Protein name:
Peroxisome proliferator-activated receptor gamma (PPAR-gamma) ;
Alternative:
Nuclear receptor subfamily 1 group C member 3 ;
Organism:
Mouse (Mus musculus).
General Annotation
Sub Unit:
Heterodimer with other nuclear receptors, such as RXRA. The heterodimer with the retinoic acid receptor RXRA is called adipocyte-specific transcription factor ARF6. Interacts with NCOA6 coactivator, leading to a strong increase in transcription of target genes. Interacts with coactivator PPARBP, leading to a mild increase in transcription of target genes. Interacts with NOCA7 in a ligand-inducible manner. Interacts with NCOA1 and NCOA2 LXXLL motifs. Interacts with NR0B2. Interacts with DNTTIP2. Interacts with PRMT2 (By similarity). Interacts with FAM120B and TGFB1I1. Interacts with PRDM16.
Function:
Receptor that binds peroxisome proliferators such as hypolipidemic drugs and fatty acids. Once activated by a ligand, the receptor binds to a promoter element in the gene for acyl-CoA oxidase and activates its transcription. It therefore controls the peroxisomal beta-oxidation pathway of fatty acids. Key regulator of adipocyte differentiation and glucose homeostasis. ARF6 acts as a key regulator of the tissue-specific adipocyte P2 (aP2) enhancer.
Subcellular Location:
Nucleus
Protein Attributes:
50:
MGETLGDSPV | DPEHGAFADA | LPMSTSQEIT | MVDTEMPFWP | TNFGISSVDL |
100:
SVMEDHSHSF | DIKPFTTVDF | SSISAPHYED | IPFTRADPMV | ADYKYDLKLQ |
150:
EYQSAIKVEP | ASPPYYSEKT | QLYNRPHEEP | SNSLMAIECR | VCGDKASGFH |
200:
YGVHACEGCK | GFFRRTIRLK | LIYDRCDLNC | RIHKKSRNKC | QYCRFQKCLA |
250:
VGMSHNAIRF | GRMPQAEKEK | LLAEISSDID | QLNPESADLR | ALAKHLYDSY |
300:
IKSFPLTKAK | ARAILTGKTT | DKSPFVIYDM | NSLMMGEDKI | KFKHITPLQE |
350:
QSKEVAIRIF | QGCQFRSVEA | VQEITEYAKN | IPGFINLDLN | DQVTLLKYGV |
400:
HEIIYTMLAS | LMNKDGVLIS | EGQGFMTREF | LKNLRKPFGD | FMEPKFEFAV |
450:
KFNALELDDS | DLAIFIAVII | LSGDRPGLLN | VKPIEDIQDN | LLQALELQLK |
500:
LNHPESSQLF | AKVLQKMTDL | RQIVTEHVQL | LHVIKKTETD | MSLHPLLQEI |
Vaild Sequence:
Related Databases
Uniprot:
ELISA Kit
CLIA Kit
Polyclonal Antibody
Monoclonal Antibody
Protein
FOR
Human
Rat
Bovine
Dog
Pig
Mouse
Rabbit
ELISA Kit for Mouse PPAR-gamma
ELISA Kit for Mouse PPAR-gamma
ELISA Kit for Mouse PPAR-gamma
ELISA Kit for Mouse PPAR-gamma
ELISA Kit for Mouse PPAR-gamma
ELISA Kit for Mouse PPAR-gamma
ELISA Kit for Mouse PPAR-gamma
CLIA Kit for Mouse PPAR-gamma
CLIA Kit for Mouse PPAR-gamma
CLIA Kit for Mouse PPAR-gamma
CLIA Kit for Mouse PPAR-gamma
CLIA Kit for Mouse PPAR-gamma
CLIA Kit for Mouse PPAR-gamma
CLIA Kit for Mouse PPAR-gamma
Polyclonal Antibody for Mouse PPAR-gamma
Polyclonal Antibody for Mouse PPAR-gamma
Polyclonal Antibody for Mouse PPAR-gamma
Polyclonal Antibody for Mouse PPAR-gamma
Polyclonal Antibody for Mouse PPAR-gamma
Polyclonal Antibody for Mouse PPAR-gamma
Polyclonal Antibody for Mouse PPAR-gamma
Monoclonal Antibody for Mouse PPAR-gamma
Monoclonal Antibody for Mouse PPAR-gamma
Monoclonal Antibody for Mouse PPAR-gamma
Monoclonal Antibody for Mouse PPAR-gamma
Monoclonal Antibody for Mouse PPAR-gamma
Monoclonal Antibody for Mouse PPAR-gamma
Monoclonal Antibody for Mouse PPAR-gamma
Protein for Mouse PPAR-gamma
Protein for Mouse PPAR-gamma
Protein for Mouse PPAR-gamma
Protein for Mouse PPAR-gamma
Protein for Mouse PPAR-gamma
Protein for Mouse PPAR-gamma
Protein for Mouse PPAR-gamma
R&D Technical Data
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Precision
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Recovery
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Linearity
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References
1.
