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Index > Protein center > Pparg(Gene name) > Rat
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  • Pparg (Gene name),
  • Peroxisome proliferator-activated receptor gamma (Protein name ),  PPARG_RAT from NCBI database.
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  • General Annotation
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  • Antigen Annotation
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  • 3D
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  • Predicted Eptitope
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  • Vaild Sequence
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  • Related Databases
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  • Gene name:
    Pparg(Nr1c3);
    Protein name:
    Peroxisome proliferator-activated receptor gamma(PPAR-gamma);
    Alternative:
    Nuclear receptor subfamily 1 group C member 3;
    Organism:
    Rat (Rattus norvegicus). 
    General Annotation
    Sub Unit:
    Heterodimer with other nuclear receptors, such as RXRA. The heterodimer with the retinoic acid receptor RXRA is called adipocyte-specific transcription factor ARF6. Interacts with NCOA6 coactivator, leading to a strong increase in transcription of target genes. Interacts with coactivator PPARBP, leading to a mild increase in transcription of target genes. Interacts with NOCA7 in a ligand-inducible manner. Interacts with NCOA1 and NCOA2 LXXLL motifs. Interacts with FAM120B, NR0B2 and TGFB1I1. Interacts with DNTTIP2. Interacts with PRDM16. Interacts with PRMT2.
    Function:
    Receptor that binds peroxisome proliferators such as hypolipidemic drugs and fatty acids. Once activated by a ligand, the receptor binds to a promoter element in the gene for acyl-CoA oxidase and activates its transcription. It therefore controls the peroxisomal beta-oxidation pathway of fatty acids. Key regulator of adipocyte differentiation and glucose homeostasis.
    Subcellular Location:
    Nucleus
    Protein Attributes:
    Sequence length:
    505
    Sequence:
    50:
    MGETLGDPPV | DPEHGAFADA | LPMSTSQEIT | MVDTEMPFWP | TNFGISSVDL | 
    100:
    SVMDDHSHSF | DIKPFTTVDF | SSISAPHYED | IPFTRADPMV | ADYKYDLKLQ | 
    150:
    EYQSAIKVEP | ASPPYYSEKT | QLYNRPHEEP | SNSLMAIECR | VCGDKASGFH | 
    200:
    YGVHACEGCK | GFFRRTIRLK | LIYDRCDLNC | RIHKKSRNKC | QYCRFQKCLA | 
    250:
    VGMSHNAIRF | GRMPQAEKEK | LLAEISSDID | QLNPESADLR | ALAKHLYDSY | 
    300:
    IKSFPLTKAK | ARAILTGKTT | DKSPFVIYDM | NSLMMGEDKI | KFKHITPLQE | 
    350:
    QSKEVAIRIF | QGCQFRSVEA | VQEITEYAKN | IPGFINLDLN | DQVTLLKYGV | 
    400:
    HEIIYTMLAS | LMNKDGVLIS | EGQGFMTREF | LKSLRKPFGD | FMEPKFEFAV | 
    450:
    KFNALELDDS | DLAIFIAVII | LSGDRPGLLN | VKPIEDIQDN | LLQALELQLK | 
    500:
    LNHPESSQLF | AKVLQKMTDL | RQIVTEHVQL | LHVIKKTETD | MSLHPLLQEI | 
    505:
    YKDLY
    3D Structure:
    N/A
    Predicted Eptitope:
    Please Sign in.
    EIAab Sequence  Vaild Sequence:
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    Related Databases
    UniGene:
    Pfam:
    SMR:
    String:
    KEGG:
    Uniprot:
     
