PROM1 ELISA Kit for Human(Homo sapiens) | EIAab.comPROM1 ELISA Kit for Human(Homo sapiens)

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Index > Protein center > PROM1(Gene name) > Human

PROM1 (Gene name),

Prominin-1 (Protein name ), PROM1_HUMAN from NCBI database.

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General Annotation

Antigen Annotation

Predicted Eptitope

Vaild Sequence

Related Databases

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Gene name:

PROM1(MSTP061;PROML1);

Protein name:

Prominin-1;

Alternative:

Prominin-like protein 1;Antigen AC133;

CD:

CD133;

Organism:

Human (Homo sapiens).

General Annotation

Sub Unit:

Interacts with CDHR1 and with actin filaments.

Function:

Binds cholesterol in cholesterol-containing plasma membrane microdomains. Proposed to play a role in apical plasma membrane organization of epithelial cells. During early retinal development acts as a key regulator of disk morphogenesis. Involved in regulation of MAPK and Akt signaling pathways. In neuroblastoma cells suppresses cell differentiation such as neurite outgrowth in a RET-dependent manner.

Subcellular Location:

Isoform 1 Apical cell membrane Multi-pass membrane protein Cell projection microvillus membrane Multi-pass membrane protein Found in extracellular membrane particles in various body fluids such as cerebrospinal fluid, saliva, seminal fluid and urine.

Protein Attributes:

Sequence length:

865

Sequence:

50:

100:

150:

200:

250:

300:

350:

400:

450:

500:

550:

600:

650:

700:

750:

800:

850:

865:

VYGIHNPVMT | SPSQH

3D Structure:

N/A

Predicted Eptitope:

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Vaild Sequence:

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Related Databases

Pfam:

PF05478

String:

O43490

KEGG:

hsa:8842

MIM:

603786

STRING:

9606.ENSP00000415481

UniGene:

Hs.614734

Uniprot:

O43490

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ELISA Kit for Human Prominin-1

Cat.:

E1952h

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Manual:

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MSDS:

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Packing:

96T

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ELISA Kit for Human Prominin-1

Cat.:

E1952m

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MSDS:

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Packing:

96T

CLIA Kit for Human Prominin-1

Cat.:

U1952m

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MSDS:

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Packing:

96T

CLIA Kit for Human Prominin-1

Cat.:

U1952h

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Manual:

Looking for manual.

MSDS:

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Packing:

96T

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Polyclonal Antibody for Human Prominin-1

Cat.:

P1952Rb-m

Price:

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Packing:

40ug/0.2ml

Polyclonal Antibody for Human Prominin-1

Cat.:

P1952Rb-h

Price:

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Packing:

40ug/0.2ml

Monoclonal Antibody for Human Prominin-1

Protein for Human Prominin-1

R&D Technical Data

For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.

Precision

For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.

Recovery

For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.

Linearity

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References

1.

"A novel five-transmembrane hematopoietic stem cell antigen: isolation, characterization, and molecular cloning."
Miraglia S. , Godfrey W. , Yin A.H. , Atkins K. , Warnke R. , Holden J.T. , Bray R.A. , Waller E.K. , Buck D.W.
Blood90:5013-5021(1997) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1);PROTEIN SEQUENCE OF 31-42; 200-211; 280-291 AND 641-656
tissue: Fetal liver.
tissue: Retinoblastoma.
2.

"AC133-2, a novel isoform of human AC133 stem cell antigen."
Yu Y. , Flint A. , Dvorin E.L. , Bischoff J.
J. Biol. Chem.277:20711-20716(2002) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 2);SUBCELLULAR LOCATION;TISSUE SPECIFICITY;GLYCOSYLATION
3.

"Identification and functional analysis of several isoforms of hematopoitic stem cell surface maker prominin-1 (AC133)."
Lin J. , Shmelkov S.V. , Karajannis M.A. , StClair R. , Walsh K. , Gordon R. , Shido K. , Lam G. , Moussazadeh N. , Shim W. , Rafii S.
Submitted (2003-10) to the EMBL/GenBank/DDBJ databases

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 3)
4.

Wang X.Y. , Zhao B. , Liu B. , Xu Y.Y. , Liu Y.Q. , Cao H.Q. , Sheng H. , Ye J. , Song L. , Wei Y.J. , Liu S. , Liu L.S. , Ding J.F. , Gao R.L. , Wu Q.Y. , Qiang B.Q. , Yuan J.G. , Liew C.C. , more...
Submitted (1998-12) to the EMBL/GenBank/DDBJ databases

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 2)
tissue: Aorta.
5.

"Complete sequencing and characterization of 21,243 full-length human cDNAs."
Ota T. , Suzuki Y. , Nishikawa T. , Otsuki T. , Sugiyama T. , Irie R. , Wakamatsu A. , Hayashi K. , Sato H. , Nagai K. , Kimura K. , Makita H. , Sekine M. , Obayashi M. , Nishi T. , Shibahara T. , Tanaka T. , Ishii S. , more...
Nat. Genet.36:40-45(2004) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 2)
6.

"Generation and annotation of the DNA sequences of human chromosomes 2 and 4."
Hillier L.W. , Graves T.A. , Fulton R.S. , Fulton L.A. , Pepin K.H. , Minx P. , Wagner-McPherson C. , Layman D. , Wylie K. , Sekhon M. , Becker M.C. , Fewell G.A. , Delehaunty K.D. , Miner T.L. , Nash W.E. , Kremitzki C. , Oddy L. , Du H. , more...
Nature434:724-731(2005) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]
7.

