Protein name:
Serum paraoxonase/arylesterase 1 (PON 1) ;
Alternative:
K-45 ;Aromatic esterase 1 (A-esterase 1) ;Serum aryldialkylphosphatase 1 ;
Organism:
Human (Homo sapiens).
General Annotation
Sub Unit:
Homodimer. Heterooligomer with phosphate-binding protein (HPBP). Interacts with CLU.
Function:
Hydrolyzes the toxic metabolites of a variety of organophosphorus insecticides. Capable of hydrolyzing a broad spectrum of organophosphate substrates and lactones, and a number of aromatic carboxylic acid esters. Mediates an enzymatic protection of low density lipoproteins against oxidative modification and the consequent series of events leading to atheroma formation.
Subcellular Location:
Secreted
extracellular space
Protein Attributes:
50:
MAKLIALTLL | GMGLALFRNH | QSSYQTRLNA | LREVQPVELP | NCNLVKGIET |
100:
GSEDLEILPN | GLAFISSGLK | YPGIKSFNPN | SPGKILLMDL | NEEDPTVLEL |
150:
GITGSKFDVS | SFNPHGISTF | TDEDNAMYLL | VVNHPDAKST | VELFKFQEEE |
200:
KSLLHLKTIR | HKLLPNLNDI | VAVGPEHFYG | TNDHYFLDPY | LQSWEMYLGL |
250:
AWSYVVYYSP | SEVRVVAEGF | DFANGINISP | DGKYVYIAEL | LAHKIHVYEK |
300:
HANWTLTPLK | SLDFNTLVDN | ISVDPETGDL | WVGCHPNGMK | IFFYDSENPP |
350:
ASEVLRIQNI | LTEEPKVTQV | YAENGTVLQG | STVASVYKGK | LLIGTVFHKA |
Vaild Sequence:
Related Databases
Uniprot:
ELISA Kit
CLIA Kit
Polyclonal Antibody
Monoclonal Antibody
Protein
FOR
Rat
Human
Mouse
Rabbit
ELISA Kit for Human PON 1
ELISA Kit for Human PON 1
ELISA Kit for Human PON 1
ELISA Kit for Human PON 1
Polyclonal Antibody for Human PON 1
Polyclonal Antibody for Human PON 1
Polyclonal Antibody for Human PON 1
Polyclonal Antibody for Human PON 1
Monoclonal Antibody for Human PON 1
Monoclonal Antibody for Human PON 1
Monoclonal Antibody for Human PON 1
Monoclonal Antibody for Human PON 1
R&D Technical Data
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Precision
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Recovery
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Linearity
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Citations
[1].
Ramadan R· Tawdy A · Abdel Hay R · Rashed L · Tawfik D
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Submitted (2005-09) to the EMBL/GenBank/DDBJ databases
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[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s)
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Brain .
13.
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Cited for : PROTEIN SEQUENCE OF 2-21;TISSUE SPECIFICITY
14.
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Cited for : PROTEIN SEQUENCE OF 2-21; 234-244; 291-305 AND 350-355;INTERACTION WITH CLU;TISSUE SPECIFICITY;DISULFIDE BOND
tissue :
Plasma .
15.
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Cited for : PROTEIN SEQUENCE OF 2-11;CATALYTIC ACTIVITY
16.
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Cited for : CATALYTIC ACTIVITY
17.
[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s)
Cited for : MUTAGENESIS OF CYS-284
18.
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Cited for : MUTAGENESIS OF 20-HIS-GLN-21;FUNCTION OF THE UNCLEAVED SIGNAL PEPTIDE
19.
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Cited for : GLYCOSYLATION [LARGE SCALE ANALYSIS] AT ASN-253
tissue :
Plasma .
20.
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Cited for : FUNCTION;CATALYTIC ACTIVITY;SUBUNIT
21.
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Cited for : GLYCOSYLATION [LARGE SCALE ANALYSIS] AT ASN-227; ASN-253 AND ASN-324
tissue :
Plasma .
