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Index > Protein center > HFE2(Gene name) > Human
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  • HFE2 (Gene name),
  • Hemojuvelin (Protein name ),  RGMC_HUMAN from NCBI database.
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  • General Annotation
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  • Antigen Annotation
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  • Gene name:
    HFE2(HJV;RGMC);
    Protein name:
    Hemojuvelin;
    Alternative:
    RGM domain family member C;Hemochromatosis type 2 protein;
    Organism:
    Human (Homo sapiens). 
    General Annotation
    Sub Unit:
    Interacts with BMP2 and BMP4 (By similarity). Interacts with BMPR1B.
    Function:
    Member of the repulsive guidance molecule (RGM) family. Involved in iron metabolism. Acts as a bone morphogenetic protein (BMP) coreceptor (By similarity). Enhancement of BMP signaling regulates hepcidin (HAMP) expression and iron metabolism (By similarity). May cooperate with hepcidin to restrict iron absorption in the gut. Could represent the cellular receptor for hepcidin.
    Subcellular Location:
    Cell membrane Lipid-anchor GPI-anchor
    Protein Attributes:
    Sequence length:
    426
    Sequence:
    50:
    MGEPGQSPSP | RSSHGSPPTL | STLTLLLLLC | GHAHSQCKIL | RCNAEYVSST | 
    100:
    LSLRGGGSSG | ALRGGGGGGR | GGGVGSGGLC | RALRSYALCT | RRTARTCRGD | 
    150:
    LAFHSAVHGI | EDLMIQHNCS | RQGPTAPPPP | RGPALPGAGS | GLPAPDPCDY | 
    200:
    EGRFSRLHGR | PPGFLHCASF | GDPHVRSFHH | HFHTCRVQGA | WPLLDNDFLF | 
    250:
    VQATSSPMAL | GANATATRKL | TIIFKNMQEC | IDQKVYQAEV | DNLPVAFEDG | 
    300:
    SINGGDRPGG | SSLSIQTANP | GNHVEIQAAY | IGTTIIIRQT | AGQLSFSIKV | 
    350:
    AEDVAMAFSA | EQDLQLCVGG | CPPSQRLSRS | ERNRRGAITI | DTARRLCKEG | 
    400:
    LPVEDAYFHS | CVFDVLISGD | PNFTVAAQAA | LEDARAFLPD | LEKLHLFPSD | 
    426:
    AGVPLSSATL | LAPLLSGLFV | LWLCIQ
    3D Structure:
    N/A
    Predicted Eptitope:
    Please Sign in.
    EIAab Sequence  Vaild Sequence:
    Please Sign in.
    Related Databases
    MIM:
    Pfam:
    String:
    UniGene:
    SMR:
    Uniprot:
     
    FOR
    ELISA Kit for Human Hemojuvelin
    Cat.:
    E1077h
    Price:
    Please sign in first.
    MSDS:
    Please sign in first.
    Packing:
    96T
    Range:
    Please sign in first.
    ELISA Kit for Human Hemojuvelin
    Cat.:
    E1077r
    Price:
    Please sign in first.
    MSDS:
    Please sign in first.
    Packing:
    96T
    ELISA Kit for Human Hemojuvelin
    Cat.:
    E1077m
    Price:
    Please sign in first.
    MSDS:
    Please sign in first.
    Packing:
    96T
    CLIA Kit for Human Hemojuvelin
    Cat.:
    U1077m
    Price:
    Please sign in first.
    MSDS:
    Please sign in first.
    Packing:
    96T
    CLIA Kit for Human Hemojuvelin
    Cat.:
    U1077r
    Price:
    Please sign in first.
    MSDS:
    Please sign in first.
    Packing:
    96T
    CLIA Kit for Human Hemojuvelin
    Cat.:
    U1077h
    Price:
    Please sign in first.
    MSDS:
    Please sign in first.
    Packing:
    96T
    Range:
    Please sign in first.
    Polyclonal Antibody for Human Hemojuvelin
    Cat.:
    P1077Rb-r
    Price:
    Please sign in first.
