ACPP ELISA Kit for Human(Homo sapiens) | EIAab.comACPP ELISA Kit for Human(Homo sapiens)

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Index > Protein center > ACPP(Gene name) > Human

ACPP (Gene name),

Prostatic acid phosphatase (Protein name ), PPAP_HUMAN from NCBI database.

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General Annotation

Antigen Annotation

Predicted Eptitope

Vaild Sequence

Related Databases

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Gene name:

ACPP;

Protein name:

Prostatic acid phosphatase(PAP);

Alternative:

Ecto-5'-nucleotidase;3.1.3.5;5'-nucleotidase(5'-NT);Thiamine monophosphatase(TMPase);

Organism:

Human (Homo sapiens).

General Annotation

Sub Unit:

Homodimer; dimer formation is required for phosphatase activity.

Function:

Isoform 2: the cellular form also has ecto-5'-nucleotidase activity in dorsal root ganglion (DRG) neurons. Generates adenosine from AMP which acts as a pain suppressor. Acts as a tumor suppressor of prostate cancer through dephosphorylation of ERBB2 and deactivation of MAPK-mediated signaling.

Subcellular Location:

Isoform 2 Cell membrane Single-pass type I membrane protein Lysosome membrane Single-pass type I membrane protein Appears to shuttle between the cell membrane and intracellular vesicles. Colocalizes with FLOT1 at cell membrane and in intracellular vesicles. Colocalizes with LAMP2 on the lysosome membrane.

Protein Attributes:

Sequence length:

386

Sequence:

50:

100:

150:

200:

250:

300:

350:

386:

CPLERFAELV | GPVIPQDWST | ECMTTNSHQG | TEDSTD

3D Structure:

N/A

Predicted Eptitope:

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Vaild Sequence:

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Related Databases

Pfam:

PF00328

SMR:

P15309

UniGene:

Hs.433060

String:

P15309

KEGG:

hsa:55

STRING:

9606.ENSP00000323036

MIM:

171790

Uniprot:

P15309

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ELISA Kit for Human PAP

Cat.:

E0168r

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96T

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ELISA Kit for Human PAP

Cat.:

E0168h

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96T

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ELISA Kit for Human PAP

Cat.:

E0168m

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96T

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ELISA Kit for Human PAP

Cat.:

E0168b

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96T

CLIA Kit for Human PAP

Cat.:

U0168b

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Packing:

96T

CLIA Kit for Human PAP

Cat.:

U0168r

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Manual:

Looking for manual.

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Packing:

96T

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CLIA Kit for Human PAP

Cat.:

U0168m

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MSDS:

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Packing:

96T

CLIA Kit for Human PAP

Cat.:

U0168h

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96T

Polyclonal Antibody for Human PAP

Cat.:

P0168Rb-m

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Packing:

40ug/0.2ml

Polyclonal Antibody for Human PAP

Cat.:

P0168Rb-r

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40ug/0.2ml

Polyclonal Antibody for Human PAP

Cat.:

P0168Rb-h

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40ug/0.2ml

Monoclonal Antibody for Human PAP

Protein for Human PAP

R&D Technical Data

For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.

Precision

For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.

Recovery

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Linearity

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References

1.

"Structure of human prostatic acid phosphatase gene."
Sharief F.S. , Li S.S.-L.
Biochem. Biophys. Res. Commun.184:1468-1476(1992) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA] (ISOFORM 1)
2.

"Covalent structure, disulfide bonding, and identification of reactive surface and active site residues of human prostatic acid phosphatase."
van Etten R.L. , Davidson R. , Stevis P.E. , Macarthur H. , Moore D.L.
J. Biol. Chem.266:2313-2319(1991) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1);PARTIAL PROTEIN SEQUENCE;DISULFIDE BONDS;ACTIVE SITE
3.

"Human prostatic acid phosphatase: cDNA cloning, gene mapping and protein sequence homology with lysosomal acid phosphatase."
Sharief F.S. , Lee H. , Leuderman M.M. , Lundwall A. , Deaven L.L. , Lee C.-L. , Li S.S.-L.
Biochem. Biophys. Res. Commun.160:79-86(1989) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1)
4.

"Molecular cloning and sequence analysis of cDNA encoding human prostatic acid phosphatase."
Vihko P. , Virkkunen P. , Henttu P. , Roiko K. , Solin T. , Huhtala M.L.
FEBS Lett.236:275-281(1988) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1);PARTIAL PROTEIN SEQUENCE
tissue: Prostate.
5.

