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Index > Protein center > PROZ(Gene name) > Human
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  • PROZ (Gene name),
  • Vitamin K-dependent protein Z (Protein name ),  PROZ_HUMAN from NCBI database.
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  • General Annotation
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  • Antigen Annotation
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  • Predicted Eptitope
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  • Vaild Sequence
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  • Gene name:
    PROZ;
    Protein name:
    Vitamin K-dependent protein Z;
    Alternative:

    Organism:
    Human (Homo sapiens). 
    General Annotation
    Sub Unit:
    N/A
    Function:
    Appears to assist hemostasis by binding thrombin and promoting its association with phospholipid vesicles.
    Subcellular Location:
    Secreted
    Protein Attributes:
    Sequence length:
    400
    Sequence:
    50:
    MAGCVPLLQG | LVLVLALHRV | EPSVFLPASK | ANDVLVRWKR | AGSYLLEELF | 
    100:
    EGNLEKECYE | EICVYEEARE | VFENEVVTDE | FWRRYKGGSP | CISQPCLHNG | 
    150:
    SCQDSIWGYT | CTCSPGYEGS | NCELAKNECH | PERTDGCQHF | CLPGQESYTC | 
    200:
    SCAQGYRLGE | DHKQCVPHDQ | CACGVLTSEK | RAPDLQDLPW | QVKLTNSEGK | 
    250:
    DFCGGVIIRE | NFVLTTAKCS | LLHRNITVKT | YFNRTSQDPL | MIKITHVHVH | 
    300:
    MRYDADAGEN | DLSLLELEWP | IQCPGAGLPV | CTPEKDFAEH | LLIPRTRGLL | 
    350:
    SGWARNGTDL | GNSLTTRPVT | LVEGEECGQV | LNVTVTTRTY | CERSSVAAMH | 
    400:
    3D Structure:
    N/A
    Predicted Eptitope:
    Please Sign in.
    EIAab Sequence  Vaild Sequence:
    Please Sign in.
    Related Databases
    Pfam:
    MIM:
    String:
    SMR:
    KEGG:
    UniGene:
    Uniprot:
     
    FOR
    ELISA Kit for Human Vitamin K-dependent protein Z
    Cat.:
    E0736h
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    MSDS:
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    Packing:
    96T
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    ELISA Kit for Human Vitamin K-dependent protein Z
    Cat.:
    E0736m
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    MSDS:
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    Packing:
    96T
    Range:
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    ELISA Kit for Human Vitamin K-dependent protein Z
    Cat.:
    E0736b
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    MSDS:
    Please sign in first.
    Packing:
    96T
    CLIA Kit for Human Vitamin K-dependent protein Z
    Cat.:
    U0736b
    Price:
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    MSDS:
    Please sign in first.
    Packing:
    96T
    CLIA Kit for Human Vitamin K-dependent protein Z
    Cat.:
    U0736m
    Price:
    Please sign in first.
    MSDS:
    Please sign in first.
    Packing:
    96T
    CLIA Kit for Human Vitamin K-dependent protein Z
    Cat.:
    U0736h
    Price:
    Please sign in first.
    MSDS:
    Please sign in first.
    Packing:
    96T
    Polyclonal Antibody for Human Vitamin K-dependent protein Z
    Cat.:
    P0736Rb-h
    Price:
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    Packing:
    40ug/0.2ml
    Polyclonal Antibody for Human Vitamin K-dependent protein Z
    Cat.:
    P0736Rb-m
    Price:
    Please sign in first.
    Packing:
    40ug/0.2ml
    Polyclonal Antibody for Human Vitamin K-dependent protein Z
    Monoclonal Antibody for Human Vitamin K-dependent protein Z
    Monoclonal Antibody for Human Vitamin K-dependent protein Z
    Monoclonal Antibody for Human Vitamin K-dependent protein Z
    Protein for Human Vitamin K-dependent protein Z
    Protein for Human Vitamin K-dependent protein Z
    Protein for Human Vitamin K-dependent protein Z

