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Index > Protein center > PRDX3(Gene name) > Human
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  • PRDX3 (Gene name),
  • Thioredoxin-dependent peroxide reductase, mitochondrial (Protein name ),  PRDX3_HUMAN from NCBI database.
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  • General Annotation
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  • Antigen Annotation
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  • 3D
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  • Predicted Eptitope
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  • Vaild Sequence
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  • Gene name:
    PRDX3(AOP1);
    Protein name:
    Thioredoxin-dependent peroxide reductase, mitochondrial;
    Alternative:
    HBC189;Antioxidant protein 1(AOP-1);Peroxiredoxin-3;Peroxiredoxin III(Prx-III);Protein MER5 homolog;
    Organism:
    Human (Homo sapiens). 
    General Annotation
    Sub Unit:
    Dodecameric ring assembled from homodimeric units; disulfide-linked, upon oxidation. The rings have an approximate diameter of 150 A and a central hole of 70 A. 3-5% of the rings are interlocked by pairs. Binds MAP3K13. Interacts with NEK6.
    Function:
    Involved in redox regulation of the cell. Protects radical-sensitive enzymes from oxidative damage by a radical-generating system. Acts synergistically with MAP3K13 to regulate the activation of NF-kappa-B in the cytosol.
    Subcellular Location:
    Mitochondrion
    Protein Attributes:
    Sequence length:
    256
    Sequence:
    50:
    MAAAVGRLLR | ASVARHVSAI | PWGISATAAL | RPAACGRTSL | TNLLCSGSSQ | 
    100:
    AKLFSTSSSC | HAPAVTQHAP | YFKGTAVVNG | EFKDLSLDDF | KGKYLVLFFY | 
    150:
    PLDFTFVCPT | EIVAFSDKAN | EFHDVNCEVV | AVSVDSHFSH | LAWINTPRKN | 
    200:
    GGLGHMNIAL | LSDLTKQISR | DYGVLLEGSG | LALRGLFIID | PNGVIKHLSV | 
    250:
    NDLPVGRSVE | ETLRLVKAFQ | YVETHGEVCP | ANWTPDSPTI | KPSPAASKEY | 
    256:
    FQKVNQ
    3D Structure:
    N/A
    Predicted Eptitope:
    Please Sign in.
    EIAab Sequence  Vaild Sequence:
    Please Sign in.
    Related Databases
    SMR:
    Pfam:
    UniGene:
    MIM:
    KEGG:
    String:
    Uniprot:
     
    FOR
    ELISA Kit for Human Thioredoxin-dependent peroxide reductase, mitochondrial
    Cat.:
    E12084h
    Price:
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    MSDS:
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    Packing:
    96T
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    ELISA Kit for Human Thioredoxin-dependent peroxide reductase, mitochondrial
    Cat.:
    E12084b
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    MSDS:
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    Packing:
    96T
    Range:
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    ELISA Kit for Human Thioredoxin-dependent peroxide reductase, mitochondrial
    Cat.:
    E12084m
    Price:
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    MSDS:
    Please sign in first.
    Packing:
    96T
    ELISA Kit for Human Thioredoxin-dependent peroxide reductase, mitochondrial
    Cat.:
    E12084r
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    MSDS:
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    Packing:
    96T
    CLIA Kit for Human Thioredoxin-dependent peroxide reductase, mitochondrial
    Cat.:
    U12084m
    Price:
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    MSDS:
    Please sign in first.
    Packing:
    96T
    CLIA Kit for Human Thioredoxin-dependent peroxide reductase, mitochondrial
    Cat.:
    U12084h
    Price:
    Please sign in first.
    MSDS:
    Please sign in first.
    Packing:
    96T
    CLIA Kit for Human Thioredoxin-dependent peroxide reductase, mitochondrial
    MSDS:
    Please sign in first.
    CLIA Kit for Human Thioredoxin-dependent peroxide reductase, mitochondrial
    Cat.:
    U12084r
    Price:
    Please sign in first.
    MSDS:
    Please sign in first.
    Packing:
    96T
    Polyclonal Antibody for Human Thioredoxin-dependent peroxide reductase, mitochondrial
    Polyclonal Antibody for Human Thioredoxin-dependent peroxide reductase, mitochondrial
    Cat.:
    P12084Rb-h
    Price:
    Please sign in first.
    Packing:
    40ug/0.2ml
    Polyclonal Antibody for Human Thioredoxin-dependent peroxide reductase, mitochondrial
    Polyclonal Antibody for Human Thioredoxin-dependent peroxide reductase, mitochondrial
    Monoclonal Antibody for Human Thioredoxin-dependent peroxide reductase, mitochondrial
    Monoclonal Antibody for Human Thioredoxin-dependent peroxide reductase, mitochondrial
    Monoclonal Antibody for Human Thioredoxin-dependent peroxide reductase, mitochondrial
    Monoclonal Antibody for Human Thioredoxin-dependent peroxide reductase, mitochondrial
    Protein for Human Thioredoxin-dependent peroxide reductase, mitochondrial
    Protein for Human Thioredoxin-dependent peroxide reductase, mitochondrial
    Protein for Human Thioredoxin-dependent peroxide reductase, mitochondrial
    Protein for Human Thioredoxin-dependent peroxide reductase, mitochondrial

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    Precision
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    Recovery
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    Linearity
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    References
    1. 1.
      "Mammalian antioxidant protein complements alkylhydroperoxide reductase (ahpC) mutation in Escherichia coli."
      Tsuji K. , Copeland N.G. , Jenkins N.A. , Obinata M.
