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Index > Protein center > PROM1(Gene name) > Human
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  • PROM1 (Gene name),
  • Prominin-1 (Protein name ),  PROM1_HUMAN from NCBI database.
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  • General Annotation
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  • Antigen Annotation
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  • Predicted Eptitope
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  • Vaild Sequence
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  • Gene name:
    PROM1(MSTP061;PROML1);
    Protein name:
    Prominin-1;
    Alternative:
    Prominin-like protein 1;Antigen AC133;
    CD:
    CD133;
    Organism:
    Human (Homo sapiens). 
    General Annotation
    Sub Unit:
    Interacts with CDHR1 and with actin filaments.
    Function:
    Binds cholesterol in cholesterol-containing plasma membrane microdomains. Proposed to play a role in apical plasma membrane organization of epithelial cells. During early retinal development acts as a key regulator of disk morphogenesis. Involved in regulation of MAPK and Akt signaling pathways. In neuroblastoma cells suppresses cell differentiation such as neurite outgrowth in a RET-dependent manner.
    Subcellular Location:
    Isoform 1 Apical cell membrane Multi-pass membrane protein Cell projection microvillus membrane Multi-pass membrane protein Found in extracellular membrane particles in various body fluids such as cerebrospinal fluid, saliva, seminal fluid and urine.
    Protein Attributes:
    Sequence length:
    865
    Sequence:
    50:
    MALVLGSLLL | LGLCGNSFSG | GQPSSTDAPK | AWNYELPATN | YETQDSHKAG | 
    100:
    PIGILFELVH | IFLYVVQPRD | FPEDTLRKFL | QKAYESKIDY | DKPETVILGL | 
    150:
    KIVYYEAGII | LCCVLGLLFI | ILMPLVGYFF | CMCRCCNKCG | GEMHQRQKEN | 
    200:
    GPFLRKCFAI | SLLVICIIIS | IGIFYGFVAN | HQVRTRIKRS | RKLADSNFKD | 
    250:
    LRTLLNETPE | QIKYILAQYN | TTKDKAFTDL | NSINSVLGGG | ILDRLRPNII | 
    300:
    PVLDEIKSMA | TAIKETKEAL | ENMNSTLKSL | HQQSTQLSSS | LTSVKTSLRS | 
    350:
    SLNDPLCLVH | PSSETCNSIR | LSLSQLNSNP | ELRQLPPVDA | ELDNVNNVLR | 
    400:
    TDLDGLVQQG | YQSLNDIPDR | VQRQTTTVVA | GIKRVLNSIG | SDIDNVTQRL | 
    450:
    PIQDILSAFS | VYVNNTESYI | HRNLPTLEEY | DSYWWLGGLV | ICSLLTLIVI | 
    500:
    FYYLGLLCGV | CGYDRHATPT | TRGCVSNTGG | VFLMVGVGLS | FLFCWILMII | 
    550:
    VVLTFVFGAN | VEKLICEPYT | SKELFRVLDT | PYLLNEDWEY | YLSGKLFNKS | 
    600:
    KMKLTFEQVY | SDCKKNRGTY | GTLHLQNSFN | ISEHLNINEH | TGSISSELES | 
    650:
    LKVNLNIFLL | GAAGRKNLQD | FAACGIDRMN | YDSYLAQTGK | SPAGVNLLSF | 
    700:
    AYDLEAKANS | LPPGNLRNSL | KRDAQTIKTI | HQQRVLPIEQ | SLSTLYQSVK | 
    750:
    ILQRTGNGLL | ERVTRILASL | DFAQNFITNN | TSSVIIEETK | KYGRTIIGYF | 
    800:
    EHYLQWIEFS | ISEKVASCKP | VATALDTAVD | VFLCSYIIDP | LNLFWFGIGK | 
    850:
    ATVFLLPALI | FAVKLAKYYR | RMDSEDVYDD | VETIPMKNME | NGNNGYHKDH | 
    865:
    VYGIHNPVMT | SPSQH
    3D Structure:
    N/A
    Predicted Eptitope:
    Please Sign in.
    EIAab Sequence  Vaild Sequence:
    Please Sign in.
    Related Databases
    Pfam:
    String:
    KEGG:
    MIM:
    UniGene:
    Uniprot:
     
    FOR
    ELISA Kit for Human Prominin-1
    Cat.:
    E1952h
    Price:
    Please sign in first.
