RARB ELISA Kit for Human(Homo sapiens) | EIAab.comRARB ELISA Kit for Human(Homo sapiens) | EIAab.com

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RARB (Gene name),

Retinoic acid receptor beta (Protein name ), RARB_HUMAN from NCBI database.

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General Annotation

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Antigen Annotation

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3D

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Predicted Eptitope

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Vaild Sequence

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Gene name:

RARB(HAP;NR1B2);

Protein name:

Retinoic acid receptor beta(RAR-beta);

Alternative:

Nuclear receptor subfamily 1 group B member 2;HBV-activated protein;RAR-epsilon;

Organism:

Human (Homo sapiens).

General Annotation

Sub Unit:

Homodimer (By similarity). Heterodimer; with a RXR molecule. Binds DNA preferentially as a RAR/RXR heterodimer (By similarity). Interacts weakly with NCOR2.

Function:

Receptor for retinoic acid. Retinoic acid receptors bind as heterodimers to their target response elements in response to their ligands, all-trans or 9-cis retinoic acid, and regulate gene expression in various biological processes. The RXR/RAR heterodimers bind to the retinoic acid response elements (RARE) composed of tandem 5'-AGGTCA-3' sites known as DR1-DR5. In the absence or presence of hormone ligand, acts mainly as an activator of gene expression due to weak binding to corepressors. In concert with RARG, required for skeletal growth, matrix homeostasis and growth plate function.

Subcellular Location:

Isoform Beta-4 Cytoplasm

Protein Attributes:

Sequence length:

455

Sequence:

50:

MTTSGHACPV | PAVNGHMTHY | PATPYPLLFP | PVIGGLSLPP | LHGLHGHPPP |

100:

SGCSTPSPAT | IETQSTSSEE | LVPSPPSPLP | PPRVYKPCFV | CQDKSSGYHY |

150:

GVSACEGCKG | FFRRSIQKNM | IYTCHRDKNC | VINKVTRNRC | QYCRLQKCFE |

200:

VGMSKESVRN | DRNKKKKETS | KQECTESYEM | TAELDDLTEK | IRKAHQETFP |

250:

SLCQLGKYTT | NSSADHRVRL | DLGLWDKFSE | LATKCIIKIV | EFAKRLPGFT |

300:

GLTIADQITL | LKAACLDILI | LRICTRYTPE | QDTMTFSDGL | TLNRTQMHNA |

350:

GFGPLTDLVF | TFANQLLPLE | MDDTETGLLS | AICLICGDRQ | DLEEPTKVDK |

400:

LQEPLLEALK | IYIRKRRPSK | PHMFPKILMK | ITDLRSISAK | GAERVITLKM |

450:

EIPGSMPPLI | QEMLENSEGH | EPLTPSSSGN | TAEHSPSISP | SSVENSGVSQ |

455:

SPLVQ

3D Structure:

N/A

Predicted Eptitope:

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Vaild Sequence:

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Related Databases

String:

KEGG:

SMR:

Pfam:

STRING:

9606.ENSP00000332296

MIM:

UniGene:

Uniprot:

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ELISA Kit for Human RAR-beta

Cat.:

E10642m

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Manual:

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MSDS:

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Packing:

96T

Range:

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ELISA Kit for Human RAR-beta

Cat.:

E10642h

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Packing:

96T

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ELISA Kit for Human RAR-beta

MSDS:

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CLIA Kit for Human RAR-beta

MSDS:

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CLIA Kit for Human RAR-beta

Cat.:

U10642h

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Manual:

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96T

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CLIA Kit for Human RAR-beta

Cat.:

U10642m

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96T

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Polyclonal Antibody for Human RAR-beta

Polyclonal Antibody for Human RAR-beta

Polyclonal Antibody for Human RAR-beta

Cat.:

P10642Rb-h

Price:

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Packing:

40ug/0.2ml

Monoclonal Antibody for Human RAR-beta

Monoclonal Antibody for Human RAR-beta

Monoclonal Antibody for Human RAR-beta

Protein for Human RAR-beta

Protein for Human RAR-beta

Protein for Human RAR-beta

R&D Technical Data

s

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For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.

For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.

For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.

s

For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.

For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.

For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.

For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.

For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.

For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.

For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.

For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.

For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.

Precision

Intra-assay Precision (Precision within an assay):Three samples of known concentration were tested twenty times on one plate to assess intra-assay precision.

Intra-Assay CV: ≤5.8%

Inter-assay Precision (Precision between assays):Three samples of known concentration were tested in five separate assays to assess inter-assay precision.

Inter-Assay CV: ≤7.2%

For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.

For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.

For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.

For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.

Intra-assay Precision (Precision within an assay):Three samples of known concentration were tested twenty times on one plate to assess intra-assay precision.

Intra-Assay CV: ≤3.9%

Inter-assay Precision (Precision between assays):Three samples of known concentration were tested in five separate assays to assess inter-assay precision.

Inter-Assay CV: ≤7.7%

For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.

For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.

For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.

For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.

For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.

For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.

For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.

For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.

For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.

Recovery

Recovery was determined by spiking various levels of RARB into serum and plasma .

Sample Type	Average(%)	Recovery Range(%)
Serum	96	92-103
Plasma	98	93-105

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Recovery was determined by spiking various levels of ACE into serum and plasma .

Sample Type	Average(%)	Recovery Range(%)
Serum	99	91-103
Plasma	98	93-106

For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.

For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.

For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.

For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.

For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.

For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.

For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.

For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.

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Linearity

The linearity of the kit was assayed by testing samples spiked with appropriate concentration of RARB and their serial dilutions. The results were demonstrated by the percentage of calculated concentration to the expected.

