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Index > Protein center > PROS1(Gene name) > Human
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  • PROS1 (Gene name),
  • Vitamin K-dependent protein S (Protein name ),  PROS_HUMAN from NCBI database.
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  • General Annotation
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  • Antigen Annotation
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  • 3D
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  • Predicted Eptitope
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  • Vaild Sequence
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  • Related Databases
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  • Citations  (3)
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  • Gene name:
    PROS1(PROS);
    Protein name:
    Vitamin K-dependent protein S;
    Alternative:

    Organism:
    Human (Homo sapiens). 
    General Annotation
    Sub Unit:
    N/A
    Function:
    Anticoagulant plasma protein; it is a cofactor to activated protein C in the degradation of coagulation factors Va and VIIIa. It helps to prevent coagulation and stimulating fibrinolysis.
    Subcellular Location:
    Secreted
    Protein Attributes:
    Sequence length:
    676
    Sequence:
    50:
    MRVLGGRCGA | LLACLLLVLP | VSEANFLSKQ | QASQVLVRKR | RANSLLEETK | 
    100:
    QGNLERECIE | ELCNKEEARE | VFENDPETDY | FYPKYLVCLR | SFQTGLFTAA | 
    150:
    RQSTNAYPDL | RSCVNAIPDQ | CSPLPCNEDG | YMSCKDGKAS | FTCTCKPGWQ | 
    200:
    GEKCEFDINE | CKDPSNINGG | CSQICDNTPG | SYHCSCKNGF | VMLSNKKDCK | 
    250:
    DVDECSLKPS | ICGTAVCKNI | PGDFECECPE | GYRYNLKSKS | CEDIDECSEN | 
    300:
    MCAQLCVNYP | GGYTCYCDGK | KGFKLAQDQK | SCEVVSVCLP | LNLDTKYELL | 
    350:
    YLAEQFAGVV | LYLKFRLPEI | SRFSAEFDFR | TYDSEGVILY | AESIDHSAWL | 
    400:
    LIALRGGKIE | VQLKNEHTSK | ITTGGDVINN | GLWNMVSVEE | LEHSISIKIA | 
    450:
    KEAVMDINKP | GPLFKPENGL | LETKVYFAGF | PRKVESELIK | PINPRLDGCI | 
    500:
    RSWNLMKQGA | SGIKEIIQEK | QNKHCLVTVE | KGSYYPGSGI | AQFHIDYNNV | 
    550:
    SSAEGWHVNV | TLNIRPSTGT | GVMLALVSGN | NTVPFAVSLV | DSTSEKSQDI | 
    600:
    LLSVENTVIY | RIQALSLCSD | QQSHLEFRVN | RNNLELSTPL | KIETISHEDL | 
    650:
    QRQLAVLDKA | MKAKVATYLG | GLPDVPFSAT | PVNAFYNGCM | EVNINGVQLD | 
    676:
    LDEAISKHND | IRAHSCPSVW | KKTKNS
    3D Structure:
    N/A
    Predicted Eptitope:
    Please Sign in.
    EIAab Sequence  Vaild Sequence:
    Please Sign in.
    Related Databases
    MIM:
    String:
    UniGene:
    KEGG:
    Pfam:
    SMR:
    Uniprot:
     
    FOR
    ELISA Kit for Human Vitamin K-dependent protein S
    Cat.:
    E1971h
    Price:
    Please sign in first.
    MSDS:
    Please sign in first.
    Packing:
    96T
    Range:
    Please sign in first.
    ELISA Kit for Human Vitamin K-dependent protein S
    Cat.:
    E1971r
    Price:
    Please sign in first.
    MSDS:
    Please sign in first.
    Packing:
    96T
    Range:
    Please sign in first.
    ELISA Kit for Human Vitamin K-dependent protein S
    Cat.:
    E1971m
    Price:
    Please sign in first.
    MSDS:
    Please sign in first.
    Packing:
    96T
    Range:
    Please sign in first.
    ELISA Kit for Human Vitamin K-dependent protein S
    Cat.:
    E1971b
    Price:
    Please sign in first.
    MSDS:
    Please sign in first.
    Packing:
    96T
    ELISA Kit for Human Vitamin K-dependent protein S
    MSDS:
    Please sign in first.
    CLIA Kit for Human Vitamin K-dependent protein S
    Cat.:
    U1971b
    Price:
    Please sign in first.
    MSDS:
    Please sign in first.
