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Index > Protein center > VCAM1(Gene name) > Human
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  • VCAM1 (Gene name),
  • Vascular cell adhesion protein 1 (Protein name ),  VCAM1_HUMAN from NCBI database.
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  • General Annotation
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  • Antigen Annotation
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  • 3D
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  • Predicted Eptitope
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  • Vaild Sequence
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  • Gene name:
    VCAM1(L1CAM);
    Protein name:
    Vascular cell adhesion protein 1(V-CAM 1;VCAM-1);
    Alternative:
    INCAM-100;
    CD:
    CD106;
    Organism:
    Human (Homo sapiens). 
    General Annotation
    Sub Unit:
    Binds to ECMV-D capsid proteins and acts as a receptor for this virus.
    Function:
    Important in cell-cell recognition. Appears to function in leukocyte-endothelial cell adhesion. Interacts with the beta-1 integrin VLA4 on leukocytes, and mediates both adhesion and signal transduction. The VCAM1/VLA4 interaction may play a pathophysiologic role both in immune responses and in leukocyte emigration to sites of inflammation.
    Subcellular Location:
    Membrane Single-pass type I membrane protein
    Protein Attributes:
    Sequence length:
    739
    Sequence:
    50:
    MPGKMVVILG | ASNILWIMFA | ASQAFKIETT | PESRYLAQIG | DSVSLTCSTT | 
    100:
    GCESPFFSWR | TQIDSPLNGK | VTNEGTTSTL | TMNPVSFGNE | HSYLCTATCE | 
    150:
    SRKLEKGIQV | EIYSFPKDPE | IHLSGPLEAG | KPITVKCSVA | DVYPFDRLEI | 
    200:
    DLLKGDHLMK | SQEFLEDADR | KSLETKSLEV | TFTPVIEDIG | KVLVCRAKLH | 
    250:
    IDEMDSVPTV | RQAVKELQVY | ISPKNTVISV | NPSTKLQEGG | SVTMTCSSEG | 
    300:
    LPAPEIFWSK | KLDNGNLQHL | SGNATLTLIA | MRMEDSGIYV | CEGVNLIGKN | 
    350:
    RKEVELIVQE | KPFTVEISPG | PRIAAQIGDS | VMLTCSVMGC | ESPSFSWRTQ | 
    400:
    IDSPLSGKVR | SEGTNSTLTL | SPVSFENEHS | YLCTVTCGHK | KLEKGIQVEL | 
    450:
    YSFPRDPEIE | MSGGLVNGSS | VTVSCKVPSV | YPLDRLEIEL | LKGETILENI | 
    500:
    EFLEDTDMKS | LENKSLEMTF | IPTIEDTGKA | LVCQAKLHID | DMEFEPKQRQ | 
    550:
    STQTLYVNVA | PRDTTVLVSP | SSILEEGSSV | NMTCLSQGFP | APKILWSRQL | 
    600:
    PNGELQPLSE | NATLTLISTK | MEDSGVYLCE | GINQAGRSRK | EVELIIQVTP | 
    650:
    KDIKLTAFPS | ESVKEGDTVI | ISCTCGNVPE | TWIILKKKAE | TGDTVLKSID | 
    700:
    GAYTIRKAQL | KDAGVYECES | KNKVGSQLRS | LTLDVQGREN | NKDYFSPELL | 
    739:
    VLYFASSLII | PAIGMIIYFA | RKANMKGSYS | LVEAQKSKV
    3D Structure:
    N/A
    Predicted Eptitope:
    Please Sign in.
    EIAab Sequence  Vaild Sequence:
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    Related Databases
    SMR:
    MIM:
    UniGene:
    String:
    KEGG:
    Pfam:
    Uniprot:
     
    FOR
    ELISA Kit for Human V-CAM 1
    Cat.:
    E0142m
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    Packing:
    96T
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    ELISA Kit for Human V-CAM 1
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    E0142d
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    Packing:
    96T
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    ELISA Kit for Human V-CAM 1
    Cat.:
    E0142h
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    96T
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    ELISA Kit for Human V-CAM 1
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    E0142r
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    MSDS:
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    Packing:
    96T
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    CLIA Kit for Human V-CAM 1
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    U0142h
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    MSDS:
    Please sign in first.
