PTHLH ELISA Kit for Human(Homo sapiens) | EIAab.comPTHLH ELISA Kit for Human(Homo sapiens)

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PTHLH (Gene name),

Parathyroid hormone-related protein (Protein name ), PTHR_HUMAN from NCBI database.

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General Annotation

Antigen Annotation

Predicted Eptitope

Vaild Sequence

Related Databases

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Gene name:

PTHLH(PTHRP);

Protein name:

Parathyroid hormone-related protein(PTH-rP;PTHrP);

Alternative:

Parathyroid hormone-like protein(PLP);

Organism:

Human (Homo sapiens).

General Annotation

Sub Unit:

PTHrP interacts with PTH1R (via N-terminal extracellular domain).

Function:

Osteostatin is a potent inhibitor of osteoclastic bone resorption.

Subcellular Location:

Cytoplasm Nucleus Secreted

Protein Attributes:

Sequence length:

177

Sequence:

50:

100:

150:

177:

GVTGSGLEGD | HLSDTSTTSL | ELDSRRH

3D Structure:

N/A

Predicted Eptitope:

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Vaild Sequence:

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Related Databases

STRING:

9606.ENSP00000379213

UniGene:

Hs.591159

SMR:

P12272

String:

P12272

Pfam:

PF01279

MIM:

168470

KEGG:

hsa:5744

Uniprot:

P12272

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ELISA Kit for Human PTH-rP

Cat.:

E0819h

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96T

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ELISA Kit for Human PTH-rP

Cat.:

E0819r

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96T

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ELISA Kit for Human PTH-rP

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E0819b

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96T

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ELISA Kit for Human PTH-rP

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E0819c

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96T

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ELISA Kit for Human PTH-rP

Cat.:

E0819m

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96T

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ELISA Kit for Human PTH-rP

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ELISA Kit for Human PTH-rP

Cat.:

E0819d

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96T

CLIA Kit for Human PTH-rP

Cat.:

U0819r

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96T

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CLIA Kit for Human PTH-rP

Cat.:

U0819h

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96T

CLIA Kit for Human PTH-rP

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CLIA Kit for Human PTH-rP

Cat.:

U0819b

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96T

CLIA Kit for Human PTH-rP

Cat.:

U0819c

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96T

CLIA Kit for Human PTH-rP

Cat.:

U0819m

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96T

CLIA Kit for Human PTH-rP

Cat.:

U0819d

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96T

Polyclonal Antibody for Human PTH-rP

Cat.:

P0819Rb-m

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40ug/0.2ml

Polyclonal Antibody for Human PTH-rP

Cat.:

P0819Rb-r

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40ug/0.2ml

Polyclonal Antibody for Human PTH-rP

Cat.:

P0819Rb-h

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40ug/0.2ml

Monoclonal Antibody for Human PTH-rP

Protein for Human PTH-rP

R&D Technical Data

12% SDS-PAGE analysis

For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.

Precision

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Recovery

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Linearity

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References

1.

"A parathyroid hormone-related protein implicated in malignant hypercalcemia: cloning and expression."
Suva L.J. , Winslow G.A. , Wettenhall R.E.H. , Hammonds R.G. , Moseley J.M. , Diefenbach-Jagger H. , Rodda C.P. , Kemp B.E. , Rodriguez H. , Chen E.Y. , Hudson P.J. , Martin T.J. , Wood W.I.
Science237:893-896(1987) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA];PARTIAL PROTEIN SEQUENCE
2.

"Identification of a cDNA encoding a parathyroid hormone-like peptide from a human tumor associated with humoral hypercalcemia of malignancy."
Mangin M. , Webb A.C. , Dreyer B.E. , Posillico J.T. , Ikeda K. , Weir E.C. , Stewart A.F. , Bander N.H. , Milstone L. , Barton D.E. , Francke U. , Broadus A.E.
Proc. Natl. Acad. Sci. U.S.A.85:597-601(1988) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [MRNA]
3.

"Characterization of the human parathyroid hormone-like peptide gene. Functional and evolutionary aspects."
Yasuda T. , Banville D. , Hendy G.N. , Goltzman D.
J. Biol. Chem.264:7720-7725(1989) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA]
4.

"Human renal carcinoma expresses two messages encoding a parathyroid hormone-like peptide: evidence for the alternative splicing of a single-copy gene."
Thiede M.A. , Strewler G.J. , Nissenson R.A. , Rosenblatt M. , Rodan G.A.
Proc. Natl. Acad. Sci. U.S.A.85:4605-4609(1988) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 2)
5.

"Cloning of human full open reading frames in Gateway(TM) system entry vector (pDONR201)."
Ebert L. , Schick M. , Neubert P. , Schatten R. , Henze S. , Korn B.
Submitted (2004-06) to the EMBL/GenBank/DDBJ databases

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1)
6.

Mural R.J. , Istrail S. , Sutton G.G. , Florea L. , Halpern A.L. , Mobarry C.M. , Lippert R. , Walenz B. , Shatkay H. , Dew I. , Miller J.R. , Flanigan M.J. , Edwards N.J. , Bolanos R. , Fasulo D. , Halldorsson B.V. , Hannenhalli S. , Turner R. , more...
Submitted (2005-07) to the EMBL/GenBank/DDBJ databases

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]
7.

"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
The MGC Project Team
Genome Res.14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 2)
tissue: Brain.
8.

"Structure of the 5' flanking region of the gene encoding human parathyroid-hormone-related protein (PTHrP)."
Suva L.J. , Mather K.A. , Gillespie M.T. , Webb G.C. , Ng K.W. , Winslow G.A. , Wood W.I. , Martin T.J. , Hudson P.J.
Gene77:95-105(1989) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE OF 1-33
tissue: Liver.
9.

