Protein name:
Pulmonary surfactant-associated protein C (SP-C) ;
Alternative:
SP5 ;Pulmonary surfactant-associated proteolipid SPL(Val) ;
Organism:
Human (Homo sapiens).
General Annotation
Function:
Pulmonary surfactant associated proteins promote alveolar stability by lowering the surface tension at the air-liquid interface in the peripheral air spaces.
Subcellular Location:
Secreted
extracellular space
surface film
Protein Attributes:
50:
MDVGSKEVLM | ESPPDYSAAP | RGRFGIPCCP | VHLKRLLIVV | VVVVLIVVVI |
100:
VGALLMGLHM | SQKHTEMVLE | MSIGAPEAQQ | RLALSEHLVT | TATFSIGSTG |
150:
LVVYDYQQLL | IAYKPAPGTC | CYIMKIAPES | IPSLEALNRK | VHNFQMECSL |
197:
QAKPAVPTSK | LGQAEGRDAG | SAPSGGDPAF | LGMAVNTLCG | EVPLYYI
Vaild Sequence:
Related Databases
Uniprot:
ELISA Kit
CLIA Kit
Polyclonal Antibody
Monoclonal Antibody
Protein
FOR
Human
Mouse
Rat
Bovine
Pig
Dog
Rabbit
Polyclonal Antibody for Human SP-C
Polyclonal Antibody for Human SP-C
Polyclonal Antibody for Human SP-C
Polyclonal Antibody for Human SP-C
Polyclonal Antibody for Human SP-C
Polyclonal Antibody for Human SP-C
Polyclonal Antibody for Human SP-C
Monoclonal Antibody for Human SP-C
Monoclonal Antibody for Human SP-C
Monoclonal Antibody for Human SP-C
Monoclonal Antibody for Human SP-C
Monoclonal Antibody for Human SP-C
Monoclonal Antibody for Human SP-C
Monoclonal Antibody for Human SP-C
R&D Technical Data
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Precision
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Recovery
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Linearity
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References
1.
"Low molecular weight human pulmonary surfactant protein (SP5): isolation, characterization, and cDNA and amino acid sequences."
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[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s)
Cited for : NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1)
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[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s)
Cited for : NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1);PROTEIN SEQUENCE OF 26-42
3.
[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s)
Cited for : NUCLEOTIDE SEQUENCE [GENOMIC DNA];ALTERNATIVE SPLICING;VARIANT THR-138
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[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s)
Cited for : NUCLEOTIDE SEQUENCE [GENOMIC DNA] (ISOFORM 1);VARIANTS THR-138 AND SER-186
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[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s)
Cited for : NUCLEOTIDE SEQUENCE [GENOMIC DNA] (ISOFORM 1);VARIANTS THR-138 AND SER-186
6.
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[
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[
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[
Abstract ]
[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s)
Cited for : NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1);VARIANTS THR-138 AND SER-186
tissue :
Lung .
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[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s)
Cited for : NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 2)
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[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s)
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[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s)
Cited for : NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA];VARIANTS THR-138 AND SER-186
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Submitted (2005-09) to the EMBL/GenBank/DDBJ databases
[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s)
Cited for : NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA];VARIANTS THR-138 AND SER-186
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[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s)
Cited for : NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1)
tissue :
Lung .
12.
[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s)
Cited for : PROTEIN SEQUENCE OF 24-58
13.
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Cited for : PALMITOYLATION AT CYS-28 AND CYS-29
14.
"High-resolution structure of a BRICHOS domain and its implications for anti-amyloid chaperone activity on lung surfactant protein C."
Willander H.
,
Askarieh G.
,
Landreh M.
,
Westermark P.
,
Nordling K.
,
Keranen H.
,
Hermansson E.
,
Hamvas A.
,
Nogee L.M.
,
Bergman T.
,
Saenz A.
,
Casals C.
,
Aqvistg J.
,
Jornvall H.
,
Berglund H.
,
Presto J.
,
Knight S.D.
,
Johansson J.
Proc. Natl. Acad. Sci. U.S.A.109:2325-2329(2012)
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Cited for : X-RAY CRYSTALLOGRAPHY (2.2 ANGSTROMS) OF 59-197;DISULFIDE BONDS
15.
"Heterozygosity for a surfactant protein C gene mutation associated with usual interstitial pneumonitis and cellular nonspecific interstitial pneumonitis in one kindred."
Thomas A.Q.
,
Lane K.
,
Phillips J.A. III
,
Prince M.
,
Markin C.
,
Speer M.
,
Schwartz D.A.
,
Gaddipati R.
,
Marney A.
,
Johnson J.
,
Roberts R.
,
Haines J.
,
Stahlman M.
,
Loyd J.E.
Am. J. Respir. Crit. Care Med.165:1322-1328(2002)
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Europe PMC ]
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Cited for : VARIANT SMDP2 GLN-188
16.
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Cited for : VARIANTS SMDP2 THR-73 AND GLN-167
17.
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Cited for : VARIANTS THR-138 AND SER-186;INVOLVEMENT IN RDS
18.
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Cited for : VARIANT SMDP2 THR-73;CHARACTERIZATION OF VARIANT SMDP2 THR-73
19.
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Cited for : VARIANT SMDP2 THR-73
20.
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Cited for : VARIANT SURFACTANT PROTEIN C DEFICIENCY ASP-116
21.
"Nonspecific interstitial pneumonia, alveolar proteinosis, and abnormal proprotein trafficking resulting from a spontaneous mutation in the surfactant protein C gene."
Stevens P.A.
,
Pettenazzo A.
,
Brasch F.
,
Mulugeta S.
,
Baritussio A.
,
Ochs M.
,
Morrison L.
,
Russo S.J.
,
Beers M.F.
Pediatr. Res.57:89-98(2005)
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Europe PMC ]
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Cited for : VARIANT SMDP2 LYS-66;CHARACTERIZATION OF VARIANT SMDP2 LYS-66