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Index > Protein center > RELN(Gene name) > Human
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  • RELN (Gene name),
  • Reelin (Protein name ),  RELN_HUMAN from NCBI database.
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  • General Annotation
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  • Antigen Annotation
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  • Gene name:
    RELN;
    Protein name:
    Reelin;
    Alternative:

    Organism:
    Human (Homo sapiens). 
    General Annotation
    Sub Unit:
    Binds to the ectodomains of VLDLR and ApoER2.
    Function:
    Extracellular matrix serine protease that plays a role in layering of neurons in the cerebral cortex and cerebellum. Regulates microtubule function in neurons and neuronal migration. Affects migration of sympathetic preganglionic neurons in the spinal cord, where it seems to act as a barrier to neuronal migration. Enzymatic activity is important for the modulation of cell adhesion. Binding to the extracellular domains of lipoprotein receptors VLDLR and ApoER2 induces tyrosine phosphorylation of Dab1 and modulation of Tau phosphorylation.
    Subcellular Location:
    Secreted extracellular space extracellular matrix
    Protein Attributes:
    Sequence length:
    3460
    Sequence:
    50:
    MERSGWARQT | FLLALLLGAT | LRARAAAGYY | PRFSPFFFLC | THHGELEGDG | 
    100:
    EQGEVLISLH | IAGNPTYYVP | GQEYHVTIST | STFFDGLLVT | GLYTSTSVQA | 
    150:
    SQSIGGSSAF | GFGIMSDHQF | GNQFMCSVVA | SHVSHLPTTN | LSFIWIAPPA | 
    200:
    GTGCVNFMAT | ATHRGQVIFK | DALAQQLCEQ | GAPTDVTVHP | HLAEIHSDSI | 
    250:
    ILRDDFDSYH | QLQLNPNIWV | ECNNCETGEQ | CGAIMHGNAV | TFCEPYGPRE | 
    300:
    LITTGLNTTT | ASVLQFSIGS | GSCRFSYSDP | SIIVLYAKNN | SADWIQLEKI | 
    350:
    RAPSNVSTII | HILYLPEDAK | GENVQFQWKQ | ENLRVGEVYE | ACWALDNILI | 
    400:
    INSAHRQVVL | EDSLDPVDTG | NWLFFPGATV | KHSCQSDGNS | IYFHGNEGSE | 
    450:
    FNFATTRDVD | LSTEDIQEQW | SEEFESQPTG | WDVLGAVIGT | ECGTIESGLS | 
    500:
    MVFLKDGERK | LCTPSMDTTG | YGNLRFYFVM | GGICDPGNSH | ENDIILYAKI | 
    550:
    EGRKEHITLD | TLSYSSYKVP | SLVSVVINPE | LQTPATKFCL | RQKNHQGHNR | 
    600:
    NVWAVDFFHV | LPVLPSTMSH | MIQFSINLGC | GTHQPGNSVS | LEFSTNHGRS | 
    650:
    WSLLHTECLP | EICAGPHLPH | STVYSSENYS | GWNRITIPLP | NAALTRNTRI | 
    700:
    RWRQTGPILG | NMWAIDNVYI | GPSCLKFCSG | RGQCTRHGCK | CDPGFSGPAC | 
    750:
    EMASQTFPMF | ISESFGSSRL | SSYHNFYSIR | GAEVSFGCGV | LASGKALVFN | 
    800:
    KDGRRQLITS | FLDSSQSRFL | QFTLRLGSKS | VLSTCRAPDQ | PGEGVLLHYS | 
