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Index > Protein center > PREX2(Gene name) > Human
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  • PREX2 (Gene name),
  • Phosphatidylinositol 3,4,5-trisphosphate-dependent Rac exchanger 2 protein (Protein name ),  PREX2_HUMAN from NCBI database.
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  • General Annotation
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  • Antigen Annotation
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  • Gene name:
    PREX2(DEPDC2);
    Protein name:
    Phosphatidylinositol 3,4,5-trisphosphate-dependent Rac exchanger 2 protein(P-Rex2;PtdIns(3,4,5)-dependent Rac exchanger 2);
    Alternative:
    DEP domain-containing protein 2;
    Organism:
    Human (Homo sapiens). 
    General Annotation
    Sub Unit:
    Interacts with RAC1.
    Function:
    Functions as a RAC1 guanine nucleotide exchange factor (GEF), activating Rac proteins by exchanging bound GDP for free GTP. Its activity is synergistically activated by phosphatidylinositol-3,4,5-triphosphate and the beta gamma subunits of heterotrimeric G protein. Mediates the activation of RAC1 in a PI3K-dependent manner. May be an important mediator of Rac signaling, acting directly downstream of both G protein-coupled receptors and phosphoinositide 3-kinase.
    Subcellular Location:
    N/A
    Protein Attributes:
    Sequence length:
    1606
    Sequence:
    50:
    MSEDSRGDSR | AESAKDLEKQ | LRLRVCVLSE | LQKTERDYVG | TLEFLVSAFL | 
    100:
    HRMNQCAASK | VDKNVTEETV | KMLFSNIEDI | LAVHKEFLKV | VEECLHPEPN | 
    150:
    AQQEVGTCFL | HFKDKFRIYD | EYCSNHEKAQ | KLLLELNKIR | TIRTFLLNCM | 
    200:
    LLGGRKNTDV | PLEGYLVTPI | QRICKYPLIL | KELLKRTPRK | HSDYAAVMEA | 
    250:
    LQAMKAVCSN | INEAKRQMEK | LEVLEEWQSH | IEGWEGSNIT | DTCTEMLMCG | 
    300:
    VLLKISSGNI | QERVFFLFDN | LLVYCKRKHR | RLKNSKASTD | GHRYLFRGRI | 
    350:
    NTEVMEVENV | DDGTADFHSS | GHIVVNGWKI | HNTAKNKWFV | CMAKTPEEKH | 
    400:
    EWFEAILKER | ERRKGLKLGM | EQDTWVMISE | QGEKLYKMMC | RQGNLIKDRK | 
    450:
    RKLTTFPKCF | LGSEFVSWLL | EIGEIHRPEE | GVHLGQALLE | NGIIHHVTDK | 
    500:
    HQFKPEQMLY | RFRYDDGTFY | PRNEMQDVIS | KGVRLYCRLH | SLFTPVIRDK | 
    550:
    DYHLRTYKSV | VMANKLIDWL | IAQGDCRTRE | EAMIFGVGLC | DNGFMHHVLE | 
    600:
    KSEFKDEPLL | FRFFSDEEME | GSNMKHRLMK | HDLKVVENVI | AKSLLIKSNE | 
    650:
    GSYGFGLEDK | NKVPIIKLVE | KGSNAEMAGM | EVGKKIFAIN | GDLVFMRPFN | 
    700:
    EVDCFLKSCL | NSRKPLRVLV | STKPRETVKI | PDSADGLGFQ | IRGFGPSVVH | 
    750:
    AVGRGTVAAA | AGLHPGQCII | KVNGINVSKE | THASVIAHVT | ACRKYRRPTK | 
    800:
    QDSIQWVYNS | IESAQEDLQK | SHSKPPGDEA | GDAFDCKVEE | VIDKFNTMAI | 
    850:
    IDGKKEHVSL | TVDNVHLEYG | VVYEYDSTAG | IKCNVVEKMI | EPKGFFSLTA | 
    900:
    KILEALAKSD | EHFVQNCTSL | NSLNEVIPTD | LQSKFSALCS | ERIEHLCQRI | 
    950:
    SSYKKFSRVL | KNRAWPTFKQ | AKSKISPLHS | SDFCPTNCHV | NVMEVSYPKT | 
    1000:
    STSLGSAFGV | QLDSRKHNSH | DKENKSSEQG | KLSPMVYIQH | TITTMAAPSG | 
    1050:
    LSLGQQDGHG | LRYLLKEEDL | ETQDIYQKLL | GKLQTALKEV | EMCVCQIDDL | 
    1100:
    LSSITYSPKL | ERKTSEGIIP | TDSDNEKGER | NSKRVCFNVA | GDEQEDSGHD | 
    1150:
    TISNRDSYSD | CNSNRNSIAS | FTSICSSQCS | SYFHSDEMDS | GDELPLSVRI | 
    1200:
    SHDKQDKIHS | CLEHLFSQVD | SITNLLKGQA | VVRAFDQTKY | LTPGRGLQEF | 
    1250:
    QQEMEPKLSC | PKRLRLHIKQ | DPWNLPSSVR | TLAQNIRKFV | EEVKCRLLLA | 
    1300:
    LLEYSDSETQ | LRRDMVFCQT | LVATVCAFSE | QLMAALNQMF | DNSKENEMET | 
    1350:
    WEASRRWLDQ | IANAGVLFHF | QSLLSPNLTD | EQAMLEDTLV | ALFDLEKVSF | 
    1400:
    YFKPSEEEPL | VANVPLTYQA | EGSRQALKVY | FYIDSYHFEQ | LPQRLKNGGG | 
    1450:
    FKIHPVLFAQ | ALESMEGYYY | RDNVSVEEFQ | AQINAASLEK | VKQYNQKLRA | 
    1500:
    FYLDKSNSPP | NSTSKAAYVD | KLMRPLNALD | ELYRLVASFI | RSKRTAACAN | 
