PRG2 ELISA Kit for Human(Homo sapiens) | EIAab.comPRG2 ELISA Kit for Human(Homo sapiens)

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Index > Protein center > PRG2(Gene name) > Human

PRG2 (Gene name),

Bone marrow proteoglycan (Protein name ), PRG2_HUMAN from NCBI database.

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General Annotation

Antigen Annotation

Predicted Eptitope

Vaild Sequence

Related Databases

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Gene name:

PRG2(MBP);

Protein name:

Bone marrow proteoglycan(BMPG);

Alternative:

Proteoglycan 2;

Organism:

Human (Homo sapiens).

General Annotation

Sub Unit:

In pregnancy serum, the proform exists as a disulfide-linked 2:2 heterotetramer with PAPPA, as a disulfide-linked 2:2 heterotetramer with AGT, and as a complex (probably a 2:2:2 heterohexamer) with AGT and C3dg.

Function:

Cytotoxin and helminthotoxin. Also induces non-cytolytic histamine release from human basophils. Involved in antiparasitic defense mechanisms and immune hypersensitivity reactions. The proform acts as a proteinase inhibitor, reducing the activity of PAPPA.

Subcellular Location:

Eosinophil granule major basic protein Cytoplasmic vesicle secretory vesicle The proform is secreted. The mature protein is found in the matrix of the eosinophil's large specific granule.

Protein Attributes:

Sequence length:

222

Sequence:

50:

100:

150:

200:

222:

CTRGGHWRRA | HCLRRLPFIC | SY

3D Structure:

N/A

Predicted Eptitope:

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Vaild Sequence:

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Related Databases

SMR:

P13727

Pfam:

PF00059

String:

P13727

UniGene:

Hs.512633

KEGG:

hsa:5553

STRING:

9606.ENSP00000312134

MIM:

605601

Uniprot:

P13727

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ELISA Kit for Human BMPG

Cat.:

E1059h

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96T

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ELISA Kit for Human BMPG

Cat.:

E1059r

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96T

ELISA Kit for Human BMPG

Cat.:

E1059m

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Packing:

96T

CLIA Kit for Human BMPG

Cat.:

U1059r

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MSDS:

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Packing:

96T

CLIA Kit for Human BMPG

Cat.:

U1059h

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Manual:

Looking for manual.

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96T

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CLIA Kit for Human BMPG

Cat.:

U1059m

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96T

Polyclonal Antibody for Human BMPG

Cat.:

P1059Rb-h

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Packing:

40ug/0.2ml

Polyclonal Antibody for Human BMPG

Cat.:

P1059Rb-m

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Packing:

40ug/0.2ml

Polyclonal Antibody for Human BMPG

Cat.:

P1059Rb-r

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Packing:

40ug/0.2ml

Monoclonal Antibody for Human BMPG

Protein for Human BMPG

R&D Technical Data

For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.

Precision

For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.

Recovery

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Linearity

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References

1.

"Acidic precursor revealed in human eosinophil granule major basic protein cDNA."
Barker R.L. , Gleich G.J. , Pease L.R.
J. Exp. Med.168:1493-1498(1988) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1);VARIANT TYR-206
tissue: Promyelocyte.
2.

Barker R.L.
Submitted (1989-10) to the EMBL/GenBank/DDBJ databases

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: SEQUENCE REVISION TO 84
3.

"Cloning and sequence analysis of the human gene encoding eosinophil major basic protein."
Barker R.L. , Loegering D.A. , Arakawa K.C. , Pease L.R. , Gleich G.J.
Gene86:285-289(1990) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA];VARIANT TYR-206
4.

"Isolation of a complementary DNA clone encoding a precursor to human eosinophil major basic protein."
McGrogan M. , Simonsen C. , Scott R. , Giffith J. , Ellis N. , Kennedy J. , Campanelli D. , Nathan C. , Gabay J.
J. Exp. Med.168:2295-2308(1988) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1);VARIANT TYR-206
5.

"Purification and cDNA cloning of a novel factor produced by a human T-cell hybridoma: sequence homology with animal lectins."
Yoshimatsu K. , Ohya Y. , Shikata Y. , Seto T. , Hasegawa Y. , Tanaka I. , Kawamura T. , Kitoh K. , Toyoshima S. , Osawa T.
Mol. Immunol.29:537-546(1992) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1);PARTIAL PROTEIN SEQUENCE;VARIANT TYR-206
6.