    850:
    YDNGITWKLL | EHYSYLSYHE | PRIISVELPG | DAKQFGIQFR | WWQPYHSSQR | 
    900:
    EDVWAIDEII | MTSVLFNSIS | LDFTNLVEVT | QSLGFYLGNV | QPYCGHDWTL | 
    950:
    CFTGDSKLAS | SMRYVETQSM | QIGASYMIQF | SLVMGCGQKY | TPHMDNQVKL | 
    1000:
    EYSTNHGLTW | HLVQEECLPS | MPSCQEFTSA | SIYHASEFTQ | WRRVIVLLPQ | 
    1050:
    KTWSSATRFR | WSQSYYTAQD | EWALDSIYIG | QQCPNMCSGH | GSCDHGICRC | 
    1100:
    DQGYQGTECH | PEAALPSTIM | SDFENQNGWE | SDWQEVIGGE | IVKPEQGCGV | 
    1150:
    ISSGSSLYFS | KAGKRQLVSW | DLDTSWVDFV | QFYIQIGGES | ASCNKPDSRE | 
    1200:
    EGVLLQYSNN | GGIQWHLLAE | MYFSDFSKPR | FVYLELPAAA | KTPCTRFRWW | 
    1250:
    QPVFSGEDYD | QWAVDDIIIL | SEKQKQIIPV | INPTLPQNFY | EKPAFDYPMN | 
    1300:
    QMSVWLMLAN | EGMVKNETFC | AATPSAMIFG | KSDGDRFAVT | RDLTLKPGYV | 
    1350:
    LQFKLNIGCA | NQFSSTAPVL | LQYSHDAGMS | WFLVKEGCYP | ASAGKGCEGN | 
    1400:
    SRELSEPTMY | HTGDFEEWTR | ITIVIPRSLA | SSKTRFRWIQ | ESSSQKNVPP | 
    1450:
    FGLDGVYISE | PCPSYCSGHG | DCISGVCFCD | LGYTAAQGTC | VSNVPNHNEM | 
    1500:
    FDRFEGKLSP | LWYKITGAQV | GTGCGTLNDG | KSLYFNGPGK | REARTVPLDT | 
    1550:
    RNIRLVQFYI | QIGSKTSGIT | CIKPRTRNEG | LIVQYSNDNG | ILWHLLRELD | 
    1600:
    FMSFLEPQII | SIDLPQDAKT | PATAFRWWQP | QHGKHSAQWA | LDDVLIGMND | 
    1650:
    SSQTGFQDKF | DGSIDLQANW | YRIQGGQVDI | DCLSMDTALI | FTENIGKPRY | 
    1700:
    AETWDFHVSA | STFLQFEMSM | GCSKPFSNSH | SVQLQYSLNN | GKDWHLVTEE | 
    1750:
    CVPPTIGCLH | YTESSIYTSE | RFQNWKRITV | YLPLSTISPR | TRFRWIQANY | 
    1800:
    TVGADSWAID | NVVLASGCPW | MCSGRGICDA | GRCVCDRGFG | GPYCVPVVPL | 
    1850:
    PSILKDDFNG | NLHPDLWPEV | YGAERGNLNG | ETIKSGTSLI | FKGEGLRMLI | 
    1900:
    SRDLDCTNTM | YVQFSLRFIA | KSTPERSHSI | LLQFSISGGI | TWHLMDEFYF | 
    1950:
    PQTTNILFIN | VPLPYTAQTN | ATRFRLWQPY | NNGKKEEIWI | VDDFIIDGNN | 
    2000:
    VNNPVMLLDT | FDFGPREDNW | FFYPGGNIGL | YCPYSSKGAP | EEDSAMVFVS | 
    2050:
    NEVGEHSITT | RDLNVNENTI | IQFEINVGCS | TDSSSADPVR | LEFSRDFGAT | 
    2100:
    WHLLLPLCYH | SSSHVSSLCS | TEHHPSSTYY | AGTMQGWRRE | VVHFGKLHLC | 
    2150:
    GSVRFRWYQG | FYPAGSQPVT | WAIDNVYIGP | QCEEMCNGQG | SCINGTKCIC | 
    2200:
    DPGYSGPTCK | ISTKNPDFLK | DDFEGQLESD | RFLLMSGGKP | SRKCGILSSG | 
    2250:
    NNLFFNEDGL | RMLMTRDLDL | SHARFVQFFM | RLGCGKGVPD | PRSQPVLLQY | 
    2300:
    SLNGGLSWSL | LQEFLFSNSS | NVGRYIALEI | PLKARSGSTR | LRWWQPSENG | 
    2350:
    HFYSPWVIDQ | ILIGGNISGN | TVLEDDFTTL | DSRKWLLHPG | GTKMPVCGST | 
    2400:
    GDALVFIEKA | STRYVVSTDV | AVNEDSFLQI | DFAASCSVTD | SCYAIELEYS | 
    2450:
