Gene name:
Qki (Qk;Qk1;Qka1) ;
Protein name:
Protein quaking (MqkI;qkI) ;
Alternative:
Organism:
Mouse (Mus musculus).
General Annotation
Sub Unit:
Homodimer. Does not require RNA to homodimerize. Able to heterodimerize with BICC1.
Function:
RNA-binding protein that plays a central role in myelinization. Also required for visceral endoderm function and blood vessel development. Binds to the 5'-NACUAAY-N(1,20)-UAAY-3' RNA core sequence. Acts by regulating pre-mRNA splicing, mRNA export, mRNA stability and protein translation, as well as cellular processes including apoptosis, cell cycle, glial cell fate and development. Required to protect and promote stability of mRNAs such as MBP and CDKN1B which promotes oligodendrocyte differentiation. Participates in mRNA transport by regulating the nuclear export of MBP mRNA. Isoform 1 is involved in regulation of mRNA splicing of MAG pre-mRNA by acting as a negative regulator of MAG exon 12 alternative splicing. Isoform 3 can induce apoptosis, while heterodimerization with other isoforms results in nuclear translocation of isoform 3 and suppression of apoptosis. Isoform 4 acts as a translational repressor for GLI1. May also play a role in smooth muscle development.
Subcellular Location:
Isoform 4
Cytoplasm
Nucleus
Isoform 4 localizes both in the cytoplasm and nucleus.
Protein Attributes:
50:
MVGEMETKEK | PKPTPDYLMQ | LMNDKKLMSS | LPNFCGIFNH | LERLLDEEIS |
100:
RVRKDMYNDT | LNGSTEKRSA | ELPDAVGPIV | QLQEKLYVPV | KEYPDFNFVG |
150:
RILGPRGLTA | KQLEAETGCK | IMVRGKGSMR | DKKKEEQNRG | KPNWEHLNED |
200:
LHVLITVEDA | QNRAEIKLKR | AVEEVKKLLV | PAAEGEDSLK | KMQLMELAIL |
250:
NGTYRDANIK | SPALAFSLAA | TAQAAPRIIT | GPAPVLPPAA | LRTPTPAGPT |
300:
IMPLIRQIQT | AVMPNGTPHP | TAAIVPPGPE | AGLIYTPYEY | PYTLAPATSI |
341:
LEYPIEPSGV | LGAVATKVRR | HDMRVHPYQR | IVTADRAATG | N
Vaild Sequence:
Related Databases
Uniprot:
ELISA Kit
CLIA Kit
Polyclonal Antibody
Monoclonal Antibody
Protein
FOR
Dog
Rat
Mouse
Human
Bovine
Pig
Chicken
Polyclonal Antibody for Mouse MqkI
Polyclonal Antibody for Mouse MqkI
Polyclonal Antibody for Mouse MqkI
Polyclonal Antibody for Mouse MqkI
Polyclonal Antibody for Mouse MqkI
Polyclonal Antibody for Mouse MqkI
Polyclonal Antibody for Mouse MqkI
Monoclonal Antibody for Mouse MqkI
Monoclonal Antibody for Mouse MqkI
Monoclonal Antibody for Mouse MqkI
Monoclonal Antibody for Mouse MqkI
Monoclonal Antibody for Mouse MqkI
Monoclonal Antibody for Mouse MqkI
Monoclonal Antibody for Mouse MqkI
R&D Technical Data
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Precision
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Recovery
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Linearity
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References
1.
[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s)
Cited for : NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 3);INVOLVEMENT IN QKV;TISSUE SPECIFICITY;MUTAGENESIS OF GLU-48
2.
[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s)
Cited for : NUCLEOTIDE SEQUENCE [GENOMIC DNA / MRNA] (ISOFORMS 2; 3; 4 AND 7);ALTERNATIVE SPLICING (ISOFORM 1)
strain :
129/J .
3.
[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s)
Cited for : NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA];ALTERNATIVE SPLICING
strain :
C57BL/6J .
4.
"The transcriptional landscape of the mammalian genome."
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more...
Science309:1559-1563(2005)
[
PubMed ]
[
Europe PMC ]
[
Abstract ]
[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s)
Cited for : NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 43-341 (ISOFORM 1)
strain :
C57BL/6J .
tissue :
Cerebellum .
tissue :
Head .
5.
[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s)
Cited for : NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1)
strain :
C57BL/6 .
tissue :
Brain .
tissue :
Embryo .
6.
[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s)
Cited for : NUCLEOTIDE SEQUENCE [GENOMIC DNA] OF 49-341;ALTERNATIVE SPLICING (ISOFORMS 1; 3; 4 AND 8);MUTAGENESIS OF VAL-157
7.
[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s)
Cited for : SUBCELLULAR LOCATION;TISSUE SPECIFICITY
8.
[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s)
Cited for : SUBUNIT;INTERACTION WITH BICC1
9.
[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s)
Cited for : TISSUE SPECIFICITY
10.
[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s)
Cited for : SUBUNIT;MUTAGENESIS OF GLU-48
11.
[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s)
Cited for : SUBUNIT;SUBCELLULAR LOCATION;MUTAGENESIS OF GLU-48; ARG-324; TYR-328 AND ARG-330
12.
[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s)
Cited for : FUNCTION;RNA-BINDING
13.
[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s)
Cited for : FUNCTION
14.
[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s)
Cited for : FUNCTION;SUBCELLULAR LOCATION;SUBUNIT
15.
[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s)
Cited for : FUNCTION;RNA-BINDING;MUTAGENESIS OF VAL-157
16.
[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s)
Cited for : FUNCTION
17.
[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s)
Cited for : FUNCTION;MUTAGENESIS OF VAL-157
18.
[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s)
Cited for : PHOSPHORYLATION;MUTAGENESIS OF 276-PRO--PRO-279; TYR-285; TYR-288; TYR-290; TYR-292 AND TYR-303
19.
[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s)
Cited for : METHYLATION
20.
[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s)
Cited for : INVOLVEMENT IN QKV
21.
[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s)
Cited for : INVOLVEMENT IN QKV
22.
[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s)
Cited for : FUNCTION
23.
[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s)
Cited for : FUNCTION
24.
[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s)
Cited for : PHOSPHORYLATION
25.
[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s)
Cited for : FUNCTION;RNA-BINDING
26.
[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s)
Cited for : RNA-BINDING
27.
[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s)
Cited for : FUNCTION