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Index > Protein center > PTN(Gene name) > Human
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  • PTN (Gene name),
  • Pleiotrophin (Protein name ),  PTN_HUMAN from NCBI database.
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  • General Annotation
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  • Antigen Annotation
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  • Predicted Eptitope
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  • Vaild Sequence
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  • Gene name:
    PTN(HBNF1;NEGF1);
    Protein name:
    Pleiotrophin(PTN);
    Alternative:
    Heparin-binding growth factor 8(HBGF-8);Heparin-binding brain mitogen(HBBM);Heparin-binding neurite outgrowth-promoting factor 1(HBNF-1);Heparin-binding growth-associated molecule(HB-GAM);Osteoblast-specific factor 1(OSF-1);
    Organism:
    Human (Homo sapiens). 
    General Annotation
    Sub Unit:
    Interacts with ALK and NEK6.
    Function:
    Secreted growth factor that induces neurite outgrowth and which is mitogenic for fibroblasts, epithelial, and endothelial cells. Binds anaplastic lymphoma kinase (ALK) which induces MAPK pathway activation, an important step in the anti-apoptotic signaling of PTN and regulation of cell proliferation.
    Subcellular Location:
    Secreted
    Protein Attributes:
    Sequence length:
    168
    Sequence:
    50:
    MQAQQYQQQR | RKFAAAFLAF | IFILAAVDTA | EAGKKEKPEK | KVKKSDCGEW | 
    100:
    QWSVCVPTSG | DCGLGTREGT | RTGAECKQTM | KTQRCKIPCN | WKKQFGAECK | 
    150:
    YQFQAWGECD | LNTALKTRTG | SLKRALHNAE | CQKTVTISKP | CGKLTKPKPQ | 
    168:
    AESKKKKKEG | KKQEKMLD
    3D Structure:
    N/A
    Predicted Eptitope:
    Please Sign in.
    EIAab Sequence  Vaild Sequence:
    Please Sign in.
    Related Databases
    SMR:
    Pfam:
    KEGG:
    UniGene:
    String:
    MIM:
    Uniprot:
     
    FOR
    ELISA Kit for Human PTN
    Cat.:
    E1309r
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    Packing:
    96T
    ELISA Kit for Human PTN
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    E1309h
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    96T
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    ELISA Kit for Human PTN
    Cat.:
    E1309c
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    ELISA Kit for Human PTN
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    E1309m
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    ELISA Kit for Human PTN
    Cat.:
    E1309p
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    MSDS:
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    ELISA Kit for Human PTN
    Cat.:
    E1309b
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    MSDS:
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    Packing:
    96T
    CLIA Kit for Human PTN
    Cat.:
    U1309h
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    Packing:
    96T
    Range:
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    CLIA Kit for Human PTN
    Cat.:
    U1309b
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    Packing:
    96T
    CLIA Kit for Human PTN
    Cat.:
    U1309p
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    CLIA Kit for Human PTN
    Cat.:
    U1309r
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    MSDS:
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    96T
    CLIA Kit for Human PTN
    Cat.:
    U1309c
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    CLIA Kit for Human PTN
    Cat.:
    U1309m
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    MSDS:
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    Packing:
    96T
    Polyclonal Antibody for Human PTN
    Cat.:
    P1309Rb-m
    Price:
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    Packing:
    40ug/0.2ml
    Polyclonal Antibody for Human PTN
    Polyclonal Antibody for Human PTN
    Polyclonal Antibody for Human PTN
    Cat.:
    P1309Rb-h
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    Packing:
    40ug/0.2ml
    Polyclonal Antibody for Human PTN
    Polyclonal Antibody for Human PTN
    Cat.:
    P1309Rb-r
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    Packing:
    40ug/0.2ml
    Monoclonal Antibody for Human PTN
    Monoclonal Antibody for Human PTN
    Monoclonal Antibody for Human PTN
    Monoclonal Antibody for Human PTN
    Monoclonal Antibody for Human PTN
    Monoclonal Antibody for Human PTN
    Protein for Human PTN
    Protein for Human PTN
    Protein for Human PTN
    Protein for Human PTN
    Protein for Human PTN
    Protein for Human PTN

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    References
    1. 1.
      "Isolation of mouse and human cDNA clones encoding a protein expressed specifically in osteoblasts and brain tissues."
      Tezuka K.I. , Takeshita S. , Hakeda Y. , Kumegawa M. , Kikuno R. , Hashimoto-Gotoh T.
      Biochem. Biophys. Res. Commun.173:246-251(1990) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [MRNA]
    2. 2.
      "Cloning and expression of a developmentally regulated protein that induces mitogenic and neurite outgrowth activity."
      Li Y.-S. , Milner P.G. , Chauhan A.K. , Watson M.A. , Hoffman R.M. , Kodner C.M. , Milbrandt J. , Deuel T.F.
      Science250:1690-1694(1990) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [MRNA]
      tissue: Placenta.
    3. 3.
      "Cloning, characterization and developmental regulation of two members of a novel human gene family of neurite outgrowth-promoting proteins."