"Human eosinophil major basic protein, a mediator of allergic inflammation, is expressed by alternative splicing from two promoters."
Li M.S. , Sun L. , Satoh T. , Fisher L.M. , Spry C.J.
Biochem. J.305:921-927(1995) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1);VARIANT TYR-206
tissue: Bone marrow.
7.

"Complete sequencing and characterization of 21,243 full-length human cDNAs."
Ota T. , Suzuki Y. , Nishikawa T. , Otsuki T. , Sugiyama T. , Irie R. , Wakamatsu A. , Hayashi K. , Sato H. , Nagai K. , Kimura K. , Makita H. , Sekine M. , Obayashi M. , Nishi T. , Shibahara T. , Tanaka T. , Ishii S. , more...
Nat. Genet.36:40-45(2004) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1);VARIANT TYR-206
tissue: Placenta.
8.

"Cloning of human full open reading frames in Gateway(TM) system entry vector (pDONR201)."
Ebert L. , Schick M. , Neubert P. , Schatten R. , Henze S. , Korn B.
Submitted (2004-05) to the EMBL/GenBank/DDBJ databases

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1);VARIANT TYR-206
9.

"A computer system platform used to predict novel genes."
Yu Z. , Zheng Z. , Tang T. , Fu Y.
Submitted (2006-07) to the EMBL/GenBank/DDBJ databases

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 2)
10.

"Human chromosome 11 DNA sequence and analysis including novel gene identification."
Taylor T.D. , Noguchi H. , Totoki Y. , Toyoda A. , Kuroki Y. , Dewar K. , Lloyd C. , Itoh T. , Takeda T. , Kim D.-W. , She X. , Barlow K.F. , Bloom T. , Bruford E. , Chang J.L. , Cuomo C.A. , Eichler E. , FitzGerald M.G. , more...
Nature440:497-500(2006) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]
11.

"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
The MGC Project Team
Genome Res.14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA];VARIANT TYR-206
tissue: Placenta.
12.

"Pro-major basic protein has three types of sugar chains at the pro-portion."
Shikata Y. , Hayashi Y. , Yoshimatsu K. , Ohya Y. , Seto T. , Fukushima K. , Yoshida Y.
Biochim. Biophys. Acta1163:243-249(1993) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: PROTEIN SEQUENCE OF 17-222;GLYCOSYLATION AT SER-24; THR-25; SER-62 AND ASN-86
tissue: Liver.
13.

"Circulating human pregnancy-associated plasma protein-A is disulfide-bridged to the proform of eosinophil major basic protein."
Oxvig C. , Sand O. , Kristensen T. , Gleich G.J. , Sottrup-Jensen L.
J. Biol. Chem.268:12243-12246(1993) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: PROTEIN SEQUENCE OF 17-26; 47-52; 98-108; 172-179 AND 210-222;SUBUNIT;INTERCHAIN DISULFIDE BOND
tissue: Serum.
14.

"Identification of angiotensinogen and complement C3dg as novel proteins binding the proform of eosinophil major basic protein in human pregnancy serum and plasma."
Oxvig C. , Haaning J. , Kristensen L. , Wagner J.M. , Rubin I. , Stigbrand T. , Gleich G.J. , Sottrup-Jensen L.
J. Biol. Chem.270:13645-13651(1995) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: PROTEIN SEQUENCE OF 17-29;SUBUNIT;DEVELOPMENTAL STAGE
tissue: Serum.
15.

"Biochemical and amino acid sequence analysis of human eosinophil granule major basic protein."
Wasmoen T.L. , Bell M.P. , Loegering D.A. , Gleich G.J. , Prendergast F.G. , McKean D.J.
J. Biol. Chem.263:12559-12563(1988) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: PROTEIN SEQUENCE OF 106-222
16.

"Antibiotic proteins of human polymorphonuclear leukocytes."
Gabay J.E. , Scott R.W. , Campanelli D. , Griffith J. , Wilde C. , Marra M.N. , Seeger M. , Nathan C.F.
Proc. Natl. Acad. Sci. U.S.A.86:5610-5614(1989) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: PROTEIN SEQUENCE OF 106-125
17.

"Eosinophil granule cationic proteins: major basic protein is distinct from the smaller subunit of eosinophil peroxidase."
Weller P.F. , Ackerman S.J. , Smith J.A.
J. Leukoc. Biol.43:1-4(1988) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: PROTEIN SEQUENCE OF 108-124
18.

"Amino acid sequence of human pregnancy-associated plasma protein-A derived from cloned cDNA."
Kristensen T. , Oxvig C. , Sand O. , Moller N.P.H. , Sottrup-Jensen L.
Biochemistry33:1592-1598(1994) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: PROTEIN SEQUENCE OF 172-179 AND 210-222;SUBUNIT
tissue: Serum.
19.

