TIMP2 Protein for Human(Homo sapiens) | EIAab.comTIMP2 Protein for Human(Homo sapiens)

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Index > Protein center > TIMP2(Gene name) > Human

TIMP2 (Gene name),

Metalloproteinase inhibitor 2 (Protein name ), TIMP2_HUMAN from NCBI database.

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General Annotation

Antigen Annotation

Predicted Eptitope

Vaild Sequence

Related Databases

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Gene name:

TIMP2;

Protein name:

Metalloproteinase inhibitor 2;

Alternative:

Tissue inhibitor of metalloproteinases 2(TIMP-2);CSC-21K;

Organism:

Human (Homo sapiens).

General Annotation

Sub Unit:

Interacts (via the C-terminal) with MMP2 (via the C-terminal PEX domain); the interaction inhibits the MMP2 activity.

Function:

Complexes with metalloproteinases (such as collagenases) and irreversibly inactivates them by binding to their catalytic zinc cofactor. Known to act on MMP-1, MMP-2, MMP-3, MMP-7, MMP-8, MMP-9, MMP-10, MMP-13, MMP-14, MMP-15, MMP-16 and MMP-19.

Subcellular Location:

Secreted

Protein Attributes:

Sequence length:

220

Sequence:

50:

100:

150:

200:

220:

CAWYRGAAPP | KQEFLDIEDP |

3D Structure:

N/A

Predicted Eptitope:

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Vaild Sequence:

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Related Databases

STRING:

9606.ENSP00000262768

Pfam:

PF00965

SMR:

P16035

KEGG:

hsa:7077

MIM:

188825

String:

P16035

UniGene:

Hs.633514

Uniprot:

P16035

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ELISA Kit for Human Metalloproteinase inhibitor 2

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E0128h

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96T

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ELISA Kit for Human Metalloproteinase inhibitor 2

Cat.:

E0128r

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96T

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ELISA Kit for Human Metalloproteinase inhibitor 2

Cat.:

E0128m

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96T

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ELISA Kit for Human Metalloproteinase inhibitor 2

Cat.:

E0128c

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96T

ELISA Kit for Human Metalloproteinase inhibitor 2

Cat.:

E0128d

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96T

ELISA Kit for Human Metalloproteinase inhibitor 2

Cat.:

E0128b

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96T

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ELISA Kit for Human Metalloproteinase inhibitor 2

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CLIA Kit for Human Metalloproteinase inhibitor 2

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CLIA Kit for Human Metalloproteinase inhibitor 2

Cat.:

U0128b

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Packing:

96T

CLIA Kit for Human Metalloproteinase inhibitor 2

Cat.:

U0128h

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96T

CLIA Kit for Human Metalloproteinase inhibitor 2

Cat.:

U0128m

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Packing:

96T

CLIA Kit for Human Metalloproteinase inhibitor 2

Cat.:

U0128r

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96T

CLIA Kit for Human Metalloproteinase inhibitor 2

Cat.:

U0128d

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96T

CLIA Kit for Human Metalloproteinase inhibitor 2

Cat.:

U0128c

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96T

Polyclonal Antibody for Human Metalloproteinase inhibitor 2

Cat.:

P0128Rb-h

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Packing:

40ug/0.2ml

Polyclonal Antibody for Human Metalloproteinase inhibitor 2

Cat.:

P0128Rb-r

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40ug/0.2ml

Polyclonal Antibody for Human Metalloproteinase inhibitor 2

Cat.:

P0128Rb-m

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40ug/0.2ml

Monoclonal Antibody for Human Metalloproteinase inhibitor 2

Protein for Human Metalloproteinase inhibitor 2

Cat.:

R0128h

Price:

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Packing:

1mg

Purity:

>90%

R&D Technical Data

For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.

Precision

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Recovery

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Linearity

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References

1.

"Tissue inhibitor of metalloproteinases-2 (TIMP-2) mRNA expression in tumor cell lines and human tumor tissues."
Stetler-Stevenson W.G. , Brown P.D. , Onisto M. , Levy A.T. , Liotta L.A.
J. Biol. Chem.265:13933-13938(1990) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [MRNA];INDUCTION
2.

"cDNA cloning and expression of a metalloproteinase inhibitor related to tissue inhibitor of metalloproteinases."
Boone T.C. , Johnson M.J. , de Clerck Y.A. , Langley K.E.
Proc. Natl. Acad. Sci. U.S.A.87:2800-2804(1990) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [MRNA]
3.

