Gene name:
Ppara (Nr1c1;Ppar) ;
Protein name:
Peroxisome proliferator-activated receptor alpha (PPAR-alpha) ;
Alternative:
Nuclear receptor subfamily 1 group C member 1 ;
Organism:
Rat (Rattus norvegicus).
General Annotation
Sub Unit:
Heterodimer; with RXRA. This heterodimerization is required for DNA binding and transactivation activity (By similarity). Interacts with AKAP13, LPIN1 and PRDM16. Also interacts with PPARBP coactivator in vitro. Interacts with NCOA3 and NCOA6 coactivators (By similarity). Interacts with CITED2; the interaction stimulates its transcriptional activity.
Function:
Ligand-activated transcription factor. Key regulator of lipid metabolism. Activated by the endogenous ligand 1-palmitoyl-2-oleoyl-sn-glycerol-3-phosphocholine (16:0/18:1-GPC). Activated by oleylethanolamide, a naturally occurring lipid that regulates satiety (By similarity). Receptor for peroxisome proliferators such as hypolipidemic drugs and fatty acids. Regulates the peroxisomal beta-oxidation pathway of fatty acids. Functions as transcription activator for the ACOX1 and P450 genes. Transactivation activity requires heterodimerization with RXRA and is antagonized by NR2C2.
Subcellular Location:
Nucleus
Protein Attributes:
50:
MVDTESPICP | LSPLEADDLE | SPLSEEFLQE | MGNIQEISQS | LGEESSGSFS |
100:
FADYQYLGSC | PGSEGSVITD | TLSPASSPSS | VSCPAVPTST | DESPGNALNI |
150:
ECRICGDKAS | GYHYGVHACE | GCKGFFRRTI | RLKLAYDKCD | RSCKIQKKNR |
200:
NKCQYCRFHK | CLSVGMSHNA | IRFGRMPRSE | KAKLKAEILT | CEHDLKDSET |
250:
ADLKSLAKRI | HEAYLKNFNM | NKVKARVILA | GKTSNNPPFV | IHDMETLCMA |
300:
EKTLVAKMVA | NGVENKEAEV | RFFHCCQCMS | VETVTELTEF | AKAIPGFANL |
350:
DLNDQVTLLK | YGVYEAIFTM | LSSLMNKDGM | LIAYGNGFIT | REFLKNLRKP |
400:
FCDIMEPKFD | FAMKFNALEL | DDSDISLFVA | AIICCGDRPG | LLNIGYIEKL |
450:
QEGIVHVLKL | HLQSNHPDDT | FLFPKLLQKM | VDLRQLVTEH | AQLVQVIKKT |
468:
ESDAALHPLL | QEIYRDMY
Vaild Sequence:
Related Databases
Uniprot:
ELISA Kit
CLIA Kit
Polyclonal Antibody
Monoclonal Antibody
Protein
FOR
Mouse
Dog
Human
Rat
ELISA Kit for Rat PPAR-alpha
ELISA Kit for Rat PPAR-alpha
ELISA Kit for Rat PPAR-alpha
ELISA Kit for Rat PPAR-alpha
CLIA Kit for Rat PPAR-alpha
CLIA Kit for Rat PPAR-alpha
CLIA Kit for Rat PPAR-alpha
CLIA Kit for Rat PPAR-alpha
Polyclonal Antibody for Rat PPAR-alpha
Polyclonal Antibody for Rat PPAR-alpha
Polyclonal Antibody for Rat PPAR-alpha
Polyclonal Antibody for Rat PPAR-alpha
Monoclonal Antibody for Rat PPAR-alpha
Monoclonal Antibody for Rat PPAR-alpha
Monoclonal Antibody for Rat PPAR-alpha
Monoclonal Antibody for Rat PPAR-alpha
Protein for Rat PPAR-alpha
Protein for Rat PPAR-alpha
Protein for Rat PPAR-alpha
Protein for Rat PPAR-alpha
R&D Technical Data
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Precision
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Recovery
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Linearity
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References
1.
[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s)
Cited for : NUCLEOTIDE SEQUENCE [MRNA]
2.
[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s)
Cited for : PHOSPHORYLATION
3.
[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s)
Cited for : INTERACTION WITH CITED2