    R&D Technical Data
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    Precision
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    Recovery
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    Linearity
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    References
    1. 1.
      "Amino acid sequence of human protein Z, a vitamin K-dependent plasma glycoprotein."
      Ichinose A. , Takeya H. , Espling E. , Iwanaga S. , Kisiel W. , Davie E.W.
      Biochem. Biophys. Res. Commun.172:1139-1144(1990) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [MRNA];GAMMA-CARBOXYGLUTAMATION AT GLU-47; GLU-48; GLU-51; GLU-55; GLU-57; GLU-60; GLU-61; GLU-66; GLU-67; GLU-70; GLU-73; GLU-75 AND GLU-80;PARTIAL PROTEIN SEQUENCE
      tissue: Liver.
    2. 2.
      "The gene for human protein Z is localized to chromosome 13 at band q34 and is coded by eight regular exons and one alternative exon."
      Fujimaki K. , Yamazaki T. , Taniwaki M. , Ichinose A.
      Biochemistry37:6838-6846(1998) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA];ALTERNATIVE SPLICING
    3. 3.
      SeattleSNPs variation discovery resource
      Submitted (2001-10) to the EMBL/GenBank/DDBJ databases
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA];VARIANTS LYS-70 AND HIS-295
    4. 4.
      NHLBI resequencing and genotyping service (RS&G)
      Submitted (2007-02) to the EMBL/GenBank/DDBJ databases
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA]
    5. 5.
      "The DNA sequence and analysis of human chromosome 13."
      Dunham A. , Matthews L.H. , Burton J. , Ashurst J.L. , Howe K.L. , Ashcroft K.J. , Beare D.M. , Burford D.C. , Hunt S.E. , Griffiths-Jones S. , Jones M.C. , Keenan S.J. , Oliver K. , Scott C.E. , Ainscough R. , Almeida J.P. , Ambrose K.D. , Andrews D.T. , more...
      Nature428:522-528(2004) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]
    6. 6.
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]
    7. 7.
      "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
      The MGC Project Team
      Genome Res.14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1)
    8. 8.
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [MRNA] OF 81-400;PROTEIN SEQUENCE OF 63-103
    9. 9.
      "Identification of a disaccharide (Xyl-Glc) and a trisaccharide (Xyl2-Glc) O-glycosidically linked to a serine residue in the first epidermal growth factor-like domain of human factors VII and IX and protein Z and bovine protein Z."
      Nishimura H. , Kawabata S. , Kisiel W. , Hase S. , Ikenaka T. , Takao T. , Shimonishi Y. , Iwanaga S.
      J. Biol. Chem.264:20320-20325(1989) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: STRUCTURE OF CARBOHYDRATE ON SER-93
    10. 10.
      "A new trisaccharide sugar chain linked to a serine residue in the first EGF-like domain of clotting factors VII and IX and protein Z."
      Iwanaga S. , Nishimura H. , Kawabata S. , Kisiel W. , Hase S. , Ikenaka T.
      Adv. Exp. Med. Biol.281:121-131(1990) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: STRUCTURE OF CARBOHYDRATE ON SER-93
    11. 11.
      "Crystal structure of protein Z-dependent inhibitor complex shows how protein Z functions as a cofactor in the membrane inhibition of factor X."
      Wei Z. , Yan Y. , Carrell R.W. , Zhou A.
      Blood114:3662-3667(2009) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: X-RAY CRYSTALLOGRAPHY (2.3 ANGSTROMS) OF 125-400 IN COMPLEX WITH SERPINA10;GLYCOSYLATION AT ASN-233;DISULFIDE BONDS;SUBUNIT
    12. 12.
      "Basis for the specificity and activation of the serpin protein Z-dependent proteinase inhibitor (ZPI) as an inhibitor of membrane-associated factor Xa."
      Huang X. , Dementiev A. , Olson S.T. , Gettins P.G.
      J. Biol. Chem.285:20399-20409(2010) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: X-RAY CRYSTALLOGRAPHY (3.26 ANGSTROMS) OF 84-400 IN COMPLEX WITH SERPINA10;GLYCOSYLATION AT ASN-99; ASN-225; ASN-233 AND ASN-332;DISULFIDE BONDS;SUBUNIT
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