Ppara ELISA Kit for Mouse(Mus musculus) | EIAab.comPpara ELISA Kit for Mouse(Mus musculus)

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Ppara (Gene name),

Peroxisome proliferator-activated receptor alpha (Protein name ), PPARA_MOUSE from NCBI database.

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General Annotation

Antigen Annotation

Predicted Eptitope

Vaild Sequence

Related Databases

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Gene name:

Ppara(Nr1c1;Ppar);

Protein name:

Peroxisome proliferator-activated receptor alpha(PPAR-alpha);

Alternative:

Nuclear receptor subfamily 1 group C member 1;

Organism:

Mouse (Mus musculus).

General Annotation

Sub Unit:

Heterodimer; with RXRA. This heterodimerization is required for DNA binding and transactivation activity. Interacts with NCOA3 coactivator. Interacts with CITED2; the interaction stimulates its transcriptional activity (By similarity). Also interacts with PPARBP in vitro. Interacts with AKAP13, LPIN1, PRDM16 and coactivator NCOA6.

Function:

Ligand-activated transcription factor. Key regulator of lipid metabolism. Activated by the endogenous ligand 1-palmitoyl-2-oleoyl-sn-glycerol-3-phosphocholine (16:0/18:1-GPC). Activated by oleylethanolamide, a naturally occurring lipid that regulates satiety (By similarity). Receptor for peroxisome proliferators such as hypolipidemic drugs and fatty acids. Regulates the peroxisomal beta-oxidation pathway of fatty acids. Functions as transcription activator for the ACOX1 and P450 genes. Transactivation activity requires heterodimerization with RXRA and is antagonized by NR2C2.

Subcellular Location:

Nucleus

Protein Attributes:

Sequence length:

468

Sequence:

50:

100:

150:

200:

250:

300:

350:

400:

450:

468:

ESDAALHPLL | QEIYRDMY

3D Structure:

N/A

Predicted Eptitope:

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Vaild Sequence:

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Related Databases

KEGG:

mmu:19013

Pfam:

PF00104

String:

P23204

UniGene:

Mm.212789

STRING:

10090.ENSMUSP00000059719

SMR:

P23204

Uniprot:

P23204

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ELISA Kit for Mouse PPAR-alpha

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E0934m

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96T

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ELISA Kit for Mouse PPAR-alpha

Cat.:

E0934d

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96T

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ELISA Kit for Mouse PPAR-alpha

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E0934h

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ELISA Kit for Mouse PPAR-alpha

Cat.:

E0934r

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96T

CLIA Kit for Mouse PPAR-alpha

Cat.:

U0934h

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96T

CLIA Kit for Mouse PPAR-alpha

Cat.:

U0934r

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Packing:

96T

CLIA Kit for Mouse PPAR-alpha

Cat.:

U0934d

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MSDS:

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Packing:

96T

CLIA Kit for Mouse PPAR-alpha

Cat.:

U0934m

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MSDS:

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Packing:

96T

Polyclonal Antibody for Mouse PPAR-alpha

Cat.:

P0934Rb-r

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40ug/0.2ml

Polyclonal Antibody for Mouse PPAR-alpha

Cat.:

P0934Rb-h

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40ug/0.2ml

Polyclonal Antibody for Mouse PPAR-alpha

Cat.:

P0934Rb-m

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Monoclonal Antibody for Mouse PPAR-alpha

Protein for Mouse PPAR-alpha

R&D Technical Data

For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.

Precision

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Recovery

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Linearity

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References

1.

"Activation of a member of the steroid hormone receptor superfamily by peroxisome proliferators."
Issemann I. , Green S.
Nature347:645-650(1990) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [MRNA]
2.

"Structure of the mouse peroxisome proliferator activated receptor alpha gene."
Gearing K.L. , Crickmore A. , Gustafsson J.-A.
Biochem. Biophys. Res. Commun.199:255-263(1994) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA]
strain: 129/Sv.
3.

