Ager ELISA Kit for Mouse(Mus musculus) | EIAab.comAger ELISA Kit for Mouse(Mus musculus)

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Ager (Gene name),

Advanced glycosylation end product-specific receptor (Protein name ), RAGE_MOUSE from NCBI database.

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General Annotation

Antigen Annotation

Predicted Eptitope

Vaild Sequence

Related Databases

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Gene name:

Ager(Rage);

Protein name:

Advanced glycosylation end product-specific receptor;

Alternative:

Receptor for advanced glycosylation end products;

Organism:

Mouse (Mus musculus).

General Annotation

Sub Unit:

Interacts with S100B and S100A1 (By similarity). Interacts with S100A12 and APP.

Function:

Mediates interactions of advanced glycosylation end products (AGE). These are nonenzymatically glycosylated proteins which accumulate in vascular tissue in aging and at an accelerated rate in diabetes. Acts as a mediator of both acute and chronic vascular inflammation in conditions such as atherosclerosis and in particular as a complication of diabetes. AGE/RAGE signaling plays an important role in regulating the production/expression of TNF-alpha, oxidative stress, and endothelial dysfunction in type 2 diabetes. Interaction with S100A12 on endothelium, mononuclear phagocytes, and lymphocytes triggers cellular activation, with generation of key proinflammatory mediators. Interaction with S100B after myocardial infarction may play a role in myocyte apoptosis by activating ERK1/2 and p53/TP53 signaling. Receptor for amyloid beta peptide. Contributes to the translocation of amyloid-beta peptide (ABPP) across the cell membrane from the extracellular to the intracellular space in cortical neurons. ABPP-initiated RAGE signaling, especially stimulation of p38 mitogen-activated protein kinase (MAPK), has the capacity to drive a transport system delivering ABPP as a complex with RAGE to the intraneuronal space. RAGE-dependent signaling in microglia contributes to neuroinflammation, amyloid accumulation, and impaired learning/memory in a mouse model of Alzheimer disease.

Subcellular Location:

Membrane Single-pass type I membrane protein

Protein Attributes:

Sequence length:

403

Sequence:

50:

100:

150:

200:

250:

300:

350:

400:

403:

GGP

3D Structure:

N/A

Predicted Eptitope:

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Vaild Sequence:

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Related Databases

Pfam:

PF08205

UniGene:

Mm.3383

SMR:

Q62151

String:

Q62151

STRING:

10090.ENSMUSP00000015596

Uniprot:

Q62151

FOR

ELISA Kit for Mouse Advanced glycosylation end product-specific receptor

Cat.:

E1956h

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Manual:

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Packing:

96T

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ELISA Kit for Mouse Advanced glycosylation end product-specific receptor

Cat.:

E1956m

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MSDS:

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Packing:

96T

ELISA Kit for Mouse Advanced glycosylation end product-specific receptor

Cat.:

E1956r

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Packing:

96T

ELISA Kit for Mouse Advanced glycosylation end product-specific receptor

Cat.:

E1956b

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MSDS:

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Packing:

96T

CLIA Kit for Mouse Advanced glycosylation end product-specific receptor

Cat.:

U1956m

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MSDS:

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Packing:

96T

CLIA Kit for Mouse Advanced glycosylation end product-specific receptor

Cat.:

U1956h

Price:

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Manual:

Looking for manual.

MSDS:

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Packing:

96T

Range:

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CLIA Kit for Mouse Advanced glycosylation end product-specific receptor

Cat.:

U1956b

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MSDS:

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Packing:

96T

CLIA Kit for Mouse Advanced glycosylation end product-specific receptor

Cat.:

U1956r

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96T

Polyclonal Antibody for Mouse Advanced glycosylation end product-specific receptor

Cat.:

P1956Rb-m

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Packing:

40ug/0.2ml

Polyclonal Antibody for Mouse Advanced glycosylation end product-specific receptor

Cat.:

P1956Rb-h

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40ug/0.2ml

Polyclonal Antibody for Mouse Advanced glycosylation end product-specific receptor

Cat.:

P1956Rb-r

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Packing:

40ug/0.2ml

Monoclonal Antibody for Mouse Advanced glycosylation end product-specific receptor

Protein for Mouse Advanced glycosylation end product-specific receptor

R&D Technical Data

For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.

Precision

For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.

Recovery

For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.

Linearity

For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.

References

1.

"Recombinant advanced glycation end product receptor pharmacokinetics in normal and diabetic rats."
Renard C. , Chappey O. , Wautier M.P. , Nagashima M. , Lundh E. , Morser J. , Zhao L. , Schmidt A.M. , Scherrmann J.M. , Wautier J.-L.
Mol. Pharmacol.52:54-62(1997) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [MRNA]
strain: BALB/c.
tissue: Lung.
2.

"RAGE mediates a novel proinflammatory axis: a central cell surface receptor for S100/calgranulin polypeptides."
Hofmann M.A. , Drury S. , Fu C. , Qu W. , Taguchi A. , Lu Y. , Avila C. , Kambham N. , Bierhaus A. , Nawroth P. , Neurath M.F. , Slattery T. , Beach D. , McClary J. , Nagashima M. , Morser J. , Stern D. , Schmidt A.M.
Cell97:889-901(1999) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: FUNCTION;INTERACTION WITH S100A12
tissue: Lung.
3.

"AGE/RAGE produces endothelial dysfunction in coronary arterioles in type 2 diabetic mice."
Gao X. , Zhang H. , Schmidt A.M. , Zhang C.
Am. J. Physiol.295:H491-H498(2008) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: FUNCTION;TISSUE SPECIFICITY
4.

"RAGE-mediated signaling contributes to intraneuronal transport of amyloid-{beta} and neuronal dysfunction."
Takuma K. , Fang F. , Zhang W. , Yan S. , Fukuzaki E. , Du H. , Sosunov A. , McKhann G. , Funatsu Y. , Nakamichi N. , Nagai T. , Mizoguchi H. , Ibi D. , Hori O. , Ogawa S. , Stern D.M. , Yamada K. , Yan S.S.
Proc. Natl. Acad. Sci. U.S.A.106:20021-20026(2009) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: FUNCTION;INTERACTION WITH APP
5.

"RAGE-dependent signaling in microglia contributes to neuroinflammation, Abeta accumulation, and impaired learning/memory in a mouse model of Alzheimer's disease."
Fang F. , Lue L.-F. , Yan S. , Xu H. , Luddy J.S. , Chen D. , Walker D.G. , Stern D.M. , Yan S. , Schmidt A.M. , Chen J.X. , Yan S.S.
FASEB J.24:1043-1055(2010) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: FUNCTION

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