"Evidence of eosinophil granule major basic protein in human placenta."
Wasmoen T.L. , McKean D.J. , Benirschke K. , Coulam C.B. , Gleich G.J.
J. Exp. Med.170:2051-2063(1989) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: PROTEIN SEQUENCE OF 177-196
tissue: Placenta.
20.

"Location and nature of carbohydrate groups in proform of human major basic protein isolated from pregnancy serum."
Oxvig C. , Haaning J. , Hojrup P. , Sottrup-Jensen L.
Biochem. Mol. Biol. Int.33:329-336(1994) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: GLYCOSYLATION AT THR-23; SER-24; THR-25; THR-34; SER-62 AND ASN-86
21.

"Localization of disulfide bridges and free sulfhydryl groups in human eosinophil granule major basic protein."
Oxvig C. , Gleich G.J. , Sottrup-Jensen L.
FEBS Lett.341:213-217(1994) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: DISULFIDE BONDS
22.

"Localization of pregnancy-associated plasma protein-A and colocalization of pregnancy-associated plasma protein-A messenger ribonucleic acid and eosinophil granule major basic protein messenger ribonucleic acid in placenta."
Bonno M. , Oxvig C. , Kephart G.M. , Wagner J.M. , Kristensen T. , Sottrup-Jensen L. , Gleich G.J.
Lab. Invest.71:560-566(1994) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: TISSUE SPECIFICITY
23.

"Messenger ribonucleic acid levels of pregnancy-associated plasma protein-A and the proform of eosinophil major basic protein: expression in human reproductive and nonreproductive tissues."
Overgaard M.T. , Oxvig C. , Christiansen M. , Lawrence J.B. , Conover C.A. , Gleich G.J. , Sottrup-Jensen L. , Haaning J.
Biol. Reprod.61:1083-1089(1999) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: TISSUE SPECIFICITY;DEVELOPMENTAL STAGE
24.

"Expression of recombinant human pregnancy-associated plasma protein-A and identification of the proform of eosinophil major basic protein as its physiological inhibitor."
Overgaard M.T. , Haaning J. , Boldt H.B. , Olsen I.M. , Laursen L.S. , Christiansen M. , Gleich G.J. , Sottrup-Jensen L. , Conover C.A. , Oxvig C.
J. Biol. Chem.275:31128-31133(2000) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: FUNCTION;SUBUNIT
25.

"Complex of pregnancy-associated plasma protein-A and the proform of eosinophil major basic protein. Disulfide structure and carbohydrate attachment sites."
Overgaard M.T. , Sorensen E.S. , Stachowiak D. , Boldt H.B. , Kristensen L. , Sottrup-Jensen L. , Oxvig C.
J. Biol. Chem.278:2106-2117(2003) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: INTERCHAIN DISULFIDE BONDS
26.

"Post-translational tyrosine nitration of eosinophil granule toxins mediated by eosinophil peroxidase."
Ulrich M. , Petre A. , Youhnovski N. , Proemm F. , Schirle M. , Schumm M. , Pero R.S. , Doyle A. , Checkel J. , Kita H. , Thiyagarajan N. , Acharya K.R. , Schmid-Grendelmeier P. , Simon H.-U. , Schwarz H. , Tsutsui M. , Shimokawa H. , Bellon G. , more...
J. Biol. Chem.283:28629-28640(2008) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NITRATION
27.

"Crystal structure of the eosinophil major basic protein at 1.8-A. An atypical lectin with a paradigm shift in specificity."
Swaminathan G.J. , Weaver A.J. , Loegering D.A. , Checkel J.L. , Leonidas D.D. , Gleich G.J. , Acharya K.R.
J. Biol. Chem.276:26197-26203(2001) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: X-RAY CRYSTALLOGRAPHY (1.8 ANGSTROMS) OF 107-222;HEPARIN-BINDING
28.

"The consensus coding sequences of human breast and colorectal cancers."
Sjoeblom T. , Jones S. , Wood L.D. , Parsons D.W. , Lin J. , Barber T.D. , Mandelker D. , Leary R.J. , Ptak J. , Silliman N. , Szabo S. , Buckhaults P. , Farrell C. , Meeh P. , Markowitz S.D. , Willis J. , Dawson D. , Willson J.K.V. , more...
Science314:268-274(2006) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: VARIANT [LARGE SCALE ANALYSIS] CYS-179

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