membrane and the cytoskeleton.
Subcellular Location:
Cell membrane
Peripheral membrane protein
Protein Attributes:
50:
MERRARSSSR | ESRGRGGRTP | HKENKRAKAE | RSGGGRGRQE | AGPEPSGSGR |
100:
AGTPGEPRAP | AATVVDVDEV | RGSGEEGTEV | VALLESERPE | EGTKSSGLGA |
150:
CEWLLVLISL | LFIIMTFPFS | IWFCVKVVQE | YERVIIFRLG | HLLPGRAKGP |
200:
GLFFFLPCLD | TYHKVDLRLQ | TLEIPFHEIV | TKDMFIMEID | AICYYRMENA |
250:
SLLLSSLAHV | SKAVQFLVQT | TMKRLLAHRS | LTEILLERKS | IAQDAKVALD |
300:
SVTCIWGIKV | ERIEIKDVRL | PAGLQHSLAV | EAEAQRQAKV | RMIAAEAEKA |
350:
ASESLRMAAE | ILSGTPAAVQ | LRYLHTLQSL | STEKPSTVVL | PLPFDLLNCL |
383:
SSPSNRTQGS | LPFPSPSKPV | EPLNPKKKDS | PML
Vaild Sequence:
Related Databases
Uniprot:
ELISA Kit
CLIA Kit
Polyclonal Antibody
Monoclonal Antibody
Protein
FOR
Human
Mouse
Rat
ELISA Kit for Human Podocin
ELISA Kit for Human Podocin
ELISA Kit for Human Podocin
CLIA Kit for Human Podocin
CLIA Kit for Human Podocin
CLIA Kit for Human Podocin
Polyclonal Antibody for Human Podocin
Polyclonal Antibody for Human Podocin
Polyclonal Antibody for Human Podocin
Monoclonal Antibody for Human Podocin
Monoclonal Antibody for Human Podocin
Monoclonal Antibody for Human Podocin
Protein for Human Podocin
Protein for Human Podocin
Protein for Human Podocin
R&D Technical Data
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Precision
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Recovery
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Linearity
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References
1.
"NPHS2, encoding the glomerular protein podocin, is mutated in autosomal recessive steroid-resistant nephrotic syndrome."
Boute N.
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Gribouval O.
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Roselli S.
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Lee H.
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[
PubMed ]
[
Europe PMC ]
[
Abstract ]
[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s)
Cited for : NUCLEOTIDE SEQUENCE [GENOMIC DNA / MRNA] (ISOFORM 1);VARIANTS NPHS2 RP CYS-92; GLN-138; GLY-160; MET-180 AND TRP-291;VARIANT LEU-20
tissue :
Kidney .
2.
[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s)
Cited for : ERRATUM
3.
"The DNA sequence and biological annotation of human chromosome 1."
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more...
Nature441:315-321(2006)
[
PubMed ]
[
Europe PMC ]
[
Abstract ]
[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s)
Cited for : NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]
4.
Mural R.J.
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Istrail S.
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Sutton G.G.
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Florea L.
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more...
Submitted (2005-07) to the EMBL/GenBank/DDBJ databases
[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s)
Cited for : NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]
5.
[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s)
Cited for : NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 2)
tissue :
Colon .
tissue :
Kidney .
6.
[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s)
Cited for : INTERACTION WITH NPHS1
7.
[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s)
Cited for : ALTERNATIVE SPLICING (ISOFORM 2);SUBCELLULAR LOCATION (ISOFORM 2);GLYCOSYLATION (ISOFORM 2)
tissue :
Kidney .
8.
"NPHS2 mutations in late-onset focal segmental glomerulosclerosis: R229Q is a common disease-associated allele."
Tsukaguchi H.
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Sudhakar A.
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Le T.C.
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Nguyen T.
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Yao J.
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Schwimmer J.A.
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Schachter A.D.
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Poch E.
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Abreu P.F.
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Appel G.B.
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Kalluri R.
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Pollak M.R.
J. Clin. Invest.110:1659-1666(2002)
[
PubMed ]
[
Europe PMC ]
[
Abstract ]
[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s)
Cited for : VARIANT GLN-229;ASSOCIATION OF VARIANT GLN-229 WITH NPHS2
9.
"NPHS2 mutations in sporadic steroid-resistant nephrotic syndrome in Japanese children."
Maruyama K.
,
Iijima K.
,
Ikeda M.
,
Kitamura A.
,
Tsukaguchi H.
,
Yoshiya K.
,
Hoshii S.
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Wada N.
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Uemura O.
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Satomura K.
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Honda M.
,
Yoshikawa N.
Pediatr. Nephrol.18:412-416(2003)
[
PubMed ]
[
Europe PMC ]
[
Abstract ]
[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s)
Cited for : VARIANT GLU-34
10.
