PTPRC ELISA Kit for Human(Homo sapiens) | EIAab.comPTPRC ELISA Kit for Human(Homo sapiens)

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Index > Protein center > PTPRC(Gene name) > Human

PTPRC (Gene name),

Receptor-type tyrosine-protein phosphatase C (Protein name ), PTPRC_HUMAN from NCBI database.

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General Annotation

Antigen Annotation

Predicted Eptitope

Vaild Sequence

Related Databases

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Gene name:

PTPRC(CD45);

Protein name:

Receptor-type tyrosine-protein phosphatase C;

Alternative:

T200;Leukocyte common antigen(L-CA);

CD:

CD45;

Organism:

Human (Homo sapiens).

General Annotation

Sub Unit:

Binds GANAB and PRKCSH (By similarity). Interacts with SKAP1. Interacts with DPP4; the interaction is enhanced in a interleukin-12-dependent manner in activated lymphocytes.

Function:

Protein tyrosine-protein phosphatase required for T-cell activation through the antigen receptor. Acts as a positive regulator of T-cell coactivation upon binding to DPP4. The first PTPase domain has enzymatic activity, while the second one seems to affect the substrate specificity of the first one. Upon T-cell activation, recruits and dephosphorylates SKAP1 and FYN.

Subcellular Location:

Membrane Single-pass type I membrane protein Membrane raft Colocalized with DPP4 in membrane rafts.

Protein Attributes:

Sequence length:

1304

Sequence:

50:

100:

150:

200:

250:

300:

350:

400:

450:

500:

550:

600:

650:

700:

750:

800:

850:

900:

950:

1000:

1050:

1100:

1150:

1200:

1250:

1300:

1304:

NQGS

3D Structure:

N/A

Predicted Eptitope:

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Vaild Sequence:

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Related Databases

Pfam:

PF12567

SMR:

P08575

MIM:

126200

String:

P08575

UniGene:

Hs.654514

Pfam:

PF00041

STRING:

9606.ENSP00000356346

KEGG:

hsa:5788

Uniprot:

P08575

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ELISA Kit for Human Receptor-type tyrosine-protein phosphatase C

Cat.:

E1030h

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96T

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ELISA Kit for Human Receptor-type tyrosine-protein phosphatase C

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E1030m

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96T

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ELISA Kit for Human Receptor-type tyrosine-protein phosphatase C

Cat.:

E1030r

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96T

CLIA Kit for Human Receptor-type tyrosine-protein phosphatase C

Cat.:

U1030m

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Packing:

96T

CLIA Kit for Human Receptor-type tyrosine-protein phosphatase C

Cat.:

U1030h

Price:

Please sign in first.

MSDS:

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Packing:

96T

CLIA Kit for Human Receptor-type tyrosine-protein phosphatase C

Cat.:

U1030r

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96T

Polyclonal Antibody for Human Receptor-type tyrosine-protein phosphatase C

Cat.:

P1030Rb-h

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40ug/0.2ml

Polyclonal Antibody for Human Receptor-type tyrosine-protein phosphatase C

Cat.:

P1030Rb-r

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40ug/0.2ml

Polyclonal Antibody for Human Receptor-type tyrosine-protein phosphatase C

Cat.:

P1030Rb-m

Price:

Please sign in first.

Packing:

40ug/0.2ml

Monoclonal Antibody for Human Receptor-type tyrosine-protein phosphatase C

Protein for Human Receptor-type tyrosine-protein phosphatase C

R&D Technical Data

For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.

Precision

For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.

Recovery

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Linearity

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References

1.

"Differential usage of three exons generates at least five different mRNAs encoding human leukocyte common antigens."
Streuli M. , Hall L.R. , Saga Y. , Schlossman S.F. , Saito H.
J. Exp. Med.166:1548-1566(1987) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1);ALTERNATIVE SPLICING
tissue: Lymphocyte.
2.

"Structural variants of human T200 glycoprotein (leukocyte-common antigen)."
Ralph S.J. , Thomas M.L. , Morton C.C. , Trowbridge I.S.
EMBO J.6:1251-1257(1987) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 2);ALTERNATIVE SPLICING
3.

"Complete sequencing and characterization of 21,243 full-length human cDNAs."
Ota T. , Suzuki Y. , Nishikawa T. , Otsuki T. , Sugiyama T. , Irie R. , Wakamatsu A. , Hayashi K. , Sato H. , Nagai K. , Kimura K. , Makita H. , Sekine M. , Obayashi M. , Nishi T. , Shibahara T. , Tanaka T. , Ishii S. , more...
Nat. Genet.36:40-45(2004) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 2)
tissue: Synovium.
4.

"Integrity of the exon 6 sequence is essential for tissue-specific alternative splicing of human leukocyte common antigen pre-mRNA."
Tsai A.Y.M. , Streuli M. , Saito H.
Mol. Cell. Biol.9:4550-4555(1989) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA] OF 146-192
5.

"Complete exon-intron organization of the human leukocyte common antigen (CD45) gene."
Hall L.R. , Streuli M. , Schlossman S.F. , Saito H.
J. Immunol.141:2781-2787(1988) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA] OF 191-1304
tissue: Placenta.
6.

