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Index > Protein center > PLN(Gene name) > Human
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  • PLN (Gene name),
  • Cardiac phospholamban (Protein name ),  PPLA_HUMAN from NCBI database.
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  • General Annotation
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  • Antigen Annotation
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  • 3D
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  • Predicted Eptitope
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  • Vaild Sequence
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  • Related Databases
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  • Gene name:
    PLN(PLB);
    Protein name:
    Cardiac phospholamban(PLB);
    Alternative:

    Organism:
    Human (Homo sapiens). 
    General Annotation
    Sub Unit:
    Homopentamer. Interacts with HAX1.
    Function:
    Phospholamban has been postulated to regulate the activity of the calcium pump of cardiac sarcoplasmic reticulum.
    Subcellular Location:
    Mitochondrion membrane Single-pass membrane protein Sarcoplasmic reticulum
    Protein Attributes:
    Sequence length:
    52
    Sequence:
    50:
    MEKVQYLTRS | AIRRASTIEM | PQQARQKLQN | LFINFCLILI | CLLLICIIVM | 
    52:
    LL
    3D Structure:
    N/A
    Predicted Eptitope:
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    EIAab Sequence  Vaild Sequence:
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    Related Databases
    KEGG:
    Pfam:
    SMR:
    String:
    MIM:
    UniGene:
    Uniprot:
     
    FOR
    ELISA Kit for Human PLB
    Cat.:
    E1884h
    Price:
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    MSDS:
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    Packing:
    96T
    Range:
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    ELISA Kit for Human PLB
    MSDS:
    Please sign in first.
    ELISA Kit for Human PLB
    Cat.:
    E1884p
    Price:
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    MSDS:
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    Packing:
    96T
    ELISA Kit for Human PLB
    Cat.:
    E1884b
    Price:
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    MSDS:
    Please sign in first.
    Packing:
    96T
    ELISA Kit for Human PLB
    Cat.:
    E1884m
    Price:
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    MSDS:
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    Packing:
    96T
    ELISA Kit for Human PLB
    Cat.:
    E1884d
    Price:
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    MSDS:
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    Packing:
    96T
    ELISA Kit for Human PLB
    Cat.:
    E1884c
    Price:
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    MSDS:
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    Packing:
    96T
    ELISA Kit for Human PLB
    Cat.:
    E1884r
    Price:
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    MSDS:
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    Packing:
    96T
    CLIA Kit for Human PLB
    Cat.:
    U1884d
    Price:
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    MSDS:
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    Packing:
    96T
    CLIA Kit for Human PLB
    Cat.:
    U1884r
    Price:
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    MSDS:
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    Packing:
    96T
    CLIA Kit for Human PLB
    Cat.:
    U1884c
    Price:
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    MSDS:
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    Packing:
    96T
    CLIA Kit for Human PLB
    Cat.:
    U1884h
    Price:
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    MSDS:
    Please sign in first.
    Packing:
    96T
    Range:
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    CLIA Kit for Human PLB
    MSDS:
    Please sign in first.
    CLIA Kit for Human PLB
    Cat.:
    U1884b
    Price:
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    MSDS:
    Please sign in first.
    Packing:
    96T
    CLIA Kit for Human PLB
    Cat.:
    U1884m
    Price:
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    MSDS:
    Please sign in first.
    Packing:
    96T
    CLIA Kit for Human PLB
    Cat.:
    U1884p
    Price:
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    MSDS:
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    Packing:
    96T
    Polyclonal Antibody for Human PLB
    Cat.:
    P1884Rb-r
    Price:
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    Packing:
    40ug/0.2ml
    Polyclonal Antibody for Human PLB
    Cat.:
    P1884Rb-h
    Price:
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    Packing:
    40ug/0.2ml
    Polyclonal Antibody for Human PLB
    Polyclonal Antibody for Human PLB
    Polyclonal Antibody for Human PLB
    Polyclonal Antibody for Human PLB
    Cat.:
    P1884Rb-m
    Price:
    Please sign in first.
    Packing:
    40ug/0.2ml
    Polyclonal Antibody for Human PLB
    Polyclonal Antibody for Human PLB
    Monoclonal Antibody for Human PLB
    Monoclonal Antibody for Human PLB
    Monoclonal Antibody for Human PLB
    Monoclonal Antibody for Human PLB
    Monoclonal Antibody for Human PLB
    Monoclonal Antibody for Human PLB
    Monoclonal Antibody for Human PLB
    Monoclonal Antibody for Human PLB
    Protein for Human PLB
    Protein for Human PLB
    Protein for Human PLB
    Protein for Human PLB
    Protein for Human PLB
    Protein for Human PLB
    Protein for Human PLB
    Protein for Human PLB

