Protein name:
Vitamin K-dependent protein C ;
Alternative:
Autoprothrombin IIA ;Anticoagulant protein C ;Blood coagulation factor XIV ;
Organism:
Human (Homo sapiens).
General Annotation
Sub Unit:
Synthesized as a single chain precursor, which is cleaved into a light chain and a heavy chain held together by a disulfide bond. The enzyme is then activated by thrombin, which cleaves a tetradecapeptide from the amino end of the heavy chain; this reaction, which occurs at the surface of endothelial cells, is strongly promoted by thrombomodulin.
Function:
Protein C is a vitamin K-dependent serine protease that regulates blood coagulation by inactivating factors Va and VIIIa in the presence of calcium ions and phospholipids.
Subcellular Location:
N/A
Protein Attributes:
50:
MWQLTSLLLF | VATWGISGTP | APLDSVFSSS | ERAHQVLRIR | KRANSFLEEL |
100:
RHSSLERECI | EEICDFEEAK | EIFQNVDDTL | AFWSKHVDGD | QCLVLPLEHP |
150:
CASLCCGHGT | CIDGIGSFSC | DCRSGWEGRF | CQREVSFLNC | SLDNGGCTHY |
200:
CLEEVGWRRC | SCAPGYKLGD | DLLQCHPAVK | FPCGRPWKRM | EKKRSHLKRD |
250:
TEDQEDQVDP | RLIDGKMTRR | GDSPWQVVLL | DSKKKLACGA | VLIHPSWVLT |
300:
AAHCMDESKK | LLVRLGEYDL | RRWEKWELDL | DIKEVFVHPN | YSKSTTDNDI |
350:
ALLHLAQPAT | LSQTIVPICL | PDSGLAEREL | NQAGQETLVT | GWGYHSSREK |
400:
EAKRNRTFVL | NFIKIPVVPH | NECSEVMSNM | VSENMLCAGI | LGDRQDACEG |
450:
DSGGPMVASF | HGTWFLVGLV | SWGEGCGLLH | NYGVYTKVSR | YLDWIHGHIR |
Vaild Sequence:
Related Databases
Uniprot:
ELISA Kit
CLIA Kit
Polyclonal Antibody
Monoclonal Antibody
Protein
FOR
Human
Rabbit
Rat
Pig
Dog
Mouse
Bovine
ELISA Kit for Human Vitamin K-dependent protein C
ELISA Kit for Human Vitamin K-dependent protein C
ELISA Kit for Human Vitamin K-dependent protein C
ELISA Kit for Human Vitamin K-dependent protein C
ELISA Kit for Human Vitamin K-dependent protein C
ELISA Kit for Human Vitamin K-dependent protein C
ELISA Kit for Human Vitamin K-dependent protein C
CLIA Kit for Human Vitamin K-dependent protein C
CLIA Kit for Human Vitamin K-dependent protein C
CLIA Kit for Human Vitamin K-dependent protein C
CLIA Kit for Human Vitamin K-dependent protein C
CLIA Kit for Human Vitamin K-dependent protein C
CLIA Kit for Human Vitamin K-dependent protein C
CLIA Kit for Human Vitamin K-dependent protein C
Polyclonal Antibody for Human Vitamin K-dependent protein C
Polyclonal Antibody for Human Vitamin K-dependent protein C
Polyclonal Antibody for Human Vitamin K-dependent protein C
Polyclonal Antibody for Human Vitamin K-dependent protein C
Polyclonal Antibody for Human Vitamin K-dependent protein C
Polyclonal Antibody for Human Vitamin K-dependent protein C
Polyclonal Antibody for Human Vitamin K-dependent protein C
Monoclonal Antibody for Human Vitamin K-dependent protein C
Monoclonal Antibody for Human Vitamin K-dependent protein C
Monoclonal Antibody for Human Vitamin K-dependent protein C
Monoclonal Antibody for Human Vitamin K-dependent protein C
Monoclonal Antibody for Human Vitamin K-dependent protein C
Monoclonal Antibody for Human Vitamin K-dependent protein C
Monoclonal Antibody for Human Vitamin K-dependent protein C
Protein for Human Vitamin K-dependent protein C
Protein for Human Vitamin K-dependent protein C
Protein for Human Vitamin K-dependent protein C
Protein for Human Vitamin K-dependent protein C
Protein for Human Vitamin K-dependent protein C
Protein for Human Vitamin K-dependent protein C
Protein for Human Vitamin K-dependent protein C
R&D Technical Data
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Precision
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Recovery
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Linearity
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References
1.
[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s)
Cited for : NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1)
2.
[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s)
Cited for : NUCLEOTIDE SEQUENCE [GENOMIC DNA];HYDROXYLATION AT ASP-113;GLYCOSYLATION AT ASN-290; ASN-355 AND ASN-371;GAMMA-CARBOXYGLUTAMATION AT GLU-48; GLU-49; GLU-56; GLU-58; GLU-61; GLU-62; GLU-67; GLU-68 AND GLU-71
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[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s)
Cited for : NUCLEOTIDE SEQUENCE [GENOMIC DNA]
4.
[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s)
Cited for : NUCLEOTIDE SEQUENCE [GENOMIC DNA]
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[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s)
Cited for : NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 2)
tissue :
Liver .
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[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s)
Cited for : NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]
7.
Mural R.J.
,
Istrail S.
,
Sutton G.G.
,
Florea L.
