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Index > Protein center > CFP(Gene name) > Human
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  • CFP (Gene name),
  • Properdin (Protein name ),  PROP_HUMAN from NCBI database.
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  • General Annotation
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  • Antigen Annotation
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  • Predicted Eptitope
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  • Vaild Sequence
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  • Gene name:
    CFP(PFC);
    Protein name:
    Properdin;
    Alternative:
    Complement factor P;
    Organism:
    Human (Homo sapiens). 
    General Annotation
    Sub Unit:
    N/A
    Function:
    A positive regulator of the alternate pathway of complement. It binds to and stabilizes the C3- and C5-convertase enzyme complexes.
    Subcellular Location:
    Secreted
    Protein Attributes:
    Sequence length:
    469
    Sequence:
    50:
    MITEGAQAPR | LLLPPLLLLL | TLPATGSDPV | LCFTQYEESS | GKCKGLLGGG | 
    100:
    VSVEDCCLNT | AFAYQKRSGG | LCQPCRSPRW | SLWSTWAPCS | VTCSEGSQLR | 
    150:
    YRRCVGWNGQ | CSGKVAPGTL | EWQLQACEDQ | QCCPEMGGWS | GWGPWEPCSV | 
    200:
    TCSKGTRTRR | RACNHPAPKC | GGHCPGQAQE | SEACDTQQVC | PTHGAWATWG | 
    250:
    PWTPCSASCH | GGPHEPKETR | SRKCSAPEPS | QKPPGKPCPG | LAYEQRRCTG | 
    300:
    LPPCPVAGGW | GPWGPVSPCP | VTCGLGQTME | QRTCNHPVPQ | HGGPFCAGDA | 
    350:
    TRTHICNTAV | PCPVDGEWDS | WGEWSPCIRR | NMKSISCQEI | PGQQSRGRTC | 
    400:
    RGRKFDGHRC | AGQQQDIRHC | YSIQHCPLKG | SWSEWSTWGL | CMPPCGPNPT | 
    450:
    RARQRLCTPL | LPKYPPTVSM | VEGQGEKNVT | FWGRPLPRCE | ELQGQKLVVE | 
    469:
    EKRPCLHVPA | CKDPEEEEL
    3D Structure:
    N/A
    Predicted Eptitope:
    Please Sign in.
    EIAab Sequence  Vaild Sequence:
    Please Sign in.
    Related Databases
    SMR:
    UniGene:
    String:
    KEGG:
    Pfam:
    MIM:
    Uniprot:
     
    FOR
    ELISA Kit for Human Properdin
    Cat.:
    E1082m
    Price:
    Please sign in first.
    MSDS:
    Please sign in first.
    Packing:
    96T
    Range:
    Please sign in first.
    ELISA Kit for Human Properdin
    Cat.:
    E1082h
    Price:
    Please sign in first.
    MSDS:
    Please sign in first.
    Packing:
    96T
    Range:
    Please sign in first.
    CLIA Kit for Human Properdin
    Cat.:
    U1082h
    Price:
    Please sign in first.
    MSDS:
    Please sign in first.
    Packing:
    96T
    Range:
    Please sign in first.
    CLIA Kit for Human Properdin
    Cat.:
    U1082m
    Price:
    Please sign in first.
    MSDS:
    Please sign in first.
    Packing:
    96T
    Polyclonal Antibody for Human Properdin
    Cat.:
    P1082Rb-h
    Price:
    Please sign in first.
    Packing:
    40ug/0.2ml
    Polyclonal Antibody for Human Properdin
    Cat.:
    P1082Rb-m
    Price:
    Please sign in first.
    Packing:
    40ug/0.2ml
    Monoclonal Antibody for Human Properdin
    Monoclonal Antibody for Human Properdin
    Protein for Human Properdin
    Protein for Human Properdin

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    Precision
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    For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.
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    Recovery
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    For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.
    For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.
    For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.
    For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.
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    Linearity
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    For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.
    For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.
    For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.
    For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.
    For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.
    For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.
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    References
    1. 1.
      "Molecular cloning of the cDNA coding for properdin, a positive regulator of the alternative pathway of human complement."
      Nolan K.F. , Schwaeble W. , Kaluz S. , Dierich M.P. , Reid K.B.M.
      Eur. J. Immunol.21:771-776(1991) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [MRNA]
    2. 2.
      "Characterization of the human properdin gene."
      Nolan K.F. , Kaluz S. , Higgins J.M. , Goundis D. , Reid K.B.M.
      Biochem. J.287:291-297(1992) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA]
    3. 3.
      "Detection of properdin mRNA in human peripheral blood monocytes and spleen."
      Weiler J.M. , Maves K.K.
      J. Lab. Clin. Med.120:762-766(1992) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [MRNA]
    4. 4.
      "Sequence-based analysis of properdin deficiency: identification of point mutations in two phenotypic forms of an X-linked immunodeficiency."
