Gene name:
LTA (TNFB;TNFSF1) ;
Protein name:
Lymphotoxin-alpha (LT-alpha) ;
Alternative:
Tumor necrosis factor ligand superfamily member 1 ;TNF-beta ;
Organism:
Human (Homo sapiens).
General Annotation
Sub Unit:
Homotrimer, and heterotrimer of either two LTB and one LTA subunits or (less prevalent) two LTA and one LTB subunits.
Function:
Cytokine that in its homotrimeric form binds to TNFRSF1A/TNFR1, TNFRSF1B/TNFBR and TNFRSF14/HVEM. In its heterotrimeric form with LTB binds to TNFRSF3/LTBR. Lymphotoxin is produced by lymphocytes and cytotoxic for a wide range of tumor cells in vitro and in vivo.
Subcellular Location:
Secreted
Membrane
The homotrimer is secreted. The heterotrimer is membrane-associated.
Protein Attributes:
50:
MTPPERLFLP | RVCGTTLHLL | LLGLLLVLLP | GAQGLPGVGL | TPSAAQTARQ |
100:
HPKMHLAHST | LKPAAHLIGD | PSKQNSLLWR | ANTDRAFLQD | GFSLSNNSLL |
150:
VPTSGIYFVY | SQVVFSGKAY | SPKATSSPLY | LAHEVQLFSS | QYPFHVPLLS |
200:
SQKMVYPGLQ | EPWLHSMYHG | AAFQLTQGDQ | LSTHTDGIPH | LVLSPSTVFF |
Vaild Sequence:
Related Databases
Uniprot:
ELISA Kit
CLIA Kit
Polyclonal Antibody
Monoclonal Antibody
Protein
FOR
Human
Mouse
Pig
Bovine
Rat
Dog
Rabbit
ELISA Kit for Human LT-alpha
ELISA Kit for Human LT-alpha
ELISA Kit for Human LT-alpha
ELISA Kit for Human LT-alpha
ELISA Kit for Human LT-alpha
ELISA Kit for Human LT-alpha
ELISA Kit for Human LT-alpha
CLIA Kit for Human LT-alpha
CLIA Kit for Human LT-alpha
CLIA Kit for Human LT-alpha
CLIA Kit for Human LT-alpha
CLIA Kit for Human LT-alpha
CLIA Kit for Human LT-alpha
CLIA Kit for Human LT-alpha
Polyclonal Antibody for Human LT-alpha
Polyclonal Antibody for Human LT-alpha
Polyclonal Antibody for Human LT-alpha
Polyclonal Antibody for Human LT-alpha
Polyclonal Antibody for Human LT-alpha
Polyclonal Antibody for Human LT-alpha
Polyclonal Antibody for Human LT-alpha
Monoclonal Antibody for Human LT-alpha
Monoclonal Antibody for Human LT-alpha
Monoclonal Antibody for Human LT-alpha
Monoclonal Antibody for Human LT-alpha
Monoclonal Antibody for Human LT-alpha
Monoclonal Antibody for Human LT-alpha
Monoclonal Antibody for Human LT-alpha
Protein for Human LT-alpha
Protein for Human LT-alpha
Protein for Human LT-alpha
Protein for Human LT-alpha
Protein for Human LT-alpha
Protein for Human LT-alpha
Protein for Human LT-alpha
R&D Technical Data
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Precision
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Recovery
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Linearity
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References
1.
"Tandem arrangement of genes coding for tumor necrosis factor (TNF-alpha) and lymphotoxin (TNF-beta) in the human genome."
Nedospasov S.A.
,
Shakhov A.N.
,
Turetskaya R.L.
,
Mett V.A.
,
Azizov M.M.
,
Georgiev G.P.
,
Korobko V.G.
,
Dobrynin V.N.
,
Filippov S.A.
,
Bystrov N.S.
,
Boldyreva E.F.
,
Chuvpilo S.A.
,
Chumakov A.M.
,
Shingarova L.N.
,
Ovchinnikov Y.A.
