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Index > Protein center > PROC(Gene name) > Human
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  • PROC (Gene name),
  • Vitamin K-dependent protein C (Protein name ),  PROC_HUMAN from NCBI database.
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  • General Annotation
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  • Antigen Annotation
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  • Vaild Sequence
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  • Gene name:
    PROC;
    Protein name:
    Vitamin K-dependent protein C;
    Alternative:
    Autoprothrombin IIA;Anticoagulant protein C;Blood coagulation factor XIV;
    Organism:
    Human (Homo sapiens). 
    General Annotation
    Sub Unit:
    Synthesized as a single chain precursor, which is cleaved into a light chain and a heavy chain held together by a disulfide bond. The enzyme is then activated by thrombin, which cleaves a tetradecapeptide from the amino end of the heavy chain; this reaction, which occurs at the surface of endothelial cells, is strongly promoted by thrombomodulin.
    Function:
    Protein C is a vitamin K-dependent serine protease that regulates blood coagulation by inactivating factors Va and VIIIa in the presence of calcium ions and phospholipids.
    Subcellular Location:
    N/A
    Protein Attributes:
    Sequence length:
    461
    Sequence:
    50:
    MWQLTSLLLF | VATWGISGTP | APLDSVFSSS | ERAHQVLRIR | KRANSFLEEL | 
    100:
    RHSSLERECI | EEICDFEEAK | EIFQNVDDTL | AFWSKHVDGD | QCLVLPLEHP | 
    150:
    CASLCCGHGT | CIDGIGSFSC | DCRSGWEGRF | CQREVSFLNC | SLDNGGCTHY | 
    200:
    CLEEVGWRRC | SCAPGYKLGD | DLLQCHPAVK | FPCGRPWKRM | EKKRSHLKRD | 
    250:
    TEDQEDQVDP | RLIDGKMTRR | GDSPWQVVLL | DSKKKLACGA | VLIHPSWVLT | 
    300:
    AAHCMDESKK | LLVRLGEYDL | RRWEKWELDL | DIKEVFVHPN | YSKSTTDNDI | 
    350:
    ALLHLAQPAT | LSQTIVPICL | PDSGLAEREL | NQAGQETLVT | GWGYHSSREK | 
    400:
    EAKRNRTFVL | NFIKIPVVPH | NECSEVMSNM | VSENMLCAGI | LGDRQDACEG | 
    450:
    DSGGPMVASF | HGTWFLVGLV | SWGEGCGLLH | NYGVYTKVSR | YLDWIHGHIR | 
    461:
    DKEAPQKSWA | P
    3D Structure:
    N/A
    Predicted Eptitope:
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    EIAab Sequence  Vaild Sequence:
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    Related Databases
    MIM:
    String:
    SMR:
    UniGene:
    Pfam:
    KEGG:
    Uniprot:
     
    FOR
    ELISA Kit for Human Vitamin K-dependent protein C
    Cat.:
    E0734h
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    MSDS:
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    Packing:
    96T
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    ELISA Kit for Human Vitamin K-dependent protein C
    MSDS:
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    ELISA Kit for Human Vitamin K-dependent protein C
    Cat.:
    E0734r
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    96T
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    ELISA Kit for Human Vitamin K-dependent protein C
    Cat.:
    E0734p
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    MSDS:
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    96T
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    ELISA Kit for Human Vitamin K-dependent protein C
    Cat.:
    E0734d
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    MSDS:
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    Packing:
    96T
    ELISA Kit for Human Vitamin K-dependent protein C
    Cat.:
    E0734m
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    MSDS:
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    Packing:
    96T
    ELISA Kit for Human Vitamin K-dependent protein C
    Cat.:
    E0734b
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    MSDS:
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    Packing:
    96T
    CLIA Kit for Human Vitamin K-dependent protein C
    Cat.:
    U0734m
    Price:
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    MSDS:
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    Packing:
    96T
    CLIA Kit for Human Vitamin K-dependent protein C
    Cat.:
    U0734p
    Price:
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    MSDS:
    Please sign in first.
    Packing:
    96T
    CLIA Kit for Human Vitamin K-dependent protein C
    Cat.:
    U0734r
    Price:
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    MSDS:
    Please sign in first.
    Packing:
    96T
    CLIA Kit for Human Vitamin K-dependent protein C
    Cat.:
    U0734h
    Price:
    Please sign in first.
    MSDS:
    Please sign in first.