[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s)
Cited for : NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 2);SUBUNIT
tissue :
Adipose tissue .
2.
[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s)
Cited for : NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1)
strain :
BALB/c .
tissue :
Heart .
3.
[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s)
Cited for : NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1)
strain :
C57BL/6 X CBA .
tissue :
Liver .
4.
[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s)
Cited for : NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1)
tissue :
Liver .
5.
[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s)
Cited for : NUCLEOTIDE SEQUENCE [MRNA]
6.
[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s)
Cited for : PROTEIN SEQUENCE OF 66-85 AND 146-160;SUBUNIT;TISSUE SPECIFICITY
tissue :
Adipose tissue .
7.
[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s)
Cited for : INTERACTION WITH PPARBP
8.
[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s)
Cited for : INTERACTION WITH NCOA6
9.
[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s)
Cited for : INTERACTION WITH TGFB1I1
10.
[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s)
Cited for : INTERACTION WITH FAM120B
11.
"PRDM16 controls a brown fat/skeletal muscle switch."
Seale P.
,
Bjork B.
,
Yang W.
,
Kajimura S.
,
Chin S.
,
Kuang S.
,
Scime A.
,
Devarakonda S.
,
Conroe H.M.
,
Erdjument-Bromage H.
,
Tempst P.
,
Rudnicki M.A.
,
Beier D.R.
,
Spiegelman B.M.
Nature454:961-967(2008)
[
PubMed ]
[
Europe PMC ]
[
Abstract ]
[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s)
Cited for : FUNCTION;INTERACTION WITH PRDM16
12.
[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s)
Cited for : INTERACTION WITH FOXO1
13.
[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s)
Cited for : FUNCTION IN ADIPOGENESIS;INTERACTION WITH PER2;PHOSPHORYLATION AT SER-112;MUTAGENESIS OF SER-112;TISSUE SPECIFICITY
14.
"A circadian-regulated gene, Nocturnin, promotes adipogenesis by stimulating PPAR-gamma nuclear translocation."
Kawai M.
,
Green C.B.
,
Lecka-Czernik B.
,
Douris N.
,
Gilbert M.R.
,
Kojima S.
,
Ackert-Bicknell C.
,
Garg N.
,
Horowitz M.C.
,
Adamo M.L.
,
Clemmons D.R.
,
Rosen C.J.
Proc. Natl. Acad. Sci. U.S.A.107:10508-10513(2010)
[
PubMed ]
[
Europe PMC ]
[
Abstract ]
[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s)
Cited for : SUBCELLULAR LOCATION;INTERACTION WITH CCRN4L
15.
"Protein phosphatase 5 mediates lipid metabolism through reciprocal control of glucocorticoid receptor and peroxisome proliferator-activated receptor-? (PPAR?)."
Hinds T.D. Jr.
,
Stechschulte L.A.
,
Cash H.A.
,
Whisler D.
,
Banerjee A.
,
Yong W.
,
Khuder S.S.
,
Kaw M.K.
,
Shou W.
,
Najjar S.M.
,
Sanchez E.R.
J. Biol. Chem.286:42911-42922(2011)
[
PubMed ]
[
Europe PMC ]
[
Abstract ]
[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s)
Cited for : FUNCTION IN ADIPOGENESIS;INTERACTION WITH PPP5C;PHOSPHORYLATION AT SER-112;DEPHOSPHORYLATION AT SER-112;MUTAGENESIS OF SER-112
16.
[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s)
Cited for : GLYCOSYLATION AT THR-84
17.
"THRAP3 interacts with HELZ2 and plays a novel role in adipocyte differentiation."
Katano-Toki A.
,
Satoh T.
,
Tomaru T.
,
Yoshino S.
,
Ishizuka T.
,
Ishii S.
,
Ozawa A.
,
Shibusawa N.
,
Tsuchiya T.
,
Saito T.
,
Shimizu H.
,
Hashimoto K.
,
Okada S.
,
Yamada M.
,
Mori M.
Mol. Endocrinol.27:769-780(2013)
[
PubMed ]
[
Europe PMC ]
[
Abstract ]
[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s)
Cited for : FUNCTION;INTERACTION WITH HELZ2 AND THRAP3;SUBCELLULAR LOCATION