    Packing:
    96T
    CLIA Kit for Human Vitamin K-dependent protein S
    MSDS:
    Please sign in first.
    CLIA Kit for Human Vitamin K-dependent protein S
    Cat.:
    U1971r
    Price:
    Please sign in first.
    MSDS:
    Please sign in first.
    Packing:
    96T
    Range:
    Please sign in first.
    CLIA Kit for Human Vitamin K-dependent protein S
    Cat.:
    U1971h
    Price:
    Please sign in first.
    MSDS:
    Please sign in first.
    Packing:
    96T
    Range:
    Please sign in first.
    CLIA Kit for Human Vitamin K-dependent protein S
    Cat.:
    U1971m
    Price:
    Please sign in first.
    MSDS:
    Please sign in first.
    Packing:
    96T
    Polyclonal Antibody for Human Vitamin K-dependent protein S
    Cat.:
    P1971Rb-r
    Price:
    Please sign in first.
    Packing:
    40ug/0.2ml
    Polyclonal Antibody for Human Vitamin K-dependent protein S
    Cat.:
    P1971Rb-m
    Price:
    Please sign in first.
    Packing:
    40ug/0.2ml
    Polyclonal Antibody for Human Vitamin K-dependent protein S
    Polyclonal Antibody for Human Vitamin K-dependent protein S
    Polyclonal Antibody for Human Vitamin K-dependent protein S
    Cat.:
    P1971Rb-h
    Price:
    Please sign in first.
    Packing:
    40ug/0.2ml
    Monoclonal Antibody for Human Vitamin K-dependent protein S
    Monoclonal Antibody for Human Vitamin K-dependent protein S
    Monoclonal Antibody for Human Vitamin K-dependent protein S
    Monoclonal Antibody for Human Vitamin K-dependent protein S
    Monoclonal Antibody for Human Vitamin K-dependent protein S
    Protein for Human Vitamin K-dependent protein S
    Protein for Human Vitamin K-dependent protein S
    Protein for Human Vitamin K-dependent protein S
    Protein for Human Vitamin K-dependent protein S
    Protein for Human Vitamin K-dependent protein S

    R&D Technical Data
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    Precision
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    Recovery
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    Linearity
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    References
    1. 1.
      "Human protein S cDNA encodes Phe-16 and Tyr 222 in consensus sequences for the post-translational processing."
      Ploos van Amstel H.K. , van der Zanden A.L. , Reitsma P.H. , Bertina R.M.
      FEBS Lett.222:186-190(1987) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [MRNA];GAMMA-CARBOXYGLUTAMATION AT GLU-47; GLU-48; GLU-55; GLU-57; GLU-60; GLU-61; GLU-66; GLU-67; GLU-70; GLU-73 AND GLU-77
    2. 2.
      "Cloning and characterization of human liver cDNA encoding a protein S precursor."
      Hoskins J. , Norman D.K. , Beckmann R.J. , Long G.L.
      Proc. Natl. Acad. Sci. U.S.A.84:349-353(1987) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [MRNA]
    3. 3.
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA]
    4. 4.
      "Intron-exon organization of the active human protein S gene PS alpha and its pseudogene PS beta: duplication and silencing during primate evolution."
      Ploos van Amstel H.K. , Reitsma P.H. , der Logt C.P. , Bertina R.M.
      Biochemistry29:7853-7861(1990) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA]
      tissue: Liver.
    5. 5.
      "Complete sequencing and characterization of 21,243 full-length human cDNAs."
      Ota T. , Suzuki Y. , Nishikawa T. , Otsuki T. , Sugiyama T. , Irie R. , Wakamatsu A. , Hayashi K. , Sato H. , Nagai K. , Kimura K. , Makita H. , Sekine M. , Obayashi M. , Nishi T. , Shibahara T. , Tanaka T. , Ishii S. , more...
      Nat. Genet.36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA]
      tissue: Trachea.
    6. 6.
      SeattleSNPs variation discovery resource
      Submitted (2003-05) to the EMBL/GenBank/DDBJ databases
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA]
    7. 7.
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]
    8. 8.
      "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
      The MGC Project Team
      Genome Res.14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA]
      tissue: Uterus.
    9. 9.
      "Isolation and sequence of the cDNA for human protein S, a regulator of blood coagulation."
      Lundwall A. , Dackowski W. , Cohen E. , Shaffer M. , Mahr A. , Dahlback B. , Stenflo J. , Wydro R.
