RBL1 ELISA Kit for Human(Homo sapiens) | EIAab.comRBL1 ELISA Kit for Human(Homo sapiens)

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RBL1 (Gene name),

Retinoblastoma-like protein 1 (Protein name ), RBL1_HUMAN from NCBI database.

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General Annotation

Antigen Annotation

Predicted Eptitope

Vaild Sequence

Related Databases

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Gene name:

RBL1;

Protein name:

Retinoblastoma-like protein 1;

Alternative:

pRb1;107 kDa retinoblastoma-associated protein(p107);

Organism:

Human (Homo sapiens).

General Annotation

Sub Unit:

Interacts with SUV420H1, SUV420H2 and USP4 (By similarity). Component of the DREAM complex (also named LINC complex) at least composed of E2F4, E2F5, LIN9, LIN37, LIN52, LIN54, MYBL1, MYBL2, RBL1, RBL2, RBBP4, TFDP1 and TFDP2. The complex exists in quiescent cells where it represses cell cycle-dependent genes. It dissociates in S phase when LIN9, LIN37, LIN52 and LIN54 form a subcomplex that binds to MYBL2. Interacts with AATF. Interacts with KDM5A. Interacts with SV40 and JC virus large T antigens.

Function:

Key regulator of entry into cell division. Directly involved in heterochromatin formation by maintaining overall chromatin structure and, in particular, that of constitutive heterochromatin by stabilizing histone methylation. Recruits and targets histone methyltransferases SUV420H1 and SUV420H2, leading to epigenetic transcriptional repression. Controls histone H4 'Lys-20' trimethylation. Probably acts as a transcription repressor by recruiting chromatin-modifying enzymes to promoters. Potent inhibitor of E2F-mediated trans-activation. Forms a complex with adenovirus E1A and with SV40 large T antigen. May bind and modulate functionally certain cellular proteins with which T and E1A compete for pocket binding. May act as a tumor suppressor.

Subcellular Location:

Nucleus

Protein Attributes:

Sequence length:

1068

Sequence:

50:

100:

150:

200:

250:

300:

350:

400:

450:

500:

550:

600:

650:

700:

750:

800:

850:

900:

950:

1000:

1050:

1068:

DDVLLKRLQD | VVSERANH

3D Structure:

N/A

Predicted Eptitope:

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Vaild Sequence:

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Related Databases

Pfam:

PF11934

STRING:

9606.ENSP00000362768

MIM:

116957

String:

P28749

SMR:

P28749

KEGG:

hsa:5933

UniGene:

Hs.207745

Uniprot:

P28749

FOR

ELISA Kit for Human Retinoblastoma-like protein 1

Cat.:

E1211h

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96T

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ELISA Kit for Human Retinoblastoma-like protein 1

Cat.:

E1211m

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Packing:

96T

CLIA Kit for Human Retinoblastoma-like protein 1

Cat.:

U1211h

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Manual:

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Packing:

96T

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CLIA Kit for Human Retinoblastoma-like protein 1

Cat.:

U1211m

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Packing:

96T

Polyclonal Antibody for Human Retinoblastoma-like protein 1

Cat.:

P1211Rb-h

Price:

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Packing:

40ug/0.2ml

Polyclonal Antibody for Human Retinoblastoma-like protein 1

Cat.:

P1211Rb-m

Price:

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Packing:

40ug/0.2ml

Monoclonal Antibody for Human Retinoblastoma-like protein 1

Protein for Human Retinoblastoma-like protein 1

R&D Technical Data

For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.

Precision

For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.

Recovery

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Linearity

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References

1.

"Inhibition of cell proliferation by p107, a relative of the retinoblastoma protein."
Zhu L. , van den Heuvel S. , Helin K. , Fattaey A. , Ewen M. , Livingston D. , Dyson N. , Harlow E.
Genes Dev.7:1111-1125(1993) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1)
2.

"Complete sequencing and characterization of 21,243 full-length human cDNAs."
Ota T. , Suzuki Y. , Nishikawa T. , Otsuki T. , Sugiyama T. , Irie R. , Wakamatsu A. , Hayashi K. , Sato H. , Nagai K. , Kimura K. , Makita H. , Sekine M. , Obayashi M. , Nishi T. , Shibahara T. , Tanaka T. , Ishii S. , more...
Nat. Genet.36:40-45(2004) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1)
tissue: Tongue.
3.

"The DNA sequence and comparative analysis of human chromosome 20."
Deloukas P. , Matthews L.H. , Ashurst J.L. , Burton J. , Gilbert J.G.R. , Jones M. , Stavrides G. , Almeida J.P. , Babbage A.K. , Bagguley C.L. , Bailey J. , Barlow K.F. , Bates K.N. , Beard L.M. , Beare D.M. , Beasley O.P. , Bird C.P. , Blakey S.E. , more...
Nature414:865-871(2001) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]
4.

