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Index > Protein center > PRDX5(Gene name) > Human
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  • PRDX5 (Gene name),
  • Peroxiredoxin-5, mitochondrial (Protein name ),  PRDX5_HUMAN from NCBI database.
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  • General Annotation
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  • Antigen Annotation
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  • 3D
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  • Predicted Eptitope
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  • Vaild Sequence
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  • Related Databases
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  • Citations  (1)
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  • Gene name:
    PRDX5(SBBI10;ACR1);
    Protein name:
    Peroxiredoxin-5, mitochondrial;
    Alternative:
    Antioxidant enzyme B166(AOEB166);Alu corepressor 1;PLP;Liver tissue 2D-page spot 71B;Peroxisomal antioxidant enzyme;Peroxiredoxin V(Prx-V);Thioredoxin peroxidase PMP20;TPx type VI;Thioredoxin reductase;
    Organism:
    Human (Homo sapiens). 
    General Annotation
    Sub Unit:
    Monomer.
    Function:
    Reduces hydrogen peroxide and alkyl hydroperoxides with reducing equivalents provided through the thioredoxin system. Involved in intracellular redox signaling.
    Subcellular Location:
    Mitochondrion Cytoplasm Peroxisome
    Protein Attributes:
    Sequence length:
    214
    Sequence:
    50:
    MGLAGVCALR | RSAGYILVGG | AGGQSAAAAA | RRYSEGEWAS | GGVRSFSRAA | 
    100:
    AAMAPIKVGD | AIPAVEVFEG | EPGNKVNLAE | LFKGKKGVLF | GVPGAFTPGC | 
    150:
    SKTHLPGFVE | QAEALKAKGV | QVVACLSVND | AFVTGEWGRA | HKAEGKVRLL | 
    200:
    ADPTGAFGKE | TDLLLDDSLV | SIFGNRRLKR | FSMVVQDGIV | KALNVEPDGT | 
    214:
    GLTCSLAPNI | ISQL
    3D Structure:
    N/A
    Predicted Eptitope:
    Please Sign in.
    EIAab Sequence  Vaild Sequence:
    Please Sign in.
    Related Databases
    KEGG:
    Pfam:
    MIM:
    SMR:
    String:
    UniGene:
    Uniprot:
     
    FOR
    ELISA Kit for Human Peroxiredoxin-5, mitochondrial
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    E0703h
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    ELISA Kit for Human Peroxiredoxin-5, mitochondrial
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    E0703r
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    ELISA Kit for Human Peroxiredoxin-5, mitochondrial
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    E0703m
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    ELISA Kit for Human Peroxiredoxin-5, mitochondrial
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    E0703b
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    Packing:
    96T
    CLIA Kit for Human Peroxiredoxin-5, mitochondrial
    Cat.:
    U0703b
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    Packing:
    96T
    CLIA Kit for Human Peroxiredoxin-5, mitochondrial
    Cat.:
    U0703m
    Price:
    Please sign in first.
    MSDS:
    Please sign in first.
    Packing:
    96T
    Range:
    Please sign in first.
    CLIA Kit for Human Peroxiredoxin-5, mitochondrial
    Cat.:
    U0703r
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    Please sign in first.
    MSDS:
    Please sign in first.
    Packing:
    96T
    Range:
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    CLIA Kit for Human Peroxiredoxin-5, mitochondrial
    Cat.:
    U0703h
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    Please sign in first.
    MSDS:
    Please sign in first.
    Packing:
    96T
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    Polyclonal Antibody for Human Peroxiredoxin-5, mitochondrial
    Polyclonal Antibody for Human Peroxiredoxin-5, mitochondrial
    Cat.:
    P0703Rb-r
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    Packing:
    40ug/0.2ml
    Polyclonal Antibody for Human Peroxiredoxin-5, mitochondrial
    Cat.:
    P0703Rb-h
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    Packing:
    40ug/0.2ml
    Polyclonal Antibody for Human Peroxiredoxin-5, mitochondrial
    Cat.:
    P0703Rb-m
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    Packing:
    40ug/0.2ml
    Monoclonal Antibody for Human Peroxiredoxin-5, mitochondrial
    Monoclonal Antibody for Human Peroxiredoxin-5, mitochondrial
    Monoclonal Antibody for Human Peroxiredoxin-5, mitochondrial
    Monoclonal Antibody for Human Peroxiredoxin-5, mitochondrial
    Protein for Human Peroxiredoxin-5, mitochondrial
    Protein for Human Peroxiredoxin-5, mitochondrial
    Protein for Human Peroxiredoxin-5, mitochondrial
    Protein for Human Peroxiredoxin-5, mitochondrial

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    Precision
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    Linearity
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    References
    1. 1.
      "A novel human DNA-binding protein with sequence similarity to a subfamily of redox proteins which is able to repress RNA-polymerase-III-driven transcription of the Alu-family retroposons in vitro."
      Kropotov A. , Sedova V. , Ivanov V. , Sazeeva N. , Tomilin A. , Krutilina R. , Oei S.L. , Griesenbeck J. , Buchlow G. , Tomilin N.
      Eur. J. Biochem.260:336-346(1999) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM MITOCHONDRIAL);VARIANT CYS-33
    2. 2.
      "Characterization of human and murine PMP20 peroxisomal proteins that exhibit antioxidant activity in vitro."
