QPCT ELISA Kit for Human(Homo sapiens) | EIAab.comQPCT ELISA Kit for Human(Homo sapiens)

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QPCT (Gene name),

Glutaminyl-peptide cyclotransferase (Protein name ), QPCT_HUMAN from NCBI database.

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General Annotation

Antigen Annotation

Predicted Eptitope

Vaild Sequence

Related Databases

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Gene name:

QPCT;

Protein name:

Glutaminyl-peptide cyclotransferase;

Alternative:

Glutaminyl-tRNA cyclotransferase;Glutaminyl cyclase(QC;sQC);Glutamyl cyclase(EC);

Organism:

Human (Homo sapiens).

General Annotation

Sub Unit:

N/A

Function:

Responsible for the biosynthesis of pyroglutamyl peptides. Has a bias against acidic and tryptophan residues adjacent to the N-terminal glutaminyl residue and a lack of importance of chain length after the second residue. Also catalyzes N-terminal pyroglutamate formation. In vitro, catalyzes pyroglutamate formation of N-terminally truncated form of APP amyloid-beta peptides [Glu-3]-beta-amyloid. May be involved in the N-terminal pyroglutamate formation of several amyloid-related plaque-forming peptides.

Subcellular Location:

Secreted

Protein Attributes:

Sequence length:

361

Sequence:

50:

100:

150:

200:

250:

300:

350:

361:

LQVFVLEYLH | L

3D Structure:

N/A

Predicted Eptitope:

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Vaild Sequence:

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Related Databases

UniGene:

Hs.79033

SMR:

Q16769

KEGG:

hsa:25797

String:

Q16769

MIM:

607065

STRING:

9606.ENSP00000344829

Pfam:

PF04389

Uniprot:

Q16769

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ELISA Kit for Human Glutaminyl-peptide cyclotransferase

Cat.:

E2087m

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96T

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ELISA Kit for Human Glutaminyl-peptide cyclotransferase

Cat.:

E2087b

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96T

ELISA Kit for Human Glutaminyl-peptide cyclotransferase

Cat.:

E2087h

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96T

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CLIA Kit for Human Glutaminyl-peptide cyclotransferase

Cat.:

U2087h

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96T

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CLIA Kit for Human Glutaminyl-peptide cyclotransferase

Cat.:

U2087m

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Packing:

96T

CLIA Kit for Human Glutaminyl-peptide cyclotransferase

Cat.:

U2087b

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MSDS:

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Packing:

96T

Polyclonal Antibody for Human Glutaminyl-peptide cyclotransferase

Cat.:

P2087Rb-m

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40ug/0.2ml

Polyclonal Antibody for Human Glutaminyl-peptide cyclotransferase

Cat.:

P2087Rb-h

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Packing:

40ug/0.2ml

Polyclonal Antibody for Human Glutaminyl-peptide cyclotransferase

Monoclonal Antibody for Human Glutaminyl-peptide cyclotransferase

Protein for Human Glutaminyl-peptide cyclotransferase

R&D Technical Data

For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.

Precision

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Recovery

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Linearity

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References

1.

"Molecular cloning, sequence analysis and expression of human pituitary glutaminyl cyclase."
Song I. , Chuang C.Z. , Bateman R.C. Jr.
J. Mol. Endocrinol.13:77-86(1994) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1)
tissue: Pituitary.
2.

"Complete sequencing and characterization of 21,243 full-length human cDNAs."
Ota T. , Suzuki Y. , Nishikawa T. , Otsuki T. , Sugiyama T. , Irie R. , Wakamatsu A. , Hayashi K. , Sato H. , Nagai K. , Kimura K. , Makita H. , Sekine M. , Obayashi M. , Nishi T. , Shibahara T. , Tanaka T. , Ishii S. , more...
Nat. Genet.36:40-45(2004) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1)
tissue: Heart.
3.

"Generation and annotation of the DNA sequences of human chromosomes 2 and 4."
Hillier L.W. , Graves T.A. , Fulton R.S. , Fulton L.A. , Pepin K.H. , Minx P. , Wagner-McPherson C. , Layman D. , Wylie K. , Sekhon M. , Becker M.C. , Fewell G.A. , Delehaunty K.D. , Miner T.L. , Nash W.E. , Kremitzki C. , Oddy L. , Du H. , more...
Nature434:724-731(2005) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]
4.