      Kretschmer P.J. , Fairhurst J.L. , Decker M.M. , Chan C.P. , Gluzman Y. , Boehlen P. , Kovesdi I.
      Growth Factors5:99-114(1991) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [MRNA];FUNCTION;INDUCTION
    4. 4.
      "Cloning, nucleotide sequence, and chromosome localization of the human pleiotrophin gene."
      Milner P.G. , Shah D. , Veile R. , Donis-Keller H. , Kumar B.V.
      Biochemistry31:12023-12028(1992) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA]
    5. 5.
      "Genomic organization of the human HBNF gene and characterization of an HBNF variant protein as a splice mutant."
      Kretschmer P.J. , Fairhurst J.L. , Hulmes J.D. , Popjes M.L. , Boehlen P. , Kovesdi I.
      Biochem. Biophys. Res. Commun.192:420-429(1993) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA]
    6. 6.
      "Bone mass loss due to estrogen deficiency is compensated in transgenic mice overexpressing human osteoblast stimulating factor-1."
      Masuda H. , Tsujimura A. , Yoshioka M. , Arai Y. , Kuboki Y. , Mukai T. , Nakamura T. , Tsuji H. , Nakagawa M. , Hashimoto-Gotoh T.
      Biochem. Biophys. Res. Commun.238:528-533(1997) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA]
    7. 7.
      "Complete sequencing and characterization of 21,243 full-length human cDNAs."
      Ota T. , Suzuki Y. , Nishikawa T. , Otsuki T. , Sugiyama T. , Irie R. , Wakamatsu A. , Hayashi K. , Sato H. , Nagai K. , Kimura K. , Makita H. , Sekine M. , Obayashi M. , Nishi T. , Shibahara T. , Tanaka T. , Ishii S. , more...
      Nat. Genet.36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA]
      tissue: Brain.
      tissue: Cerebellum.
    8. 8.
      "Cloning of human full open reading frames in Gateway(TM) system entry vector (pDONR201)."
      Ebert L. , Schick M. , Neubert P. , Schatten R. , Henze S. , Korn B.
      Submitted (2004-06) to the EMBL/GenBank/DDBJ databases
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA]
    9. 9.
      "Cloning of human full-length CDSs in BD Creator(TM) system donor vector."
      Kalnine N. , Chen X. , Rolfs A. , Halleck A. , Hines L. , Eisenstein S. , Koundinya M. , Raphael J. , Moreira D. , Kelley T. , LaBaer J. , Lin Y. , Phelan M. , Farmer A.
      Submitted (2004-10) to the EMBL/GenBank/DDBJ databases
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA]
    10. 11.
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]
    11. 12.
      "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
      The MGC Project Team
      Genome Res.14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA]
      tissue: Prostate.
    12. 13.
      "Amino-terminal sequences of a novel heparin-binding protein from human, bovine, rat, and chick brain: high interspecies homology."
      Huber D. , Gautschi-Sova P. , Bohlen P.
      Neurochem. Res.15:435-439(1990) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: PROTEIN SEQUENCE OF 33-58
      tissue: Brain.
    13. 14.
      "A heparin-binding growth factor secreted from breast cancer cells homologous to a developmentally regulated cytokine."
      Wellsein A. , Fang W. , Khatri A. , Lu Y. , Swain S.S. , Dickson R.B. , Sasse J. , Riegel A.T. , Lippman M.E.
      J. Biol. Chem.267:2582-2587(1992) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: PROTEIN SEQUENCE OF 33-52
    14. 15.
      "Identification of novel heparin-releasable proteins, as well as the cytokines midkine and pleiotrophin, in human postheparin plasma."
      Novotny W.F. , Maffi T. , Mehta R.L. , Milner P.G.
      Arterioscler. Thromb.13:1798-1805(1993) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: PROTEIN SEQUENCE OF 33-49;INDUCTION
      tissue: Plasma.
    15. 16.
      "Comparison of the disulfide bond arrangements of human recombinant and bovine brain heparin binding neurite-promoting factors."
      Hulmes J.D. , Seddon A.P. , Decker M.M. , Bohlen P.
      Biochem. Biophys. Res. Commun.192:738-746(1993) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: DISULFIDE BONDS
    16. 17.
      "Identification of anaplastic lymphoma kinase as a receptor for the growth factor pleiotrophin."
      Stoica G.E. , Kuo A. , Aigner A. , Sunitha I. , Souttou B. , Malerczyk C. , Caughey D.J. , Wen D. , Karavanov A. , Riegel A.T. , Wellstein A.
      J. Biol. Chem.276:16772-16779(2001) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: INTERACTION WITH ALK;FUNCTION
    17. 18.
      "Characterization of hNek6 interactome reveals an important role for its short N-terminal domain and colocalization with proteins at the centrosome."
      Vaz Meirelles G. , Ferreira Lanza D.C. , da Silva J.C. , Santana Bernachi J. , Paes Leme A.F. , Kobarg J.
      J. Proteome Res.9:6298-6316(2010) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: INTERACTION WITH NEK6;PHOSPHORYLATION BY NEK6
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