Mural R.J. , Istrail S. , Sutton G.G. , Florea L. , Halpern A.L. , Mobarry C.M. , Lippert R. , Walenz B. , Shatkay H. , Dew I. , Miller J.R. , Flanigan M.J. , Edwards N.J. , Bolanos R. , Fasulo D. , Halldorsson B.V. , Hannenhalli S. , Turner R. , more...
Submitted (2005-07) to the EMBL/GenBank/DDBJ databases

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]
8.

"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
The MGC Project Team
Genome Res.14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 2)
tissue: Colon.
9.

"AC133, a novel marker for human hematopoietic stem and progenitor cells."
Yin A.H. , Miraglia S. , Zanjani E.D. , Almeida-Porada G. , Ogawa M. , Leary A.G. , Olweus J. , Kearney J. , Buck D.W.
Blood90:5002-5012(1997) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: CHARACTERIZATION
tissue: Fetal liver.
10.

"Differential expression of prominin-1 (CD133) and prominin-2 in major cephalic exocrine glands of adult mice."
Jaszai J. , Janich P. , Farkas L.M. , Fargeas C.A. , Huttner W.B. , Corbeil D.
Histochem. Cell Biol.128:409-419(2007) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: TISSUE SPECIFICITY
11.

"Nomenclature of prominin-1 (CD133) splice variants - an update."
Fargeas C.A. , Huttner W.B. , Corbeil D.
Tissue Antigens69:602-606(2007) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NOMENCLATURE OF ISOFORMS
12.

"The stem cell marker prominin-1/CD133 on membrane particles in human cerebrospinal fluid offers novel approaches for studying central nervous system disease."
Huttner H.B. , Janich P. , Koehrmann M. , Jaszai J. , Siebzehnrubl F. , Bluemcke I. , Suttorp M. , Gahr M. , Kuhnt D. , Nimsky C. , Krex D. , Schackert G. , Loewenbrueck K. , Reichmann H. , Juettler E. , Hacke W. , Schellinger P.D. , Schwab S. , more...
Stem Cells26:698-705(2008) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: SUBCELLULAR LOCATION
13.

"Release of extracellular membrane vesicles from microvilli of epithelial cells is enhanced by depleting membrane cholesterol."
Marzesco A.M. , Wilsch-Brauninger M. , Dubreuil V. , Janich P. , Langenfeld K. , Thiele C. , Huttner W.B. , Corbeil D.
FEBS Lett.583:897-902(2009) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: SUBCELLULAR LOCATION
14.

"CD133 suppresses neuroblastoma cell differentiation via signal pathway modification."
Takenobu H. , Shimozato O. , Nakamura T. , Ochiai H. , Yamaguchi Y. , Ohira M. , Nakagawara A. , Kamijo T.
Oncogene30:97-105(2011) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: FUNCTION
15.

"A frameshift mutation in prominin (mouse)-like 1 causes human retinal degeneration."
Maw M.A. , Corbeil D. , Koch J. , Hellwig A. , Wilson-Wheeler J.C. , Bridges R.J. , Kumaramanickavel G. , John S. , Nancarrow D. , Roeper K. , Weigmann A. , Huttner W.B. , Denton M.J.
Hum. Mol. Genet.9:27-34(2000) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: INVOLVEMENT IN RP41
16.

"Severe retinitis pigmentosa mapped to 4p15 and associated with a novel mutation in the PROM1 gene."
Zhang Q. , Zulfiqar F. , Xiao X. , Riazuddin S.A. , Ahmad Z. , Caruso R. , MacDonald I. , Sieving P. , Riazuddin S. , Hejtmancik J.F.
Hum. Genet.122:293-299(2007) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: INVOLVEMENT IN RP41
17.

"System-wide temporal characterization of the proteome and phosphoproteome of human embryonic stem cell differentiation."
Rigbolt K.T. , Prokhorova T.A. , Akimov V. , Henningsen J. , Johansen P.T. , Kratchmarova I. , Kassem M. , Mann M. , Olsen J.V. , Blagoev B.
Sci. Signal.4:RS3-RS3(2011) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-863;IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS]
18.

"Post-translational regulation of CD133 by ATase1/ATase2-mediated lysine acetylation."
Mak A.B. , Pehar M. , Nixon A.M. , Williams R.A. , Uetrecht A.C. , Puglielli L. , Moffat J.
J. Mol. Biol.426:2175-2182(2014) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: IDENTIFICATION BY MASS SPECTROMETRY;FUNCTION;SUBCELLULAR LOCATION;ACETYLATION AT LYS-225; LYS-257 AND LYS-264 BY NAT8 AND NAT8B;MUTAGENESIS OF LYS-225; LYS-257 AND LYS-264;INTERACTION WITH NAT8 AND NAT8B
19.

"Mutant prominin 1 found in patients with macular degeneration disrupts photoreceptor disk morphogenesis in mice."
Yang Z. , Chen Y. , Lillo C. , Chien J. , Yu Z. , Michaelides M. , Klein M. , Howes K.A. , Li Y. , Kaminoh Y. , Chen H. , Zhao C. , Chen Y. , Al-Sheikh Y.T. , Karan G. , Corbeil D. , Escher P. , Kamaya S. , more...
J. Clin. Invest.118:2908-2916(2008) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: VARIANT CORD12/STGD4/MCDR2 CYS-373;INTERACTION WITH CDHR1 AND ACTIN;CHARACTERIZATION OF VARIANT CORD12/STGD4/MCDR2 CYS-373

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