    MSDS:
    Please sign in first.
    Packing:
    96T
    Range:
    Please sign in first.
    ELISA Kit for Human Prominin-1
    Cat.:
    E1952m
    Price:
    Please sign in first.
    MSDS:
    Please sign in first.
    Packing:
    96T
    CLIA Kit for Human Prominin-1
    Cat.:
    U1952m
    Price:
    Please sign in first.
    MSDS:
    Please sign in first.
    Packing:
    96T
    CLIA Kit for Human Prominin-1
    Cat.:
    U1952h
    Price:
    Please sign in first.
    MSDS:
    Please sign in first.
    Packing:
    96T
    Range:
    Please sign in first.
    Polyclonal Antibody for Human Prominin-1
    Cat.:
    P1952Rb-m
    Price:
    Please sign in first.
    Packing:
    40ug/0.2ml
    Polyclonal Antibody for Human Prominin-1
    Cat.:
    P1952Rb-h
    Price:
    Please sign in first.
    Packing:
    40ug/0.2ml
    Monoclonal Antibody for Human Prominin-1
    Monoclonal Antibody for Human Prominin-1
    Protein for Human Prominin-1
    Protein for Human Prominin-1

    R&D Technical Data
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    For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.
    For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.
    For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.
    For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.
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    Precision
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    For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.
    For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.
    For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.
    For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.
    For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.
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    Recovery
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    For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.
    For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.
    For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.
    For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.
    For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.
    For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.
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    Linearity
    For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.
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    For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.
    For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.
    For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.
    For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.
    For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.
    For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.
    For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.
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    References
    1. 1.
      "A novel five-transmembrane hematopoietic stem cell antigen: isolation, characterization, and molecular cloning."
      Miraglia S. , Godfrey W. , Yin A.H. , Atkins K. , Warnke R. , Holden J.T. , Bray R.A. , Waller E.K. , Buck D.W.
      Blood90:5013-5021(1997) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1);PROTEIN SEQUENCE OF 31-42; 200-211; 280-291 AND 641-656
      tissue: Fetal liver.
      tissue: Retinoblastoma.
    2. 2.
      "AC133-2, a novel isoform of human AC133 stem cell antigen."
      Yu Y. , Flint A. , Dvorin E.L. , Bischoff J.
      J. Biol. Chem.277:20711-20716(2002) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 2);SUBCELLULAR LOCATION;TISSUE SPECIFICITY;GLYCOSYLATION
    3. 3.
      "Identification and functional analysis of several isoforms of hematopoitic stem cell surface maker prominin-1 (AC133)."
      Lin J. , Shmelkov S.V. , Karajannis M.A. , StClair R. , Walsh K. , Gordon R. , Shido K. , Lam G. , Moussazadeh N. , Shim W. , Rafii S.
      Submitted (2003-10) to the EMBL/GenBank/DDBJ databases
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 3)
    4. 4.
      Wang X.Y. , Zhao B. , Liu B. , Xu Y.Y. , Liu Y.Q. , Cao H.Q. , Sheng H. , Ye J. , Song L. , Wei Y.J. , Liu S. , Liu L.S. , Ding J.F. , Gao R.L. , Wu Q.Y. , Qiang B.Q. , Yuan J.G. , Liew C.C. , more...
      Submitted (1998-12) to the EMBL/GenBank/DDBJ databases
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 2)
      tissue: Aorta.
    5. 5.
      "Complete sequencing and characterization of 21,243 full-length human cDNAs."
      Ota T. , Suzuki Y. , Nishikawa T. , Otsuki T. , Sugiyama T. , Irie R. , Wakamatsu A. , Hayashi K. , Sato H. , Nagai K. , Kimura K. , Makita H. , Sekine M. , Obayashi M. , Nishi T. , Shibahara T. , Tanaka T. , Ishii S. , more...
      Nat. Genet.36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 2)
    6. 6.
      "Generation and annotation of the DNA sequences of human chromosomes 2 and 4."
      Hillier L.W. , Graves T.A. , Fulton R.S. , Fulton L.A. , Pepin K.H. , Minx P. , Wagner-McPherson C. , Layman D. , Wylie K. , Sekhon M. , Becker M.C. , Fewell G.A. , Delehaunty K.D. , Miner T.L. , Nash W.E. , Kremitzki C. , Oddy L. , Du H. , more...