"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
The MGC Project Team
Genome Res.14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA]
strain: FVB/N.
tissue: Kidney.
4.

"Chromosomal localisation, inducibility, tissue-specific expression and strain differences in three murine peroxisome-proliferator-activated-receptor genes."
Jones P.S. , Savory R. , Barratt P. , Bell A.R. , Gray T.J.B. , Jenkins N.A. , Gilbert D.J. , Copeland N.G. , Bell D.R.
Eur. J. Biochem.233:219-226(1995) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [MRNA] OF 413-468
strain: Swiss Webster.
tissue: Liver.
5.

"Isolation and characterization of PBP, a protein that interacts with peroxisome proliferator-activated receptor."
Zhu Y. , Qi C. , Jain S. , Rao M.S. , Reddy J.K.
J. Biol. Chem.272:25500-25506(1997) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: INTERACTION WITH PPARBP
6.

"Characterization of Brx, a novel Dbl family member that modulates estrogen receptor action."
Rubino D. , Driggers P. , Arbit D. , Kemp L. , Miller B. , Coso O. , Pagliai K. , Gray K. , Gutkind S. , Segars J.
Oncogene16:2513-2526(1998) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: INTERACTION WITH AKAP13
7.

"Isolation and characterization of peroxisome proliferator-activated receptor (PPAR) interacting protein (PRIP) as a coactivator for PPAR."
Zhu Y.-J. , Kan L. , Qi C. , Kanwar Y.S. , Yeldandi A.V. , Rao M.S. , Reddy J.K.
J. Biol. Chem.275:13510-13516(2000) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: INTERACTION WITH NCOA6
8.

"Oleylethanolamide regulates feeding and body weight through activation of the nuclear receptor PPAR-alpha."
Fu J. , Gaetani S. , Oveisi F. , Lo Verme J. , Serrano A. , Rodriguez De Fonseca F. , Rosengarth A. , Luecke H. , Di Giacomo B. , Tarzia G. , Piomelli D.
Nature425:90-93(2003) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: IDENTIFICATION AS RECEPTOR FOR OLEYLETHANOLAMIDE;FUNCTION
9.

"Lipin 1 is an inducible amplifier of the hepatic PGC-1alpha/PPARalpha regulatory pathway."
Finck B.N. , Gropler M.C. , Chen Z. , Leone T.C. , Croce M.A. , Harris T.E. , Lawrence J.C. Jr. , Kelly D.P.
Cell Metab.4:199-210(2006) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: INTERACTION WITH LIPN1
10.

"PRDM16 controls a brown fat/skeletal muscle switch."
Seale P. , Bjork B. , Yang W. , Kajimura S. , Chin S. , Kuang S. , Scime A. , Devarakonda S. , Conroe H.M. , Erdjument-Bromage H. , Tempst P. , Rudnicki M.A. , Beier D.R. , Spiegelman B.M.
Nature454:961-967(2008) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: INTERACTION WITH PRDM16
11.

"Identification of a physiologically relevant endogenous ligand for PPARalpha in liver."
Chakravarthy M.V. , Lodhi I.J. , Yin L. , Malapaka R.R. , Xu H.E. , Turk J. , Semenkovich C.F.
Cell138:476-488(2009) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: IDENTIFICATION OF 1-PALMITOYL-2-OLEOYL-SN-GLYCEROL-3-PHOSPHOCHOLINE AS A PHYSIOLOGICAL LIGAND;DNA-BINDING;FUNCTION;MUTAGENESIS OF CYS-119 AND CYS-122
12.

"The mammalian clock component PERIOD2 coordinates circadian output by interaction with nuclear receptors."
Schmutz I. , Ripperger J.A. , Baeriswyl-Aebischer S. , Albrecht U.
Genes Dev.24:345-357(2010) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: FUNCTION IN CIRCADIAN RHYTHMS;INTERACTION WITH PER2;SUBCELLULAR LOCATION;MUTAGENESIS OF LYS-292 AND 459-LEU--TYR-468

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