NPEPPS ELISA Kit for Human(Homo sapiens) | EIAab.comNPEPPS ELISA Kit for Human(Homo sapiens)

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NPEPPS (Gene name),

Puromycin-sensitive aminopeptidase (Protein name ), PSA_HUMAN from NCBI database.

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General Annotation

Antigen Annotation

Predicted Eptitope

Vaild Sequence

Related Databases

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Gene name:

NPEPPS(PSA);

Protein name:

Puromycin-sensitive aminopeptidase(PSA);

Alternative:

Cytosol alanyl aminopeptidase(AAP-S);

Organism:

Human (Homo sapiens).

General Annotation

Sub Unit:

Monomer.

Function:

Aminopeptidase with broad substrate specificity for several peptides. Involved in proteolytic events essential for cell growth and viability. May act as regulator of neuropeptide activity. Plays a role in the antigen-processing pathway for MHC class I molecules. Involved in the N-terminal trimming of cytotoxic T cell epitope precursors. Digests the poly-Q peptides found in many cellular proteins. Digests tau from normal brain more efficiently than tau from Alzheimer disease brain.

Subcellular Location:

Cytoplasm cytosol Nucleus

Protein Attributes:

Sequence length:

919

Sequence:

50:

100:

150:

200:

250:

300:

350:

400:

450:

500:

550:

600:

650:

700:

750:

800:

850:

900:

919:

DAESIHQYLL | QRKASPPTV

3D Structure:

N/A

Predicted Eptitope:

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Vaild Sequence:

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Related Databases

KEGG:

hsa:9520

MIM:

606793

SMR:

P55786

STRING:

9606.ENSP00000320324

UniGene:

Hs.443837

Pfam:

PF01433

String:

P55786

Pfam:

PF11838

Uniprot:

P55786

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ELISA Kit for Human PSA

Cat.:

E2017h

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Manual:

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MSDS:

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Packing:

96T

Range:

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ELISA Kit for Human PSA

Cat.:

E2017m

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MSDS:

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Packing:

96T

CLIA Kit for Human PSA

Cat.:

U2017h

Price:

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MSDS:

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Packing:

96T

CLIA Kit for Human PSA

Cat.:

U2017m

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MSDS:

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Packing:

96T

Polyclonal Antibody for Human PSA

Cat.:

P2017Rb-m

Price:

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Packing:

40ug/0.2ml

Polyclonal Antibody for Human PSA

Cat.:

P2017Rb-h

Price:

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Packing:

40ug/0.2ml

Monoclonal Antibody for Human PSA

Protein for Human PSA

R&D Technical Data

For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.

Precision

For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.

Recovery

For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.

Linearity

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References

1.

"Cloning of the human puromycin-sensitive aminopeptidase and evidence for expression in neurons."
Tobler A.R. , Constam D.B. , Schmitt-Graeff A. , Malipiero U. , Schlapbach R. , Fontana A.
J. Neurochem.68:889-897(1997) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1)
tissue: Fetal brain.
2.

"Complete sequencing and characterization of 21,243 full-length human cDNAs."
Ota T. , Suzuki Y. , Nishikawa T. , Otsuki T. , Sugiyama T. , Irie R. , Wakamatsu A. , Hayashi K. , Sato H. , Nagai K. , Kimura K. , Makita H. , Sekine M. , Obayashi M. , Nishi T. , Shibahara T. , Tanaka T. , Ishii S. , more...
Nat. Genet.36:40-45(2004) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 2)
tissue: Tongue.
3.

"DNA sequence of human chromosome 17 and analysis of rearrangement in the human lineage."
Zody M.C. , Garber M. , Adams D.J. , Sharpe T. , Harrow J. , Lupski J.R. , Nicholson C. , Searle S.M. , Wilming L. , Young S.K. , Abouelleil A. , Allen N.R. , Bi W. , Bloom T. , Borowsky M.L. , Bugalter B.E. , Butler J. , Chang J.L. , more...
Nature440:1045-1049(2006) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]
4.

"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
The MGC Project Team
Genome Res.14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 31-919 (ISOFORM 1)
tissue: Lung.
5.

"Human puromycin-sensitive aminopeptidase: cloning of 3' UTR, evidence for a polymorphism at a.a. 140 and refined chromosomal localization to 17q21."
Bauer W.O. , Nanda I. , Beck G. , Schmid M. , Jakob F.
Cytogenet. Cell Genet.92:221-224(2001) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [MRNA] OF 45-919 (ISOFORM 1)
tissue: Skeletal muscle.
6.

"Cloning and analysis of the gene for the human puromycin-sensitive aminopeptidase."
Thompson M.W. , Tobler A. , Fontana A. , Hersh L.B.
Biochem. Biophys. Res. Commun.258:234-240(1999) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA] OF 45-85
7.

"Puromycin-sensitive alanyl aminopeptidase from human liver cytosol: purification and characterization."
Yamamoto Y. , Li Y.H. , Ushiyama I. , Nishimura A. , Ohkubo I. , Nishi K.
Forensic Sci. Int.113:143-146(2000) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: PROTEIN SEQUENCE OF 46-105;FUNCTION;ENZYME REGULATION;BIOPHYSICOCHEMICAL PROPERTIES;SUBUNIT;SUBCELLULAR LOCATION;TISSUE SPECIFICITY
tissue: Liver.
8.

"Two new proteases in the MHC class I processing pathway."
Stoltze L. , Schirle M. , Schwarz G. , Schroter C. , Thompson M.W. , Hersh L.B. , Kalbacher H. , Stevanovic S. , Rammensee H.G. , Schild H.
Nat. Immunol.1:413-418(2000) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: FUNCTION
9.

"Mutation of active site residues of the puromycin-sensitive aminopeptidase: conversion of the enzyme into a catalytically inactive binding protein."
Thompson M.W. , Govindaswami M. , Hersh L.B.
Arch. Biochem. Biophys.413:236-242(2003) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: MUTAGENESIS OF GLU-353 AND TYR-438;ACTIVE SITE
10.

"Degradation of tau protein by puromycin-sensitive aminopeptidase in vitro."
Sengupta S. , Horowitz P.M. , Karsten S.L. , Jackson G.R. , Geschwind D.H. , Fu Y. , Berry R.W. , Binder L.I.
Biochemistry45:15111-15119(2006) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: FUNCTION;ENZYME REGULATION;BIOPHYSICOCHEMICAL PROPERTIES
11.

"Puromycin-sensitive aminopeptidase is the major peptidase responsible for digesting polyglutamine sequences released by proteasomes during protein degradation."
Bhutani N. , Venkatraman P. , Goldberg A.L.
EMBO J.26:1385-1396(2007) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: FUNCTION;ENZYME REGULATION
12.

"Cytosolic aminopeptidases influence MHC class I-mediated antigen presentation in an allele-dependent manner."
Kim E. , Kwak H. , Ahn K.
J. Immunol.183:7379-7387(2009) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: FUNCTION
13.

"Initial characterization of the human central proteome."
Burkard T.R. , Planyavsky M. , Kaupe I. , Breitwieser F.P. , Buerckstuemmer T. , Bennett K.L. , Superti-Furga G. , Colinge J.
BMC Syst. Biol.5:17-17(2011) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS]

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