"Parathyroid hormone-related protein purified from a human lung cancer cell line."
Moseley J.M. , Kubota M. , Diefenbach-Jagger H. , Wettenhall R.E.H. , Kemp B.E. , Suva L.J. , Rodda C.P. , Ebeling P.R. , Hudson P.J. , Zajac J.D. , Martin T.J.
Proc. Natl. Acad. Sci. U.S.A.84:5048-5052(1987) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: PROTEIN SEQUENCE OF 37-52
10.

"Isolation and characterization of the human parathyroid hormone-like peptide gene."
Mangin M. , Ikeda K. , Dreyer B.E. , Broadus A.E.
Proc. Natl. Acad. Sci. U.S.A.86:2408-2412(1989) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: ALTERNATIVE SPLICING (ISOFORM 3)
11.

"A carboxyl-terminal peptide from the parathyroid hormone-related protein inhibits bone resorption by osteoclasts."
Fenton A.J. , Kemp B.E. , Kent G.N. , Moseley J.M. , Zheng M.H. , Rowe D.J. , Britto J.M. , Martin T.J. , Nicholson G.C.
Endocrinology129:1762-1768(1991) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: CHARACTERIZATION OF OSTEOSTATIN ACTIVITY
12.

"A potent inhibitor of osteoclastic bone resorption within a highly conserved pentapeptide region of parathyroid hormone-related protein; PTHrP107-111."
Fenton A.J. , Kemp B.E. , Hammonds R.G. , Mitchelhill K. , Moseley J.M. , Martin T.J. , Nicholson G.C.
Endocrinology129:3424-3426(1991) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: CHARACTERIZATION OF OSTEOSTATIN ACTIVITY
13.

"C-terminal parathyroid hormone-related protein inhibits proliferation and differentiation of human osteoblast-like cells."
Martinez M.E. , Garcia-Ocana A. , Sanchez M. , Medina S. , del Campo T. , Valin A. , Sanchez-Cabezudo M.J. , Esbrit P.
J. Bone Miner. Res.12:778-785(1997) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: CHARACTERIZATION OF OSTEOSTATIN ACTIVITY
14.

"Parathyroid hormone-related protein-(107-139) inhibits bone resorption in vivo."
Cornish J. , Callon K.E. , Nicholson G.C. , Reid I.R.
Endocrinology138:1299-1304(1997) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: CHARACTERIZATION OF OSTEOSTATIN ACTIVITY
15.

"Parathyroid hormone-related protein (PTHrP): a nucleocytoplasmic shuttling protein with distinct paracrine and intracrine roles."
Jans D.A. , Thomas R.J. , Gillespie M.T.
Vitam. Horm.66:345-384(2003) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOCYTOPLASMIC SHUTTLING
16.

"Molecular dissection of the importin beta1-recognized nuclear targeting signal of parathyroid hormone-related protein."
Lam M.H. , Hu W. , Xiao C.Y. , Gillespie M.T. , Jans D.A.
Biochem. Biophys. Res. Commun.282:629-634(2001) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEAR LOCALIZATION SIGNAL
17.

"Minireview: parathyroid hormone-related protein as an intracrine factor -- trafficking mechanisms and functional consequences."
Fiaschi-Taesch N.M. , Stewart A.F.
Endocrinology144:407-411(2003) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: REVIEW
18.

"PTHrP promotes colon cancer cell migration and invasion in an integrin alpha6beta4-dependent manner through activation of Rac1."
Mula R.V. , Bhatia V. , Falzon M.
Cancer Lett.298:119-127(2010) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: FUNCTION
19.

"The structure of human parathyroid hormone-related protein(1-34) in near-physiological solution."
Weidler M. , Marx U.C. , Seidel G. , Schafer W. , Hoffmann E. , Esswein A. , Rosch P.
FEBS Lett.444:239-244(1999) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: STRUCTURE BY NMR OF 37-70
20.

"Molecular basis for the recognition of a nonclassical nuclear localization signal by importin beta."
Cingolani G. , Bednenko J. , Gillespie M.T. , Gerace L.
Mol. Cell10:1345-1353(2002) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: X-RAY CRYSTALLOGRAPHY (2.9 ANGSTROMS) OF 103-130
21.

"Structural basis for parathyroid hormone-related protein binding to the parathyroid hormone receptor and design of conformation-selective peptides."
Pioszak A.A. , Parker N.R. , Gardella T.J. , Xu H.E.
J. Biol. Chem.284:28382-28391(2009) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: X-RAY CRYSTALLOGRAPHY (1.94 ANGSTROMS) OF 48-70 IN COMPLEX WITH PTH1R;INTERACTION WITH PTH1R;MUTAGENESIS OF ARG-57; PHE-59; LEU-60; LEU-63; ILE-64 AND HIS-68
22.

"The consensus coding sequences of human breast and colorectal cancers."
Sjoeblom T. , Jones S. , Wood L.D. , Parsons D.W. , Lin J. , Barber T.D. , Mandelker D. , Leary R.J. , Ptak J. , Silliman N. , Szabo S. , Buckhaults P. , Farrell C. , Meeh P. , Markowitz S.D. , Willis J. , Dawson D. , Willson J.K.V. , more...
Science314:268-274(2006) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: VARIANT [LARGE SCALE ANALYSIS] THR-169
23.

"Deletion and point mutations of PTHLH cause brachydactyly type E."
Klopocki E. , Hennig B.P. , Dathe K. , Koll R. , de Ravel T. , Baten E. , Blom E. , Gillerot Y. , Weigel J.F. , Krueger G. , Hiort O. , Seemann P. , Mundlos S.
Am. J. Hum. Genet.86:434-439(2010) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: VARIANTS BDE2 PRO-44 AND PRO-60

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