      Proc. Natl. Acad. Sci. U.S.A.83:6716-6720(1986) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [MRNA] OF 27-676
    10. 10.
      "Identification of eight point mutations in protein S deficiency type I -- analysis of 15 pedigrees."
      Gomez E. , Poort S.R. , Bertina R.M. , Reitsma P.H.
      Thromb. Haemost.73:750-755(1995) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA] OF 500-519;VARIANTS THPH5 VAL-381 AND GLY-508
    11. 11.
      "Human plasma N-glycoproteome analysis by immunoaffinity subtraction, hydrazide chemistry, and mass spectrometry."
      Liu T. , Qian W.-J. , Gritsenko M.A. , Camp D.G. II , Monroe M.E. , Moore R.J. , Smith R.D.
      J. Proteome Res.4:2070-2080(2005) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: GLYCOSYLATION [LARGE SCALE ANALYSIS] AT ASN-530
      tissue: Plasma.
    12. 12.
      "Solution structure of the Ca2+-binding EGF3-4 pair from vitamin K-dependent protein S: identification of an unusual fold in EGF3."
      Drakenberg T. , Ghasriani H. , Thulin E. , Thamlitz A.M. , Muranyi A. , Annila A. , Stenflo J.
      Biochemistry44:8782-8789(2005) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: STRUCTURE BY NMR OF 200-286;DISULFIDE BONDS
    13. 13.
      "Heerlen polymorphism of protein S, an immunologic polymorphism due to dimorphism of residue 460."
      Bertina R.M. , Ploos van Amstel H.K. , van Wijngaarden A. , Coenen J. , Leemhuis M.P. , Deutz-Terlouw P.P. , van der Linden I.K. , Reitsma P.H.
      Blood76:538-548(1990) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: VARIANT PRO-501
    14. 14.
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: VARIANT THPH5 SER-258
    15. 15.
      "Protein S Tokushima: abnormal molecule with a substitution of Glu for Lys-155 in the second epidermal growth factor-like domain of protein S."
      Hayashi T. , Nishioka J. , Shigekiyo T. , Saito S. , Suzuki K.
      Blood83:683-690(1994) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: VARIANT THPH5 TOKUSHIMA GLU-196
    16. 16.
      "Identification of 15 different candidate causal point mutations and three polymorphisms in 19 patients with protein S deficiency using a scanning method for the analysis of the protein S active gene."
      Gandrille S. , Borgel D. , Eschwege-Gufflet V. , Aillaud M. , Dreyfus M. , Matheron C. , Gaussem P. , Abgrall J.F. , Jude B. , Sie P. , Toulon P. , Aiach M.
      Blood85:130-138(1995) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: VARIANTS THPH5 LEU-40; HIS-41; ALA-67; CYS-72; MET-78; HIS-90; ASN-144; GLY-245; LYS-249; TRP-265; ARG-265 AND ASN-376;VARIANTS LEU-76 AND VAL-385
    17. 17.
      "Detection and characterization of seven novel protein S (PROS) gene lesions: evaluation of reverse transcript-polymerase chain reaction as a mutation screening strategy."
      Formstone C.J. , Wacey A.I. , Berg L.-P. , Rahman S. , Bevan D. , Rowley M. , Voke J. , Bernardi F. , Legnani C. , Simioni P. , Girolami A. , Tuddenham E.G.D. , Kakkar V.V. , Cooper D.N.
      Blood86:2632-2641(1995) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: VARIANTS THPH5 SER-258 AND THR-611
    18. 18.
      "Protein S deficiency type I: identification of point mutations in 9 of 10 families."
      Mustafa S. , Pabinger I. , Mannhalter C.
      Blood86:3444-3451(1995) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: VARIANTS THPH5 PRO-351; SER-552; GLN-584 AND PRO-616
    19. 19.
      "Identification of two novel point mutations in the human protein S gene associated with familial protein S deficiency and thrombosis."
      Li M. , Long G.L.
      Arterioscler. Thromb. Vasc. Biol.16:1407-1415(1996) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: VARIANT THPH5 SER-644
    20. 20.
      "Molecular basis of a hereditary type I protein S deficiency caused by a substitution of Cys for Arg474."
      Yamazaki T. , Katsumi A. , Kagami K. , Okamoto Y. , Sugiura I. , Hamaguchi M. , Kojima T. , Takamatsu J. , Saito H.
      Blood87:4643-4650(1996) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: VARIANT THPH5 CYS-515;CHARACTERIZATION OF VARIANT PROS1 DEFICIENCY CYS-515;MUTAGENESIS OF ARG-515
    21. 21.
