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Index > Protein center > UBE2B(Gene name) > Human
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  • UBE2B (Gene name),
  • Ubiquitin-conjugating enzyme E2 B (Protein name ),  UBE2B_HUMAN from NCBI database.
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  • General Annotation
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  • Antigen Annotation
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  • 3D
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  • Predicted Eptitope
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  • Vaild Sequence
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  • Gene name:
    UBE2B(RAD6B);
    Protein name:
    Ubiquitin-conjugating enzyme E2 B;
    Alternative:
    Ubiquitin carrier protein B;RAD6 homolog B(HR6B;hHR6B);Ubiquitin-protein ligase B;Ubiquitin-conjugating enzyme E2-17 kDa;
    Organism:
    Human (Homo sapiens). 
    General Annotation
    Sub Unit:
    Interacts with RAD18, UBR2 and WAC.
    Function:
    Accepts ubiquitin from the E1 complex and catalyzes its covalent attachment to other proteins. In association with the E3 enzyme BRE1 (RNF20 and/or RNF40), it plays a role in transcription regulation by catalyzing the monoubiquitination of histone H2B at 'Lys-120' to form H2BK120ub1. H2BK120ub1 gives a specific tag for epigenetic transcriptional activation, elongation by RNA polymerase II, telomeric silencing, and is also a prerequisite for H3K4me and H3K79me formation. In vitro catalyzes 'Lys-11'-, as well as 'Lys-48'- and 'Lys-63'-linked polyubiquitination. Required for postreplication repair of UV-damaged DNA. Associates to the E3 ligase RAD18 to form the UBE2B-RAD18 ubiquitin ligase complex involved in mono-ubiquitination of DNA-associated PCNA on 'Lys-164'. May be involved in neurite outgrowth.
    Subcellular Location:
    Cell membrane Nucleus In peripheral neurons, expressed both at the plasma membrane and in nuclei.
    Protein Attributes:
    Sequence length:
    152
    Sequence:
    50:
    MSTPARRRLM | RDFKRLQEDP | PVGVSGAPSE | NNIMQWNAVI | FGPEGTPFED | 
    100:
    GTFKLVIEFS | EEYPNKPPTV | RFLSKMFHPN | VYADGSICLD | ILQNRWSPTY | 
    150:
    DVSSILTSIQ | SLLDEPNPNS | PANSQAAQLY | QENKREYEKR | VSAIVEQSWN | 
    152:
    DS
    3D Structure:
    N/A
    Predicted Eptitope:
    Please Sign in.
    EIAab Sequence  Vaild Sequence:
    Please Sign in.
    Related Databases
    String:
    KEGG:
    SMR:
    UniGene:
    Pfam:
    MIM:
    Uniprot:
     
    FOR
    ELISA Kit for Human Ubiquitin-conjugating enzyme E2 B
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    E1063h
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    ELISA Kit for Human Ubiquitin-conjugating enzyme E2 B
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    E1063r
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    ELISA Kit for Human Ubiquitin-conjugating enzyme E2 B
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    E1063b
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    ELISA Kit for Human Ubiquitin-conjugating enzyme E2 B
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    E1063m
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    ELISA Kit for Human Ubiquitin-conjugating enzyme E2 B
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    CLIA Kit for Human Ubiquitin-conjugating enzyme E2 B
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    U1063r
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    CLIA Kit for Human Ubiquitin-conjugating enzyme E2 B
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    U1063b
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    CLIA Kit for Human Ubiquitin-conjugating enzyme E2 B
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    U1063h
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    CLIA Kit for Human Ubiquitin-conjugating enzyme E2 B
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    U1063m
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    Packing:
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    CLIA Kit for Human Ubiquitin-conjugating enzyme E2 B
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    Polyclonal Antibody for Human Ubiquitin-conjugating enzyme E2 B
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    P1063Rb-m
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    40ug/0.2ml
    Polyclonal Antibody for Human Ubiquitin-conjugating enzyme E2 B
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    P1063Rb-r
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    Packing:
    40ug/0.2ml
    Polyclonal Antibody for Human Ubiquitin-conjugating enzyme E2 B
    Polyclonal Antibody for Human Ubiquitin-conjugating enzyme E2 B
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    P1063Rb-h
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    Packing:
    40ug/0.2ml
    Polyclonal Antibody for Human Ubiquitin-conjugating enzyme E2 B
    Monoclonal Antibody for Human Ubiquitin-conjugating enzyme E2 B
    Monoclonal Antibody for Human Ubiquitin-conjugating enzyme E2 B
    Monoclonal Antibody for Human Ubiquitin-conjugating enzyme E2 B
    Monoclonal Antibody for Human Ubiquitin-conjugating enzyme E2 B
    Monoclonal Antibody for Human Ubiquitin-conjugating enzyme E2 B
    Protein for Human Ubiquitin-conjugating enzyme E2 B
    Protein for Human Ubiquitin-conjugating enzyme E2 B
    Protein for Human Ubiquitin-conjugating enzyme E2 B
    Protein for Human Ubiquitin-conjugating enzyme E2 B
    Protein for Human Ubiquitin-conjugating enzyme E2 B

    R&D Technical Data
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    Precision
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    Recovery
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    Linearity
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    References
    1. 1.