    Packing:
    96T
    CLIA Kit for Human Vitamin K-dependent protein C
    Cat.:
    U0734d
    Price:
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    MSDS:
    Please sign in first.
    Packing:
    96T
    CLIA Kit for Human Vitamin K-dependent protein C
    MSDS:
    Please sign in first.
    CLIA Kit for Human Vitamin K-dependent protein C
    Cat.:
    U0734b
    Price:
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    MSDS:
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    Packing:
    96T
    Polyclonal Antibody for Human Vitamin K-dependent protein C
    Polyclonal Antibody for Human Vitamin K-dependent protein C
    Cat.:
    P0734Rb-r
    Price:
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    Packing:
    40ug/0.2ml
    Polyclonal Antibody for Human Vitamin K-dependent protein C
    Polyclonal Antibody for Human Vitamin K-dependent protein C
    Cat.:
    P0734Rb-h
    Price:
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    Packing:
    40ug/0.2ml
    Polyclonal Antibody for Human Vitamin K-dependent protein C
    Cat.:
    P0734Rb-m
    Price:
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    Packing:
    40ug/0.2ml
    Polyclonal Antibody for Human Vitamin K-dependent protein C
    Polyclonal Antibody for Human Vitamin K-dependent protein C
    Monoclonal Antibody for Human Vitamin K-dependent protein C
    Monoclonal Antibody for Human Vitamin K-dependent protein C
    Monoclonal Antibody for Human Vitamin K-dependent protein C
    Monoclonal Antibody for Human Vitamin K-dependent protein C
    Monoclonal Antibody for Human Vitamin K-dependent protein C
    Monoclonal Antibody for Human Vitamin K-dependent protein C
    Monoclonal Antibody for Human Vitamin K-dependent protein C
    Protein for Human Vitamin K-dependent protein C
    Protein for Human Vitamin K-dependent protein C
    Protein for Human Vitamin K-dependent protein C
    Protein for Human Vitamin K-dependent protein C
    Protein for Human Vitamin K-dependent protein C
    Protein for Human Vitamin K-dependent protein C
    Protein for Human Vitamin K-dependent protein C

    R&D Technical Data
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    Precision
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    Recovery
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    Linearity
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    References
    1. 1.
      "The structure and evolution of a 461 amino acid human protein C precursor and its messenger RNA, based upon the DNA sequence of cloned human liver cDNAs."
      Beckmann R.J. , Schmidt R.J. , Santerre R.F. , Plutzky J. , Crabtree G.R. , Long G.L.
      Nucleic Acids Res.13:5233-5247(1985) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1)
    2. 2.
      "The nucleotide sequence of the gene for human protein C."
      Foster D.C. , Yoshitake S. , Davie E.W.
      Proc. Natl. Acad. Sci. U.S.A.82:4673-4677(1985) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA];HYDROXYLATION AT ASP-113;GLYCOSYLATION AT ASN-290; ASN-355 AND ASN-371;GAMMA-CARBOXYGLUTAMATION AT GLU-48; GLU-49; GLU-56; GLU-58; GLU-61; GLU-62; GLU-67; GLU-68 AND GLU-71
    3. 3.
      "Evolution and organization of the human protein C gene."
      Plutzky J. , Hoskins J.A. , Long G.L. , Crabtree G.R.
      Proc. Natl. Acad. Sci. U.S.A.83:546-550(1986) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA]
    4. 4.
      SeattleSNPs variation discovery resource
      Submitted (2001-06) to the EMBL/GenBank/DDBJ databases
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA]
    5. 5.
      "Complete sequencing and characterization of 21,243 full-length human cDNAs."
      Ota T. , Suzuki Y. , Nishikawa T. , Otsuki T. , Sugiyama T. , Irie R. , Wakamatsu A. , Hayashi K. , Sato H. , Nagai K. , Kimura K. , Makita H. , Sekine M. , Obayashi M. , Nishi T. , Shibahara T. , Tanaka T. , Ishii S. , more...
      Nat. Genet.36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 2)
      tissue: Liver.
    6. 6.
      "Generation and annotation of the DNA sequences of human chromosomes 2 and 4."
      Hillier L.W. , Graves T.A. , Fulton R.S. , Fulton L.A. , Pepin K.H. , Minx P. , Wagner-McPherson C. , Layman D. , Wylie K. , Sekhon M. , Becker M.C. , Fewell G.A. , Delehaunty K.D. , Miner T.L. , Nash W.E. , Kremitzki C. , Oddy L. , Du H. , more...
