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Index > Protein center > PRDX6(Gene name) > Human
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  • PRDX6 (Gene name),
  • Peroxiredoxin-6 (Protein name ),  PRDX6_HUMAN from NCBI database.
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  • General Annotation
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  • Antigen Annotation
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  • 3D
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  • Predicted Eptitope
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  • Vaild Sequence
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  • Related Databases
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  • Citations  (2)
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  • Gene name:
    PRDX6(AOP2;KIAA0106);
    Protein name:
    Peroxiredoxin-6;
    Alternative:
    1.11.1.9;Non-selenium glutathione peroxidase(NSGPx);Liver 2D page spot 40;Antioxidant protein 2;3.1.1.-;Acidic calcium-independent phospholipase A2(aiPLA2);Red blood cells page spot 12;1-Cys peroxiredoxin(1-Cys PRX);24 kDa protein;
    Organism:
    Human (Homo sapiens). 
    General Annotation
    Sub Unit:
    Homotetramer. Interacts with GSTP1; mediates PRDX6 glutathionylation and regeneration. May interact with HTR2A (By similarity). Interacts with APEX1 and STH.
    Function:
    Involved in redox regulation of the cell. Can reduce H(2)O(2) and short chain organic, fatty acid, and phospholipid hydroperoxides. May play a role in the regulation of phospholipid turnover as well as in protection against oxidative injury.
    Subcellular Location:
    Cytoplasm Lysosome Cytoplasmic vesicle Also found in lung secretory organelles.
    Protein Attributes:
    Sequence length:
    224
    Sequence:
    50:
    MPGGLLLGDV | APNFEANTTV | GRIRFHDFLG | DSWGILFSHP | RDFTPVCTTE | 
    100:
    LGRAAKLAPE | FAKRNVKLIA | LSIDSVEDHL | AWSKDINAYN | CEEPTEKLPF | 
    150:
    PIIDDRNREL | AILLGMLDPA | EKDEKGMPVT | ARVVFVFGPD | KKLKLSILYP | 
    200:
    ATTGRNFDEI | LRVVISLQLT | AEKRVATPVD | WKDGDSVMVL | PTIPEEEAKK | 
    224:
    LFPKGVFTKE | LPSGKKYLRY | TPQP
    3D Structure:
    N/A
    Predicted Eptitope:
    Please Sign in.
    EIAab Sequence  Vaild Sequence:
    Please Sign in.
    Related Databases
    KEGG:
    SMR:
    UniGene:
    String:
    Pfam:
    MIM:
    Uniprot:
     
    FOR
    ELISA Kit for Human Peroxiredoxin-6
    Cat.:
    E1751r
    Price:
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    MSDS:
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    Packing:
    96T
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    ELISA Kit for Human Peroxiredoxin-6
    Cat.:
    E1751c
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    MSDS:
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    Packing:
    96T
    ELISA Kit for Human Peroxiredoxin-6
    Cat.:
    E1751b
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    MSDS:
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    Packing:
    96T
    ELISA Kit for Human Peroxiredoxin-6
    Cat.:
    E1751p
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    MSDS:
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    Packing:
    96T
    ELISA Kit for Human Peroxiredoxin-6
    Cat.:
    E1751h
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    MSDS:
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    ELISA Kit for Human Peroxiredoxin-6
    Cat.:
    E1751m
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    MSDS:
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    Packing:
    96T
    CLIA Kit for Human Peroxiredoxin-6
    Cat.:
    U1751r
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    MSDS:
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    Packing:
    96T
    CLIA Kit for Human Peroxiredoxin-6
    Cat.:
    U1751b
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    MSDS:
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    Packing:
    96T
    CLIA Kit for Human Peroxiredoxin-6
    Cat.:
    U1751h
    Price:
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    MSDS:
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    Packing:
    96T
    Range:
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    CLIA Kit for Human Peroxiredoxin-6
    Cat.:
    U1751c
    Price:
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    MSDS:
    Please sign in first.
    Packing:
    96T
    CLIA Kit for Human Peroxiredoxin-6
    Cat.:
    U1751m
    Price:
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    MSDS:
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    Packing:
    96T
    CLIA Kit for Human Peroxiredoxin-6
    Cat.:
    U1751p
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    MSDS:
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    Packing:
    96T
    Polyclonal Antibody for Human Peroxiredoxin-6
    Cat.:
    P1751Rb-h
    Price:
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    Packing:
    40ug/0.2ml
    Polyclonal Antibody for Human Peroxiredoxin-6
    Polyclonal Antibody for Human Peroxiredoxin-6
    Cat.:
    P1751Rb-m
    Price:
    Please sign in first.
