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Index > Protein center > PON3(Gene name) > Human
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  • PON3 (Gene name),
  • Serum paraoxonase/lactonase 3 (Protein name ),  PON3_HUMAN from NCBI database.
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  • General Annotation
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  • Antigen Annotation
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  • 3D
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  • Predicted Eptitope
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  • Vaild Sequence
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  • Gene name:
    PON3;
    Protein name:
    Serum paraoxonase/lactonase 3;
    Alternative:

    Organism:
    Human (Homo sapiens). 
    General Annotation
    Sub Unit:
    Homodimer.
    Function:
    Has low activity towards the organophosphate paraxon and aromatic carboxylic acid esters. Rapidly hydrolyzes lactones such as statin prodrugs (e.g. lovastatin). Hydrolyzes aromatic lactones and 5- or 6-member ring lactones with aliphatic substituents but not simple lactones or those with polar substituents.
    Subcellular Location:
    Secreted extracellular space
    Protein Attributes:
    Sequence length:
    354
    Sequence:
    50:
    MGKLVALVLL | GVGLSLVGEM | FLAFRERVNA | SREVEPVEPE | NCHLIEELES | 
    100:
    GSEDIDILPS | GLAFISSGLK | YPGMPNFAPD | EPGKIFLMDL | NEQNPRAQAL | 
    150:
    EISGGFDKEL | FNPHGISIFI | DKDNTVYLYV | VNHPHMKSTV | EIFKFEEQQR | 
    200:
    SLVYLKTIKH | ELLKSVNDIV | VLGPEQFYAT | RDHYFTNSLL | SFFEMILDLR | 
    250:
    WTYVLFYSPR | EVKVVAKGFC | SANGITVSAD | QKYVYVADVA | AKNIHIMEKH | 
    300:
    DNWDLTQLKV | IQLGTLVDNL | TVDPATGDIL | AGCHPNPMKL | LNYNPEDPPG | 
    350:
    SEVLRIQNVL | SEKPRVSTVY | ANNGSVLQGT | SVASVYHGKI | LIGTVFHKTL | 
    354:
    YCEL
    3D Structure:
    N/A
    Predicted Eptitope:
    Please Sign in.
    EIAab Sequence  Vaild Sequence:
    Please Sign in.
    Related Databases
    UniGene:
    Pfam:
    KEGG:
    MIM:
    SMR:
    String:
    Uniprot:
     
    FOR
    ELISA Kit for Human Serum paraoxonase/lactonase 3
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    E10065h
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    ELISA Kit for Human Serum paraoxonase/lactonase 3
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    E10065m
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    Packing:
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    ELISA Kit for Human Serum paraoxonase/lactonase 3
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    E10065r
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    ELISA Kit for Human Serum paraoxonase/lactonase 3
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    CLIA Kit for Human Serum paraoxonase/lactonase 3
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    U10065r
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    Packing:
    96T
    CLIA Kit for Human Serum paraoxonase/lactonase 3
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    U10065h
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    MSDS:
    Please sign in first.
    Packing:
    96T
    Range:
    Please sign in first.
    CLIA Kit for Human Serum paraoxonase/lactonase 3
    MSDS:
    Please sign in first.
    CLIA Kit for Human Serum paraoxonase/lactonase 3
    Cat.:
    U10065m
    Price:
    Please sign in first.
    MSDS:
    Please sign in first.
    Packing:
    96T
    Polyclonal Antibody for Human Serum paraoxonase/lactonase 3
    Cat.:
    P10065Rb-h
    Price:
    Please sign in first.
    Packing:
    40ug/0.2ml
    Polyclonal Antibody for Human Serum paraoxonase/lactonase 3
    Polyclonal Antibody for Human Serum paraoxonase/lactonase 3
    Polyclonal Antibody for Human Serum paraoxonase/lactonase 3
    Monoclonal Antibody for Human Serum paraoxonase/lactonase 3
    Monoclonal Antibody for Human Serum paraoxonase/lactonase 3
    Monoclonal Antibody for Human Serum paraoxonase/lactonase 3
    Monoclonal Antibody for Human Serum paraoxonase/lactonase 3
    Protein for Human Serum paraoxonase/lactonase 3
    Protein for Human Serum paraoxonase/lactonase 3
    Protein for Human Serum paraoxonase/lactonase 3
    Protein for Human Serum paraoxonase/lactonase 3

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    Linearity
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    References
    1. 1.
      "Human paraoxanase-3 is an HDL-associated enzyme."
      Reddy S.T. , Wadleigh D.J. , Grijalva V. , Ng C. , Hama S. , Gangopadhyay A. , Khorsan R. , Shih D. , Lusis A.J. , Navab M. , Fogelman A.M.
      Submitted (2000-11) to the EMBL/GenBank/DDBJ databases
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [MRNA]
      tissue: Hepatoma.
    2. 2.
      "Human PON3 has lactonase activity."
      Draganov D.I. , Watson C.E.
      Submitted (2000-12) to the EMBL/GenBank/DDBJ databases
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [MRNA]
      tissue: Liver.
    3. 3.
      SeattleSNPs variation discovery resource
      Submitted (2004-11) to the EMBL/GenBank/DDBJ databases
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA];VARIANTS LYS-146 AND ASP-179
    4. 5.
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]
    5. 6.
      "The DNA sequence of human chromosome 7."
      Hillier L.W. , Fulton R.S. , Fulton L.A. , Graves T.A. , Pepin K.H. , Wagner-McPherson C. , Layman D. , Maas J. , Jaeger S. , Walker R. , Wylie K. , Sekhon M. , Becker M.C. , O'Laughlin M.D. , Schaller M.E. , Fewell G.A. , Delehaunty K.D. , Miner T.L. , more...
      Nature424:157-164(2003) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]
    6. 7.
      "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
      The MGC Project Team
      Genome Res.14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA]
      tissue: Liver.
    7. 8.
      "The human serum paraoxonase/arylesterase gene (PON1) is one member of a multigene family."
      Primo-Parmo S.L. , Sorenson R.C. , Teiber J. , La Du B.N.
      Genomics33:498-507(1996) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [MRNA] OF 14-354
      tissue: Liver.
    8. 9.
      "Human paraoxonases (PON1, PON2, and PON3) are lactonases with overlapping and distinct substrate specificities."
      Draganov D.I. , Teiber J.F. , Speelman A. , Osawa Y. , Sunahara R. , La Du B.N.
      J. Lipid Res.46:1239-1247(2005) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: FUNCTION;CATALYTIC ACTIVITY;SUBUNIT
    9. 10.
      "Human plasma N-glycoproteome analysis by immunoaffinity subtraction, hydrazide chemistry, and mass spectrometry."
      Liu T. , Qian W.-J. , Gritsenko M.A. , Camp D.G. II , Monroe M.E. , Moore R.J. , Smith R.D.
      J. Proteome Res.4:2070-2080(2005) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: GLYCOSYLATION [LARGE SCALE ANALYSIS] AT ASN-323
      tissue: Plasma.
    10. 11.
      "Quantitative phosphoproteomic analysis of T cell receptor signaling reveals system-wide modulation of protein-protein interactions."
      Mayya V. , Lundgren D.H. , Hwang S.-I. , Rezaul K. , Wu L. , Eng J.K. , Rodionov V. , Han D.K.
      Sci. Signal.2:RA46-RA46(2009) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-165;IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS]
      tissue: Leukemic T-cell.
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