T-cell surface glycoprotein CD8 alpha chain;
T-lymphocyte differentiation antigen T8/Leu-2;
Human (Homo sapiens).
In general heterodimer of an alpha and a beta chain linked by two disulfide bonds. Can also form homodimers. Shown to be expressed as heterodimer on thymocytes and as homodimer on peripheral blood T-lymphocytes. Interacts with the MHC class I HLA-A/B2M dimer. Interacts with LCK in a zinc-dependent manner.
Identifies cytotoxic/suppressor T-cells that interact with MHC class I bearing targets. CD8 is thought to play a role in the process of T-cell mediated killing. CD8 alpha chains binds to class I MHC molecules alpha-3 domains.
MALPVTALLL | PLALLLHAAR | PSQFRVSPLD | RTWNLGETVE | LKCQVLLSNP |
TSGCSWLFQP | RGAAASPTFL | LYLSQNKPKA | AEGLDTQRFS | GKRLGDTFVL |
TLSDFRRENE | GYYFCSALSN | SIMYFSHFVP | VFLPAKPTTT | PAPRPPTPAP |
TIASQPLSLR | PEACRPAAGG | AVHTRGLDFA | CDIYIWAPLA | GTCGVLLLSL |
VITLYCNHRN | RRRVCKCPRP | VVKSGDKPSL | SARYV