    Packing:
    96T
    Range:
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    CLIA Kit for Human V-CAM 1
    Cat.:
    U0142r
    Price:
    Please sign in first.
    MSDS:
    Please sign in first.
    Packing:
    96T
    CLIA Kit for Human V-CAM 1
    Cat.:
    U0142m
    Price:
    Please sign in first.
    MSDS:
    Please sign in first.
    Packing:
    96T
    CLIA Kit for Human V-CAM 1
    Cat.:
    U0142d
    Price:
    Please sign in first.
    MSDS:
    Please sign in first.
    Packing:
    96T
    Range:
    Please sign in first.
    Polyclonal Antibody for Human V-CAM 1
    Polyclonal Antibody for Human V-CAM 1
    Cat.:
    P0142Rb-h
    Price:
    Please sign in first.
    Packing:
    40ug/0.2ml
    Polyclonal Antibody for Human V-CAM 1
    Cat.:
    P0142Rb-m
    Price:
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    Packing:
    40ug/0.2ml
    Polyclonal Antibody for Human V-CAM 1
    Cat.:
    P0142Rb-r
    Price:
    Please sign in first.
    Packing:
    40ug/0.2ml
    Monoclonal Antibody for Human V-CAM 1
    Monoclonal Antibody for Human V-CAM 1
    Monoclonal Antibody for Human V-CAM 1
    Monoclonal Antibody for Human V-CAM 1
    Protein for Human V-CAM 1
    Cat.:
    R0142h
    Price:
    Please sign in first.
    Packing:
    1mg
    Purity:
    >90%
    Protein for Human V-CAM 1
    Protein for Human V-CAM 1
    Protein for Human V-CAM 1

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    Linearity
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    References
    1. 1.
      "Direct expression cloning of vascular cell adhesion molecule 1, a cytokine-induced endothelial protein that binds to lymphocytes."
      Osborn L. , Hession C. , Tizard R. , Vassallo C. , Luhowskyj S. , Chi-Rosso G. , Lobb R.
      Cell59:1203-1211(1989) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 2)
    2. 2.
      "Full length vascular cell adhesion molecule 1 (VCAM-1)."
      Polte T. , Newman W. , Gopal T.V.
      Nucleic Acids Res.18:5901-5901(1990) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1)
      tissue: Umbilical vein.
    3. 3.
      "Cloning of an alternate form of vascular cell adhesion molecule-1 (VCAM1)."
      Hession C. , Tizard R. , Vassallo C. , Schiffer S.B. , Goff D. , Moy P. , Chi-Rosso G. , Luhowskyj S. , Lobb R. , Osborn L.
      J. Biol. Chem.266:6682-6685(1991) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1)
    4. 4.
      "Gene structure, chromosomal location, and basis for alternative mRNA splicing of the human VCAM1 gene."
      Cybulsky M.I. , Fries J.W.U. , Williams A.J. , Sultan P. , Eddy R. , Byers M. , Shows T. , Gimbrone M.A. Jr. , Collins T.
      Proc. Natl. Acad. Sci. U.S.A.88:7859-7863(1991) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA] (ISOFORM 1);ALTERNATIVE SPLICING
    5. 5.
      SeattleSNPs variation discovery resource
      Submitted (2002-08) to the EMBL/GenBank/DDBJ databases
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA];VARIANTS PHE-318; ALA-384; ALA-413 AND LEU-716
    6. 6.
      "Complete sequencing and characterization of 21,243 full-length human cDNAs."
      Ota T. , Suzuki Y. , Nishikawa T. , Otsuki T. , Sugiyama T. , Irie R. , Wakamatsu A. , Hayashi K. , Sato H. , Nagai K. , Kimura K. , Makita H. , Sekine M. , Obayashi M. , Nishi T. , Shibahara T. , Tanaka T. , Ishii S. , more...