Mural R.J. , Istrail S. , Sutton G.G. , Florea L. , Halpern A.L. , Mobarry C.M. , Lippert R. , Walenz B. , Shatkay H. , Dew I. , Miller J.R. , Flanigan M.J. , Edwards N.J. , Bolanos R. , Fasulo D. , Halldorsson B.V. , Hannenhalli S. , Turner R. , more...
Submitted (2005-09) to the EMBL/GenBank/DDBJ databases

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]
5.

"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
The MGC Project Team
Genome Res.14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 2)
tissue: Testis.
6.

"Molecular cloning, chromosomal mapping, and expression of the cDNA for p107, a retinoblastoma gene product-related protein."
Ewen M.E. , Xing Y. , Lawrence J.B. , Livingston D.M.
Cell66:1155-1164(1991) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [MRNA] OF 134-1068 (ISOFORM 1);PARTIAL PROTEIN SEQUENCE
7.

"Differential roles of two tandem E2F sites in repression of the human p107 promoter by retinoblastoma and p107 proteins."
Zhu L. , Zhu L. , Xie E. , Chang L.S.
Mol. Cell. Biol.15:3552-3562(1995) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA] OF 1-52
8.

"Reversal of growth suppression by p107 via direct phosphorylation by cyclin D1/cyclin-dependent kinase 4."
Leng X. , Noble M. , Adams P.D. , Qin J. , Harper J.W.
Mol. Cell. Biol.22:2242-2254(2002) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: PROTEIN SEQUENCE OF 320-334; 364-374; 635-657; 949-977 AND 1006-1012;PHOSPHORYLATION AT THR-332; THR-369; THR-385; SER-640; SER-762; SER-964; SER-975; SER-988; THR-997 AND SER-1009;MUTAGENESIS OF SER-640; SER-643; SER-650 AND 657-LYS--LEU-660;IDENTIFICATION BY MASS SPECTROMETRY
9.

"The cellular 107K protein that binds to adenovirus E1A also associates with the large T antigens of SV40 and JC virus."
Dyson N. , Buchkovich K. , Whyte P. , Harlow E.
Cell58:249-255(1989) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: INTERACTION WITH SV40 AND JC VIRUS LARGE T ANTIGEN
10.

"Differential specificity for binding of retinoblastoma binding protein 2 to RB, p107, and TATA-binding protein."
Kim Y.W. , Otterson G.A. , Kratzke R.A. , Coxon A.B. , Kaye F.J.
Mol. Cell. Biol.14:7256-7264(1994) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: INTERACTION WITH KDM5A
11.

"Che-1 affects cell growth by interfering with the recruitment of HDAC1 by Rb."
Bruno T. , De Angelis R. , De Nicola F. , Barbato C. , Di Padova M. , Corbi N. , Libri V. , Benassi B. , Mattei E. , Chersi A. , Soddu S. , Floridi A. , Passananti C. , Fanciulli M.
Cancer Cell2:387-399(2002) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: INTERACTION WITH AATF
12.

"Distinct phosphorylation events regulate p130- and p107-mediated repression of E2F-4."
Farkas T. , Hansen K. , Holm K. , Lukas J. , Bartek J.
J. Biol. Chem.277:26741-26752(2002) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: PHOSPHORYLATION AT THR-369 AND SER-650
13.

"Structure of the Rb C-terminal domain bound to E2F1-DP1: a mechanism for phosphorylation-induced E2F release."
Rubin S.M. , Gall A.-L. , Zheng N. , Pavletich N.P.
Cell123:1093-1106(2005) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: INTERACTION WITH WITH E2F4 AND TFDP1
14.

"LINC, a human complex that is related to pRB-containing complexes in invertebrates regulates the expression of G2/M genes."
Schmit F. , Korenjak M. , Mannefeld M. , Schmitt K. , Franke C. , von Eyss B. , Gagrica S. , Haenel F. , Brehm A. , Gaubatz S.
Cell Cycle6:1903-1913(2007) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: IDENTIFICATION IN THE DREAM COMPLEX
15.

"Quantitative phosphoproteomic analysis of T cell receptor signaling reveals system-wide modulation of protein-protein interactions."
Mayya V. , Lundgren D.H. , Hwang S.-I. , Rezaul K. , Wu L. , Eng J.K. , Rodionov V. , Han D.K.
Sci. Signal.2:RA46-RA46(2009) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT THR-385; SER-749 AND SER-762;IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS]
tissue: Leukemic T-cell.

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