"Nucleotide sequence of human prostatic acid phosphatase determined from a full-length cDNA clone."
Tailor P.G. , Govindan M.V. , Patel P.C.
Nucleic Acids Res.18:4928-4928(1990) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1)
tissue: Prostate.
6.

"Nucleotide sequence of human prostatic acid phosphatase ACPP gene, including seven Alu repeats."
Sharief F.S. , Li S.S.-L.
Biochem. Mol. Biol. Int.33:561-565(1994) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA] (ISOFORM 1)
7.

"Acid phosphatase prostate mRNA,nirs splice variant1."
Sameshima E. , Tabata Y. , Hayashi A. , Iida K. , Mitsuyama M. , Kanai S. , Furuya T. , Saito T.
Submitted (2003-02) to the EMBL/GenBank/DDBJ databases

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 3)
8.

"Complete sequencing and characterization of 21,243 full-length human cDNAs."
Ota T. , Suzuki Y. , Nishikawa T. , Otsuki T. , Sugiyama T. , Irie R. , Wakamatsu A. , Hayashi K. , Sato H. , Nagai K. , Kimura K. , Makita H. , Sekine M. , Obayashi M. , Nishi T. , Shibahara T. , Tanaka T. , Ishii S. , more...
Nat. Genet.36:40-45(2004) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 3)
tissue: Prostate.
9.

"The DNA sequence, annotation and analysis of human chromosome 3."
Muzny D.M. , Scherer S.E. , Kaul R. , Wang J. , Yu J. , Sudbrak R. , Buhay C.J. , Chen R. , Cree A. , Ding Y. , Dugan-Rocha S. , Gill R. , Gunaratne P. , Harris R.A. , Hawes A.C. , Hernandez J. , Hodgson A.V. , Hume J. , more...
Nature440:1194-1198(2006) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]
10.

Mural R.J. , Istrail S. , Sutton G.G. , Florea L. , Halpern A.L. , Mobarry C.M. , Lippert R. , Walenz B. , Shatkay H. , Dew I. , Miller J.R. , Flanigan M.J. , Edwards N.J. , Bolanos R. , Fasulo D. , Halldorsson B.V. , Hannenhalli S. , Turner R. , more...
Submitted (2005-09) to the EMBL/GenBank/DDBJ databases

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]
11.

"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
The MGC Project Team
Genome Res.14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORMS 1 AND 2);VARIANTS ASN-15; VAL-124; ARG-226; HIS-330 AND ALA-360
tissue: Prostate.
12.

"Structures of the carbohydrate moieties of human prostatic acid phosphatase elucidated by H1 nuclear magnetic resonance spectroscopy."
Risley J.M. , Van Etten R.L.
Arch. Biochem. Biophys.258:404-412(1987) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: STRUCTURE OF CARBOHYDRATES
13.

"Covalent modification and site-directed mutagenesis of an active site tryptophan of human prostatic acid phosphatase."
Zhang Z. , Ostanin K. , Van Etten R.L.
Acta Biochim. Pol.44:659-672(1997) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: IDENTIFICATION BY MASS SPECTROMETRY;ENZYME REGULATION;MUTAGENESIS OF TRP-206
14.

"Prostatic acid phosphatase degrades lysophosphatidic acid in seminal plasma."
Tanaka M. , Kishi Y. , Takanezawa Y. , Kakehi Y. , Aoki J. , Arai H.
FEBS Lett.571:197-204(2004) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: FUNCTION;ENZYME ACTIVITY
15.

"Prostatic acid phosphatase is not a prostate specific target."
Quintero I.B. , Araujo C.L. , Pulkka A.E. , Wirkkala R.S. , Herrala A.M. , Eskelinen E.-L. , Jokitalo E. , Hellstroem P.A. , Tuominen H.J. , Hirvikoski P.P. , Vihko P.T.
Cancer Res.67:6549-6554(2007) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: ALTERNATIVE SPLICING;SUBCELLULAR LOCATION;TISSUE SPECIFICITY
16.

