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Index > Protein center > IL5RA(Gene name) > Human
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  • IL5RA (Gene name),
  • Interleukin-5 receptor subunit alpha (Protein name ),  IL5RA_HUMAN from NCBI database.
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  • General Annotation
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  • Antigen Annotation
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  • Gene name:
    IL5RA(IL5R);
    Protein name:
    Interleukin-5 receptor subunit alpha(IL-5 receptor subunit alpha;IL-5R subunit alpha;IL-5R-alpha;IL-5RA);
    Alternative:
    CDw125;
    CD:
    CD125;
    Organism:
    Human (Homo sapiens). 
    General Annotation
    Sub Unit:
    Heterodimer of an alpha and a beta subunit. The beta subunit is common to the IL3, IL5 and GM-CSF receptors. Interacts with SDCBP.
    Function:
    This is the receptor for interleukin-5. The alpha chain binds to IL5.
    Subcellular Location:
    Membrane Single-pass type I membrane protein
    Protein Attributes:
    Sequence length:
    420
    Sequence:
    50:
    MIIVAHVLLI | LLGATEILQA | DLLPDEKISL | LPPVNFTIKV | TGLAQVLLQW | 
    100:
    KPNPDQEQRN | VNLEYQVKIN | APKEDDYETR | ITESKCVTIL | HKGFSASVRT | 
    150:
    ILQNDHSLLA | SSWASAELHA | PPGSPGTSIV | NLTCTTNTTE | DNYSRLRSYQ | 
    200:
    VSLHCTWLVG | TDAPEDTQYF | LYYRYGSWTE | ECQEYSKDTL | GRNIACWFPR | 
    250:
    TFILSKGRDW | LAVLVNGSSK | HSAIRPFDQL | FALHAIDQIN | PPLNVTAEIE | 
    300:
    GTRLSIQWEK | PVSAFPIHCF | DYEVKIHNTR | NGYLQIEKLM | TNAFISIIDD | 
    350:
    LSKYDVQVRA | AVSSMCREAG | LWSEWSQPIY | VGNDEHKPLR | EWFVIVIMAT | 
    400:
    ICFILLILSL | ICKICHLWIK | LFPPIPAPKS | NIKDLFVTTN | YEKAGSSETE | 
    420:
    IEVICYIEKP | GVETLEDSVF | 
    3D Structure:
    N/A
    Predicted Eptitope:
    Please Sign in.
    EIAab Sequence  Vaild Sequence:
    Please Sign in.
    Related Databases
    SMR:
    String:
    UniGene:
    MIM:
    Pfam:
    KEGG:
    Uniprot:
     
    FOR
    ELISA Kit for Human IL-5 receptor subunit alpha
    Cat.:
    E0186h
    Price:
    Please sign in first.
    MSDS:
    Please sign in first.
    Packing:
    96T
    Range:
    Please sign in first.
    ELISA Kit for Human IL-5 receptor subunit alpha
    Cat.:
    E0186m
    Price:
    Please sign in first.
    MSDS:
    Please sign in first.
    Packing:
    96T
    Range:
    Please sign in first.
    CLIA Kit for Human IL-5 receptor subunit alpha
    Cat.:
    U0186m
    Price:
    Please sign in first.
    MSDS:
    Please sign in first.
    Packing:
    96T
    Range:
    Please sign in first.
    CLIA Kit for Human IL-5 receptor subunit alpha
    Cat.:
    U0186h
    Price:
    Please sign in first.
    MSDS:
    Please sign in first.
    Packing:
    96T
    Range:
    Please sign in first.
    Polyclonal Antibody for Human IL-5 receptor subunit alpha
    Cat.:
    P0186Rb-m
    Price:
    Please sign in first.
    Packing:
    40ug/0.2ml
    Polyclonal Antibody for Human IL-5 receptor subunit alpha
    Cat.:
    P0186Rb-h
    Price:
    Please sign in first.
