Protein name:
Lysosomal protective protein ;
Alternative:
Carboxypeptidase L ;Carboxypeptidase C ;Protective protein cathepsin A (PPCA) ;Cathepsin A ;Protective protein for beta-galactosidase ;
Organism:
Human (Homo sapiens).
General Annotation
Sub Unit:
Heterodimer of a 32 kDa chain and a 20 kDa chain; disulfide-linked.
Function:
Protective protein appears to be essential for both the activity of beta-galactosidase and neuraminidase, it associates with these enzymes and exerts a protective function necessary for their stability and activity. This protein is also a carboxypeptidase and can deamidate tachykinins.
Subcellular Location:
Lysosome
Protein Attributes:
50:
MIRAAPPPLF | LLLLLLLLLV | SWASRGEAAP | DQDEIQRLPG | LAKQPSFRQY |
100:
SGYLKGSGSK | HLHYWFVESQ | KDPENSPVVL | WLNGGPGCSS | LDGLLTEHGP |
150:
FLVQPDGVTL | EYNPYSWNLI | ANVLYLESPA | GVGFSYSDDK | FYATNDTEVA |
200:
QSNFEALQDF | FRLFPEYKNN | KLFLTGESYA | GIYIPTLAVL | VMQDPSMNLQ |
250:
GLAVGNGLSS | YEQNDNSLVY | FAYYHGLLGN | RLWSSLQTHC | CSQNKCNFYD |
300:
NKDLECVTNL | QEVARIVGNS | GLNIYNLYAP | CAGGVPSHFR | YEKDTVVVQD |
350:
LGNIFTRLPL | KRMWHQALLR | SGDKVRMDPP | CTNTTAASTY | LNNPYVRKAL |
400:
NIPEQLPQWD | MCNFLVNLQY | RRLYRSMNSQ | YLKLLSSQKY | QILLYNGDVD |
450:
MACNFMGDEW | FVDSLNQKME | VQRRPWLVKY | GDSGEQIAGF | VKEFSHIAFL |
480:
TIKGAGHMVP | TDKPLAAFTM | FSRFLNKQPY |
Vaild Sequence:
Related Databases
Uniprot:
ELISA Kit
CLIA Kit
Polyclonal Antibody
Monoclonal Antibody
Protein
FOR
Human
Mouse
Bovine
ELISA Kit for Human Lysosomal protective protein
ELISA Kit for Human Lysosomal protective protein
ELISA Kit for Human Lysosomal protective protein
CLIA Kit for Human Lysosomal protective protein
CLIA Kit for Human Lysosomal protective protein
CLIA Kit for Human Lysosomal protective protein
Polyclonal Antibody for Human Lysosomal protective protein
Polyclonal Antibody for Human Lysosomal protective protein
Polyclonal Antibody for Human Lysosomal protective protein
Monoclonal Antibody for Human Lysosomal protective protein
Monoclonal Antibody for Human Lysosomal protective protein
Monoclonal Antibody for Human Lysosomal protective protein
Protein for Human Lysosomal protective protein
Protein for Human Lysosomal protective protein
Protein for Human Lysosomal protective protein
R&D Technical Data
For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.
For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.
For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.
For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.
For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.
For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.
For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.
For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.
For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.
For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.
For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.
For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.
For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.
For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.
For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.
Precision
For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.
For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.
For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.
For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.
For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.
For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.
For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.
For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.
For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.
For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.
For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.
For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.
For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.
For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.
For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.
Recovery
For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.
For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.
For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.
For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.
For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.
For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.
For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.
For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.
For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.
For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.
For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.
For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.
For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.
For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.
For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.
Linearity
For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.
For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.
For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.
For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.
For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.
For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.
For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.
For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.
For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.
For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.
For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.
For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.
For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.
For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.
For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.
References
1.
[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s)
Cited for : NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1);PARTIAL PROTEIN SEQUENCE
2.
"Complete sequencing and characterization of 21,243 full-length human cDNAs."
Ota T.
,
Suzuki Y.
,
Nishikawa T.
,
Otsuki T.
,
Sugiyama T.
,
Irie R.
,
Wakamatsu A.
,
Hayashi K.
,
Sato H.
,
Nagai K.
,
Kimura K.
,
Makita H.
,
Sekine M.
,
Obayashi M.
,
Nishi T.
,
Shibahara T.
,
Tanaka T.
,
Ishii S.
,
Yamamoto J.
,
Saito K.
,
Kawai Y.