[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s)
Cited for : VARIANTS NPHS2 THR-29; LEU-118; CYS-168; HIS-168; SER-168; VAL-172; THR-208; 236-LEU--ARG-238 DEL; SER-238 AND GLU-260;VARIANTS VAL-61; GLN-237 AND VAL-242
11.
[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s)
Cited for : VARIANTS ALA-44 AND VAL-61
12.
"Disruption of PTPRO causes childhood-onset nephrotic syndrome."
Ozaltin F.
,
Ibsirlioglu T.
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Taskiran E.Z.
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Baydar D.E.
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Kaymaz F.
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Buyukcelik M.
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Am. J. Hum. Genet.89:139-147(2011)
[
PubMed ]
[
Europe PMC ]
[
Abstract ]
[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s)
Cited for : VARIANT GLN-229
13.
"Clinical value of NPHS2 analysis in early- and adult-onset steroid-resistant nephrotic syndrome."
Santin S.
,
Tazon-Vega B.
,
Silva I.
,
Cobo M.A.
,
Gimenez I.
,
Ruiz P.
,
Garcia-Maset R.
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Bernis C.
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Morales San Jose M.D.
,
Pintos G.
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Sala P.
,
Raspall F.
,
Vila A.
,
Daza M.
,
Vazquez M.
,
Ecija L.
,
Espinosa M.
,
Poveda R.
,
Mirapeix E.
,
Vallejo G.
,
Aparicio C.
,
Rosell J.
,
de Sotto D.
,
Muley R.
,
Montenegro J.
,
Gonzalez D.
,
Barajas de Frutos D.
,
Trillo E.
,
Gainza de los Rios F.J.
,
Justa M.L.
,
Hidalgo-Barquero E.
more...
Clin. J. Am. Soc. Nephrol.6:344-354(2011)
[
PubMed ]
[
Europe PMC ]
[
Abstract ]
[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s)
Cited for : VARIANTS NPHS2 PRO-116; ILE-187; ILE-221 AND ALA-281;VARIANT GLN-264
14.
"NPHS2 p.V290M mutation in late-onset steroid-resistant nephrotic syndrome."
Kerti A.
,
Csohany R.
,
Szabo A.
,
Arkossy O.
,
Sallay P.
,
Moriniere V.
,
Vega-Warner V.
,
Nyiro G.
,
Lakatos O.
,
Szabo T.
,
Lipska B.S.
,
Schaefer F.
,
Antignac C.
,
Reusz G.
,
Tulassay T.
,
Tory K.
Pediatr. Nephrol.28:751-757(2013)
[
PubMed ]
[
Europe PMC ]
[
Abstract ]
[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s)
Cited for : VARIANTS NPHS2 GLN-138 AND MET-290
15.
[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s)
Cited for : VARIANT GLN-229;POSSIBLE ROLE AS DISEASE MODIFIER IN NPHS2
16.
"NPHS2 mutations in steroid-resistant nephrotic syndrome: a mutation update and the associated phenotypic spectrum."
Bouchireb K.
,
Boyer O.
,
Gribouval O.
,
Nevo F.
,
Huynh-Cong E.
,
Moriniere V.
,
Campait R.
,
Ars E.
,
Brackman D.
,
Dantal J.
,
Eckart P.
,
Gigante M.
,
Lipska B.S.
,
Liutkus A.
,
Megarbane A.
,
Mohsin N.
,
Ozaltin F.
,
Saleem M.A.
,
Schaefer F.
,
Soulami K.
,
Torra R.
,
Garcelon N.
,
Mollet G.
,
Dahan K.
,
Antignac C.
more...
Hum. Mutat.35:178-186(2014)
[
PubMed ]
[
Europe PMC ]
[
Abstract ]
[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s)
Cited for : VARIANTS NPHS2 SER-97; PRO-107; SER-122; VAL-175; TYR-183; LYS-281; LYS-296; VAL-309; ILE-315 AND GLY-333;VARIANTS LEU-20; GLN-237 AND GLN-264
17.
"Mutation-dependent recessive inheritance of NPHS2-associated steroid-resistant nephrotic syndrome."
Tory K.
,
Menyhard D.K.
,
Woerner S.
,
Nevo F.
,
Gribouval O.
,
Kerti A.
,
Straner P.
,
Arrondel C.
,
Cong E.H.
,
Tulassay T.
,
Mollet G.
,
Perczel A.
,
Antignac C.
Nat. Genet.46:299-304(2014)
[
PubMed ]
[
Europe PMC ]
[
Abstract ]
[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s)
Cited for : VARIANT GLN-229;ASSOCIATION OF VARIANT GLN-229 WITH NPHS2