"Semen-derived amyloid fibrils drastically enhance HIV infection."
Munch J. , Rucker E. , Standker L. , Adermann K. , Goffinet C. , Schindler M. , Wildum S. , Chinnadurai R. , Rajan D. , Specht A. , Gimenez-Gallego G. , Sanchez P.C. , Fowler D.M. , Koulov A. , Kelly J.W. , Mothes W. , Grivel J.C. , Margolis L. , more...
Cell131:1059-1071(2007) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: PROTEOLYTIC PROCESSING;IDENTIFICATION BY MASS SPECTROMETRY;ROLE IN HIV INFECTION
17.

"Integral and associated lysosomal membrane proteins."
Schroeder B. , Wrocklage C. , Pan C. , Jaeger R. , Koesters B. , Schaefer H. , Elsaesser H.-P. , Mann M. , Hasilik A.
Traffic8:1676-1686(2007) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: SUBCELLULAR LOCATION [LARGE SCALE ANALYSIS]
tissue: Placenta.
18.

"Fibrils of prostatic acid phosphatase fragments boost infections with XMRV (xenotropic murine leukemia virus-related virus), a human retrovirus associated with prostate cancer."
Hong S. , Klein E.A. , Das Gupta J. , Hanke K. , Weight C.J. , Nguyen C. , Gaughan C. , Kim K.A. , Bannert N. , Kirchhoff F. , Munch J. , Silverman R.H.
J. Virol.83:6995-7003(2009) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: PROTEOLYTIC PROCESSING;ROLE IN XMRV INFECTION
19.

"The main green tea polyphenol epigallocatechin-3-gallate counteracts semen-mediated enhancement of HIV infection."
Hauber I. , Hohenberg H. , Holstermann B. , Hunstein W. , Hauber J.
Proc. Natl. Acad. Sci. U.S.A.106:9033-9038(2009) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: DEGRADATION OF SEVI AMYLOID FIBRILS
20.

"Aminoquinoline surfen inhibits the action of SEVI (semen-derived enhancer of viral infection)."
Roan N.R. , Sowinski S. , Munch J. , Kirchhoff F. , Greene W.C.
J. Biol. Chem.285:1861-1869(2010) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: INHIBITION OF SEVI ACTIVITY
21.

"Human prostatic acid phosphatase, an authentic tyrosine phosphatase, dephosphorylates ErbB-2 and regulates prostate cancer cell growth."
Chuang T.D. , Chen S.J. , Lin F.F. , Veeramani S. , Kumar S. , Batra S.K. , Tu Y. , Lin M.F.
J. Biol. Chem.285:23598-23606(2010) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: FUNCTION
22.

"Prostatic acid phosphatase expression in human tissues."
Graddis T.J. , McMahan C.J. , Tamman J. , Page K.J. , Trager J.B.
Int. J. Clin. Exp. Pathol.4:295-306(2011) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: TISSUE SPECIFICITY
23.

"Structural origins of L(+)-tartrate inhibition of human prostatic acid phosphatase."
Lacount M.W. , Handy G. , Lebioda L.
J. Biol. Chem.273:30406-30409(1998) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: X-RAY CRYSTALLOGRAPHY (2.9 ANGSTROMS) IN COMPLEX WITH N-PROPYL-L-TARTRAMATE
24.

"Crystal structure of human prostatic acid phosphatase."
Jakob C.G. , Lewinski K. , Kuciel R. , Ostrowski W. , Lebioda L.
Prostate42:211-218(2000) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: X-RAY CRYSTALLOGRAPHY (3.2 ANGSTROMS) OF 33-374;DISULFIDE BONDS;GLYCOSYLATION AT ASN-94 AND ASN-220
25.

"Crystal structures of human prostatic acid phosphatase in complex with a phosphate ion and alpha-benzylaminobenzylphosphonic acid update the mechanistic picture and offer new insights into inhibitor design."
Ortlund E. , LaCount M.W. , Lebioda L.
Biochemistry42:383-389(2003) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: X-RAY CRYSTALLOGRAPHY (2.9 ANGSTROMS) OF 33-386 IN COMPLEX WITH A PHOSPHATE ION AND INHIBITOR ALPHA-BENZYLAMINOBENZYLPHOSPHONIC ACID;DISULFIDE BONDS;GLYCOSYLATION AT ASN-220 AND ASN-333
26.

"NMR structure in a membrane environment reveals putative amyloidogenic regions of the SEVI precursor peptide PAP(248-286)."
Nanga R.P. , Brender J.R. , Vivekanandan S. , Popovych N. , Ramamoorthy A.
J. Am. Chem. Soc.131:17972-17979(2009) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: STRUCTURE BY NMR OF 248-286

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