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Index > Protein center > SFTPC(Gene name) > Human
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  • SFTPC (Gene name),
  • Pulmonary surfactant-associated protein C (Protein name ),  PSPC_HUMAN from NCBI database.
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  • General Annotation
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  • Antigen Annotation
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  • 3D
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  • Predicted Eptitope
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  • Vaild Sequence
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  • Related Databases
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  • Gene name:
    SFTPC(SFTP2);
    Protein name:
    Pulmonary surfactant-associated protein C(SP-C);
    Alternative:
    SP5;Pulmonary surfactant-associated proteolipid SPL(Val);
    Organism:
    Human (Homo sapiens). 
    General Annotation
    Sub Unit:
    Function:
    Pulmonary surfactant associated proteins promote alveolar stability by lowering the surface tension at the air-liquid interface in the peripheral air spaces.
    Subcellular Location:
    Secreted extracellular space surface film
    Protein Attributes:
    Sequence length:
    197
    Sequence:
    50:
    MDVGSKEVLM | ESPPDYSAAP | RGRFGIPCCP | VHLKRLLIVV | VVVVLIVVVI | 
    100:
    VGALLMGLHM | SQKHTEMVLE | MSIGAPEAQQ | RLALSEHLVT | TATFSIGSTG | 
    150:
    LVVYDYQQLL | IAYKPAPGTC | CYIMKIAPES | IPSLEALNRK | VHNFQMECSL | 
    197:
    QAKPAVPTSK | LGQAEGRDAG | SAPSGGDPAF | LGMAVNTLCG | EVPLYYI
    3D Structure:
    N/A
    Predicted Eptitope:
    Please Sign in.
    EIAab Sequence  Vaild Sequence:
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    Related Databases
    MIM:
    KEGG:
    SMR:
    UniGene:
    String:
    Pfam:
    Uniprot:
     
    FOR
    ELISA Kit for Human SP-C
    Cat.:
    E1623h
    Price:
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    MSDS:
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    Packing:
    96T
    Range:
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    ELISA Kit for Human SP-C
    Cat.:
    E1623m
    Price:
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    MSDS:
    Please sign in first.
    Packing:
    96T
    Range:
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    ELISA Kit for Human SP-C
    Cat.:
    E1623r
    Price:
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    MSDS:
    Please sign in first.
    Packing:
    96T
    Range:
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    ELISA Kit for Human SP-C
    Cat.:
    E1623b
    Price:
    Please sign in first.
    MSDS:
    Please sign in first.
    Packing:
    96T
    Range:
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    ELISA Kit for Human SP-C
    Cat.:
    E1623p
    Price:
    Please sign in first.
    MSDS:
    Please sign in first.
    Packing:
    96T
    Range:
    Please sign in first.
    ELISA Kit for Human SP-C
    Cat.:
    E1623d
    Price:
    Please sign in first.
    MSDS:
    Please sign in first.
    Packing:
    96T
    ELISA Kit for Human SP-C
    MSDS:
    Please sign in first.
    CLIA Kit for Human SP-C
    Cat.:
    U1623d
    Price:
    Please sign in first.
    MSDS:
    Please sign in first.
    Packing:
    96T
    CLIA Kit for Human SP-C
    Cat.:
    U1623p
    Price:
    Please sign in first.
    MSDS:
    Please sign in first.
    Packing:
    96T
    CLIA Kit for Human SP-C
    Cat.:
    U1623b
    Price:
    Please sign in first.
    MSDS:
    Please sign in first.
    Packing:
    96T
    Range:
    Please sign in first.
    CLIA Kit for Human SP-C
    MSDS:
    Please sign in first.
    CLIA Kit for Human SP-C
    Cat.:
    U1623r
    Price:
    Please sign in first.
    MSDS:
    Please sign in first.
    Packing:
    96T
    Range:
    Please sign in first.
    CLIA Kit for Human SP-C
    Cat.:
    U1623m
    Price:
    Please sign in first.
    MSDS:
    Please sign in first.
    Packing:
    96T
    Range:
    Please sign in first.
    CLIA Kit for Human SP-C
    Cat.:
    U1623h
    Price:
    Please sign in first.
    MSDS:
    Please sign in first.
    Packing:
    96T
    Range:
    Please sign in first.