22.
"Serendipitous discovery and X-ray structure of a human phosphate binding apolipoprotein."
Morales R.
,
Berna A.
,
Carpentier P.
,
Contreras-Martel C.
,
Renault F.
,
Nicodeme M.
,
Chesne-Seck M.-L.
,
Bernier F.
,
Dupuy J.
,
Schaeffer C.
,
Diemer H.
,
van Dorsselaer A.
,
Fontecilla-Camps J.C.
,
Masson P.
,
Rochu D.
,
Chabriere E.
Structure14:601-609(2006)
[
PubMed ]
[
Europe PMC ]
[
Abstract ]
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Cited for : INTERACTION WITH HPBP
23.
[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s)
Cited for : GLYCOSYLATION [LARGE SCALE ANALYSIS] AT ASN-253 AND ASN-324
tissue :
Liver .
24.
"Structure and evolution of the serum paraoxonase family of detoxifying and anti-atherosclerotic enzymes."
Harel M.
,
Aharoni A.
,
Gaidukov L.
,
Brumshtein B.
,
Khersonsky O.
,
Meged R.
,
Dvir H.
,
Ravelli R.B.G.
,
McCarthy A.
,
Toker L.
,
Silman I.
,
Sussman J.L.
,
Tawfik D.S.
Nat. Struct. Mol. Biol.11:412-419(2004)
[
PubMed ]
[
Europe PMC ]
[
Abstract ]
[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s)
Cited for : X-RAY CRYSTALLOGRAPHY (2.2 ANGSTROMS) IN COMPLEX WITH CALCIUM IONS;MUTAGENESIS OF HIS-115 AND HIS-134;CATALYTIC ACTIVITY;DISULFIDE BOND
25.
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Cited for : VARIANT ARG-192
26.
[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s)
Cited for : ASSOCIATION WITH DIABETIC RETINOPATHY SUSCEPTIBILITY
27.
"New paraoxonase 1 polymorphism I102V and the risk of prostate cancer in Finnish men."
Marchesani M.
,
Hakkarainen A.
,
Tuomainen T.P.
,
Kaikkonen J.
,
Pukkala E.
,
Uimari P.
,
Seppala E.
,
Matikainen M.
,
Kallioniemi O.-P.
,
Schleutker J.
,
Lehtimaki T.
,
Salonen J.T.
J. Natl. Cancer Inst.95:812-818(2003)
[
PubMed ]
[
Europe PMC ]
[
Abstract ]
[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s)
Cited for : VARIANT VAL-102
28.
"DNA sequencing of a cytogenetically normal acute myeloid leukaemia genome."
Ley T.J.
,
Mardis E.R.
,
Ding L.
,
Fulton B.
,
McLellan M.D.
,
Chen K.
,
Dooling D.
,
Dunford-Shore B.H.
,
McGrath S.
,
Hickenbotham M.
,
Cook L.
,
Abbott R.
,
Larson D.E.
,
Koboldt D.C.
,
Pohl C.
,
Smith S.
,
Hawkins A.
,
Abbott S.
,
Locke D.
,
Hillier L.W.
,
Miner T.
,
Fulton L.
,
Magrini V.
,
Wylie T.
,
Glasscock J.
,
Conyers J.
,
Sander N.
,
Shi X.
,
Osborne J.R.
,
Minx P.
,
Gordon D.
,
Chinwalla A.
,
Zhao Y.
,
Ries R.E.
,
Payton J.E.
,
Westervelt P.
,
Tomasson M.H.
,
Watson M.
,
Baty J.
,
Ivanovich J.
,
Heath S.
,
Shannon W.D.
,
Nagarajan R.
,
Walter M.J.
,
Link D.C.
,
Graubert T.A.
,
DiPersio J.F.
,
Wilson R.K.
more...
Nature456:66-72(2008)
[
PubMed ]
[
Europe PMC ]
[
Abstract ]
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Cited for : VARIANT [LARGE SCALE ANALYSIS] ARG-192