      "Molecular basis of protein S deficiency in three families also showing independent inheritance of factor V Leiden."
      Beauchamp N.J. , Daly M.E. , Cooper P.C. , Makris M. , Preston F.E. , Peake I.R.
      Blood88:1700-1707(1996) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: VARIANTS THPH5 TYR-186; THR-611 AND LEU-665
    22. 22.
      "Identification of 19 protein S gene mutations in patients with phenotypic protein S deficiency and thrombosis."
      Protein S study group , Simmonds R.E. , Ireland H. , Kunz G. , Lane D.A.
      Blood88:4195-4204(1996) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: VARIANTS THPH5 GLU-50; ALA-67; GLU-95; TYR-186; SER-241; PRO-324; ASP-381; SER-449 AND ARG-666;VARIANT PRO-501
    23. 23.
      "Molecular basis for protein S hereditary deficiency: genetic defects observed in 118 patients with type I and type IIa deficiencies."
      The French network on molecular abnormalities responsible for protein C and protein S deficiencies , Borgel D. , Duchemin J. , Alhenc-Gelas M. , Matheron C. , Aiach M. , Gandrille S.
      J. Lab. Clin. Med.128:218-227(1996) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: VARIANTS THPH5 SER-111; GLY-157; GLY-161; GLU-364; PRO-446; ARG-475; ALA-501; MET-508; CYS-515; PRO-525; ALA-532; TYR-568; ARG-575 AND ARG-666;VARIANT PRO-501
    24. 24.
      "Five novel mutations of the protein S active gene (PROS 1) in 8 Norman families."
      Duchemin J. , Borg J.-Y. , Borgel D. , Vasse M. , Leveque H. , Aiach M. , Gandrille S.
      Thromb. Haemost.75:437-444(1996) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: VARIANTS THPH5 PRO-300 AND ARG-666
    25. 25.
      "Identification of three novel mutations in hereditary protein S deficiency."
      Bustorff T.C. , Freire I. , Gago T. , Crespo F. , David D.
      Thromb. Haemost.77:21-25(1997) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: VARIANT THPH5 PHE-639
    26. 26.
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: VARIANTS THPH5 ASP-68; ARG-95 AND SER-336
    27. 27.
      "Protein S gene analysis reveals the presence of a cosegregating mutation in most pedigrees with type I but not type III PS deficiency."
      Espinosa-Parrilla Y. , Morell M. , Souto J.C. , Tirado I. , Fontcuberta J. , Estivill X. , Sala N.
      Hum. Mutat.14:30-39(1999) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: VARIANTS THPH5 CYS-482; CYS-485 AND GLY-561;VARIANTS PRO-501 AND MET-559
    28. 28.
      "Poor relationship between phenotypes of protein S deficiency and mutations in the protein S alpha gene."
      Hermida J. , Faioni E.M. , Mannucci P.M.
      Thromb. Haemost.82:1634-1638(1999) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: VARIANTS THPH5 ALA-67; GLY-129; PHE-175; PRO-515; LEU-562 AND ASP-638;VARIANTS LEU-76 AND ASP-638
    29. 29.
      "Genetic analysis, phenotypic diagnosis, and risk of venous thrombosis in families with inherited deficiencies of protein S."
      Makris M. , Leach M. , Beauchamp N.J. , Daly M.E. , Cooper P.C. , Hampton K.K. , Bayliss P. , Peake I.R. , Miller G.J. , Preston F.E.
      Blood95:1935-1941(2000) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: VARIANTS THPH5 TYR-166; GLY-247; THR-611; ARG-622 AND ARG-666
    30. 30.
      "Optimization of a simple and rapid single-strand conformation analysis for detection of mutations in the PROS1 gene: identification of seven novel mutations and three novel, apparently neutral, variants."
      Espinosa-Parrilla Y. , Morell M. , Borrell M. , Souto J.C. , Fontcuberta J. , Estivill X. , Sala N.
      Hum. Mutat.15:463-473(2000) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: VARIANTS THPH5 HIS-15; LYS-233; THR-640 AND LEU-667;VARIANTS SER-98 AND MET-559
    31. 31.
      "DNA sequence analysis of protein S deficiency -- identification of four point mutations in twelve Japanese subjects."
      Iwaki T. , Mastushita T. , Kobayashi T. , Yamamoto Y. , Nomura Y. , Kagami K. , Nakayama T. , Sugiura I. , Kojima T. , Takamatsu J. , Kanayama N. , Saito H.