    Packing:
    40ug/0.2ml
    Polyclonal Antibody for Human Peroxiredoxin-6
    Polyclonal Antibody for Human Peroxiredoxin-6
    Polyclonal Antibody for Human Peroxiredoxin-6
    Cat.:
    P1751Rb-r
    Price:
    Please sign in first.
    Packing:
    40ug/0.2ml
    Monoclonal Antibody for Human Peroxiredoxin-6
    Monoclonal Antibody for Human Peroxiredoxin-6
    Monoclonal Antibody for Human Peroxiredoxin-6
    Monoclonal Antibody for Human Peroxiredoxin-6
    Monoclonal Antibody for Human Peroxiredoxin-6
    Monoclonal Antibody for Human Peroxiredoxin-6
    Protein for Human Peroxiredoxin-6
    Protein for Human Peroxiredoxin-6
    Protein for Human Peroxiredoxin-6
    Protein for Human Peroxiredoxin-6
    Protein for Human Peroxiredoxin-6
    Protein for Human Peroxiredoxin-6

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    Recovery
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    Linearity
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    References
    1. 1.
      "Identification of a human cDNA clone for lysosomal type Ca2+-independent phospholipase A2 and properties of the expressed protein."
      Kim T.-S. , Sundaresh C.S. , Feinstein S.I. , Dodia C. , Skach W.R. , Jain M.K. , Nagase T. , Seki N. , Ishikawa K. , Nomura N. , Fisher A.B.
      J. Biol. Chem.272:2542-2550(1997) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [MRNA]
    2. 2.
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: ERRATUM
    3. 3.
      "The human homologue of a bovine non-selenium glutathione peroxidase is a novel keratinocyte growth factor-regulated gene."
      Frank S. , Munz B. , Werner S.
      Oncogene14:915-921(1997) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [MRNA]
    4. 4.
      "Prediction of the coding sequences of unidentified human genes. III. The coding sequences of 40 new genes (KIAA0081-KIAA0120) deduced by analysis of cDNA clones from human cell line KG-1."
      Nagase T. , Miyajima N. , Tanaka A. , Sazuka T. , Seki N. , Sato S. , Tabata S. , Ishikawa K. , Kawarabayasi Y. , Kotani H. , Nomura N.
      DNA Res.2:37-43(1995) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA]
      tissue: Bone marrow.
    5. 5.
      "Complete sequencing and characterization of 21,243 full-length human cDNAs."
      Ota T. , Suzuki Y. , Nishikawa T. , Otsuki T. , Sugiyama T. , Irie R. , Wakamatsu A. , Hayashi K. , Sato H. , Nagai K. , Kimura K. , Makita H. , Sekine M. , Obayashi M. , Nishi T. , Shibahara T. , Tanaka T. , Ishii S. , more...
      Nat. Genet.36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA]
    6. 6.
      NIEHS SNPs program
      Submitted (2005-10) to the EMBL/GenBank/DDBJ databases
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA]
    7. 7.
      "The DNA sequence and biological annotation of human chromosome 1."
      Gregory S.G. , Barlow K.F. , McLay K.E. , Kaul R. , Swarbreck D. , Dunham A. , Scott C.E. , Howe K.L. , Woodfine K. , Spencer C.C.A. , Jones M.C. , Gillson C. , Searle S. , Zhou Y. , Kokocinski F. , McDonald L. , Evans R. , Phillips K. , more...
      Nature441:315-321(2006) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]
    8. 8.
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]
    9. 9.
      "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
      The MGC Project Team
      Genome Res.14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA]
      tissue: Fetal brain.
      tissue: Testis.
    10. 10.
      "Exploring proteomes and analyzing protein processing by mass spectrometric identification of sorted N-terminal peptides."
      Gevaert K. , Goethals M. , Martens L. , Van Damme J. , Staes A. , Thomas G.R. , Vandekerckhove J.
      Nat. Biotechnol.21:566-569(2003) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: PROTEIN SEQUENCE OF 2-22
      tissue: Platelet.
    11. 11.
      Lubec G. , Vishwanath V. , Chen W.-Q. , Sun Y.
      Submitted (2008-12) to the UniProtKB
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: PROTEIN SEQUENCE OF 2-22; 25-53; 85-106; 133-142; 145-155; 163-173 AND 175-199;IDENTIFICATION BY MASS SPECTROMETRY
      tissue: Brain.
      tissue: Cajal-Retzius cell.
      tissue: Fetal brain cortex.
    12. 12.
      "Human liver protein map: a reference database established by microsequencing and gel comparison."