    R&D Technical Data
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    Precision
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    Linearity
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    References
    1. 1.
      "Structure of the rabbit phospholamban gene, cloning of the human cDNA, and assignment of the gene to human chromosome 6."
      Fujii J. , Zarain-Herzberg A. , Willard H.F. , Tada M. , Maclennan D.H.
      J. Biol. Chem.266:11669-11675(1991) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [MRNA]
    2. 2.
      "Cloning of human cardiac phospholamban."
      Salvatore C.A. , Jacobson M.A.
      Submitted (1991-03) to the EMBL/GenBank/DDBJ databases
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [MRNA]
    3. 3.
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA]
    4. 4.
      "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
      The MGC Project Team
      Genome Res.14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA]
      tissue: Liver.
    5. 5.
      "Mutation of the phospholamban promoter associated with hypertrophic cardiomyopathy."
      Minamisawa S. , Sato Y. , Tatsuguchi Y. , Fujino T. , Imamura S. , Uetsuka Y. , Nakazawa M. , Matsuoka R.
      Biochem. Biophys. Res. Commun.304:1-4(2003) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: INVOLVEMENT IN CMH18
    6. 6.
      "Myotonic dystrophy protein kinase phosphorylates phospholamban and regulates calcium uptake in cardiomyocyte sarcoplasmic reticulum."
      Kaliman P. , Catalucci D. , Lam J.T. , Kondo R. , Gutierrez J.C. , Reddy S. , Palacin M. , Zorzano A. , Chien K.R. , Ruiz-Lozano P.
      J. Biol. Chem.280:8016-8021(2005) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: PHOSPHORYLATION AT SER-16 BY DMPK
    7. 7.
      "Ca2+-calmodulin-dependent protein kinase expression and signalling in skeletal muscle during exercise."
      Rose A.J. , Kiens B. , Richter E.A.
      J. Physiol. (Lond.)574:889-903(2006) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: PHOSPHORYLATION AT THR-17 BY CAMK2
    8. 8.
      "Phospholamban interacts with HAX-1, a mitochondrial protein with anti-apoptotic function."
      Vafiadaki E. , Sanoudou D. , Arvanitis D.A. , Catino D.H. , Kranias E.G. , Kontrogianni-Konstantopoulos A.
      J. Mol. Biol.367:65-79(2007) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: INTERACTION WITH HAX1;SUBCELLULAR LOCATION;TISSUE SPECIFICITY
    9. 9.
      "Lethal, hereditary mutants of phospholamban elude phosphorylation by protein kinase A."
      Ceholski D.K. , Trieber C.A. , Holmes C.F. , Young H.S.
      J. Biol. Chem.287:26596-26605(2012) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: FUNCTION;CHARACTERIZATION OF VARIANTS CMD1P CYS-9 AND ARG-14 DEL;SUBCELLULAR LOCATION;PHOSPHORYLATION AT SER-16;MUTAGENESIS OF ARG-9; ARG-13; ARG-14; SER-16 AND THR-17
    10. 10.
      "Solution structure of the cytoplasmic domain of phospholamban: phosphorylation leads to a local perturbation in secondary structure."
      Mortishire-Smith R.J. , Pitzenberger S.M. , Burke C.J. , Middaugh C.R. , Garsky V.M. , Johnson R.G.
      Biochemistry34:7603-7613(1995) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: STRUCTURE BY NMR OF 1-25
    11. 11.
      "Computational searching and mutagenesis suggest a structure for the pentameric transmembrane domain of phospholamban."
      Adams P.D. , Arkin I.T. , Engelman D.M. , Bruenger A.T.
      Nat. Struct. Biol.2:154-162(1995) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: 3D-STRUCTURE MODELING
    12. 12.
      "Using experimental information to produce a model of the transmembrane domain of the ion channel phospholamban."
      Herzyk P. , Hubbard R.E.
      Biophys. J.74:1203-1214(1998) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: 3D-STRUCTURE MODELING
    13. 13.
      "The structure of phospholamban pentamer reveals a channel-like architecture in membranes."
      Oxenoid K. , Chou J.J.
      Proc. Natl. Acad. Sci. U.S.A.102:10870-10875(2005) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: STRUCTURE BY NMR;SUBCELLULAR LOCATION;SUBUNIT
    14. 14.
      "Structure determination of symmetric homo-oligomers by a complete search of symmetry configuration space, using NMR restraints and van der Waals packing."
      Potluri S. , Yan A.K. , Chou J.J. , Donald B.R. , Bailey-Kellogg C.
      Proteins65:203-219(2006) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: STRUCTURE BY NMR;SUBUNIT
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      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: VARIANT CMD1P CYS-9;CHARACTERIZATION OF VARIANT CMD1P CYS-9
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      "A mutation in the human phospholamban gene, deleting arginine 14, results in lethal, hereditary cardiomyopathy."
      Haghighi K. , Kolokathis F. , Gramolini A.O. , Waggoner J.R. , Pater L. , Lynch R.A. , Fan G.C. , Tsiapras D. , Parekh R.R. , Dorn G.W. II , MacLennan D.H. , Kremastinos D.T. , Kranias E.G.
      Proc. Natl. Acad. Sci. U.S.A.103:1388-1393(2006) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: VARIANT CMD1P ARG-14 DEL;CHARACTERIZATION OF VARIANT CMD1P ARG-14 DEL
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      "Hydrophobic imbalance in the cytoplasmic domain of phospholamban is a determinant for lethal dilated cardiomyopathy."
      Ceholski D.K. , Trieber C.A. , Young H.S.
      J. Biol. Chem.287:16521-16529(2012) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: CHARACTERIZATION OF VARIANTS CMD1P CYS-9 AND ARG-14 DEL;FUNCTION;SUBCELLULAR LOCATION
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