      Semin. Thromb. Hemost.27:155-160(2001) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: VARIANTS THPH5 ASN-243 AND PRO-339
    32. 32.
      "Characterization and structural impact of five novel PROS1 mutations in eleven protein S-deficient families."
      Andersen B.D. , Bisgaard M.L. , Lind B. , Philips M. , Villoutreix B.O. , Thorsen S.
      Thromb. Haemost.86:1392-1399(2001) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: VARIANTS THPH5 CYS-149; ARG-383; LYS-390 AND SER-526
    33. 33.
      "Protein S Gla-domain mutations causing impaired Ca(2+)-induced phospholipid binding and severe functional protein S deficiency."
      Rezende S.M. , Lane D.A. , Mille-Baker B. , Samama M.M. , Conard J. , Simmonds R.E.
      Blood100:2812-2819(2002) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: VARIANTS THPH5 ASP-52 AND MET-78;CHARACTERIZATION OF VARIANTS THPH5 ASP-52 AND MET-78
    34. 34.
      "Genetic and phenotypic variability between families with hereditary protein S deficiency."
      Rezende S.M. , Lane D.A. , Zoeller B. , Mille-Baker B. , Laffan M. , Dalhbaeck B. , Simmonds R.E.
      Thromb. Haemost.87:258-265(2002) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: VARIANTS THPH5 GLU-18; CYS-90; LYS-233; SER-258; VAL-336 AND PRO-664;CHARACTERIZATION OF VARIANTS THPH5 GLU-18; CYS-90; LYS-233; SER-258 VAL-336 AND PRO-664
    35. 35.
      "Four missense mutations identified in the protein S gene of thrombosis patients with protein S deficiency: effects on secretion and anticoagulant activity of protein S."
      Tsuda H. , Urata M. , Tsuda T. , Wakiyama M. , Iida H. , Nakahara M. , Kinoshita S. , Hamasaki N.
      Thromb. Res.105:233-239(2002) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: VARIANTS THPH5 ARG-95; GLU-196; ILE-630 AND CYS-636;CHARACTERIZATION OF VARIANTS THPH5 ARG-95; GLU-196; ILE-630 AND CYS-636
    36. 36.
      "Familial thrombophilia is an oligogenetic disease: involvement of the prothrombin G20210A, PROC and PROS gene mutations."
      Boinot C. , Borgel D. , Kitzis A. , Guicheteau M. , Aiach M. , Alhenc-Gelas M.
      Blood Coagul. Fibrinolysis14:191-196(2003) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: VARIANTS THPH5 CYS-101 AND ASN-144;VARIANT SER-168
    37. 37.
      "Identification of protein Salpha gene mutations including four novel mutations in eight unrelated patients with protein S deficiency."
      Okada H. , Takagi A. , Murate T. , Adachi T. , Yamamoto K. , Matsushita T. , Takamatsu J. , Sugita K. , Sugimoto M. , Yoshioka A. , Yamazaki T. , Saito H. , Kojima T.
      Br. J. Haematol.126:219-225(2004) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: VARIANTS THPH5 LEU-87; TYR-121; GLU-196; HIS-355 AND LEU-667
    38. 38.
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: VARIANTS THPH5 ALA-67; TYR-88; GLY-129; ASN-144; PHE-175; GLY-204; CYS-266; SER-267; ASP-336; ARG-357; PRO-446; PRO-515; ASP-521; LYS-611; ASP-638 AND TYR-639;VARIANTS LEU-76; PRO-501; MET-559; LEU-562 AND HIS-583;CHARACTERIZATION OF VARIANTS PROS1 DEFICIENCY ALA-67; TYR-88; GLY-129; PHE-175; GLY-204; CYS-266; SER-267; ASP-336; ARG-357; PRO-446; PRO-515; ASP-521; LYS-611; ASP-638 AND TYR-639;CHARACTERIZATION OF VARIANTS LEU-76; LEU-562 AND HIS-583
    39. 39.
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: VARIANT [LARGE SCALE ANALYSIS] GLY-545
    40. 40.
      "Intracerebral mass bleeding in a term neonate: manifestation of hereditary protein S deficiency with a new mutation in the PROS1 gene."
      Fischer D. , Porto L. , Stoll H. , Geisen C. , Schloesser R.L.
      Neonatology98:337-340(2010) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: VARIANT THPH6 CYS-234
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