    VDLGLSWHPL | VRDCLPTNVE | CSRYHLQRIL | VSDTFNKWTR | ITLPLPPYTR | 
    2500:
    SQATRFRWHQ | PAPFDKQQTW | AIDNVYIGDG | CIDMCSGHGR | CIQGNCVCDE | 
    2550:
    QWGGLYCDDP | ETSLPTQLKD | NFNRAPSSQN | WLTVNGGKLS | TVCGAVASGM | 
    2600:
    ALHFSGGCSR | LLVTVDLNLT | NAEFIQFYFM | YGCLITPNNR | NQGVLLEYSV | 
    2650:
    NGGITWNLLM | EIFYDQYSKP | GFVNILLPPD | AKEIATRFRW | WQPRHDGLDQ | 
    2700:
    NDWAIDNVLI | SGSADQRTVM | LDTFSSAPVP | QHERSPADAG | PVGRIAFDMF | 
    2750:
    MEDKTSVNEH | WLFHDDCTVE | RFCDSPDGVM | LCGSHDGREV | YAVTHDLTPT | 
    2800:
    EGWIMQFKIS | VGCKVSEKIA | QNQIHVQYST | DFGVSWNYLV | PQCLPADPKC | 
    2850:
    SGSVSQPSVF | FPTKGWKRIT | YPLPESLVGN | PVRFRFYQKY | SDMQWAIDNF | 
    2900:
    YLGPGCLDNC | RGHGDCLREQ | CICDPGYSGP | NCYLTHTLKT | FLKERFDSEE | 
    2950:
    IKPDLWMSLE | GGSTCTECGI | LAEDTALYFG | GSTVRQAVTQ | DLDLRGAKFL | 
    3000:
    QYWGRIGSEN | NMTSCHRPIC | RKEGVLLDYS | TDGGITWTLL | HEMDYQKYIS | 
    3050:
    VRHDYILLPE | DALTNTTRLR | WWQPFVISNG | IVVSGVERAQ | WALDNILIGG | 
    3100:
    AEINPSQLVD | TFDDEGTSHE | ENWSFYPNAV | RTAGFCGNPS | FHLYWPNKKK | 
    3150:
    DKTHNALSSR | ELIIQPGYMM | QFKIVVGCEA | TSCGDLHSVM | LEYTKDARSD | 
    3200:
    SWQLVQTQCL | PSSSNSIGCS | PFQFHEATIY | NSVNSSSWKR | ITIQLPDHVS | 
    3250:
    SSATQFRWIQ | KGEETEKQSW | AIDHVYIGEA | CPKLCSGHGY | CTTGAICICD | 
    3300:
    ESFQGDDCSV | FSHDLPSYIK | DNFESARVTE | ANWETIQGGV | IGSGCGQLAP | 
    3350:
    YAHGDSLYFN | GCQIRQAATK | PLDLTRASKI | MFVLQIGSMS | QTDSCNSDLS | 
    3400:
    GPHAVDKAVL | LQYSVNNGIT | WHVIAQHQPK | DFTQAQRVSY | NVPLEARMKG | 
    3450:
    VLLRWWQPRH | NGTGHDQWAL | DHVEVVLVST | RKQNYMMNFS | RQHGLRHFYN | 
    3460:
    RRRRSLRRYP | 
    3D Structure:
    N/A
    Predicted Eptitope:
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    EIAab Sequence  Vaild Sequence:
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    Related Databases
    KEGG:
    UniGene:
    MIM:
    String:
    Pfam:
    SMR:
    Pfam:
    Uniprot:
     
    FOR
    ELISA Kit for Human Reelin
    Cat.:
    E2134h
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    96T
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    ELISA Kit for Human Reelin
    MSDS:
    Please sign in first.
    ELISA Kit for Human Reelin
    Cat.:
    E2134m
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    MSDS:
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    Packing:
    96T
    Range:
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    ELISA Kit for Human Reelin
    Cat.:
    E2134r
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    MSDS:
    Please sign in first.