      Yamashita H. , Avraham S. , Jiang S. , London R. , Van Veldhoven P.P. , Subramani S. , Rogers R.A. , Avraham H.
      J. Biol. Chem.274:29897-29904(1999) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM CYTOPLASMIC+PEROXISOMAL);CHARACTERIZATION
    3. 3.
      "Cloning and characterization of AOEB166, a novel mammalian antioxidant enzyme of the peroxiredoxin family."
      Knoops B. , Clippe A. , Bogard C. , Arsalane K. , Wattiez R. , Hermans C. , Duconseille E. , Falmagne P. , Bernard A.
      J. Biol. Chem.274:30451-30458(1999) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM MITOCHONDRIAL);PROTEIN SEQUENCE OF 54-90;TISSUE SPECIFICITY;SUBCELLULAR LOCATION;CHARACTERIZATION;VARIANT CYS-33
      tissue: Lung.
    4. 4.
      "Mouse peroxiredoxin V is a thioredoxin peroxidase that inhibits p53-induced apoptosis."
      Zhou Y. , Kok K.H. , Chun A.C.S. , Wong C.M. , Wu H.W. , Lin M.C.M. , Fung P.C.W. , Kung H.-F. , Jin D.-Y.
      Biochem. Biophys. Res. Commun.268:921-927(2000) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM CYTOPLASMIC+PEROXISOMAL);VARIANT CYS-33
    5. 5.
      "Identification of a new type of mammalian peroxiredoxin that forms an intramolecular disulfide as a reaction intermediate."
      Seo M.S. , Kang S.W. , Kim K. , Baines I.C. , Lee T.H. , Rhee S.G.
      J. Biol. Chem.275:20346-20354(2000) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [MRNA];MUTAGENESIS;CHARACTERIZATION
    6. 6.
      "A new type of human thiol peroxidase (Human TPx type VI)."
      Kim I.H. , Jeong W.
      Submitted (1999-09) to the EMBL/GenBank/DDBJ databases
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM CYTOPLASMIC+PEROXISOMAL)
    7. 7.
      Zhang W. , Li N. , Wan T. , Cao X.
      Submitted (2000-03) to the EMBL/GenBank/DDBJ databases
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM MITOCHONDRIAL);VARIANT CYS-33
    8. 8.
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM CYTOPLASMIC+PEROXISOMAL)
      tissue: Adrenal gland.
    9. 9.
      "Cloning of human full open reading frames in Gateway(TM) system entry vector (pDONR201)."
      Ebert L. , Schick M. , Neubert P. , Schatten R. , Henze S. , Korn B.
      Submitted (2004-06) to the EMBL/GenBank/DDBJ databases
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM MITOCHONDRIAL);VARIANT CYS-33
    10. 10.
      NIEHS SNPs program
      Submitted (2005-10) to the EMBL/GenBank/DDBJ databases
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA];VARIANT CYS-33
    11. 11.
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]
    12. 12.
      "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
      The MGC Project Team
      Genome Res.14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORMS MITOCHONDRIAL; 3 AND 4);VARIANT CYS-33
      tissue: Brain.
      tissue: Medulla oblongata.
    13. 13.
      "Human liver protein map: a reference database established by microsequencing and gel comparison."
      Hochstrasser D.F. , Frutiger S. , Paquet N. , Bairoch A. , Ravier F. , Pasquali C. , Sanchez J.-C. , Tissot J.-D. , Bjellqvist B. , Vargas R. , Appel R.D. , Hughes G.J.
      Electrophoresis13:992-1001(1992) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: PROTEIN SEQUENCE OF 54-63
      tissue: Liver.
    14. 14.
      "Lysine acetylation targets protein complexes and co-regulates major cellular functions."
      Choudhary C. , Kumar C. , Gnad F. , Nielsen M.L. , Rehman M. , Walther T.C. , Olsen J.V. , Mann M.
      Science325:834-840(2009) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: ACETYLATION [LARGE SCALE ANALYSIS] AT LYS-83;IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS]
    15. 15.
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS]
    16. 16.
      "Crystal structure of human peroxiredoxin 5, a novel type of mammalian peroxiredoxin at 1.5-A resolution."
      Declercq J.-P. , Evrard C. , Clippe A. , Stricht D.V. , Bernard A. , Knoops B.
      J. Mol. Biol.311:751-759(2001) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: X-RAY CRYSTALLOGRAPHY (1.5 ANGSTROMS)
    17. 17.
      "The crystal structures of oxidized forms of human peroxiredoxin 5 with an intramolecular disulfide bond confirm the proposed enzymatic mechanism for atypical 2-Cys peroxiredoxins."
      Smeets A. , Marchand C. , Linard D. , Knoops B. , Declercq J.P.
      Arch. Biochem. Biophys.477:98-104(2008) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: X-RAY CRYSTALLOGRAPHY (1.83 ANGSTROMS) OF 54-214;DISULFIDE BOND
    18. 18.
      "Structural evidence that peroxiredoxin catalytic power is based on transition-state stabilization."
      Hall A. , Parsonage D. , Poole L.B. , Karplus P.A.
      J. Mol. Biol.402:194-209(2010) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: X-RAY CRYSTALLOGRAPHY (1.45 ANGSTROMS) OF 54-214 IN COMPLEX WITH DITHIOTHREITOL;ACTIVE SITE
    19. 19.
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: VARIANT [LARGE SCALE ANALYSIS] LEU-157
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