Mural R.J. , Istrail S. , Sutton G. , Florea L. , Halpern A.L. , Mobarry C.M. , Lippert R. , Walenz B. , Shatkay H. , Dew I. , Miller J.R. , Flanigan M.J. , Edwards N.J. , Bolanos R. , Fasulo D. , Halldorsson B.V. , Hannenhalli S. , Turner R. , more...
Submitted (2005-09) to the EMBL/GenBank/DDBJ databases

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]
5.

"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
The MGC Project Team
Genome Res.14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1);VARIANT PRO-360
tissue: Lung.
tissue: Pancreas.
6.

"Glutaminyl cyclases unfold glutamyl cyclase activity under mild acid conditions."
Schilling S. , Hoffmann T. , Manhart S. , Hoffmann M. , Demuth H.U.
FEBS Lett.563:191-196(2004) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: FUNCTION AS GLUTAMYL CYCLASE
7.

"Isolation of an isoenzyme of human glutaminyl cyclase: retention in the Golgi complex suggests involvement in the protein maturation machinery."
Cynis H. , Rahfeld J.U. , Stephan A. , Kehlen A. , Koch B. , Wermann M. , Demuth H.U. , Schilling S.
J. Mol. Biol.379:966-980(2008) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: FUNCTION;CATALYTIC ACTIVITY;SUBCELLULAR LOCATION
8.

"Crystal structures of human glutaminyl cyclase, an enzyme responsible for protein N-terminal pyroglutamate formation."
Huang K.-F. , Liu Y.-L. , Cheng W.-J. , Ko T.-P. , Wang A.H.-J.
Proc. Natl. Acad. Sci. U.S.A.102:13117-13122(2005) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: X-RAY CRYSTALLOGRAPHY (1.66 ANGSTROMS) OF 33-361;CATALYTIC ACTIVITY;MUTAGENESIS OF LYS-144; PHE-146; GLU-201; TRP-207; ASP-248; GLN-304; ASP-305; PHE-325 AND TRP-329;CHARACTERIZATION OF VARIANT TRP-54
9.

"A conserved hydrogen-bond network in the catalytic centre of animal glutaminyl cyclases is critical for catalysis."
Huang K.F. , Wang Y.R. , Chang E.C. , Chou T.L. , Wang A.H.
Biochem. J.411:181-190(2008) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: X-RAY CRYSTALLOGRAPHY (1.66 ANGSTROMS) OF 33-361 OF MUTANTS ALA-160; GLY-160; ASP-201; LEU-201; GLN-201; ALA-248; GLN-248; ALA-305; GLU-305 AND LEU-319 IN COMPLEX WITH ZINC IONS;CATALYTIC ACTIVITY;COFACTOR;ACTIVE SITE;MUTAGENESIS OF SER-160; GLU-201; ASP-248; ASP-305 AND HIS-319
10.

"Structures of glycosylated mammalian glutaminyl cyclases reveal conformational variability near the active center."
Ruiz-Carrillo D. , Koch B. , Parthier C. , Wermann M. , Dambe T. , Buchholz M. , Ludwig H.H. , Heiser U. , Rahfeld J.U. , Stubbs M.T. , Schilling S. , Demuth H.U.
Biochemistry50:6280-6288(2011) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: X-RAY CRYSTALLOGRAPHY (2.1 ANGSTROMS) OF 38-361;GLYCOSYLATION AT ASN-49;DISULFIDE BOND
11.

"Structures of human Golgi-resident glutaminyl cyclase and its complexes with inhibitors reveal a large loop movement upon inhibitor binding."
Huang K.F. , Liaw S.S. , Huang W.L. , Chia C.Y. , Lo Y.C. , Chen Y.L. , Wang A.H.
J. Biol. Chem.286:12439-12449(2011) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: X-RAY CRYSTALLOGRAPHY (1.95 ANGSTROMS) OF 33-361 IN COMPLEX WITH ZINC IONS;CATALYTIC ACTIVITY;FUNCTION;COFACTOR

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