    Packing:
    96T
    ELISA Kit for Human Reelin
    Cat.:
    E2134c
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    MSDS:
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    Packing:
    96T
    CLIA Kit for Human Reelin
    Cat.:
    U2134h
    Price:
    Please sign in first.
    MSDS:
    Please sign in first.
    Packing:
    96T
    CLIA Kit for Human Reelin
    Cat.:
    U2134r
    Price:
    Please sign in first.
    MSDS:
    Please sign in first.
    Packing:
    96T
    CLIA Kit for Human Reelin
    Cat.:
    U2134c
    Price:
    Please sign in first.
    MSDS:
    Please sign in first.
    Packing:
    96T
    CLIA Kit for Human Reelin
    MSDS:
    Please sign in first.
    CLIA Kit for Human Reelin
    Cat.:
    U2134m
    Price:
    Please sign in first.
    MSDS:
    Please sign in first.
    Packing:
    96T
    Polyclonal Antibody for Human Reelin
    Polyclonal Antibody for Human Reelin
    Polyclonal Antibody for Human Reelin
    Cat.:
    P2134Rb-m
    Price:
    Please sign in first.
    Packing:
    40ug/0.2ml
    Polyclonal Antibody for Human Reelin
    Cat.:
    P2134Rb-r
    Price:
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    Packing:
    40ug/0.2ml
    Polyclonal Antibody for Human Reelin
    Cat.:
    P2134Rb-h
    Price:
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    Packing:
    40ug/0.2ml
    Monoclonal Antibody for Human Reelin
    Monoclonal Antibody for Human Reelin
    Monoclonal Antibody for Human Reelin
    Monoclonal Antibody for Human Reelin
    Monoclonal Antibody for Human Reelin
    Protein for Human Reelin
    Protein for Human Reelin
    Protein for Human Reelin
    Protein for Human Reelin
    Protein for Human Reelin

    R&D Technical Data
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    Precision
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    Recovery
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    Linearity
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    References
    1. 1.
      "The human reelin gene: isolation, sequencing, and mapping on chromosome 7."
      DeSilva U. , D'Arcangelo G. , Braden V.V. , Chen J. , Miao G.G. , Curran T. , Green E.D.
      Genome Res.7:157-164(1997) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1)
    2. 2.
      "The DNA sequence of human chromosome 7."
      Hillier L.W. , Fulton R.S. , Fulton L.A. , Graves T.A. , Pepin K.H. , Wagner-McPherson C. , Layman D. , Maas J. , Jaeger S. , Walker R. , Wylie K. , Sekhon M. , Becker M.C. , O'Laughlin M.D. , Schaller M.E. , Fewell G.A. , Delehaunty K.D. , Miner T.L. , more...
      Nature424:157-164(2003) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]
    3. 4.
      "Evolutionarily conserved, alternative splicing of reelin during brain development."
      Lambert de Rouvroit C. , Bernier B. , Royaux I. , de Bergeyck V. , Goffinet A.M.
      Exp. Neurol.156:229-238(1999) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: ALTERNATIVE SPLICING
    4. 5.
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: TISSUE SPECIFICITY
    5. 6.
      "Autosomal recessive lissencephaly with cerebellar hypoplasia is associated with human RELN mutations."
      Hong S.E. , Shugart Y.Y. , Huang D.T. , Shahwan S.A. , Grant P.E. , Hourihane J.O.B. , Martin N.D.T. , Walsh C.A.
      Nat. Genet.26:93-96(2000) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: INVOLVEMENT IN LIS2
    6. 7.
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: ERRATUM
    7. 8.
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: POLYMORPHISM
    8. 9.
      "Glycoproteomics analysis of human liver tissue by combination of multiple enzyme digestion and hydrazide chemistry."
      Chen R. , Jiang X. , Sun D. , Han G. , Wang F. , Ye M. , Wang L. , Zou H.
      J. Proteome Res.8:651-661(2009) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: GLYCOSYLATION [LARGE SCALE ANALYSIS] AT ASN-305; ASN-1920 AND ASN-3015
      tissue: Liver.
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