      Hochstrasser D.F. , Frutiger S. , Paquet N. , Bairoch A. , Ravier F. , Pasquali C. , Sanchez J.-C. , Tissot J.-D. , Bjellqvist B. , Vargas R. , Appel R.D. , Hughes G.J.
      Electrophoresis13:992-1001(1992) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: PROTEIN SEQUENCE OF 2-15
      tissue: Liver.
    13. 13.
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: PROTEIN SEQUENCE OF 2-13
      tissue: Erythrocyte.
    14. 14.
      "DNA probes built and sequenced for microarrays hybridisations."
      Dominguez O. , Lombardia L.
      Submitted (2004-09) to the EMBL/GenBank/DDBJ databases
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [MRNA] OF 14-99
    15. 15.
      "Characterization of a mammalian peroxiredoxin that contains one conserved cysteine."
      Kang S.W. , Baines I.C. , Rhee S.G.
      J. Biol. Chem.273:6303-6311(1998) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: CHARACTERIZATION;MUTAGENESIS
    16. 16.
      "1-Cys peroxiredoxin, a bifunctional enzyme with glutathione peroxidase and phospholipase A2 activities."
      Chen J.-W. , Dodia C. , Feinstein S.I. , Jain M.K. , Fisher A.B.
      J. Biol. Chem.275:28421-28427(2000) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: CHARACTERIZATION;MUTAGENESIS
    17. 17.
      "A method for detection of overoxidation of cysteines: peroxiredoxins are oxidized in vivo at the active-site cysteine during oxidative stress."
      Wagner E. , Luche S. , Penna L. , Chevallet M. , van Dorsselaer A. , Leize-Wagner E. , Rabilloud T.
      Biochem. J.366:777-785(2002) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: OVEROXIDATION AT CYS-47
    18. 18.
      "Saitohin, which is nested in the tau locus and confers allele-specific susceptibility to several neurodegenerative diseases, interacts with peroxiredoxin 6."
      Gao L. , Tse S.-W. , Conrad C. , Andreadis A.
      J. Biol. Chem.280:39268-39272(2005) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: SUBCELLULAR LOCATION;INTERACTION WITH STH
    19. 19.
      "Immunoaffinity profiling of tyrosine phosphorylation in cancer cells."
      Rush J. , Moritz A. , Lee K.A. , Guo A. , Goss V.L. , Spek E.J. , Zhang H. , Zha X.-M. , Polakiewicz R.D. , Comb M.J.
      Nat. Biotechnol.23:94-101(2005) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT TYR-89;IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS]
    20. 20.
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT THR-44;IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS]
      tissue: Cervix carcinoma.
    21. 21.
      "APE1/Ref-1 interacts with NPM1 within nucleoli and plays a role in the rRNA quality control process."
      Vascotto C. , Fantini D. , Romanello M. , Cesaratto L. , Deganuto M. , Leonardi A. , Radicella J.P. , Kelley M.R. , D'Ambrosio C. , Scaloni A. , Quadrifoglio F. , Tell G.
      Mol. Cell. Biol.29:1834-1854(2009) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: INTERACTION WITH APEX1;IDENTIFICATION BY MASS SPECTROMETRY;SUBCELLULAR LOCATION
    22. 22.
      "Lysine acetylation targets protein complexes and co-regulates major cellular functions."
      Choudhary C. , Kumar C. , Gnad F. , Nielsen M.L. , Rehman M. , Walther T.C. , Olsen J.V. , Mann M.
      Science325:834-840(2009) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: ACETYLATION [LARGE SCALE ANALYSIS] AT LYS-63 AND LYS-209;IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS]
    23. 23.
      "Quantitative phosphoproteomics reveals widespread full phosphorylation site occupancy during mitosis."
      Olsen J.V. , Vermeulen M. , Santamaria A. , Kumar C. , Miller M.L. , Jensen L.J. , Gnad F. , Cox J. , Jensen T.S. , Nigg E.A. , Brunak S. , Mann M.
      Sci. Signal.3:RA3-RA3(2010) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT THR-44;IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS]
      tissue: Cervix carcinoma.
    24. 24.
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS]
    25. 25.
      "The novel protein MANI modulates neurogenesis and neurite-cone growth."
      Mishra M. , Akatsu H. , Heese K.
      J. Cell. Mol. Med.15:1713-1725(2011) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: INTERACTION WITH FAM168B
    26. 26.
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS]
    27. 27.
      "Crystal structure of a novel human peroxidase enzyme at 2.0-A resolution."
      Choi H.-J. , Kang S.W. , Yang C.-H. , Rhee S.G. , Ryu S.-E.
      Nat. Struct. Biol.5:400-406(1998) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: X-RAY CRYSTALLOGRAPHY (2.0 ANGSTROMS)
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