    1550:
    TACSASGVGL | LSVSSELCNR | LGACHIIMCS | SGVHRCTLSV | TLEQAIILAR | 
    1600:
    SHGLPPRYIM | QATDVMRKQG | ARVQNTAKNL | GVRDRTPQSA | PRLYKLCEPP | 
    1606:
    PPAGEE
    3D Structure:
    N/A
    Predicted Eptitope:
    Please Sign in.
    EIAab Sequence  Vaild Sequence:
    Please Sign in.
    Related Databases
    KEGG:
    SMR:
    String:
    UniGene:
    Pfam:
    MIM:
    Uniprot:
     
    FOR
    ELISA Kit for Human P-Rex2
    Cat.:
    E4467h
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    Packing:
    96T
    Range:
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    ELISA Kit for Human P-Rex2
    Cat.:
    E4467m
    Price:
    Please sign in first.
    MSDS:
    Please sign in first.
    Packing:
    96T
    CLIA Kit for Human P-Rex2
    Cat.:
    U4467h
    Price:
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    MSDS:
    Please sign in first.
    Packing:
    96T
    Range:
    Please sign in first.
    CLIA Kit for Human P-Rex2
    Cat.:
    U4467m
    Price:
    Please sign in first.
    MSDS:
    Please sign in first.
    Packing:
    96T
    Polyclonal Antibody for Human P-Rex2
    Cat.:
    P4467Rb-m
    Price:
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    Packing:
    40ug/0.2ml
    Polyclonal Antibody for Human P-Rex2
    Cat.:
    P4467Rb-h
    Price:
    Please sign in first.
    Packing:
    40ug/0.2ml
    Monoclonal Antibody for Human P-Rex2
    Monoclonal Antibody for Human P-Rex2
    Protein for Human P-Rex2
    Protein for Human P-Rex2

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    Precision
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    Recovery
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    Linearity
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    For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.
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    References
    1. 1.
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1);FUNCTION;TISSUE SPECIFICITY
      tissue: Brain.
      tissue: Skeletal muscle.
    2. 2.
      "Cloning and characterization of P-Rex2: an inositol polyphosphate 4-phosphatase domain containing guanine nucleotide exchange factor."
      Joseph R.E. , Norris F.A.
      Submitted (2003-12) to the EMBL/GenBank/DDBJ databases
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORMS 1 AND 3)
      tissue: Mammary gland.
    3. 4.
      "Complete sequencing and characterization of 21,243 full-length human cDNAs."
      Ota T. , Suzuki Y. , Nishikawa T. , Otsuki T. , Sugiyama T. , Irie R. , Wakamatsu A. , Hayashi K. , Sato H. , Nagai K. , Kimura K. , Makita H. , Sekine M. , Obayashi M. , Nishi T. , Shibahara T. , Tanaka T. , Ishii S. , more...
      Nat. Genet.36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 33-1606 (ISOFORM 4);NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 216-1588 (ISOFORM 3);NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 549-1588 (ISOFORM 1)
      tissue: Embryo.
      tissue: Teratocarcinoma.
    4. 5.
      "P-REX2, a novel PI-3-kinase sensitive Rac exchange factor."
      Rosenfeldt H. , Vazquez-Prado J. , Gutkind J.S.
      FEBS Lett.572:167-171(2004) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: IDENTIFICATION (ISOFORMS 2 AND 3);FUNCTION;ALTERNATIVE SPLICING
    5. 6.
      "Substrate specificity and recognition is conferred by the pleckstrin homology domain of the Dbl family guanine nucleotide exchange factor P-Rex2."
      Joseph R.E. , Norris F.A.
      J. Biol. Chem.280:27508-27512(2005) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: FUNCTION
    6. 7.
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: VARIANTS [LARGE SCALE ANALYSIS] ILE-537 AND GLU-1571
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