Cold Spring Harb. Symp. Quant. Biol.51:611-624(1986)
[
PubMed ]
[
Europe PMC ]
[
Abstract ]
[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s)
Cited for : NUCLEOTIDE SEQUENCE [GENOMIC DNA]
2.
[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s)
Cited for : NUCLEOTIDE SEQUENCE [GENOMIC DNA]
3.
[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s)
Cited for : NUCLEOTIDE SEQUENCE [MRNA]
4.
"Cloning and expression of cDNA for human lymphotoxin, a lymphokine with tumour necrosis activity."
Gray P.W.
,
Aggarwal B.B.
,
Benton C.V.
,
Bringman T.S.
,
Henzel W.J.
,
Jarrett J.A.
,
Leung D.W.
,
Moffat B.
,
Ng P.
,
Svedersky L.P.
,
Palladino M.A.
,
Nedwin G.E.
Nature312:721-724(1984)
[
PubMed ]
[
Europe PMC ]
[
Abstract ]
[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s)
Cited for : NUCLEOTIDE SEQUENCE [MRNA]
5.
[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s)
Cited for : NUCLEOTIDE SEQUENCE [MRNA]
6.
"Dense Alu clustering and a potential new member of the NF kappa B family within a 90 kilobase HLA class III segment."
Iris F.J.M.
,
Bougueleret L.
,
Prieur S.
,
Caterina D.
,
Primas G.
,
Perrot V.
,
Jurka J.
,
Rodriguez-Tome P.
,
Claverie J.-M.
,
Dausset J.
,
Cohen D.
Nat. Genet.3:137-145(1993)
[
PubMed ]
[
Europe PMC ]
[
Abstract ]
[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s)
Cited for : NUCLEOTIDE SEQUENCE [GENOMIC DNA]
7.
[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s)
Cited for : NUCLEOTIDE SEQUENCE [GENOMIC DNA]
8.
[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s)
Cited for : NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]
9.
"Homo sapiens 2,229,817bp genomic DNA of 6p21.3 HLA class I region."
Shiina S.
,
Tamiya G.
,
Oka A.
,
Inoko H.
Submitted (1999-09) to the EMBL/GenBank/DDBJ databases
[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s)
Cited for : NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]
10.
[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s)
Cited for : NUCLEOTIDE SEQUENCE [GENOMIC DNA];VARIANTS ARG-13; PRO-51 AND ASN-60
11.
[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s)
Cited for : NUCLEOTIDE SEQUENCE [GENOMIC DNA];VARIANTS ARG-13; PRO-51 AND ASN-60
12.
[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s)
Cited for : NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA];VARIANT ARG-13
tissue :
Lymph .
13.
[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s)
Cited for : PARTIAL PROTEIN SEQUENCE;GLYCOSYLATION AT THR-41 AND ASN-96;VARIANT ASN-60
14.
[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s)
Cited for : X-RAY CRYSTALLOGRAPHY (1.9 ANGSTROMS)
15.
[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s)
Cited for : X-RAY CRYSTALLOGRAPHY (2.85 ANGSTROMS) OF 61-205 OF COMPLEX WITH TNFR1
16.
[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s)
Cited for : VARIANT ASN-60
17.
[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s)
Cited for : VARIANT PRO-125
18.
[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s)
Cited for : INVOLVEMENT IN PSORIATIC ARTHRITIS SUSCEPTIBILITY
19.
"Stepwise replication identifies a low-producing lymphotoxin-alpha allele as a major risk factor for early-onset leprosy."
Alcaies A.
,
Alter A.
,
Antoni G.
,
Orlova M.
,
Nguyen V.T.
,
Singh M.
,
Vanderborght P.R.
,
Katoch K.
,
Mira M.T.
,
Vu H.T.
,
Ngyuen T.H.
,
Nguyen N.B.
,
Moraes M.
,
Mehra N.
,
Schurr E.
,
Abel L.
Nat. Genet.39:517-522(2007)
[
PubMed ]
[
Europe PMC ]
[
Abstract ]
[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s)
Cited for : INVOLVEMENT IN LPRS4