      Nature434:724-731(2005) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]
    7. 7.
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]
    8. 8.
      "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
      The MGC Project Team
      Genome Res.14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1)
      tissue: Colon.
    9. 9.
      "Protein C Osaka 10 with aberrant propeptide processing: loss of anticoagulant activity due to an amino acid substitution in the protein C precursor."
      Miyata T. , Zheng Y.-Z. , Sakata T. , Kato H.
      Thromb. Haemost.74:1003-1008(1995) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: PROTEIN SEQUENCE OF 42-57;VARIANT THPH3 SER-42
      tissue: Blood.
    10. 10.
      "An abnormal protein C (protein C Yonago) with an amino acid substitution of Gly for Arg-15 caused by a single base mutation of C to G in codon 57 (CGG-->GGG). Deteriorated calcium-dependent conformation of the gamma-carboxyglutamic acid domain relevant to a thrombotic tendency."
      Mimuro J. , Muramatsu S. , Kaneko M. , Yoshitake S. , Iijima K. , Nakamura K. , Sakata Y. , Matsuda M.
      Int. J. Hematol.57:9-14(1993) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA] OF 43-64;VARIANT PROC DEFICIENCY GLY-57
    11. 11.
      "Characterization of a cDNA coding for human protein C."
      Foster D.C. , Davie E.W.
      Proc. Natl. Acad. Sci. U.S.A.81:4766-4770(1984) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [MRNA] OF 106-461 (ISOFORM 1)
    12. 12.
      "Homozygous type I protein C deficiency in two unrelated families exhibiting thrombophilia related to Ala136-->Pro or Arg286-->His mutations."
      Long G.L. , Tomczak J.A. , Rainville I.R. , Dreyfus M. , Schramm W. , Schwarz H.P.
      Thromb. Haemost.72:526-533(1994) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA] OF 134-178 AND 267-332;VARIANTS THPH4 PRO-178 AND HIS-328
    13. 13.
      "Beta protein C is not glycosylated at asparagine 329. The rate of translation may influence the frequency of usage at asparagine-X-cysteine sites."
      Miletich J.P. , Broze G.J. Jr.
      J. Biol. Chem.265:11397-11404(1990) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: GLYCOSYLATION AT ASN-371
    14. 14.
      "O-linked fucose is present in the first epidermal growth factor domain of factor XII but not protein C."
      Harris R.J. , Ling V.T. , Spellman M.W.
      J. Biol. Chem.267:5102-5107(1992) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: HYDROXYLATION
    15. 15.
      "Human plasma N-glycoproteome analysis by immunoaffinity subtraction, hydrazide chemistry, and mass spectrometry."
      Liu T. , Qian W.-J. , Gritsenko M.A. , Camp D.G. II , Monroe M.E. , Moore R.J. , Smith R.D.
      J. Proteome Res.4:2070-2080(2005) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: GLYCOSYLATION [LARGE SCALE ANALYSIS] AT ASN-290
      tissue: Plasma.
    16. 16.
      "Human urinary glycoproteomics; attachment site specific analysis of N-and O-linked glycosylations by CID and ECD."
      Halim A. , Nilsson J. , Ruetschi U. , Hesse C. , Larson G.
      Mol. Cell. Proteomics0:0-0(2011) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: GLYCOSYLATION AT THR-19;STRUCTURE OF CARBOHYDRATES;IDENTIFICATION BY MASS SPECTROMETRY
    17. 17.
      "Models of the serine protease domain of the human antithrombotic plasma factor activated protein C and its zymogen."
      Fisher C.L. , Greengard J.S. , Griffin J.H.
      Protein Sci.3:588-599(1994) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: 3D-STRUCTURE MODELING OF 175-450
    18. 18.
      "The 2.8 A crystal structure of Gla-domainless activated protein C."
      Mather T. , Oganessyan V. , Hof P. , Huber R. , Foundling S. , Esmon C. , Bode W.
      EMBO J.15:6822-6831(1996) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: X-RAY CRYSTALLOGRAPHY (2.8 ANGSTROMS) OF 84-461
    19. 19.
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: REVIEW ON PROC VARIANTS
    20. 20.
      "Hereditary thrombophilia: identification of nonsense and missense mutations in the protein C gene."
      Romeo G. , Hassan H.J. , Staempfli S. , Roncuzzi L. , Cianetti L. , Leonardi A. , Vicente V. , Mannucci P.M. , Bertina R.M. , Peschle C. , Cortese R.