,
Halpern A.L.
,
Mobarry C.M.
,
Lippert R.
,
Walenz B.
,
Shatkay H.
,
Dew I.
,
Miller J.R.
,
Flanigan M.J.
,
Edwards N.J.
,
Bolanos R.
,
Fasulo D.
,
Halldorsson B.V.
,
Hannenhalli S.
,
Turner R.
,
Yooseph S.
,
Lu F.
,
Nusskern D.R.
,
Shue B.C.
,
Zheng X.H.
,
Zhong F.
,
Delcher A.L.
,
Huson D.H.
,
Kravitz S.A.
,
Mouchard L.
,
Reinert K.
,
Remington K.A.
,
Clark A.G.
,
Waterman M.S.
,
Eichler E.E.
,
Adams M.D.
,
Hunkapiller M.W.
,
Myers E.W.
,
Venter J.C.
more...
Submitted (2005-07) to the EMBL/GenBank/DDBJ databases
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Cited for : NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]
8.
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Cited for : NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1)
tissue :
Colon .
9.
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Cited for : PROTEIN SEQUENCE OF 42-57;VARIANT THPH3 SER-42
tissue :
Blood .
10.
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Cited for : NUCLEOTIDE SEQUENCE [GENOMIC DNA] OF 43-64;VARIANT PROC DEFICIENCY GLY-57
11.
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Cited for : NUCLEOTIDE SEQUENCE [MRNA] OF 106-461 (ISOFORM 1)
12.
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Cited for : NUCLEOTIDE SEQUENCE [GENOMIC DNA] OF 134-178 AND 267-332;VARIANTS THPH4 PRO-178 AND HIS-328
13.
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Cited for : GLYCOSYLATION AT ASN-371
14.
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Cited for : HYDROXYLATION
15.
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Cited for : GLYCOSYLATION [LARGE SCALE ANALYSIS] AT ASN-290
tissue :
Plasma .
16.
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Cited for : GLYCOSYLATION AT THR-19;STRUCTURE OF CARBOHYDRATES;IDENTIFICATION BY MASS SPECTROMETRY
17.
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Cited for : 3D-STRUCTURE MODELING OF 175-450
18.
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Cited for : X-RAY CRYSTALLOGRAPHY (2.8 ANGSTROMS) OF 84-461
19.
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Cited for : REVIEW ON PROC VARIANTS
20.
"Hereditary thrombophilia: identification of nonsense and missense mutations in the protein C gene."
Romeo G.
,
Hassan H.J.
,
Staempfli S.
,
Roncuzzi L.
,
Cianetti L.
,
Leonardi A.
,
Vicente V.
,
Mannucci P.M.
,
Bertina R.M.
,
Peschle C.
,
Cortese R.
Proc. Natl. Acad. Sci. U.S.A.84:2829-2832(1987)
[
PubMed ]
[
Europe PMC ]
[
Abstract ]
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Cited for : VARIANT THPH3 CYS-444
21.
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Cited for : VARIANT THPH3 TRP-211
22.
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Cited for : VARIANT THPH3 CYS-272
23.
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Cited for : VARIANTS THPH3 ALA-62 AND MET-76
24.
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Cited for : VARIANT THPH4 ASP-418
25.
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Cited for : VARIANT THPH4 LEU-289
26.
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Cited for : VARIANTS THPH3 GLN-220 AND TRP-220
27.
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Cited for : VARIANT THPH3 GLN-220
28.
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Cited for : VARIANT THPH4 SER-334
29.
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Cited for : VARIANTS TRP-38; CYS-42; HIS-42; GLN-271 AND ASN-294
30.
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Cited for : VARIANTS GLY-14; GLN-211; TYR-244; GLN-253; LEU-321; CYS-328; ILE-385; THR-388 AND VAL-388
31.
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Cited for : VARIANT THPH3 TRP-57
32.
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Cited for : VARIANTS THPH3 ARG-145; LEU-210; TRP-211; THR-243; LEU-321; MET-340 AND TYR-426
33.
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Cited for : VARIANT THPH3 SER-423
34.
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Cited for : VARIANT PRO-312
35.
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Cited for : VARIANT THPH4 144-ASN-GLY-145 DELINS LYS
36.
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Cited for : VARIANT THPH4 ALA-367
37.
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Cited for : VARIANTS THPH3 LEU-369; ARG-392; ASN-401 AND HIS-441
38.
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Cited for : VARIANT ASP-49
39.
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Cited for : VARIANTS CYS-89; PRO-220 AND THR-301
40.
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Cited for : VARIANTS THPH3 TRP-57; ARG-114; ARG-324; CYS-328 AND LEU-369;VARIANT THR-43
41.
"Two novel (R(-11)C; T394D) and two repeat missense mutations in the protein C gene associated with venous thrombosis in six kindreds."
Ireland H.A.
,
Boisclair M.D.
,
Taylor J.
,
Thompson E.
,
Thein S.L.
,
Girolami A.
,
de Caterina M.
,
Scopacasa F.
,
de Stefano V.
,
Leone G.
,
Finazzi G.
,
Cohen H.
,
Lane D.A.
Hum. Mutat.7:176-179(1996)
[
PubMed ]
[
Europe PMC ]
[
Abstract ]
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Cited for : VARIANTS THPH3 CYS-32 AND ASN-436
42.
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Cited for : VARIANTS THPH3 GLN-220 AND MET-340