    Polyclonal Antibody for Human SP-C
    Cat.:
    P1623Rb-h
    Price:
    Please sign in first.
    Packing:
    40ug/0.2ml
    Polyclonal Antibody for Human SP-C
    Cat.:
    P1623Rb-r
    Price:
    Please sign in first.
    Packing:
    40ug/0.2ml
    Polyclonal Antibody for Human SP-C
    Polyclonal Antibody for Human SP-C
    Polyclonal Antibody for Human SP-C
    Polyclonal Antibody for Human SP-C
    Cat.:
    P1623Rb-m
    Price:
    Please sign in first.
    Packing:
    40ug/0.2ml
    Polyclonal Antibody for Human SP-C
    Monoclonal Antibody for Human SP-C
    Monoclonal Antibody for Human SP-C
    Monoclonal Antibody for Human SP-C
    Monoclonal Antibody for Human SP-C
    Monoclonal Antibody for Human SP-C
    Monoclonal Antibody for Human SP-C
    Monoclonal Antibody for Human SP-C
    Protein for Human SP-C
    Protein for Human SP-C
    Protein for Human SP-C
    Protein for Human SP-C
    Protein for Human SP-C
    Protein for Human SP-C
    Protein for Human SP-C

    R&D Technical Data
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    Precision
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    Recovery
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    Linearity
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    References
    1. 1.
      "Low molecular weight human pulmonary surfactant protein (SP5): isolation, characterization, and cDNA and amino acid sequences."
      Warr R.G. , Hawgood S. , Buckley D.I. , Crisp T.M. , Schilling J. , Benson B.J. , Ballard P.L. , Clements J.A. , White R.T.
      Proc. Natl. Acad. Sci. U.S.A.84:7915-7919(1987) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1)
    2. 2.
      "cDNA, deduced polypeptide structure and chromosomal assignment of human pulmonary surfactant proteolipid, SPL(pVal)."
      Glasser S.W. , Korfhagen T.R. , Weaver T.E. , Clark J.C. , Pilot-Matias T. , Meuth J. , Fox J.L. , Whitsett J.A.
      J. Biol. Chem.263:9-12(1988) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1);PROTEIN SEQUENCE OF 26-42
    3. 3.
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA];ALTERNATIVE SPLICING;VARIANT THR-138
    4. 4.
      "Human surfactant protein-C: genetic homogeneity and expression in RDS; comparison with other species."
      Hatzis D. , Deiter G. , deMello D.E. , Floros J.
      Exp. Lung Res.20:57-72(1994) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA] (ISOFORM 1);VARIANTS THR-138 AND SER-186
    5. 5.
      Frerking I. , Stevens P. , Pison U. , Witt H.
      Submitted (2003-08) to the EMBL/GenBank/DDBJ databases
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA] (ISOFORM 1);VARIANTS THR-138 AND SER-186
    6. 6.
      "Complete sequencing and characterization of 21,243 full-length human cDNAs."
      Ota T. , Suzuki Y. , Nishikawa T. , Otsuki T. , Sugiyama T. , Irie R. , Wakamatsu A. , Hayashi K. , Sato H. , Nagai K. , Kimura K. , Makita H. , Sekine M. , Obayashi M. , Nishi T. , Shibahara T. , Tanaka T. , Ishii S. , more...
      Nat. Genet.36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1);VARIANTS THR-138 AND SER-186
      tissue: Lung.
    7. 7.
      "A computer system platform used to predict novel genes."
      Yu Z. , Zheng Z. , Tang T. , Fu Y.
      Submitted (2006-07) to the EMBL/GenBank/DDBJ databases
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 2)
    8. 8.
      SeattleSNPs variation discovery resource
      Submitted (2003-07) to the EMBL/GenBank/DDBJ databases
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA];VARIANTS THR-138 AND SER-186
    9. 10.
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA];VARIANTS THR-138 AND SER-186
    10. 11.
      "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
      The MGC Project Team
      Genome Res.14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1)
      tissue: Lung.
    11. 12.
      "Hydrophobic 3.7 kDa surfactant polypeptide: structural characterization of the human and bovine forms."
      Johansson J. , Joernvall H. , Eklund A. , Christensen N. , Robertson B. , Curstedt T.