      Proc. Natl. Acad. Sci. U.S.A.84:2829-2832(1987) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: VARIANT THPH3 CYS-444
    21. 21.
      "Protein C London 1: recurrent mutation at Arg-169 (CGG-->TGG) in the protein C gene causing thrombosis."
      Grundy C.B. , Chitolie A. , Talbot S. , Bevan D. , Kakkar V.V. , Cooper D.N.
      Nucleic Acids Res.17:10513-10513(1989) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: VARIANT THPH3 TRP-211
    22. 22.
      "The spectrum of genetic defects in a panel of 40 Dutch families with symptomatic protein C deficiency type I: heterogeneity and founder effects."
      Reitsma P.H. , Poort S.R. , Allaart C.F. , Briet E. , Bertina R.M.
      Blood78:890-894(1991) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: VARIANT THPH3 CYS-272
    23. 23.
      "Protein CVermont: symptomatic type II protein C deficiency associated with two GLA domain mutations."
      Bovill E.G. , Tomczak J.A. , Grant B. , Bhushan F. , Pillemer E. , Rainville I.R. , Long G.L.
      Blood79:1456-1465(1992) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: VARIANTS THPH3 ALA-62 AND MET-76
    24. 24.
      "Protein C deficiency Hong Kong 1 and 2: hereditary protein C deficiency caused by two mutant alleles, a 5-nucleotide deletion and a missense mutation."
      Sugahara Y. , Miura O. , Yuen P. , Aoki N.
      Blood80:126-133(1992) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: VARIANT THPH4 ASP-418
    25. 25.
      "A novel homozygous missense mutation in the protein C (PROC) gene causing recurrent venous thrombosis."
      Grundy C.B. , Chisholm M. , Kakkar V.V. , Cooper D.N.
      Hum. Genet.89:683-684(1992) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: VARIANT THPH4 LEU-289
    26. 26.
      "Two different missense mutations at Arg 178 of the protein C (PROC) gene causing recurrent venous thrombosis."
      Grundy C.B. , Schulman S. , Tengborn L. , Kakkar V.V. , Cooper D.N.
      Hum. Genet.89:685-686(1992) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: VARIANTS THPH3 GLN-220 AND TRP-220
    27. 27.
      "Two novel mutations responsible for hereditary type I protein C deficiency: characterization by denaturing gradient gel electrophoresis."
      Gandrille S. , Vidaud M. , Aiach M. , Alhenc-Gelas M. , Fischer A.M. , Gouault-Heilman M. , Toulon P. , Fiessinger J.-N. , Goossens M.
      Hum. Mutat.1:491-500(1992) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: VARIANT THPH3 GLN-220
    28. 28.
      "Homozygous protein C deficiency: identification of a novel missense mutation that causes impaired secretion of the mutant protein C."
      Yamamoto K. , Matsushita T. , Sugiura I. , Takamatsu J. , Iwasaki E. , Wada H. , Deguchi K. , Shirakawa S. , Saito H.
      J. Lab. Clin. Med.119:682-689(1992) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: VARIANT THPH4 SER-334
    29. 29.
      "Five novel mutations located in exons III and IX of the protein C gene in patients presenting with defective protein C anticoagulant activity."
      Gandrille S. , Alhenc-Gelas M. , Gaussem P. , Aillaud M.-F. , Dupuy E. , Juhan-Vague I. , Aiach M.
      Blood82:159-168(1993) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: VARIANTS TRP-38; CYS-42; HIS-42; GLN-271 AND ASN-294
    30. 30.
      "Twelve novel and two recurrent mutations in 14 Austrian families with hereditary protein C deficiency."
      Poort S.R. , Pabinger-Fasching I. , Mannhalter C. , Reitsma P.H. , Bertina R.M.
      Blood Coagul. Fibrinolysis4:273-280(1993) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: VARIANTS GLY-14; GLN-211; TYR-244; GLN-253; LEU-321; CYS-328; ILE-385; THR-388 AND VAL-388
    31. 31.
      "A Gla domain mutation (Arg 15-->Trp) in the protein C (PROC) gene causing type 2 protein C deficiency and recurrent venous thrombosis."
      Millar D.S. , Grundy C.B. , Bignell P. , Moffat E.H. , Martin R. , Kakkar V.V. , Cooper D.N.
      Blood Coagul. Fibrinolysis4:345-347(1993) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: VARIANT THPH3 TRP-57
    32. 32.