    Packing:
    40ug/0.2ml
    Polyclonal Antibody for Human Hemojuvelin
    Cat.:
    P1077Rb-h
    Price:
    Please sign in first.
    Packing:
    40ug/0.2ml
    Polyclonal Antibody for Human Hemojuvelin
    Cat.:
    P1077Rb-m
    Price:
    Please sign in first.
    Packing:
    40ug/0.2ml
    Monoclonal Antibody for Human Hemojuvelin
    Monoclonal Antibody for Human Hemojuvelin
    Monoclonal Antibody for Human Hemojuvelin
    Protein for Human Hemojuvelin
    Protein for Human Hemojuvelin
    Protein for Human Hemojuvelin

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    Precision
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    Linearity
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    References
    1. 1.
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM A);ALTERNATIVE SPLICING;TISSUE SPECIFICITY;VARIANTS HFE2A ASN-222 AND VAL-320
      tissue: Liver.
    2. 2.
      "Complete sequencing and characterization of 21,243 full-length human cDNAs."
      Ota T. , Suzuki Y. , Nishikawa T. , Otsuki T. , Sugiyama T. , Irie R. , Wakamatsu A. , Hayashi K. , Sato H. , Nagai K. , Kimura K. , Makita H. , Sekine M. , Obayashi M. , Nishi T. , Shibahara T. , Tanaka T. , Ishii S. , more...
      Nat. Genet.36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORMS A AND B)
      tissue: Liver.
      tissue: Skeletal muscle.
    3. 3.
      NIEHS SNPs program
      Submitted (2005-11) to the EMBL/GenBank/DDBJ databases
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA]
    4. 4.
      "The DNA sequence and biological annotation of human chromosome 1."
      Gregory S.G. , Barlow K.F. , McLay K.E. , Kaul R. , Swarbreck D. , Dunham A. , Scott C.E. , Howe K.L. , Woodfine K. , Spencer C.C.A. , Jones M.C. , Gillson C. , Searle S. , Zhou Y. , Kokocinski F. , McDonald L. , Evans R. , Phillips K. , more...
      Nature441:315-321(2006) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]
    5. 5.
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]
    6. 6.
      "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
      The MGC Project Team
      Genome Res.14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORMS B AND C)
      tissue: PNS.
      tissue: Skeletal muscle.
    7. 7.
      "Bone morphogenetic protein signaling by hemojuvelin regulates hepcidin expression."
      Babitt J.L. , Huang F.W. , Wrighting D.M. , Xia Y. , Sidis Y. , Samad T.A. , Campagna J.A. , Chung R.T. , Schneyer A.L. , Woolf C.J. , Andrews N.C. , Lin H.Y.
      Nat. Genet.38:531-539(2006) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: INTERACTION WITH BMPR1B
    8. 8.
      "Molecular mechanisms of the defective hepcidin inhibition in TMPRSS6 mutations associated with iron-refractory iron deficiency anemia."
      Silvestri L. , Guillem F. , Pagani A. , Nai A. , Oudin C. , Silva M. , Toutain F. , Kannengiesser C. , Beaumont C. , Camaschella C. , Grandchamp B.
      Blood113:5605-5608(2009) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: INTERACTION WITH TMPRSS6
    9. 9.
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: VARIANTS HFE2A PRO-85; ARG-99; ASP-168; SER-170; GLU-172; CYS-191; ARG-205; VAL-250; TRP-288 AND VAL-320
    10. 10.
      "Genetic abnormalities and juvenile hemochromatosis: mutations of the HJV gene encoding hemojuvelin."
      Lee P.L. , Beutler E. , Rao S.V. , Barton J.C.
      Blood103:4669-4671(2004) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: VARIANTS HFE2A ARG-80; PRO-101; ASN-222 AND VAL-320
    11. 11.
      "Hemojuvelin (HJV) mutations in persons of European, African-American and Asian ancestry with adult onset haemochromatosis."
      Lee P.L. , Barton J.C. , Brandhagen D. , Beutler E.
      Br. J. Haematol.127:224-229(2004) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: VARIANTS HFE2A VAL-320 AND TRP-321
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