      Westberg J. , Fredrikson G.N. , Truedsson L. , Sjoeholm A.G. , Uhlen M.
      Genomics29:1-8(1995) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA];VARIANT PFC TYPE-II DEFICIENCY TRP-100
    5. 5.
      SeattleSNPs variation discovery resource
      Submitted (2003-05) to the EMBL/GenBank/DDBJ databases
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA];VARIANTS MET-53; LEU-204 AND SER-250
    6. 6.
      "The DNA sequence of the human X chromosome."
      Ross M.T. , Grafham D.V. , Coffey A.J. , Scherer S. , McLay K. , Muzny D. , Platzer M. , Howell G.R. , Burrows C. , Bird C.P. , Frankish A. , Lovell F.L. , Howe K.L. , Ashurst J.L. , Fulton R.S. , Sudbrak R. , Wen G. , Jones M.C. , more...
      Nature434:325-337(2005) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]
    7. 7.
      "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
      The MGC Project Team
      Genome Res.14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA]
      tissue: Spleen.
    8. 8.
      "Properdin, the positive regulator of complement, is highly C-mannosylated."
      Hartmann S. , Hofsteenge J.
      J. Biol. Chem.275:28569-28574(2000) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: GLYCOSYLATION AT TRP-83; TRP-86; TRP-139; TRP-142; TRP-145; TRP-196; TRP-199; TRP-260; TRP-263; TRP-321; TRP-324; TRP-382; TRP-385 AND TRP-388
    9. 9.
      "C-mannosylation and O-fucosylation of thrombospondin type 1 repeats."
      Gonzalez de Peredo A. , Klein D. , Macek B. , Hess D. , Peter-Katalinic J. , Hofsteenge J.
      Mol. Cell. Proteomics1:11-18(2002) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: GLYCOSYLATION AT THR-92; THR-151; SER-208 AND THR-272
    10. 10.
      "Human plasma N-glycoproteome analysis by immunoaffinity subtraction, hydrazide chemistry, and mass spectrometry."
      Liu T. , Qian W.-J. , Gritsenko M.A. , Camp D.G. II , Monroe M.E. , Moore R.J. , Smith R.D.
      J. Proteome Res.4:2070-2080(2005) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: GLYCOSYLATION [LARGE SCALE ANALYSIS] AT ASN-428
      tissue: Plasma.
    11. 11.
      "Native polymeric forms of properdin selectively bind to targets and promote activation of the alternative pathway of complement."
      Ferreira V.P. , Cortes C. , Pangburn M.K.
      Immunobiology215:932-940(2010) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: FUNCTION;SUBUNIT
    12. 12.
      "A strategy for precise and large scale identification of core fucosylated glycoproteins."
      Jia W. , Lu Z. , Fu Y. , Wang H.P. , Wang L.H. , Chi H. , Yuan Z.F. , Zheng Z.B. , Song L.N. , Han H.H. , Liang Y.M. , Wang J.L. , Cai Y. , Zhang Y.K. , Deng Y.L. , Ying W.T. , He S.M. , Qian X.H.
      Mol. Cell. Proteomics8:913-923(2009) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: GLYCOSYLATION AT ASN-428
    13. 13.
      "The dimeric and trimeric solution structures of the multidomain complement protein properdin by X-ray scattering, analytical ultracentrifugation and constrained modelling."
      Sun Z. , Reid K.B. , Perkins S.J.
      J. Mol. Biol.343:1327-1343(2004) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: X-RAY SCATTERING SOLUTION STRUCTURE OF 28-469 IN DIMERIC AND TRIMERIC FORMS;TSP DOMAINS;SUBUNIT
    14. 14.
      "Molecular characterization of properdin deficiency type III: dysfunction produced by a single point mutation in exon 9 of the structural gene causing a tyrosine to aspartic acid interchange."
      Fredrikson G.N. , Westberg J. , Kuijper E.J. , Tijssen C.C. , Sjoeholm A.G. , Uhlen M. , Truedsson L.
      J. Immunol.157:3666-3671(1996) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: VARIANT PFD ASP-414
    15. 15.
      "Expression of properdin in complete and incomplete deficiency: normal in vitro synthesis by monocytes in two cases with properdin deficiency type II due to distinct mutations."
      Fredrikson G.N. , Gullstrand B. , Westberg J. , Sjoeholm A.G. , Uhlen M. , Truedsson L.
      J. Clin. Immunol.18:272-282(1998) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: VARIANT PFD ARG-343
    16. 16.
      "Molecular characterisation of 10 Dutch properdin type I deficient families: mutation analysis and X-inactivation studies."
      van den Bogaard R. , Fijen C.A.P. , Schipper M.G.J. , de Galan L. , Kuijper E.J. , Mannens M.M.A.M.
      Eur. J. Hum. Genet.8:513-518(2000) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: VARIANT PFD VAL-298
    17. 17.
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: VARIANT [LARGE SCALE ANALYSIS] ILE-3
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