      Nature434:724-731(2005) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]
    7. 7.
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]
    8. 8.
      "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
      The MGC Project Team
      Genome Res.14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 2)
      tissue: Colon.
    9. 9.
      "AC133, a novel marker for human hematopoietic stem and progenitor cells."
      Yin A.H. , Miraglia S. , Zanjani E.D. , Almeida-Porada G. , Ogawa M. , Leary A.G. , Olweus J. , Kearney J. , Buck D.W.
      Blood90:5002-5012(1997) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: CHARACTERIZATION
      tissue: Fetal liver.
    10. 10.
      "Differential expression of prominin-1 (CD133) and prominin-2 in major cephalic exocrine glands of adult mice."
      Jaszai J. , Janich P. , Farkas L.M. , Fargeas C.A. , Huttner W.B. , Corbeil D.
      Histochem. Cell Biol.128:409-419(2007) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: TISSUE SPECIFICITY
    11. 11.
      "Nomenclature of prominin-1 (CD133) splice variants - an update."
      Fargeas C.A. , Huttner W.B. , Corbeil D.
      Tissue Antigens69:602-606(2007) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NOMENCLATURE OF ISOFORMS
    12. 12.
      "The stem cell marker prominin-1/CD133 on membrane particles in human cerebrospinal fluid offers novel approaches for studying central nervous system disease."
      Huttner H.B. , Janich P. , Koehrmann M. , Jaszai J. , Siebzehnrubl F. , Bluemcke I. , Suttorp M. , Gahr M. , Kuhnt D. , Nimsky C. , Krex D. , Schackert G. , Loewenbrueck K. , Reichmann H. , Juettler E. , Hacke W. , Schellinger P.D. , Schwab S. , more...
      Stem Cells26:698-705(2008) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: SUBCELLULAR LOCATION
    13. 13.
      "Release of extracellular membrane vesicles from microvilli of epithelial cells is enhanced by depleting membrane cholesterol."
      Marzesco A.M. , Wilsch-Brauninger M. , Dubreuil V. , Janich P. , Langenfeld K. , Thiele C. , Huttner W.B. , Corbeil D.
      FEBS Lett.583:897-902(2009) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: SUBCELLULAR LOCATION
    14. 14.
      "CD133 suppresses neuroblastoma cell differentiation via signal pathway modification."
      Takenobu H. , Shimozato O. , Nakamura T. , Ochiai H. , Yamaguchi Y. , Ohira M. , Nakagawara A. , Kamijo T.
      Oncogene30:97-105(2011) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: FUNCTION
    15. 15.
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: INVOLVEMENT IN RP41
    16. 16.
      "Severe retinitis pigmentosa mapped to 4p15 and associated with a novel mutation in the PROM1 gene."
      Zhang Q. , Zulfiqar F. , Xiao X. , Riazuddin S.A. , Ahmad Z. , Caruso R. , MacDonald I. , Sieving P. , Riazuddin S. , Hejtmancik J.F.
      Hum. Genet.122:293-299(2007) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: INVOLVEMENT IN RP41
    17. 17.
      "System-wide temporal characterization of the proteome and phosphoproteome of human embryonic stem cell differentiation."
      Rigbolt K.T. , Prokhorova T.A. , Akimov V. , Henningsen J. , Johansen P.T. , Kratchmarova I. , Kassem M. , Mann M. , Olsen J.V. , Blagoev B.
      Sci. Signal.4:RS3-RS3(2011) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-863;IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS]
    18. 18.
      "Post-translational regulation of CD133 by ATase1/ATase2-mediated lysine acetylation."
      Mak A.B. , Pehar M. , Nixon A.M. , Williams R.A. , Uetrecht A.C. , Puglielli L. , Moffat J.
      J. Mol. Biol.426:2175-2182(2014) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: IDENTIFICATION BY MASS SPECTROMETRY;FUNCTION;SUBCELLULAR LOCATION;ACETYLATION AT LYS-225; LYS-257 AND LYS-264 BY NAT8 AND NAT8B;MUTAGENESIS OF LYS-225; LYS-257 AND LYS-264;INTERACTION WITH NAT8 AND NAT8B
    19. 19.
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: VARIANT CORD12/STGD4/MCDR2 CYS-373;INTERACTION WITH CDHR1 AND ACTIN;CHARACTERIZATION OF VARIANT CORD12/STGD4/MCDR2 CYS-373
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