    FOR
    ELISA Kit for Rat PPAR-gamma
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    E0886h
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    ELISA Kit for Rat PPAR-gamma
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    E0886r
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    ELISA Kit for Rat PPAR-gamma
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    E0886b
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    ELISA Kit for Rat PPAR-gamma
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    E0886d
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    ELISA Kit for Rat PPAR-gamma
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    ELISA Kit for Rat PPAR-gamma
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    E0886m
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    96T
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    ELISA Kit for Rat PPAR-gamma
    MSDS:
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    CLIA Kit for Rat PPAR-gamma
    Cat.:
    U0886r
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    MSDS:
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    Packing:
    96T
    CLIA Kit for Rat PPAR-gamma
    Cat.:
    U0886p
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    MSDS:
    Please sign in first.
    Packing:
    96T
    CLIA Kit for Rat PPAR-gamma
    MSDS:
    Please sign in first.
    CLIA Kit for Rat PPAR-gamma
    Cat.:
    U0886h
    Price:
    Please sign in first.
    MSDS:
    Please sign in first.
    Packing:
    96T
    CLIA Kit for Rat PPAR-gamma
    Cat.:
    U0886m
    Price:
    Please sign in first.
    MSDS:
    Please sign in first.
    Packing:
    96T
    CLIA Kit for Rat PPAR-gamma
    Cat.:
    U0886d
    Price:
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    MSDS:
    Please sign in first.
    Packing:
    96T
    CLIA Kit for Rat PPAR-gamma
    Cat.:
    U0886b
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    MSDS:
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    Packing:
    96T
    Polyclonal Antibody for Rat PPAR-gamma
    Polyclonal Antibody for Rat PPAR-gamma
    Polyclonal Antibody for Rat PPAR-gamma
    Polyclonal Antibody for Rat PPAR-gamma
    Cat.:
    P0886Rb-m
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    Packing:
    40ug/0.2ml
    Polyclonal Antibody for Rat PPAR-gamma
    Cat.:
    P0886Rb-h
    Price:
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    Packing:
    40ug/0.2ml
    Polyclonal Antibody for Rat PPAR-gamma
    Polyclonal Antibody for Rat PPAR-gamma
    Cat.:
    P0886Rb-r
    Price:
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    Packing:
    40ug/0.2ml
    Monoclonal Antibody for Rat PPAR-gamma
    Monoclonal Antibody for Rat PPAR-gamma
    Monoclonal Antibody for Rat PPAR-gamma
    Monoclonal Antibody for Rat PPAR-gamma
    Monoclonal Antibody for Rat PPAR-gamma
    Monoclonal Antibody for Rat PPAR-gamma
    Monoclonal Antibody for Rat PPAR-gamma
    Protein for Rat PPAR-gamma
    Protein for Rat PPAR-gamma
    Protein for Rat PPAR-gamma
    Protein for Rat PPAR-gamma
    Protein for Rat PPAR-gamma
    Protein for Rat PPAR-gamma
    Protein for Rat PPAR-gamma

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    Linearity
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    L

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    References
    1. 1.
      "Rat peroxisome proliferator-activated receptors and brown adipose tissue function during cold acclimatization."
      Guardiola-Diaz H.M. , Rehnmark S. , Usuda N. , Albrektsen T. , Feltkamp D. , Gustafsson J.-A. , Alexson S.E.H.
      J. Biol. Chem.274:23368-23377(1999) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORMS 1 AND 2)
      strain: Sprague-Dawley.
      tissue: Brown adipose tissue.
    2. 2.
      "Down-regulation of PPAR gammma."
      Tanaka T. , Itoh H.
      Submitted (1998-08) to the EMBL/GenBank/DDBJ databases
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 2)
      strain: Sprague-Dawley.
      tissue: Adipose tissue.
    3. 3.
      Escher P.
      Submitted (2001-01) to the EMBL/GenBank/DDBJ databases
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 2)
    4. 4.
      "Molecular cloning of rat PPAR-gamma gene."
      Miyakita A. , Okuno S. , Watanabe T.K. , Oga K. , Tsuji A. , Hishigaki H. , Suto T. , Nakagawa K. , Nakahara Y. , Higashi K.
      Submitted (1998-02) to the EMBL/GenBank/DDBJ databases
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1)
      tissue: Adipocyte.
    5. 5.
      "Photoreceptor phagocytosis selectively activates PPARgamma expression in retinal pigment epithelial cells."
      Ershov A.V. , Bazan N.G.
      J. Neurosci. Res.60:328-337(2000) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1)
      strain: Long Evans.
    6. 6.
      "Inhibition of adipogenesis through MAP kinase-mediated phosphorylation of PPARgamma."
      Hu E. , Kim J.B. , Sarraf P. , Spiegelman B.M.
      Science274:2100-2103(1996) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: PHOSPHORYLATION
    7. 7.
      "Transcriptional activation by peroxisome proliferator-activated receptor gamma is inhibited by phosphorylation at a consensus mitogen-activated protein kinase site."
      Adams M. , Reginato M.J. , Shao D. , Lazar M.A. , Chatterjee V.K.
      J. Biol. Chem.272:5128-5132(1997) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: PHOSPHORYLATION AT SER-112;MUTAGENESIS OF SER-112
    8. 8.
      "Insulin- and mitogen-activated protein kinase-mediated phosphorylation and activation of peroxisome proliferator-activated receptor gamma."
      Zhang B. , Berger J. , Zhou G. , Elbrecht A. , Biswas S. , White-Carrington S. , Szalkowski D. , Moller D.E.
      J. Biol. Chem.271:31771-31774(1996) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: PHOSPHORYLATION
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