Protein name:
Advanced glycosylation end product-specific receptor ;
Alternative:
Receptor for advanced glycosylation end products ;
Organism:
Rat (Rattus norvegicus).
General Annotation
Sub Unit:
Interacts with S100A12 and APP (By similarity). Interacts with S100B and S100A1.
Function:
Mediates interactions of advanced glycosylation end products (AGE). These are nonenzymatically glycosylated proteins which accumulate in vascular tissue in aging and at an accelerated rate in diabetes. Acts as a mediator of both acute and chronic vascular inflammation in conditions such as atherosclerosis and in particular as a complication of diabetes. AGE/RAGE signaling plays an important role in regulating the production/expression of TNF-alpha, oxidative stress, and endothelial dysfunction in type 2 diabetes. Interaction with S100A12 on endothelium, mononuclear phagocytes, and lymphocytes triggers cellular activation, with generation of key proinflammatory mediators. Receptor for amyloid beta peptide. Contributes to the translocation of amyloid-beta peptide (ABPP) across the cell membrane from the extracellular to the intracellular space in cortical neurons. ABPP-initiated RAGE signaling, especially stimulation of p38 mitogen-activated protein kinase (MAPK), has the capacity to drive a transport system delivering ABPP as a complex with RAGE to the intraneuronal space (By similarity). Interaction with S100B after myocardial infarction may play a role in myocyte apoptosis by activating ERK1/2 and p53/TP53 signaling.
Subcellular Location:
Membrane
Single-pass type I membrane protein
Protein Attributes:
50:
MPTGTVARAW | VLVLALWGAV | AGGQNITARI | GEPLMLSCKG | APKKPTQKLE |
100:
WKLNTGRTEA | WKVLSPQGDP | WDSVARILPN | GSLLLPAIGI | VDEGTFRCRA |
150:
TNRLGKEVKS | NYRVRVYQIP | GKPEIVNPAS | ELTANVPNKV | GTCVSEGSYP |
200:
AGTLSWHLDG | KPLIPDGKGT | VVKEETRRHP | ETGLFTLRSE | LTVTPAQGGT |
250:
TPTYSCSFSL | GLPRRRPLNT | APIQPRVREP | LPPEGIQLLV | EPEGGTVAPG |
300:
GTVTLTCAIS | AQPPPQIHWI | KDGTPLPLAP | SPVLLLPEVG | HEDEGIYSCV |
350:
ATHPSHGPQE | SPPVNIRVTE | TGDEGQAAGS | VDGSGLGTLA | LALGILGGLG |
400:
IAALLIGAIL | WRKRQPRLEE | RKAPESQEDE | EERAELNQSE | EAEMPENGAG |
Vaild Sequence:
Related Databases
Uniprot:
ELISA Kit
CLIA Kit
Polyclonal Antibody
Monoclonal Antibody
Protein
FOR
Human
Mouse
Rat
Bovine
ELISA Kit for Rat Advanced glycosylation end product-specific receptor
ELISA Kit for Rat Advanced glycosylation end product-specific receptor
ELISA Kit for Rat Advanced glycosylation end product-specific receptor
ELISA Kit for Rat Advanced glycosylation end product-specific receptor
CLIA Kit for Rat Advanced glycosylation end product-specific receptor
CLIA Kit for Rat Advanced glycosylation end product-specific receptor
CLIA Kit for Rat Advanced glycosylation end product-specific receptor
CLIA Kit for Rat Advanced glycosylation end product-specific receptor
Polyclonal Antibody for Rat Advanced glycosylation end product-specific receptor
Polyclonal Antibody for Rat Advanced glycosylation end product-specific receptor
Polyclonal Antibody for Rat Advanced glycosylation end product-specific receptor
Polyclonal Antibody for Rat Advanced glycosylation end product-specific receptor
Monoclonal Antibody for Rat Advanced glycosylation end product-specific receptor
Monoclonal Antibody for Rat Advanced glycosylation end product-specific receptor
Monoclonal Antibody for Rat Advanced glycosylation end product-specific receptor
Monoclonal Antibody for Rat Advanced glycosylation end product-specific receptor
Protein for Rat Advanced glycosylation end product-specific receptor
Protein for Rat Advanced glycosylation end product-specific receptor
Protein for Rat Advanced glycosylation end product-specific receptor
Protein for Rat Advanced glycosylation end product-specific receptor
R&D Technical Data
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Precision
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Recovery
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Linearity
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References
1.
[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s)
Cited for : NUCLEOTIDE SEQUENCE [MRNA]
strain :
Sprague-Dawley .
tissue :
Lung .
2.
[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s)
Cited for : FUNCTION;SUBCELLULAR LOCATION;INTERACTION WITH S100B AND S100A1;INDUCTION;TISSUE SPECIFICITY