Gene name:
PREX2 (DEPDC2) ;
Protein name:
Phosphatidylinositol 3,4,5-trisphosphate-dependent Rac exchanger 2 protein (P-Rex2;PtdIns(3,4,5)-dependent Rac exchanger 2) ;
Alternative:
DEP domain-containing protein 2 ;
Organism:
Human (Homo sapiens).
General Annotation
Sub Unit:
Interacts with RAC1.
Function:
Functions as a RAC1 guanine nucleotide exchange factor (GEF), activating Rac proteins by exchanging bound GDP for free GTP. Its activity is synergistically activated by phosphatidylinositol-3,4,5-triphosphate and the beta gamma subunits of heterotrimeric G protein. Mediates the activation of RAC1 in a PI3K-dependent manner. May be an important mediator of Rac signaling, acting directly downstream of both G protein-coupled receptors and phosphoinositide 3-kinase.
Subcellular Location:
N/A
Protein Attributes:
50:
MSEDSRGDSR | AESAKDLEKQ | LRLRVCVLSE | LQKTERDYVG | TLEFLVSAFL |
100:
HRMNQCAASK | VDKNVTEETV | KMLFSNIEDI | LAVHKEFLKV | VEECLHPEPN |
150:
AQQEVGTCFL | HFKDKFRIYD | EYCSNHEKAQ | KLLLELNKIR | TIRTFLLNCM |
200:
LLGGRKNTDV | PLEGYLVTPI | QRICKYPLIL | KELLKRTPRK | HSDYAAVMEA |
250:
LQAMKAVCSN | INEAKRQMEK | LEVLEEWQSH | IEGWEGSNIT | DTCTEMLMCG |
300:
VLLKISSGNI | QERVFFLFDN | LLVYCKRKHR | RLKNSKASTD | GHRYLFRGRI |
350:
NTEVMEVENV | DDGTADFHSS | GHIVVNGWKI | HNTAKNKWFV | CMAKTPEEKH |
400:
EWFEAILKER | ERRKGLKLGM | EQDTWVMISE | QGEKLYKMMC | RQGNLIKDRK |
450:
RKLTTFPKCF | LGSEFVSWLL | EIGEIHRPEE | GVHLGQALLE | NGIIHHVTDK |
500:
HQFKPEQMLY | RFRYDDGTFY | PRNEMQDVIS | KGVRLYCRLH | SLFTPVIRDK |
550:
DYHLRTYKSV | VMANKLIDWL | IAQGDCRTRE | EAMIFGVGLC | DNGFMHHVLE |
600:
KSEFKDEPLL | FRFFSDEEME | GSNMKHRLMK | HDLKVVENVI | AKSLLIKSNE |
650:
GSYGFGLEDK | NKVPIIKLVE | KGSNAEMAGM | EVGKKIFAIN | GDLVFMRPFN |
700:
EVDCFLKSCL | NSRKPLRVLV | STKPRETVKI | PDSADGLGFQ | IRGFGPSVVH |
750:
AVGRGTVAAA | AGLHPGQCII | KVNGINVSKE | THASVIAHVT | ACRKYRRPTK |
800:
QDSIQWVYNS | IESAQEDLQK | SHSKPPGDEA | GDAFDCKVEE | VIDKFNTMAI |
850:
IDGKKEHVSL | TVDNVHLEYG | VVYEYDSTAG | IKCNVVEKMI | EPKGFFSLTA |
900:
KILEALAKSD | EHFVQNCTSL | NSLNEVIPTD | LQSKFSALCS | ERIEHLCQRI |
950:
SSYKKFSRVL | KNRAWPTFKQ | AKSKISPLHS | SDFCPTNCHV | NVMEVSYPKT |
1000:
STSLGSAFGV | QLDSRKHNSH | DKENKSSEQG | KLSPMVYIQH | TITTMAAPSG |
1050:
LSLGQQDGHG | LRYLLKEEDL | ETQDIYQKLL | GKLQTALKEV | EMCVCQIDDL |
1100:
LSSITYSPKL | ERKTSEGIIP | TDSDNEKGER | NSKRVCFNVA | GDEQEDSGHD |
1150:
TISNRDSYSD | CNSNRNSIAS | FTSICSSQCS | SYFHSDEMDS | GDELPLSVRI |
1200:
SHDKQDKIHS | CLEHLFSQVD | SITNLLKGQA | VVRAFDQTKY | LTPGRGLQEF |
1250:
QQEMEPKLSC | PKRLRLHIKQ | DPWNLPSSVR | TLAQNIRKFV | EEVKCRLLLA |
1300:
LLEYSDSETQ | LRRDMVFCQT | LVATVCAFSE | QLMAALNQMF | DNSKENEMET |
1350:
WEASRRWLDQ | IANAGVLFHF | QSLLSPNLTD | EQAMLEDTLV | ALFDLEKVSF |
1400:
YFKPSEEEPL | VANVPLTYQA | EGSRQALKVY | FYIDSYHFEQ | LPQRLKNGGG |
1450:
FKIHPVLFAQ | ALESMEGYYY | RDNVSVEEFQ | AQINAASLEK | VKQYNQKLRA |
1500:
FYLDKSNSPP | NSTSKAAYVD | KLMRPLNALD | ELYRLVASFI | RSKRTAACAN |
1550:
TACSASGVGL | LSVSSELCNR | LGACHIIMCS | SGVHRCTLSV | TLEQAIILAR |
1600:
SHGLPPRYIM | QATDVMRKQG | ARVQNTAKNL | GVRDRTPQSA | PRLYKLCEPP |
Vaild Sequence:
Related Databases
Uniprot:
ELISA Kit
CLIA Kit
Polyclonal Antibody
Monoclonal Antibody
Protein
FOR
Human
Mouse
ELISA Kit for Human P-Rex2
ELISA Kit for Human P-Rex2
CLIA Kit for Human P-Rex2
CLIA Kit for Human P-Rex2
Polyclonal Antibody for Human P-Rex2
Polyclonal Antibody for Human P-Rex2
Monoclonal Antibody for Human P-Rex2
Monoclonal Antibody for Human P-Rex2
R&D Technical Data
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Precision
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Recovery
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Linearity
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References
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Europe PMC ]
[
Abstract ]
[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s)
Cited for : NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1);FUNCTION;TISSUE SPECIFICITY
tissue :
Brain .
tissue :
Skeletal muscle .
2.
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[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s)
Cited for : NUCLEOTIDE SEQUENCE [MRNA] (ISOFORMS 1 AND 3)
tissue :
Mammary gland .
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[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s)
Cited for : NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]
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[
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[
Europe PMC ]
[
Abstract ]
[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s)
Cited for : NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 33-1606 (ISOFORM 4);NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 216-1588 (ISOFORM 3);NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 549-1588 (ISOFORM 1)
tissue :
Embryo .
tissue :
Teratocarcinoma .
5.
[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s)
Cited for : IDENTIFICATION (ISOFORMS 2 AND 3);FUNCTION;ALTERNATIVE SPLICING
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[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s)
Cited for : FUNCTION
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[
PubMed ]
[
Europe PMC ]
[
Abstract ]
[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s)
Cited for : VARIANTS [LARGE SCALE ANALYSIS] ILE-537 AND GLU-1571