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Index > Protein center > PSEN2(Gene name) > Human
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  • PSEN2 (Gene name),
  • Presenilin-2 (Protein name ),  PSN2_HUMAN from NCBI database.
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  • General Annotation
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  • Antigen Annotation
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  • 3D
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  • Predicted Eptitope
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  • Vaild Sequence
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  • Gene name:
    PSEN2(AD4;PS2;PSNL2;STM2);
    Protein name:
    Presenilin-2(PS-2);
    Alternative:
    STM-2;E5-1;AD3LP;AD5;
    Organism:
    Human (Homo sapiens). 
    General Annotation
    Sub Unit:
    Interacts with DOCK3 (By similarity). Homodimer. Component of the gamma-secretase complex, a complex composed of a presenilin homodimer (PSEN1 or PSEN2), nicastrin (NCSTN), APH1 (APH1A or APH1B) and PEN2. Such minimal complex is sufficient for secretase activity, although other components may exist. Interacts with HERPUD1, FLNA, FLNB and PARL.
    Function:
    Probable catalytic subunit of the gamma-secretase complex, an endoprotease complex that catalyzes the intramembrane cleavage of integral membrane proteins such as Notch receptors and APP (beta-amyloid precursor protein). Requires the other members of the gamma-secretase complex to have a protease activity. May play a role in intracellular signaling and gene expression or in linking chromatin to the nuclear membrane. May function in the cytoplasmic partitioning of proteins.
    Subcellular Location:
    Endoplasmic reticulum membrane Multi-pass membrane protein Golgi apparatus membrane Multi-pass membrane protein
    Protein Attributes:
    Sequence length:
    448
    Sequence:
    50:
    MLTFMASDSE | EEVCDERTSL | MSAESPTPRS | CQEGRQGPED | GENTAQWRSQ | 
    100:
    ENEEDGEEDP | DRYVCSGVPG | RPPGLEEELT | LKYGAKHVIM | LFVPVTLCMI | 
    150:
    VVVATIKSVR | FYTEKNGQLI | YTPFTEDTPS | VGQRLLNSVL | NTLIMISVIV | 
    200:
    VMTIFLVVLY | KYRCYKFIHG | WLIMSSLMLL | FLFTYIYLGE | VLKTYNVAMD | 
    250:
    YPTLLLTVWN | FGAVGMVCIH | WKGPLVLQQA | YLIMISALMA | LVFIKYLPEW | 
    300:
    SAWVILGAIS | VYDLVAVLCP | KGPLRMLVET | AQERNEPIFP | ALIYSSAMVW | 
    350:
    TVGMAKLDPS | SQGALQLPYD | PEMEEDSYDS | FGEPSYPEVF | EPPLTGYPGE | 
    400:
    ELEEEEERGV | KLGLGDFIFY | SVLVGKAAAT | GSGDWNTTLA | CFVAILIGLC | 
    448:
    LTLLLLAVFK | KALPALPISI | TFGLIFYFST | DNLVRPFMDT | LASHQLYI
    3D Structure:
    N/A
    Predicted Eptitope:
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    EIAab Sequence  Vaild Sequence:
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    Related Databases
    SMR:
    MIM:
    UniGene:
    Pfam:
    KEGG:
    String:
    Uniprot:
     
    FOR
    ELISA Kit for Human PS-2
    Cat.:
    E1274h
    Price:
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    MSDS:
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    Packing:
    96T
    Range:
    Please sign in first.
    ELISA Kit for Human PS-2
    Cat.:
    E1274b
    Price:
    Please sign in first.
    MSDS:
    Please sign in first.
    Packing:
    96T
    Range:
    Please sign in first.
    ELISA Kit for Human PS-2
    Cat.:
    E1274p
    Price:
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    MSDS:
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    Packing:
    96T
    ELISA Kit for Human PS-2
    Cat.:
    E1274m
    Price:
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    MSDS:
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    Packing:
    96T
    ELISA Kit for Human PS-2
    Cat.:
    E1274c
    Price:
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    MSDS:
    Please sign in first.
    Packing:
    96T
    ELISA Kit for Human PS-2
    Cat.:
    E1274r
    Price:
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    MSDS:
    Please sign in first.
    Packing:
    96T
    CLIA Kit for Human PS-2
    Cat.:
    U1274b
    Price:
    Please sign in first.
    MSDS:
    Please sign in first.
    Packing:
    96T
    CLIA Kit for Human PS-2
    Cat.:
    U1274p
    Price:
    Please sign in first.
    MSDS:
    Please sign in first.
    Packing:
    96T
    CLIA Kit for Human PS-2
    Cat.:
    U1274m
    Price:
    Please sign in first.
    MSDS:
    Please sign in first.
    Packing:
    96T
    CLIA Kit for Human PS-2
    Cat.:
    U1274c
    Price:
    Please sign in first.
    MSDS:
    Please sign in first.
    Packing:
    96T
    CLIA Kit for Human PS-2
    Cat.:
    U1274h
    Price:
    Please sign in first.
    MSDS:
    Please sign in first.
    Packing:
    96T
    Range:
    Please sign in first.
    CLIA Kit for Human PS-2
    Cat.:
    U1274r
    Price:
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    MSDS:
    Please sign in first.
    Packing:
    96T
    Polyclonal Antibody for Human PS-2
    Polyclonal Antibody for Human PS-2
    Polyclonal Antibody for Human PS-2
    Cat.:
    P1274Rb-m
    Price:
    Please sign in first.
    Packing:
    40ug/0.2ml
    Polyclonal Antibody for Human PS-2
    Cat.:
    P1274Rb-r
    Price:
    Please sign in first.
    Packing:
    40ug/0.2ml
    Polyclonal Antibody for Human PS-2
    Cat.:
    P1274Rb-h
    Price:
    Please sign in first.
    Packing:
    40ug/0.2ml
    Polyclonal Antibody for Human PS-2
    Monoclonal Antibody for Human PS-2
    Monoclonal Antibody for Human PS-2
    Monoclonal Antibody for Human PS-2
    Monoclonal Antibody for Human PS-2
    Monoclonal Antibody for Human PS-2
    Monoclonal Antibody for Human PS-2
    Protein for Human PS-2
    Protein for Human PS-2
    Protein for Human PS-2
    Protein for Human PS-2
    Protein for Human PS-2
    Protein for Human PS-2

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    Precision
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    Recovery
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    Linearity
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    References
    1. 1.
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [MRNA];VARIANT AD4 ILE-141
    2. 2.
      "Familial Alzheimer's disease in kindreds with missense mutations in a gene on chromosome 1 related to the Alzheimer's disease type 3 gene."
      Rogaev E.I. , Sherrington R. , Rogaeva E.A. , Levesque G. , Ikeda M. , Liang Y. , Chi H. , Lin C. , Holman K. , Tsuda T. , Mar L. , Sorbi S. , Nacmias B. , Piacentini S. , Amaducci L. , Chumakov I. , Cohen D. , Lannfelt L. , more...
      Nature376:775-778(1995) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [MRNA];VARIANTS AD4 ILE-141 AND VAL-239
      tissue: Brain.
      tissue: Colon.
    3. 3.
      "Identification and expression analysis of a potential familial Alzheimer disease gene on chromosome 1 related to AD3."
      Li J. , Ma J. , Potter H.
      Proc. Natl. Acad. Sci. U.S.A.92:12180-12184(1995) [PubMed] [Europe PMC] [Abstract]
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    4. 4.
      "Genomic structure and expression of STM2, the chromosome 1 familial Alzheimer disease gene."
      Levy-Lahad E. , Poorkaj P. , Wang K. , Fu Y.H. , Oshima J. , Mulligan J. , Schellenberg G.D.
      Genomics34:198-204(1996) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA]
    5. 5.
      "Cloning of human full-length CDSs in BD Creator(TM) system donor vector."
      Kalnine N. , Chen X. , Rolfs A. , Halleck A. , Hines L. , Eisenstein S. , Koundinya M. , Raphael J. , Moreira D. , Kelley T. , LaBaer J. , Lin Y. , Phelan M. , Farmer A.
      Submitted (2003-05) to the EMBL/GenBank/DDBJ databases
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    6. 6.
      "Complete sequencing and characterization of 21,243 full-length human cDNAs."
      Ota T. , Suzuki Y. , Nishikawa T. , Otsuki T. , Sugiyama T. , Irie R. , Wakamatsu A. , Hayashi K. , Sato H. , Nagai K. , Kimura K. , Makita H. , Sekine M. , Obayashi M. , Nishi T. , Shibahara T. , Tanaka T. , Ishii S. , more...
      Nat. Genet.36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 3)
      tissue: Testis.
    7. 7.
      "The DNA sequence and biological annotation of human chromosome 1."
      Gregory S.G. , Barlow K.F. , McLay K.E. , Kaul R. , Swarbreck D. , Dunham A. , Scott C.E. , Howe K.L. , Woodfine K. , Spencer C.C.A. , Jones M.C. , Gillson C. , Searle S. , Zhou Y. , Kokocinski F. , McDonald L. , Evans R. , Phillips K. , more...
      Nature441:315-321(2006) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]
    8. 8.
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]
    9. 9.
      "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
      The MGC Project Team
      Genome Res.14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA]
      tissue: Muscle.
    10. 10.
      Xu Y. , Hu X. , Zhou Y. , Peng X. , Yuan J. , Qiang B.
      Submitted (2001-09) to the EMBL/GenBank/DDBJ databases
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE OF 1-390
    11. 11.
      "Alzheimer-associated presenilins 1 and 2: neuronal expression in brain and localization to intracellular membranes in mammalian cells."
      Kovacs D.M. , Fausett H.J. , Page K.J. , Kim T.-W. , Moir R.D. , Merriam D.E. , Hollister R.D. , Hallmark O.G. , Mancini R. , Felsenstein K.M. , Hyman B.T. , Tanzi R.E. , Wasco W.
      Nat. Med.2:224-229(1996) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: SUBCELLULAR LOCATION;TISSUE SPECIFICITY
    12. 12.
      "Interaction of presenilins with the filamin family of actin-binding proteins."
      Zhang W. , Han S.W. , McKeel D.W. , Goate A. , Wu J.Y.
      J. Neurosci.18:914-922(1998) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: INTERACTION WITH FLNA AND FLNB
    13. 13.
      "A loss of function mutation of presenilin-2 interferes with amyloid beta-peptide production and notch signaling."
      Steiner H. , Duff K. , Capell A. , Romig H. , Grim M.G. , Lincoln S. , Hardy J. , Yu X. , Picciano M. , Fechteler K. , Citron M. , Kopan R. , Pesold B. , Keck S. , Baader M. , Tomita T. , Iwatsubo T. , Baumeister R. , more...
      J. Biol. Chem.274:28669-28673(1999) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: FUNCTION;ACTIVE SITE ASP-366;MUTAGENESIS OF ASP-366
    14. 14.
      "The transmembrane aspartates in presenilin 1 and 2 are obligatory for gamma-secretase activity and amyloid beta-protein generation."
      Kimberly W.T. , Xia W. , Rahmati T. , Wolfe M.S. , Selkoe D.J.
      J. Biol. Chem.275:3173-3178(2000) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: FUNCTION;ACTIVE SITES ASP-263 AND ASP-366;MUTAGENESIS OF ASP-263 AND ASP-366
    15. 15.
      "Endoplasmic reticulum stress-inducible protein, Herp, enhances presenilin-mediated generation of amyloid beta-protein."
      Sai X. , Kawamura Y. , Kokame K. , Yamaguchi H. , Shiraishi H. , Suzuki R. , Suzuki T. , Kawaichi M. , Miyata T. , Kitamura T. , De Strooper B. , Yanagisawa K. , Komano H.
      J. Biol. Chem.277:12915-12920(2002) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: INTERACTION WITH HERPUD1
    16. 16.
      "Presenilin mutations in Alzheimer's disease."
      Cruts M. , van Broeckhoven C.
      Hum. Mutat.11:183-190(1998) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: REVIEW ON VARIANTS
    17. 17.
      "Consensus analysis of signal peptide peptidase and homologous human aspartic proteases reveals opposite topology of catalytic domains compared with presenilins."
      Friedmann E. , Lemberg M.K. , Weihofen A. , Dev K.K. , Dengler U. , Rovelli G. , Martoglio B.
      J. Biol. Chem.279:50790-50798(2004) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: TOPOLOGY
    18. 18.
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS]
      tissue: Cervix carcinoma.
    19. 19.
      "Lys-N and trypsin cover complementary parts of the phosphoproteome in a refined SCX-based approach."
      Gauci S. , Helbig A.O. , Slijper M. , Krijgsveld J. , Heck A.J. , Mohammed S.
      Anal. Chem.81:4493-4501(2009) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS]
    20. 20.
      "Quantitative phosphoproteomics reveals widespread full phosphorylation site occupancy during mitosis."
      Olsen J.V. , Vermeulen M. , Santamaria A. , Kumar C. , Miller M.L. , Jensen L.J. , Gnad F. , Cox J. , Jensen T.S. , Nigg E.A. , Brunak S. , Mann M.
      Sci. Signal.3:RA3-RA3(2010) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-22 AND SER-25;IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS]
      tissue: Cervix carcinoma.
    21. 21.
      "Estimation of the genetic contribution of presenilin-1 and -2 mutations in a population-based study of presenile Alzheimer disease."
      Cruts M. , van Duijn C.M. , Backhovens H. , van den Broeck M. , Wehnert A. , Serneels S. , Sherrington R. , Hutton M. , Hardy J. , St George-Hyslop P.H. , Hofman A. , van Broeckhoven C.
      Hum. Mol. Genet.7:43-51(1998) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: VARIANT AD4 HIS-62
    22. 22.
      "A novel mutation in the predicted TM2 domain of the presenilin 2 gene in Spanish patient with late-onset Alzheimer's disease."
      Lao J.I. , Beyer K. , Fernandez-Novoa L. , Cacabelos R.
      Neurogenetics1:293-296(1998) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: VARIANT AD4 ILE-148
    23. 23.
      "High prevalence of pathogenic mutations in patients with early-onset dementia detected by sequence analyses of four different genes."
      Finckh U. , Mueller-Thomsen T. , Mann U. , Eggers C. , Marksteiner J. , Meins W. , Binetti G. , Alberici A. , Hock C. , Nitsch R.M. , Gal A.
      Am. J. Hum. Genet.66:110-117(2000) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: VARIANTS AD4 PRO-122 AND ILE-239
    24. 24.
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: VARIANT CMD1V LEU-130
    25. 25.
      "Identification of PSEN1 and PSEN2 gene mutations and variants in Turkish dementia patients."
      Lohmann E. , Guerreiro R.J. , Erginel-Unaltuna N. , Gurunlian N. , Bilgic B. , Gurvit H. , Hanagasi H.A. , Luu N. , Emre M. , Singleton A.
      Neurobiol. Aging33:1850.E17-1850.E27(2012) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: VARIANTS AD4 HIS-62; TRP-71 AND LEU-130
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