      "The human ubiquitin carrier protein E2(Mr = 17,000) is homologous to the yeast DNA repair gene RAD6."
      Schneider R. , Eckerskorn C. , Lottspeich F. , Schweiger M.
      EMBO J.9:1431-1435(1990) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [MRNA];PARTIAL PROTEIN SEQUENCE
      tissue: Placenta.
    2. 2.
      "Mammalian mRNAs encoding protein closely related to ubiquitin-conjugating enzyme encoded by yeast DNA repair gene RAD6."
      Woffendin C. , Chen Z.Y. , Staskus K. , Retzel E.F. , Plagemann P.G.
      Biochim. Biophys. Acta1090:81-85(1991) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [MRNA]
      tissue: Brain.
    3. 3.
      "Structural and functional conservation of two human homologs of the yeast DNA repair gene RAD6."
      Koken M.H.M. , Reynolds P. , Jaspers-Dekker I. , Prakash L. , Prakash S. , Bootsma D. , Hoeijmakers J.H.J.
      Proc. Natl. Acad. Sci. U.S.A.88:8865-8869(1991) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [MRNA];FUNCTION
    4. 4.
      "Cloning of human full-length CDSs in BD Creator(TM) system donor vector."
      Kalnine N. , Chen X. , Rolfs A. , Halleck A. , Hines L. , Eisenstein S. , Koundinya M. , Raphael J. , Moreira D. , Kelley T. , LaBaer J. , Lin Y. , Phelan M. , Farmer A.
      Submitted (2003-05) to the EMBL/GenBank/DDBJ databases
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA]
    5. 5.
      "Cloning of human full open reading frames in Gateway(TM) system entry vector (pDONR201)."
      Ebert L. , Schick M. , Neubert P. , Schatten R. , Henze S. , Korn B.
      Submitted (2004-05) to the EMBL/GenBank/DDBJ databases
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA]
    6. 6.
      "Complete sequencing and characterization of 21,243 full-length human cDNAs."
      Ota T. , Suzuki Y. , Nishikawa T. , Otsuki T. , Sugiyama T. , Irie R. , Wakamatsu A. , Hayashi K. , Sato H. , Nagai K. , Kimura K. , Makita H. , Sekine M. , Obayashi M. , Nishi T. , Shibahara T. , Tanaka T. , Ishii S. , more...
      Nat. Genet.36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA]
      tissue: Brain.
    7. 7.
      NIEHS SNPs program
      Submitted (2005-06) to the EMBL/GenBank/DDBJ databases
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA]
    8. 8.
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]
    9. 9.
      "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
      The MGC Project Team
      Genome Res.14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA]
      tissue: Bone marrow.
      tissue: Brain.
    10. 10.
      "The human RAD18 gene product interacts with HHR6A and HHR6B."
      Xin H. , Lin W. , Sumanasekera W. , Zhang Y. , Wu X. , Wang Z.
      Nucleic Acids Res.28:2847-2854(2000) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: INTERACTION WITH RAD18
    11. 11.
      "The human homolog of yeast BRE1 functions as a transcriptional coactivator through direct activator interactions."
      Kim J. , Hake S.B. , Roeder R.G.
      Mol. Cell20:759-770(2005) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: FUNCTION
    12. 12.
      "Human SHPRH suppresses genomic instability through proliferating cell nuclear antigen polyubiquitination."
      Motegi A. , Sood R. , Moinova H. , Markowitz S.D. , Liu P.P. , Myung K.
      J. Cell Biol.175:703-708(2006) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: FUNCTION
    13. 13.
      "Human SHPRH is a ubiquitin ligase for Mms2-Ubc13-dependent polyubiquitylation of proliferating cell nuclear antigen."
      Unk I. , Hajdu I. , Fatyol K. , Szakal B. , Blastyak A. , Bermudez V. , Hurwitz J. , Prakash L. , Prakash S. , Haracska L.
      Proc. Natl. Acad. Sci. U.S.A.103:18107-18112(2006) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: FUNCTION
    14. 14.
      "The E2 ubiquitin-conjugating enzymes direct polyubiquitination to preferred lysines."
      David Y. , Ziv T. , Admon A. , Navon A.
      J. Biol. Chem.285:8595-8604(2010) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: FUNCTION
    15. 15.
      "WAC, a functional partner of RNF20/40, regulates histone H2B ubiquitination and gene transcription."
      Zhang F. , Yu X.
      Mol. Cell41:384-397(2011) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: INTERACTION WITH WAC
    16. 16.
      "The NMR structure of the class I human ubiquitin-conjugating enzyme 2b."
      Miura T. , Klaus W. , Ross A. , Guntert P. , Senn H.
      J. Biomol. NMR22:89-92(2002) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: STRUCTURE BY NMR
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