,
Isono Y.
,
Nakamura Y.
,
Nagahari K.
,
Murakami K.
,
Yasuda T.
,
Iwayanagi T.
,
Wagatsuma M.
,
Shiratori A.
,
Sudo H.
,
Hosoiri T.
,
Kaku Y.
,
Kodaira H.
,
Kondo H.
,
Sugawara M.
,
Takahashi M.
,
Kanda K.
,
Yokoi T.
,
Furuya T.
,
Kikkawa E.
,
Omura Y.
,
Abe K.
,
Kamihara K.
,
Katsuta N.
,
Sato K.
,
Tanikawa M.
,
Yamazaki M.
,
Ninomiya K.
,
Ishibashi T.
,
Yamashita H.
,
Murakawa K.
,
Fujimori K.
,
Tanai H.
,
Kimata M.
,
Watanabe M.
,
Hiraoka S.
,
Chiba Y.
,
Ishida S.
,
Ono Y.
,
Takiguchi S.
,
Watanabe S.
,
Yosida M.
,
Hotuta T.
,
Kusano J.
,
Kanehori K.
,
Takahashi-Fujii A.
,
Hara H.
,
Tanase T.-O.
,
Nomura Y.
,
Togiya S.
,
Komai F.
,
Hara R.
,
Takeuchi K.
,
Arita M.
,
Imose N.
,
Musashino K.
,
Yuuki H.
,
Oshima A.
,
Sasaki N.
,
Aotsuka S.
,
Yoshikawa Y.
,
Matsunawa H.
,
Ichihara T.
,
Shiohata N.
,
Sano S.
,
Moriya S.
,
Momiyama H.
,
Satoh N.
,
Takami S.
,
Terashima Y.
,
Suzuki O.
,
Nakagawa S.
,
Senoh A.
,
Mizoguchi H.
,
Goto Y.
,
Shimizu F.
,
Wakebe H.
,
Hishigaki H.
,
Watanabe T.
,
Sugiyama A.
,
Takemoto M.
,
Kawakami B.
,
Yamazaki M.
,
Watanabe K.
,
Kumagai A.
,
Itakura S.
,
Fukuzumi Y.
,
Fujimori Y.
,
Komiyama M.
,
Tashiro H.
,
Tanigami A.
,
Fujiwara T.
,
Ono T.
,
Yamada K.
,
Fujii Y.
,
Ozaki K.
,
Hirao M.
,
Ohmori Y.
,
Kawabata A.
,
Hikiji T.
,
Kobatake N.
,
Inagaki H.
,
Ikema Y.
,
Okamoto S.
,
Okitani R.
,
Kawakami T.
,
Noguchi S.
,
Itoh T.
,
Shigeta K.
,
Senba T.
,
Matsumura K.
,
Nakajima Y.
,
Mizuno T.
,
Morinaga M.
,
Sasaki M.
,
Togashi T.
,
Oyama M.
,
Hata H.
,
Watanabe M.
,
Komatsu T.
,
Mizushima-Sugano J.
,
Satoh T.
,
Shirai Y.
,
Takahashi Y.
,
Nakagawa K.
,
Okumura K.
,
Nagase T.
,
Nomura N.
,
Kikuchi H.
,
Masuho Y.
,
Yamashita R.
,
Nakai K.
,
Yada T.
,
Nakamura Y.
,
Ohara O.
,
Isogai T.
,
Sugano S.
more...
Nat. Genet.36:40-45(2004)
[
PubMed ]
[
Europe PMC ]
[
Abstract ]
[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s)
Cited for : NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1)
tissue :
Brain .
3.
"The DNA sequence and comparative analysis of human chromosome 20."
Deloukas P.
,
Matthews L.H.
,
Ashurst J.L.
,
Burton J.
,
Gilbert J.G.R.
,
Jones M.
,
Stavrides G.
,
Almeida J.P.
,
Babbage A.K.
,
Bagguley C.L.
,
Bailey J.
,
Barlow K.F.
,
Bates K.N.
,
Beard L.M.
,
Beare D.M.
,
Beasley O.P.
,
Bird C.P.
,
Blakey S.E.
,
Bridgeman A.M.
,
Brown A.J.
,
Buck D.
,
Burrill W.D.
,
Butler A.P.
,
Carder C.
,
Carter N.P.
,
Chapman J.C.
,
Clamp M.
,
Clark G.
,
Clark L.N.
,
Clark S.Y.
,
Clee C.M.