Sample	1：2	1:4	1:8	1:16
serum(n=5)	90-102%	92-101%	91-99%	93-100%
EDTA plasma(n=5)	94-103%	91-105%	92-106%	94-102%
heparin plasma(n=5)	93-105%	90-107%	95-101%	91-107%

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For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.

For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.

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The linearity of the kit was assayed by testing samples spiked with appropriate concentration of ACE and their serial dilutions. The results were demonstrated by the percentage of calculated concentration to the expected.

Sample	1：2	1:4	1:8	1:16
serum(n=5)	92-105%	90-101%	95-105%	92-109%
EDTA plasma(n=5)	89-95%	93105%	89-94%	90-106%
heparin plasma(n=5)	93-104%	94-110%	101-111%	91-110%

For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.

For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.

For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.

For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.

For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.

For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.

For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.

For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.

For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.

References

1.

"A new retinoic acid receptor identified from a hepatocellular carcinoma."
Benbrook D. , Lernherdt E. , Pfahl M.
Nature333:669-672(1988) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM BETA-2)
tissue: Placenta.
2.

"A novel steroid thyroid hormone receptor-related gene inappropriately expressed in human hepatocellular carcinoma."
de The H. , Marchio A. , Tiollais P. , Dejean A.
Nature330:667-670(1987) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM BETA-2)
3.

"Elevated retinoic acid receptor beta(4) protein in human breast tumor cells with nuclear and cytoplasmic localization."
Sommer K.M. , Chen L.I. , Treuting P.M. , Smith L.T. , Swisshelm K.
Proc. Natl. Acad. Sci. U.S.A.96:8651-8656(1999) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM BETA-4)
tissue: Mammary tumor.
4.

"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
The MGC Project Team
Genome Res.14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM BETA-2)
tissue: Placenta.
5.

"Mouse and human retinoic acid receptor beta 2 promoters: sequence comparison and localization of retinoic acid responsiveness."
Shen S. , Kruyt F.A. , den Hertog J. , van der Saag P.T. , Kruijer W.
DNA Seq.2:111-119(1991) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA] OF 1-52 (ISOFORM BETA-2)
6.

"Fetal isoform of human retinoic acid receptor beta expressed in small cell lung cancer lines."
Houle B. , Pelletier M. , Wu J. , Goodyer C. , Bradley W.E.
Cancer Res.54:365-369(1994) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA] OF 1-72 (ISOFORM BETA-1)
7.

"Hepatitis B virus DNA integration in a sequence homologous to v-erb-A and steroid receptor genes in a hepatocellular carcinoma."
Dejean A. , Bougueleret L. , Grzeschik K.-H. , Tiollais P.
Nature322:70-72(1986) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA] OF 61-109
8.

"Hepatitis B virus as an insertional mutagene in a human hepatocellular carcinoma."
Dejean A. , de The H.
Mol. Biol. Med.7:213-222(1990) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA] OF 61-109
tissue: Liver.
9.

"Identification of a second human retinoic acid receptor."
Brand N. , Petkovitch M. , Krust A. , Chambon P. , de The H. , Marchio A. , Tiollais P. , Dejean A.
Nature332:850-853(1988) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: IDENTIFICATION OF LIGAND
10.

"Retinoic acid receptors beta and gamma do not repress, but instead activate target gene transcription in both the absence and presence of hormone ligand."
Hauksdottir H. , Farboud B. , Privalsky M.L.
Mol. Endocrinol.17:373-385(2003) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: FUNCTION;HETERODIMERIZATION;INTERACTION WITH NCOR2;MUTAGENESIS OF THR-188; ILE-191; LEU-222; GLY-223 AND ALA-232
11.

"Homo- and heteronuclear NMR studies of the human retinoic acid receptor beta DNA-binding domain: sequential assignments and identification of secondary structure elements."
Kathira M. , Knegtel R.M.A. , Boelens R. , Eib D. , Schilthuis J.G. , van der Saag P.T. , Kaptein R.
Biochemistry31:6474-6480(1992) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: STRUCTURE BY NMR OF 82-160
12.

"The solution structure of the human retinoic acid receptor-beta DNA-binding domain."
Knegtel R.M.A. , Katahira M. , Schilthuis J.G. , Bonvin A.M. , Boelens R. , Eib D. , van der Saag P.T. , Kaptein R.
J. Biomol. NMR3:1-17(1993) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: STRUCTURE BY NMR OF 82-160
13.

"The consensus coding sequences of human breast and colorectal cancers."
Sjoeblom T. , Jones S. , Wood L.D. , Parsons D.W. , Lin J. , Barber T.D. , Mandelker D. , Leary R.J. , Ptak J. , Silliman N. , Szabo S. , Buckhaults P. , Farrell C. , Meeh P. , Markowitz S.D. , Willis J. , Dawson D. , Willson J.K.V. , more...
Science314:268-274(2006) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: VARIANT [LARGE SCALE ANALYSIS] ILE-90
14.

"Recessive and dominant mutations in retinoic acid receptor beta in cases with microphthalmia and diaphragmatic hernia."
Srour M. , Chitayat D. , Caron V. , Chassaing N. , Bitoun P. , Patry L. , Cordier M.P. , Capo-Chichi J.M. , Francannet C. , Calvas P. , Ragge N. , Dobrzeniecka S. , Hamdan F.F. , Rouleau G.A. , Tremblay A. , Michaud J.L.
Am. J. Hum. Genet.93:765-772(2013) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: VARIANTS MCOPS12 SER-394 AND CYS-394;CHARACTERIZATION OF VARIANTS MCOPS12 SER-394 AND CYS-394

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