"The leukocyte common antigen (CD45): a putative receptor-linked protein tyrosine phosphatase."
Charbonneau H. , Tonks N.K. , Walsh K.A. , Fischer E.H.
Proc. Natl. Acad. Sci. U.S.A.85:7182-7186(1988) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: FUNCTION
7.

"Distinct functional roles of the two intracellular phosphatase like domains of the receptor-linked protein tyrosine phosphatases LCA and LAR."
Streuli M. , Krueger N.X. , Thai T. , Tang M. , Saito H.
EMBO J.9:2399-2407(1990) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: MUTAGENESIS
8.

"SKAP55 coupled with CD45 positively regulates T-cell receptor-mediated gene transcription."
Wu L. , Fu J. , Shen S.-H.
Mol. Cell. Biol.22:2673-2686(2002) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: INTERACTION WITH SKAP1;MUTAGENESIS OF CYS-851;FUNCTION
9.

"A role for interleukin-12 in the regulation of T cell plasma membrane compartmentation."
Salgado F.J. , Lojo J. , Alonso-Lebrero J.L. , Lluis C. , Franco R. , Cordero O.J. , Nogueira M.
J. Biol. Chem.278:24849-24857(2003) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: INTERACTION WITH DPP4;SUBCELLULAR LOCATION
10.

"Phosphorylation analysis of primary human T lymphocytes using sequential IMAC and titanium oxide enrichment."
Carrascal M. , Ovelleiro D. , Casas V. , Gay M. , Abian J.
J. Proteome Res.7:5167-5176(2008) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-973;IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS]
tissue: T-cell.
11.

"Glycoproteomics analysis of human liver tissue by combination of multiple enzyme digestion and hydrazide chemistry."
Chen R. , Jiang X. , Sun D. , Han G. , Wang F. , Ye M. , Wang L. , Zou H.
J. Proteome Res.8:651-661(2009) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: GLYCOSYLATION [LARGE SCALE ANALYSIS] AT ASN-232 AND ASN-335
tissue: Liver.
12.

"Mass-spectrometric identification and relative quantification of N-linked cell surface glycoproteins."
Wollscheid B. , Bausch-Fluck D. , Henderson C. , O'Brien R. , Bibel M. , Schiess R. , Aebersold R. , Watts J.D.
Nat. Biotechnol.27:378-386(2009) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: GLYCOSYLATION [LARGE SCALE ANALYSIS] AT ASN-232; ASN-240; ASN-276; ASN-284; ASN-335; ASN-419; ASN-488 AND ASN-497
tissue: Leukemic T-cell.
13.

"Quantitative phosphoproteomic analysis of T cell receptor signaling reveals system-wide modulation of protein-protein interactions."
Mayya V. , Lundgren D.H. , Hwang S.-I. , Rezaul K. , Wu L. , Eng J.K. , Rodionov V. , Han D.K.
Sci. Signal.2:RA46-RA46(2009) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-973 AND SER-1297;IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS]
tissue: Leukemic T-cell.
14.

"Initial characterization of the human central proteome."
Burkard T.R. , Planyavsky M. , Kaupe I. , Breitwieser F.P. , Buerckstuemmer T. , Bennett K.L. , Superti-Furga G. , Colinge J.
BMC Syst. Biol.5:17-17(2011) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS]
15.

"Structural basis for the function and regulation of the receptor protein tyrosine phosphatase CD45."
Nam H.J. , Poy F. , Saito H. , Frederick C.A.
J. Exp. Med.201:441-452(2005) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: X-RAY CRYSTALLOGRAPHY (2.9 ANGSTROMS) OF 622-1231 ALONE AND IN COMPLEX WITH PHOSPHOPEPTIDE
16.

"A point mutation in PTPRC is associated with the development of multiple sclerosis."
Jacobsen M. , Schweer D. , Ziegler A. , Gaber R. , Schock S. , Schwinzer R. , Wonigeit K. , Lindert R.-B. , Kantarci O. , Schaefer-Klein J. , Schipper H.I. , Oertel W.H. , Heidenreich F. , Weinshenker B.G. , Sommer N. , Hemmer B.
Nat. Genet.26:495-499(2000) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: INVOLVEMENT IN SUSCEPTIBILITY TO MS
17.

"A deletion in the gene encoding the CD45 antigen in a patient with SCID."
Tchilian E.Z. , Wallace D.L. , Wells R.S. , Flower D.R. , Morgan G. , Beverley P.C.L.
J. Immunol.166:1308-1313(2001) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: VARIANT T(-)B(+)NK(+) SCID 362-GLU-TYR-363 DEL;CHARACTERIZATION OF VARIANT T(-)B(+)NK(+) SCID 362-GLU-TYR-363 DEL
18.

"The consensus coding sequences of human breast and colorectal cancers."
Sjoeblom T. , Jones S. , Wood L.D. , Parsons D.W. , Lin J. , Barber T.D. , Mandelker D. , Leary R.J. , Ptak J. , Silliman N. , Szabo S. , Buckhaults P. , Farrell C. , Meeh P. , Markowitz S.D. , Willis J. , Dawson D. , Willson J.K.V. , more...
Science314:268-274(2006) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: VARIANTS [LARGE SCALE ANALYSIS] ALA-228 AND ARG-863

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