      FEBS Lett.232:61-64(1988) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: PROTEIN SEQUENCE OF 24-58
    12. 13.
      "Hydrophobic surfactant-associated polypeptides: SP-C is a lipopeptide with two palmitoylated cysteine residues, whereas SP-B lacks covalently linked fatty acyl groups."
      Curstedt T. , Johansson J. , Persson P. , Eklund A. , Robertson B. , Loewenadler B. , Joernvall H.
      Proc. Natl. Acad. Sci. U.S.A.87:2985-2989(1990) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: PALMITOYLATION AT CYS-28 AND CYS-29
    13. 14.
      "High-resolution structure of a BRICHOS domain and its implications for anti-amyloid chaperone activity on lung surfactant protein C."
      Willander H. , Askarieh G. , Landreh M. , Westermark P. , Nordling K. , Keranen H. , Hermansson E. , Hamvas A. , Nogee L.M. , Bergman T. , Saenz A. , Casals C. , Aqvistg J. , Jornvall H. , Berglund H. , Presto J. , Knight S.D. , Johansson J.
      Proc. Natl. Acad. Sci. U.S.A.109:2325-2329(2012) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: X-RAY CRYSTALLOGRAPHY (2.2 ANGSTROMS) OF 59-197;DISULFIDE BONDS
    14. 15.
      "Heterozygosity for a surfactant protein C gene mutation associated with usual interstitial pneumonitis and cellular nonspecific interstitial pneumonitis in one kindred."
      Thomas A.Q. , Lane K. , Phillips J.A. III , Prince M. , Markin C. , Speer M. , Schwartz D.A. , Gaddipati R. , Marney A. , Johnson J. , Roberts R. , Haines J. , Stahlman M. , Loyd J.E.
      Am. J. Respir. Crit. Care Med.165:1322-1328(2002) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: VARIANT SMDP2 GLN-188
    15. 16.
      "Mutation of SFTPC in infantile pulmonary alveolar proteinosis with or without fibrosing lung disease."
      Tredano M. , Griese M. , Brasch F. , Schumacher S. , de Blic J. , Marque S. , Houdayer C. , Elion J. , Couderc R. , Bahuau M.
      Am. J. Med. Genet. A126:18-26(2004) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: VARIANTS SMDP2 THR-73 AND GLN-167
    16. 17.
      "Surfactant protein C gene variation in the Finnish population -association with perinatal respiratory disease."
      Lahti M. , Marttila R. , Hallman M.
      Eur. J. Hum. Genet.12:312-320(2004) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: VARIANTS THR-138 AND SER-186;INVOLVEMENT IN RDS
    17. 18.
      "Interstitial lung disease in a baby with a de novo mutation in the SFTPC gene."
      Brasch F. , Griese M. , Tredano M. , Johnen G. , Ochs M. , Rieger C. , Mulugeta S. , Mueller K.M. , Bahuau M. , Beers M.F.
      Eur. Respir. J.24:30-39(2004) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: VARIANT SMDP2 THR-73;CHARACTERIZATION OF VARIANT SMDP2 THR-73
    18. 19.
      "Variable phenotype associated with SP-C gene mutations: fatal case with the I73T mutation."
      Percopo S. , Cameron H.S. , Nogee L.M. , Pettinato G. , Montella S. , Santamaria F.
      Eur. Respir. J.24:1072-1073(2004) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: VARIANT SMDP2 THR-73
    19. 20.
      "Hydroxychloroquine and surfactant protein C deficiency."
      Rosen D.M. , Waltz D.A.
      N. Engl. J. Med.352:207-208(2005) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: VARIANT SURFACTANT PROTEIN C DEFICIENCY ASP-116
    20. 21.
      "Nonspecific interstitial pneumonia, alveolar proteinosis, and abnormal proprotein trafficking resulting from a spontaneous mutation in the surfactant protein C gene."
      Stevens P.A. , Pettenazzo A. , Brasch F. , Mulugeta S. , Baritussio A. , Ochs M. , Morrison L. , Russo S.J. , Beers M.F.
      Pediatr. Res.57:89-98(2005) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: VARIANT SMDP2 LYS-66;CHARACTERIZATION OF VARIANT SMDP2 LYS-66
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