    Packing:
    40ug/0.2ml
    Monoclonal Antibody for Human IL-5 receptor subunit alpha
    Monoclonal Antibody for Human IL-5 receptor subunit alpha
    Protein for Human IL-5 receptor subunit alpha
    Protein for Human IL-5 receptor subunit alpha

    R&D Technical Data
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    For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.
    For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.
    For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.
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    Precision
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    For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.
    For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.
    For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.
    For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.
    For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.
    For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.
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    Recovery
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    For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.
    For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.
    For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.
    For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.
    For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.
    For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.
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    Linearity
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    For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.
    For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.
    For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.
    For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.
    For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.
    For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.
    For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.
    References
    1. 1.
      "A human high affinity interleukin-5 receptor (IL5R) is composed of an IL5-specific alpha chain and a beta chain shared with the receptor for GM-CSF."
      Tavernier J. , Devos R. , Cornelis S. , Tuypens T. , van der Heyden J. , Fiers W. , Plaetinck G.
      Cell66:1175-1184(1991) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 2)
    2. 2.
      "Molecular cloning and expression of the human interleukin 5 receptor."
      Murata Y. , Takaki S. , Migita M. , Kikuchi Y. , Tominaga A. , Takatsu K.
      J. Exp. Med.175:341-351(1992) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORMS 1 AND 3);VARIANT VAL-129
      tissue: Peripheral blood.
    3. 3.
      "Molecular basis of the membrane-anchored and two soluble isoforms of the human interleukin 5 receptor alpha subunit."
      Tavernier J. , Tuypens T. , Plaetinck G. , Verhee A. , Fiers W. , Devos R.
      Proc. Natl. Acad. Sci. U.S.A.89:7041-7045(1992) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORMS 1 AND 3)
    4. 4.
      "Isolation of the variants for human interleukin-5 receptor alpha subunit."
      Ishihara K. , Yamada M. , Hirasawa N. , Ohuchi K.
      Submitted (2006-12) to the EMBL/GenBank/DDBJ databases
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 5)
    5. 5.
      "Complete sequencing and characterization of 21,243 full-length human cDNAs."
      Ota T. , Suzuki Y. , Nishikawa T. , Otsuki T. , Sugiyama T. , Irie R. , Wakamatsu A. , Hayashi K. , Sato H. , Nagai K. , Kimura K. , Makita H. , Sekine M. , Obayashi M. , Nishi T. , Shibahara T. , Tanaka T. , Ishii S. , more...
      Nat. Genet.36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 4)
      tissue: Trachea.
    6. 6.
      SeattleSNPs variation discovery resource
      Submitted (2004-06) to the EMBL/GenBank/DDBJ databases
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA];VARIANTS VAL-129 AND ALA-262
    7. 7.
      "The DNA sequence, annotation and analysis of human chromosome 3."
      Muzny D.M. , Scherer S.E. , Kaul R. , Wang J. , Yu J. , Sudbrak R. , Buhay C.J. , Chen R. , Cree A. , Ding Y. , Dugan-Rocha S. , Gill R. , Gunaratne P. , Harris R.A. , Hawes A.C. , Hernandez J. , Hodgson A.V. , Hume J. , more...
      Nature440:1194-1198(2006) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]
    8. 8.
      "Molecular roots of degenerate specificity in syntenin's PDZ2 domain: reassessment of the PDZ recognition paradigm."
      Kang B.S. , Cooper D.R. , Devedjiev Y. , Derewenda U. , Derewenda Z.S.
      Structure11:845-853(2003) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: X-RAY CRYSTALLOGRAPHY (1.35 ANGSTROMS) OF 413-420 IN COMPLEX WITH SDCBP
    9. 9.
      "Structure analysis of the IL-5 ligand-receptor complex reveals a wrench-like architecture for IL-5Ralpha."
      Patino E. , Kotzsch A. , Saremba S. , Nickel J. , Schmitz W. , Sebald W. , Mueller T.D.
      Structure19:1864-1875(2011) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: X-RAY CRYSTALLOGRAPHY (2.55 ANGSTROMS) OF 20-332 IN COMPLEX WITH IL5;DISULFIDE BONDS
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