,
Clegg S.
,
Cobley V.E.
,
Collier R.E.
,
Connor R.E.
,
Corby N.R.
,
Coulson A.
,
Coville G.J.
,
Deadman R.
,
Dhami P.D.
,
Dunn M.
,
Ellington A.G.
,
Frankland J.A.
,
Fraser A.
,
French L.
,
Garner P.
,
Grafham D.V.
,
Griffiths C.
,
Griffiths M.N.D.
,
Gwilliam R.
,
Hall R.E.
,
Hammond S.
,
Harley J.L.
,
Heath P.D.
,
Ho S.
,
Holden J.L.
,
Howden P.J.
,
Huckle E.
,
Hunt A.R.
,
Hunt S.E.
,
Jekosch K.
,
Johnson C.M.
,
Johnson D.
,
Kay M.P.
,
Kimberley A.M.
,
King A.
,
Knights A.
,
Laird G.K.
,
Lawlor S.
,
Lehvaeslaiho M.H.
,
Leversha M.A.
,
Lloyd C.
,
Lloyd D.M.
,
Lovell J.D.
,
Marsh V.L.
,
Martin S.L.
,
McConnachie L.J.
,
McLay K.
,
McMurray A.A.
,
Milne S.A.
,
Mistry D.
,
Moore M.J.F.
,
Mullikin J.C.
,
Nickerson T.
,
Oliver K.
,
Parker A.
,
Patel R.
,
Pearce T.A.V.
,
Peck A.I.
,
Phillimore B.J.C.T.
,
Prathalingam S.R.
,
Plumb R.W.
,
Ramsay H.
,
Rice C.M.
,
Ross M.T.
,
Scott C.E.
,
Sehra H.K.
,
Shownkeen R.
,
Sims S.
,
Skuce C.D.
,
Smith M.L.
,
Soderlund C.
,
Steward C.A.
,
Sulston J.E.
,
Swann R.M.
,
Sycamore N.
,
Taylor R.
,
Tee L.
,
Thomas D.W.
,
Thorpe A.
,
Tracey A.
,
Tromans A.C.
,
Vaudin M.
,
Wall M.
,
Wallis J.M.
,
Whitehead S.L.
,
Whittaker P.
,
Willey D.L.
,
Williams L.
,
Williams S.A.
,
Wilming L.
,
Wray P.W.
,
Hubbard T.
,
Durbin R.M.
,
Bentley D.R.
,
Beck S.
,
Rogers J.
more...
Nature414:865-871(2001)
[
PubMed ]
[
Europe PMC ]
[
Abstract ]
[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s)
Cited for : NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]
4.
[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s)
Cited for : NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1)
tissue :
Placenta .
tissue :
Skin .
5.
[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s)
Cited for : PROTEIN SEQUENCE OF 29-53 AND 327-351
tissue :
Platelet .
6.
[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s)
Cited for : PROTEIN SEQUENCE OF 29-37
tissue :
Platelet .
7.
[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s)
Cited for : FUNCTION;MUTAGENESIS
8.
[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s)
Cited for : GLYCOSYLATION [LARGE SCALE ANALYSIS] AT ASN-145
tissue :
Platelet .
9.
[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s)
Cited for : GLYCOSYLATION [LARGE SCALE ANALYSIS] AT ASN-145 AND ASN-333
tissue :
Liver .
10.
[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s)
Cited for : IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS]
11.
[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s)
Cited for : X-RAY CRYSTALLOGRAPHY (2.2 ANGSTROMS)
12.
[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s)
Cited for : VARIANT GSL VAL-440
13.
[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s)
Cited for : VARIANTS GSL ARG-49; ARG-65; LEU-90; ASN-249 AND CYS-395
14.
"Molecular and biochemical analysis of protective protein/cathepsin A mutations: correlation with clinical severity in galactosialidosis."
Zhou X.Y.
,
van der Spoel A.
,
Rottier R.
,
Hale G.
,
Willemsen R.
,
Berry G.T.
,
Strisciuglio P.
,
Morrone A.
,
Zammarchi E.
,
Andria G.
,
d'Azzo A.
Hum. Mol. Genet.5:1977-1987(1996)
[
PubMed ]
[
Europe PMC ]
[
Abstract ]
[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s)
Cited for : VARIANTS GSL TYR-51; MET-132; PRO-236; ASN-249; THR-406; SER-439 AND VAL-440
15.
[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s)
Cited for : VARIANT GSL GLU-453