      "Genetic mutations in ten unrelated American patients with symptomatic type 1 protein C deficiency."
      Tsay W. , Greengard J.S. , Montgomery R.R. , McPherson R.A. , Fucci J.C. , Koerper M.A. , Coughlin J. , Griffin J.H.
      Blood Coagul. Fibrinolysis4:791-796(1993) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: VARIANTS THPH3 ARG-145; LEU-210; TRP-211; THR-243; LEU-321; MET-340 AND TYR-426
    33. 33.
      "Symptomatic type II protein C deficiency caused by a missense mutation (Gly 381-->Ser) in the substrate-binding pocket."
      Marchetti G. , Patracchini P. , Gemmati D. , Castaman G. , Rodeghiero F. , Wacey A. , Cooper D.N. , Tuddenham E.G. , Bernardi F.
      Br. J. Haematol.84:285-289(1993) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: VARIANT THPH3 SER-423
    34. 34.
      "First de novo mutations in the protein C gene of two patients with type I deficiency: a missense mutation and a splice site deletion."
      Gandrille S. , Jude B. , Alhenc-Gelas M. , Emmerich J. , Aiach M.
      Blood84:2566-2570(1994) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: VARIANT PRO-312
    35. 35.
      "A homozygous deletion/insertion mutation in the protein C (PROC) gene causing neonatal Purpura fulminans: prenatal diagnosis in an at-risk pregnancy."
      Millar D.S. , Allgrove J. , Rodeck C. , Kakkar V.V. , Cooper D.N.
      Blood Coagul. Fibrinolysis5:647-649(1994) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: VARIANT THPH4 144-ASN-GLY-145 DELINS LYS
    36. 36.
      "A novel homozygous missense mutation (Val 325-->Ala) in the protein C gene causing neonatal purpura fulminans."
      Witt I. , Beck S. , Seydewitz H.H. , Tasangil C. , Schenck W.
      Blood Coagul. Fibrinolysis5:651-653(1994) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: VARIANT THPH4 ALA-367
    37. 37.
      "Six missense mutations associated with type I and type II protein C deficiency and implications obtained from molecular modelling."
      Zheng Y.-Z. , Sakata T. , Matsusue T. , Umeyama H. , Kato H. , Miyata T.
      Blood Coagul. Fibrinolysis5:687-696(1994) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: VARIANTS THPH3 LEU-369; ARG-392; ASN-401 AND HIS-441
    38. 38.
      "Influence of six mutations of the protein C gene on the Gla domain conformation and calcium affinity."
      Gaussem P. , Gandrille S. , Duchemin J. , Emmerich J. , Alhenc-Gelas M. , Aillaud M.-F. , Aiach M.
      Thromb. Haemost.71:748-754(1994) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: VARIANT ASP-49
    39. 39.
      "Three novel mutations in the protein C (PROC) gene causing venous thrombosis."
      Millar D.S. , Bevan D. , Chitolie A. , Reynaud J. , Chisholm M. , Kakkar V.V. , Cooper D.N.
      Blood Coagul. Fibrinolysis6:138-140(1995) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: VARIANTS CYS-89; PRO-220 AND THR-301
    40. 40.
      "Six different point mutations in seven Danish families with symptomatic protein C deficiency."
      Lind B. , Schwartz M. , Thorsen S.
      Thromb. Haemost.73:186-193(1995) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: VARIANTS THPH3 TRP-57; ARG-114; ARG-324; CYS-328 AND LEU-369;VARIANT THR-43
    41. 41.
      "Two novel (R(-11)C; T394D) and two repeat missense mutations in the protein C gene associated with venous thrombosis in six kindreds."
      Ireland H.A. , Boisclair M.D. , Taylor J. , Thompson E. , Thein S.L. , Girolami A. , de Caterina M. , Scopacasa F. , de Stefano V. , Leone G. , Finazzi G. , Cohen H. , Lane D.A.
      Hum. Mutat.7:176-179(1996) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: VARIANTS THPH3 CYS-32 AND ASN-436
    42. 42.
      "Type I protein C deficiency in French Canadians: evidence of a founder effect and association of specific protein C gene mutations with plasma protein C levels."
      Couture P. , Demers C. , Morissette J. , Delage R. , Jomphe M. , Couture L. , Simard J.
      Thromb. Haemost.80:551-556(1998) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: VARIANTS THPH3 GLN-220 AND MET-340
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