      Biochem. J.307:377-381(1995) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1)
      tissue: Blood.
    2. 2.
      "Complete sequencing and characterization of 21,243 full-length human cDNAs."
      Ota T. , Suzuki Y. , Nishikawa T. , Otsuki T. , Sugiyama T. , Irie R. , Wakamatsu A. , Hayashi K. , Sato H. , Nagai K. , Kimura K. , Makita H. , Sekine M. , Obayashi M. , Nishi T. , Shibahara T. , Tanaka T. , Ishii S. , more...
      Nat. Genet.36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1)
      tissue: Lung.
    3. 3.
      "Cloning of human full open reading frames in Gateway(TM) system entry vector (pDONR201)."
      Ebert L. , Schick M. , Neubert P. , Schatten R. , Henze S. , Korn B.
      Submitted (2004-05) to the EMBL/GenBank/DDBJ databases
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1)
    4. 4.
      "Cloning of human full-length CDSs in BD Creator(TM) system donor vector."
      Kalnine N. , Chen X. , Rolfs A. , Halleck A. , Hines L. , Eisenstein S. , Koundinya M. , Raphael J. , Moreira D. , Kelley T. , LaBaer J. , Lin Y. , Phelan M. , Farmer A.
      Submitted (2004-10) to the EMBL/GenBank/DDBJ databases
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1)
    5. 5.
      NIEHS SNPs program
      Submitted (2005-11) to the EMBL/GenBank/DDBJ databases
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA];VARIANTS ARG-55; THR-218 AND ILE-234
    6. 6.
      "The DNA sequence and comparative analysis of human chromosome 10."
      Deloukas P. , Earthrowl M.E. , Grafham D.V. , Rubenfield M. , French L. , Steward C.A. , Sims S.K. , Jones M.C. , Searle S. , Scott C. , Howe K. , Hunt S.E. , Andrews T.D. , Gilbert J.G.R. , Swarbreck D. , Ashurst J.L. , Taylor A. , Battles J. , more...
      Nature429:375-381(2004) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]
    7. 7.
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]
    8. 8.
      "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
      The MGC Project Team
      Genome Res.14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1)
      tissue: Bone marrow.
      tissue: Skeletal muscle.
      tissue: Testis.
      tissue: Urinary bladder.
      tissue: Uterus.
    9. 9.
      "Human liver protein map: a reference database established by microsequencing and gel comparison."
      Hochstrasser D.F. , Frutiger S. , Paquet N. , Bairoch A. , Ravier F. , Pasquali C. , Sanchez J.-C. , Tissot J.-D. , Bjellqvist B. , Vargas R. , Appel R.D. , Hughes G.J.
      Electrophoresis13:992-1001(1992) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: PROTEIN SEQUENCE OF 63-72 (ISOFORM 1)
      tissue: Liver.
    10. 10.
      Lubec G. , Vishwanath V. , Chen W.-Q. , Sun Y.
      Submitted (2008-12) to the UniProtKB
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: PROTEIN SEQUENCE OF 74-93; 149-166 AND 171-214 (ISOFORM 1);IDENTIFICATION BY MASS SPECTROMETRY
      tissue: Brain.
      tissue: Cajal-Retzius cell.
      tissue: Fetal brain cortex.
    11. 11.
      "A method for detection of overoxidation of cysteines: peroxiredoxins are oxidized in vivo at the active-site cysteine during oxidative stress."
      Wagner E. , Luche S. , Penna L. , Chevallet M. , van Dorsselaer A. , Leize-Wagner E. , Rabilloud T.
      Biochem. J.366:777-785(2002) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: OVEROXIDATION AT CYS-108
    12. 12.
      "Mixed lineage kinase LZK and antioxidant protein-1 activate NF-kappaB synergistically."
      Masaki M. , Ikeda A. , Shiraki E. , Oka S. , Kawasaki T.
      Eur. J. Biochem.270:76-83(2003) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: FUNCTION;INTERACTION WITH MAP3K13
    13. 13.
      "Reconstitution of the mitochondrial PrxIII antioxidant defence pathway: general properties and factors affecting PrxIII activity and oligomeric state."
      Cao Z. , Bhella D. , Lindsay J.G.
      J. Mol. Biol.372:1022-1033(2007) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: SUBUNIT
    14. 14.
      "Lysine acetylation targets protein complexes and co-regulates major cellular functions."
      Choudhary C. , Kumar C. , Gnad F. , Nielsen M.L. , Rehman M. , Walther T.C. , Olsen J.V. , Mann M.
      Science325:834-840(2009) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: ACETYLATION [LARGE SCALE ANALYSIS] AT LYS-91;IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS]
    15. 15.
      "Characterization of hNek6 interactome reveals an important role for its short N-terminal domain and colocalization with proteins at the centrosome."
      Vaz Meirelles G. , Ferreira Lanza D.C. , da Silva J.C. , Santana Bernachi J. , Paes Leme A.F. , Kobarg J.
      J. Proteome Res.9:6298-6316(2010) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: INTERACTION WITH NEK6
    16. 16.
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS]
    17. 17.
      "Mutations in LRRK2 increase phosphorylation of peroxiredoxin 3 exacerbating oxidative stress-induced neuronal death."
      Angeles D.C. , Gan B.H. , Onstead L. , Zhao Y. , Lim K.L. , Dachsel J. , Melrose H. , Farrer M. , Wszolek Z.K. , Dickson D.W. , Tan E.K.
      Hum. Mutat.32:1390-1397(2011) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: INTERACTION WITH LRRK2;PHOSPHORYLATION AT THR-146;MUTAGENESIS OF THR-146
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