"Structure and characterization of the human tissue inhibitor of metalloproteinases-2 gene."
Hammani K. , Blakis A. , Morsette D. , Bowcock A. , Schmutte C. , Henriet P. , Declerck Y.A.
J. Biol. Chem.271:25498-25505(1996) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA]
tissue: Placenta.
4.

"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
The MGC Project Team
Genome Res.14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA]
tissue: Placenta.
tissue: Skin.
5.

Malik K. , Sejima H. , Aoki T. , Iwata K.
Submitted (1990-08) to the EMBL/GenBank/DDBJ databases

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE OF 30-214
6.

"Tissue inhibitor of metalloproteinase (TIMP-2). A new member of the metalloproteinase inhibitor family."
Stetler-Stevenson W.G. , Krutzsch H.C. , Liotta L.A.
J. Biol. Chem.264:17374-17378(1989) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: PROTEIN SEQUENCE OF 27-219;FUNCTION
7.

"TIMP-2: identification and characterization of a new member of the metalloproteinase inhibitor family."
Stetler-Stevenson W.G. , Krutzsch H.C. , Liotta L.A.
Matrix Suppl.1:299-306(1992) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: PROTEIN SEQUENCE OF 27-219
8.

"Human 72-kilodalton type IV collagenase forms a complex with a tissue inhibitor of metalloproteases designated TIMP-2."
Goldberg G.I. , Marmer B.L. , Grant G.A. , Eisen A.Z. , Wilhelm S. , He C.
Proc. Natl. Acad. Sci. U.S.A.86:8207-8211(1989) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: PROTEIN SEQUENCE OF 30-51; 124-141 AND 159-173;FUNCTION
9.

"Isolation and characterization of tissue inhibitors of metalloproteinases (TIMP-1 and TIMP-2) from human rheumatoid synovial fluid."
Osthues A. , Knaueper V. , Oberhoff R. , Reinke H. , Tschesche H.
FEBS Lett.296:16-20(1992) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: PROTEIN SEQUENCE OF 27-41
tissue: Synovial fluid.
10.

"Characterization of the promoter of the gene encoding human tissue inhibitor of metalloproteinases-2 (TIMP-2)."
de Clerck Y.A. , Darville M.I. , Eeckhout Y. , Rousseau G.G.
Gene139:185-191(1994) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA] OF 1-50
11.

"Binding of tissue inhibitor of metalloproteinases 2 to two distinct sites on human 72-kDa gelatinase. Identification of a stabilization site."
Howard E.W. , Banda M.J.
J. Biol. Chem.266:17972-17977(1991) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: INTERACTION WITH MMP2
12.

"Human cervical tumor cell (SiHa) surface alphavbeta3 integrin receptor has associated matrix metalloproteinase (MMP-2) activity."
Chattopadhyay N. , Mitra A. , Frei E. , Chatterjee A.
J. Cancer Res. Clin. Oncol.127:653-658(2001) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: INTERACTION WITH MMP2;FUNCTION
13.

"Solution structure of the active domain of tissue inhibitor of metalloproteinases-2. A new member of the OB fold protein family."
Williamson R.A. , Martorell G. , Carr M.D. , Murphy G. , Docherty A.J.P. , Freedman R.B. , Feeney J.
Biochemistry33:11745-11759(1994) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: STRUCTURE BY NMR OF 27-153
14.

"High resolution structure of the N-terminal domain of tissue inhibitor of metalloproteinases-2 and characterization of its interaction site with matrix metalloproteinase-3."
Muskett F.W. , Frenkiel T.A. , Feeney J. , Freedman R.B. , Carr M.D. , Williamson R.A.
J. Biol. Chem.273:21736-21743(1998) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: STRUCTURE BY NMR OF 27-153
15.

"Three-dimensional structure of human tissue inhibitor of metalloproteinases-2 at 2.1-A resolution."
Tuuttila A. , Morgunova E. , Bergmann U. , Lindqvist Y. , Maskos K. , Fernandez-Catalan C. , Bode W. , Tryggvason K. , Schneider G.
J. Mol. Biol.284:1133-1140(1998) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: X-RAY CRYSTALLOGRAPHY (2.10 ANGSTROMS) OF 27-220
16.

"Structural insight into the complex formation of latent matrix metalloproteinase 2 with tissue inhibitor of metalloproteinase 2."
Morgunova E. , Tuuttila A. , Bergmann U. , Tryggvason K.
Proc. Natl. Acad. Sci. U.S.A.99:7414-7419(2002) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: X-RAY CRYSTALLOGRAPHY (3.10 ANGSTROMS) IN COMPLEX WITH MMP-2;DISULFIDE BOND

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