      Nat. Genet.36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORMS 1 AND 3)
      tissue: Placenta.
      tissue: Tongue.
    7. 7.
      "The DNA sequence and biological annotation of human chromosome 1."
      Gregory S.G. , Barlow K.F. , McLay K.E. , Kaul R. , Swarbreck D. , Dunham A. , Scott C.E. , Howe K.L. , Woodfine K. , Spencer C.C.A. , Jones M.C. , Gillson C. , Searle S. , Zhou Y. , Kokocinski F. , McDonald L. , Evans R. , Phillips K. , more...
      Nature441:315-321(2006) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]
    8. 8.
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]
    9. 9.
      "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
      The MGC Project Team
      Genome Res.14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1)
      tissue: Retinal pigment epithelium.
    10. 10.
      "Characterization of the promoter for vascular cell adhesion molecule-1 (VCAM-1)."
      Iademarco M.F. , McQuillan J.J. , Rosen G.D. , Dean D.C.
      J. Biol. Chem.267:16323-16329(1992) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA] OF 1-21
    11. 11.
      "Alternative splicing of human VCAM-1 in activated vascular endothelium."
      Cybulsky M.I. , Fries J.W. , Williams A.J. , Sultan P. , Davis V.M. , Gimbrone M.A. Jr. , Collins T.
      Am. J. Pathol.138:815-820(1991) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE OF 25-686 (ISOFORMS 1 AND 2)
      tissue: Umbilical vein endothelial cell.
    12. 12.
      "Activated endothelium binds lymphocytes through a novel binding site in the alternately spliced domain of vascular cell adhesion molecule-1."
      Osborn L. , Vassallo C. , Benjamin C.D.
      J. Exp. Med.176:99-107(1992) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE OF 25-402 (ISOFORMS 1 AND 2);CELL ADHESION DOMAIN
      tissue: Endothelial cell.
    13. 13.
      "Signal peptide prediction based on analysis of experimentally verified cleavage sites."
      Zhang Z. , Henzel W.J.
      Protein Sci.13:2819-2824(2004) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: PROTEIN SEQUENCE OF 25-39
    14. 14.
      "Human plasma N-glycoproteome analysis by immunoaffinity subtraction, hydrazide chemistry, and mass spectrometry."
      Liu T. , Qian W.-J. , Gritsenko M.A. , Camp D.G. II , Monroe M.E. , Moore R.J. , Smith R.D.
      J. Proteome Res.4:2070-2080(2005) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: GLYCOSYLATION [LARGE SCALE ANALYSIS] AT ASN-561
      tissue: Plasma.
    15. 15.
      "Crystal structure of an integrin-binding fragment of vascular cell adhesion molecule-1 at 1.8-A resolution."
      Jones E.Y. , Harlos K. , Bottomley M.J. , Robinson R.C. , Driscoll P.C. , Edwards R.M. , Clements J.M. , Dudgeon T.J. , Stuart D.I.
      Nature373:539-544(1995) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: X-RAY CRYSTALLOGRAPHY (1.8 ANGSTROMS) OF 25-226
    16. 16.
      "The crystal structure of an N-terminal two-domain fragment of vascular cell adhesion molecule 1 (VCAM-1): a cyclic peptide based on the domain 1 C-D loop can inhibit VCAM-1-alpha 4 integrin interaction."
      Wang J.-H. , Pepinsky R.B. , Stehle T. , Liu J.-H. , Karpusas M. , Browning B. , Osborn L.
      Proc. Natl. Acad. Sci. U.S.A.92:5714-5718(1995) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: X-RAY CRYSTALLOGRAPHY (1.9 ANGSTROMS) OF 25-220
    17. 17.
      "Structure of a functional fragment of VCAM-1 refined at 1.9-A resolution."
      Wang J.-H. , Stehle T. , Pepinsky R.B. , Liu J.-H. , Karpusas M. , Osborn L.
      Acta Crystallogr. D52:369-379(1996) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: X-RAY CRYSTALLOGRAPHY (1.9 ANGSTROMS) OF 25-220
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