Gene name:
PRAME(MAPE;OIP4);
Protein name:
Melanoma antigen preferentially expressed in tumors;
Alternative:
Preferentially expressed antigen of melanoma;Opa-interacting protein 4(OIP-4);
Organism:
Human (Homo sapiens).
General Annotation
Sub Unit:
Interacts with RARA (via the ligand-binding domain); the interaction is direct and ligand (retinoic acid)-dependent. Interacts with EZH2; required to repress RAR signaling.
Function:
Functions as a transcriptional repressor, inhibiting the signaling of retinoic acid through the retinoic acid receptors RARA, RARB and RARG. Prevents retinoic acid-induced cell proliferation arrest, differentiation and apoptosis.
Subcellular Location:
Nucleus
Cell membrane
Protein Attributes:
50:
MERRRLWGSI | QSRYISMSVW | TSPRRLVELA | GQSLLKDEAL | AIAALELLPR |
100:
ELFPPLFMAA | FDGRHSQTLK | AMVQAWPFTC | LPLGVLMKGQ | HLHLETFKAV |
150:
LDGLDVLLAQ | EVRPRRWKLQ | VLDLRKNSHQ | DFWTVWSGNR | ASLYSFPEPE |
200:
AAQPMTKKRK | VDGLSTEAEQ | PFIPVEVLVD | LFLKEGACDE | LFSYLIEKVK |
250:
RKKNVLRLCC | KKLKIFAMPM | QDIKMILKMV | QLDSIEDLEV | TCTWKLPTLA |
300:
KFSPYLGQMI | NLRRLLLSHI | HASSYISPEK | EEQYIAQFTS | QFLSLQCLQA |
350:
LYVDSLFFLR | GRLDQLLRHV | MNPLETLSIT | NCRLSEGDVM | HLSQSPSVSQ |
400:
LSVLSLSGVM | LTDVSPEPLQ | ALLERASATL | QDLVFDECGI | TDDQLLALLP |
450:
SLSHCSQLTT | LSFYGNSISI | SALQSLLQHL | IGLSNLTHVL | YPVPLESYED |
500:
IHGTLHLERL | AYLHARLREL | LCELGRPSMV | WLSANPCPHC | GDRTFYDPEP |
Vaild Sequence:
Related Databases
Uniprot: