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Index > Protein center > SFTPB(Gene name) > Human
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  • SFTPB (Gene name),
  • Pulmonary surfactant-associated protein B (Protein name ),  PSPB_HUMAN from NCBI database.
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  • General Annotation
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  • Antigen Annotation
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  • 3D
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  • Predicted Eptitope
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  • Vaild Sequence
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  • Gene name:
    SFTPB(SFTP3);
    Protein name:
    Pulmonary surfactant-associated protein B(SP-B);
    Alternative:
    6 kDa protein;18 kDa pulmonary-surfactant protein;Pulmonary surfactant-associated proteolipid SPL(Phe);
    Organism:
    Human (Homo sapiens). 
    General Annotation
    Sub Unit:
    Homodimer; disulfide-linked.
    Function:
    Pulmonary surfactant-associated proteins promote alveolar stability by lowering the surface tension at the air-liquid interface in the peripheral air spaces. SP-B increases the collapse pressure of palmitic acid to nearly 70 millinewtons per meter.
    Subcellular Location:
    Secreted extracellular space surface film
    Protein Attributes:
    Sequence length:
    381
    Sequence:
    50:
    MAESHLLQWL | LLLLPTLCGP | GTAAWTTSSL | ACAQGPEFWC | QSLEQALQCR | 
    100:
    ALGHCLQEVW | GHVGADDLCQ | ECEDIVHILN | KMAKEAIFQD | TMRKFLEQEC | 
    150:
    NVLPLKLLMP | QCNQVLDDYF | PLVIDYFQNQ | TDSNGICMHL | GLCKSRQPEP | 
    200:
    EQEPGMSDPL | PKPLRDPLPD | PLLDKLVLPV | LPGALQARPG | PHTQDLSEQQ | 
    250:
    FPIPLPYCWL | CRALIKRIQA | MIPKGALAVA | VAQVCRVVPL | VAGGICQCLA | 
    300:
    ERYSVILLDT | LLGRMLPQLV | CRLVLRCSMD | DSAGPRSPTG | EWLPRDSECH | 
    350:
    LCMSVTTQAG | NSSEQAIPQA | MLQACVGSWL | DREKCKQFVE | QHTPQLLTLV | 
    381:
    PRGWDAHTTC | QALGVCGTMS | SPLQCIHSPD | L
    3D Structure:
    N/A
    Predicted Eptitope:
    Please Sign in.
    EIAab Sequence  Vaild Sequence:
    Please Sign in.
    Related Databases
    String:
    SMR:
    UniGene:
    KEGG:
    MIM:
    Pfam:
    Uniprot:
     
    FOR
    ELISA Kit for Human SP-B
    Cat.:
    E1622b
    Price:
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    MSDS:
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    Packing:
    96T
    Range:
    Please sign in first.
    ELISA Kit for Human SP-B
    Cat.:
    E1622h
    Price:
    Please sign in first.
    MSDS:
    Please sign in first.
    Packing:
    96T
    Range:
    Please sign in first.
    ELISA Kit for Human SP-B
    Cat.:
    E1622p
    Price:
    Please sign in first.
    MSDS:
    Please sign in first.
    Packing:
    96T
    Range:
    Please sign in first.
    ELISA Kit for Human SP-B
    MSDS:
    Please sign in first.
    ELISA Kit for Human SP-B
    Cat.:
    E1622m
    Price:
    Please sign in first.
    MSDS:
    Please sign in first.
    Packing:
    96T
    ELISA Kit for Human SP-B
    Cat.:
    E1622r
    Price:
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    MSDS:
    Please sign in first.
    Packing:
    96T
    ELISA Kit for Human SP-B
    Cat.:
    E1622d
    Price:
    Please sign in first.
    MSDS:
    Please sign in first.
    Packing:
    96T
    CLIA Kit for Human SP-B
    Cat.:
    U1622p
    Price:
    Please sign in first.
    MSDS:
    Please sign in first.
    Packing:
    96T
    CLIA Kit for Human SP-B
    Cat.:
    U1622r
    Price:
    Please sign in first.
    MSDS:
    Please sign in first.
    Packing:
    96T
    CLIA Kit for Human SP-B
    Cat.:
    U1622m
    Price:
    Please sign in first.
    MSDS:
    Please sign in first.
    Packing:
    96T
    CLIA Kit for Human SP-B
    Cat.:
    U1622d
    Price:
    Please sign in first.
    MSDS:
    Please sign in first.
    Packing:
    96T
    CLIA Kit for Human SP-B
    Cat.:
    U1622h
    Price:
    Please sign in first.
    MSDS:
    Please sign in first.
    Packing:
    96T
    Range:
    Please sign in first.
    CLIA Kit for Human SP-B
    Cat.:
    U1622b
    Price:
    Please sign in first.
    MSDS:
    Please sign in first.
    Packing:
    96T
    Range:
    Please sign in first.
    CLIA Kit for Human SP-B
    MSDS:
    Please sign in first.
    Polyclonal Antibody for Human SP-B
    Cat.:
    P1622Rb-m
    Price:
    Please sign in first.
    Packing:
    40ug/0.2ml
    Polyclonal Antibody for Human SP-B
    Polyclonal Antibody for Human SP-B
    Cat.:
    P1622Rb-r
    Price:
    Please sign in first.
    Packing:
    40ug/0.2ml
    Polyclonal Antibody for Human SP-B
    Cat.:
    P1622Rb-h
    Price:
    Please sign in first.
    Packing:
    40ug/0.2ml
    Polyclonal Antibody for Human SP-B
    Polyclonal Antibody for Human SP-B
    Polyclonal Antibody for Human SP-B
    Monoclonal Antibody for Human SP-B
    Monoclonal Antibody for Human SP-B
    Monoclonal Antibody for Human SP-B
    Monoclonal Antibody for Human SP-B
    Monoclonal Antibody for Human SP-B
    Monoclonal Antibody for Human SP-B
    Monoclonal Antibody for Human SP-B
    Protein for Human SP-B
    Cat.:
    R1622h
    Price:
    Please sign in first.
    Packing:
    1mg
    Purity:
    >90%
    Protein for Human SP-B
    Protein for Human SP-B
    Protein for Human SP-B
    Protein for Human SP-B
    Protein for Human SP-B
    Protein for Human SP-B

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    References
    1. 1.
      "Isolation of a cDNA clone encoding a high molecular weight precursor to a 6-kDa pulmonary surfactant-associated protein."
      Jacobs K.A. , Phelps D.S. , Steinbrink R. , Fisch J. , Kriz R. , Mitsock L. , Dougherty J.P. , Taeusch H.W. , Floros J.
      J. Biol. Chem.262:9808-9811(1987) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [MRNA];PROTEIN SEQUENCE OF 201-214
      tissue: Lung.
    2. 2.
      "Structure and organization of the gene encoding human pulmonary surfactant proteolipid SP-B."
      Pilot-Matias T.J. , Kister S.E. , Fox J.L. , Kropp K. , Glasser S.W. , Whitsett J.A.
      DNA8:75-86(1989) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA];VARIANT ARG-228
    3. 3.
      SeattleSNPs variation discovery resource
      Submitted (2001-07) to the EMBL/GenBank/DDBJ databases
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA];VARIANTS ILE-131; PHE-176 AND HIS-272
    4. 4.
      "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
      The MGC Project Team
      Genome Res.14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA]
      tissue: Brain.
    5. 5.
      "cDNA and deduced amino acid sequence of human pulmonary surfactant-associated proteolipid SPL(Phe)."
      Glasser S.W. , Korfhagen T.R. , Weaver T. , Pilot-Matias T. , Fox J.L. , Whitsett J.A.
      Proc. Natl. Acad. Sci. U.S.A.84:4007-4011(1987) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [MRNA] OF 99-381;VARIANT ARG-228
    6. 6.
      "Use of human surfactant low molecular weight apoproteins in the reconstitution of surfactant biologic activity."
      Revak S.D. , Merritt T.A. , Degryse E. , Stefani L. , Courtney M. , Hallman M. , Cochrane C.G.
      J. Clin. Invest.81:826-833(1988) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [MRNA] OF 139-381
    7. 7.
      "Human surfactant polypeptide SP-B. Disulfide bridges, C-terminal end, and peptide analysis of the airway form."
      Johansson J. , Joernvall H. , Curstedt T.
      FEBS Lett.301:165-167(1992) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: PROTEIN SEQUENCE OF 201-279;DISULFIDE BONDS;VARIANT ILE-228
    8. 8.
      "Conformational mapping of the N-terminal segment of surfactant protein B in lipid using 13C-enhanced Fourier transform infrared spectroscopy."
      Gordon L.M. , Lee K.Y. , Lipp M.M. , Zasadzinski J.A. , Walther F.J. , Sherman M.A. , Waring A.J.
      J. Pept. Res.55:330-347(2000) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: STRUCTURE BY FTIR OF 201-225
    9. 9.
      "Structure of mini-B, a functional fragment of surfactant protein B, in detergent micelles."
      Sarker M. , Waring A.J. , Walther F.J. , Keough K.M. , Booth V.
      Biochemistry46:11047-11056(2007) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: STRUCTURE BY NMR OF 208-278
    10. 10.
      "Partial deficiency of surfactant protein B in an infant with chronic lung disease."
      Ballard P.L. , Nogee L.M. , Beers M.F. , Ballard R.A. , Planer B.C. , Polk L. , deMello D.E. , Moxley M.A. , Longmore W.J.
      Pediatrics96:1046-1052(1995) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: VARIANT SMDP1 CYS-236
    11. 11.
      "Polymorphisms of human SP-A, SP-B, and SP-D genes: association of SP-B Thr131Ile with ARDS."
      Lin Z. , Pearson C. , Chinchilli V. , Pietschmann S.M. , Luo J. , Pison U. , Floros J.
      Clin. Genet.58:181-191(2000) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: VARIANT ILE-131
    12. 12.
      "Surfactant proteins A and B as interactive genetic determinants of neonatal respiratory distress syndrome."
      Haataja R. , Raemet M. , Marttila R. , Hallman M.
      Hum. Mol. Genet.9:2751-2760(2000) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: INVOLVEMENT IN SUSCEPTIBILITY TO RDS
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