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Index > Protein center > RGS3(Gene name) > Human
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  • RGS3 (Gene name),
  • Regulator of G-protein signaling 3 (Protein name ),  RGS3_HUMAN from NCBI database.
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  • General Annotation
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  • Antigen Annotation
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  • Predicted Eptitope
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  • Gene name:
    RGS3;
    Protein name:
    Regulator of G-protein signaling 3(RGP3;RGS3);
    Alternative:

    Organism:
    Human (Homo sapiens). 
    General Annotation
    Sub Unit:
    Binds EFNB1 and EFNB2 (By similarity). Binds the GNB1-GNG2 heterodimer.
    Function:
    Down-regulates signaling from heterotrimeric G-proteins by increasing the GTPase activity of the alpha subunits, thereby driving them into their inactive GDP-bound form. Down-regulates G-protein-mediated release of inositol phosphates and activation of MAP kinases.
    Subcellular Location:
    Cytoplasm Nucleus Cell membrane Peripheral membrane protein Long isoforms are cytoplasmic and associated with the plasma membrane. Short isoforms are nuclear.
    Protein Attributes:
    Sequence length:
    1198
    Sequence:
    50:
    MPVIPALWEV | EMGRSQGQEI | ETILANRSHS | DSTPLPNFLS | GSHRPECCTC | 
    100:
    RLLTASGAQD | SLPFGRRLYS | GPWRSCEEVC | HVSVLSVLST | SCGLSLSLPI | 
    150:
    FPGWMEWLSP | DIALPRRDEW | TQTSPARKRI | THAKVQGAGQ | LRLSIDAQDR | 
    200:
    VLLLHIIEGK | GLISKQPGTC | DPYVKISLIP | EDSRLRHQKT | QTVPDCRDPA | 
    250:
    FHEHFFFPVQ | EEDDQKRLLV | TVWNRASQSR | QSGLIGCMSF | GVKSLLTPDK | 
    300:
    EISGWYYLLG | EHLGRTKHLK | VARRRLRPLR | DPLLRMPGGG | DTENGKKLKI | 
    350:
    TIPRGKDGFG | FTICCDSPVR | VQAVDSGGPA | ERAGLQQLDT | VLQLNERPVE | 
    400:
    HWKCVELAHE | IRSCPSEIIL | LVWRMVPQVK | PGPDGGVLRR | ASCKSTHDLQ | 
    450:
    SPPNKREKNC | THGVQARPEQ | RHSCHLVCDS | SDGLLLGGWE | RYTEVAKRGG | 
    500:
    QHTLPALSRA | TAPTDPNYII | LAPLNPGSQL | LRPVYQEDTI | PEESGSPSKG | 
    550:
    KSYTGLGKKS | RLMKTVQTMK | GHGNYQNCPV | VRPHATHSSY | GTYVTLAPKV | 
    600:
    LVFPVFVQPL | DLCNPARTLL | LSEELLLYEG | RNKAAEVTLF | AYSDLLLFTK | 
    650:
    EDEPGRCDVL | RNPLYLQSVK | LQEGSSEDLK | FCVLYLAEKA | ECLFTLEAHS | 
    700:
    QEQKKRVCWC | LSENIAKQQQ | LAASPPDSKM | FETEADEKRE | MALEEGKGPG | 
    750:
    AEDSPPSKEP | SPGQELPPGQ | DLPPNKDSPS | GQEPAPSQEP | LSSKDSATSE | 
    800:
    GSPPGPDAPP | SKDVPPCQEP | PPAQDLSPCQ | DLPAGQEPLP | HQDPLLTKDL | 
    850:
    PAIQESPTRD | LPPCQDLPPS | QVSLPAKALT | EDTMSSGDLL | AATGDPPAAP | 
    900:
    RPAFVIPEVR | LDSTYSQKAG | AEQGCSGDEE | DAEEAEEVEE | GEEGEEDEDE | 
    950:
    DTSDDNYGER | SEAKRSSMIE | TGQGAEGGLS | LRVQNSLRRR | THSEGSLLQE | 
    1000:
    PRGPCFASDT | TLHCSDGEGA | ASTWGMPSPS | TLKKELGRNG | GSMHHLSLFF | 
    1050:
    TGHRKMSGAD | TVGDDDEASR | KRKSKNLAKD | MKNKLGIFRR | RNESPGAPPA | 
    1100:
    GKADKMMKSF | KPTSEEALKW | GESLEKLLVH | KYGLAVFQAF | LRTEFSEENL | 
    1150:
    EFWLACEDFK | KVKSQSKMAS | KAKKIFAEYI | AIQACKEVNL | DSYTREHTKD | 
    1198:
    NLQSVTRGCF | DLAQKRIFGL | MEKDSYPRFL | RSDLYLDLIN | QKKMSPPL
    3D Structure:
    N/A
    Predicted Eptitope:
    Please Sign in.
    EIAab Sequence  Vaild Sequence:
    Please Sign in.
    Related Databases
    UniGene:
    String:
    SMR:
    Pfam:
    MIM:
    KEGG:
    Uniprot:
     
    FOR
    ELISA Kit for Human RGP3
    Cat.:
    E0251m
    Price:
    Please sign in first.
    MSDS:
    Please sign in first.
    Packing:
    96T
    Range:
    Please sign in first.
    ELISA Kit for Human RGP3
    Cat.:
    E0251h
    Price:
    Please sign in first.
    MSDS:
    Please sign in first.
    Packing:
    96T
    Range:
    Please sign in first.
    ELISA Kit for Human RGP3
    Cat.:
    E0251r
    Price:
    Please sign in first.
    MSDS:
    Please sign in first.
    Packing:
    96T
    CLIA Kit for Human RGP3
    Cat.:
    U0251h
    Price:
    Please sign in first.
    MSDS:
    Please sign in first.
    Packing:
    96T
    Range:
    Please sign in first.
    CLIA Kit for Human RGP3
    Cat.:
    U0251r
    Price:
    Please sign in first.
    MSDS:
    Please sign in first.
    Packing:
    96T
    CLIA Kit for Human RGP3
    Cat.:
    U0251m
    Price:
    Please sign in first.
    MSDS:
    Please sign in first.
    Packing:
    96T
    Polyclonal Antibody for Human RGP3
    Cat.:
    P0251Rb-m
    Price:
    Please sign in first.
    Packing:
    40ug/0.2ml
    Polyclonal Antibody for Human RGP3
    Cat.:
    P0251Rb-r
    Price:
    Please sign in first.
    Packing:
    40ug/0.2ml
    Polyclonal Antibody for Human RGP3
    Cat.:
    P0251Rb-h
    Price:
    Please sign in first.
    Packing:
    40ug/0.2ml
    Monoclonal Antibody for Human RGP3
    Monoclonal Antibody for Human RGP3
    Monoclonal Antibody for Human RGP3
    Protein for Human RGP3
    Protein for Human RGP3
    Protein for Human RGP3

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    Precision
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    Linearity
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    References
    1. 1.
      "Inhibition of G-protein-mediated MAP kinase activation by a new mammalian gene family."
      Druey K.M. , Blumer K.J. , Kang V.H. , Kehrl J.H.
      Nature379:742-746(1996) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1);FUNCTION
    2. 2.
      "Additional 5' exons in the RGS3 locus generate multiple mRNA transcripts, one of which accounts for the origin of human PDZ-RGS3."
      Kehrl J.H. , Srikumar D. , Harrison K. , Wilson G.L. , Shi C.S.
      Genomics79:860-868(2002) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORMS 4; 6 AND 8);NUCLEOTIDE SEQUENCE [MRNA] OF 105-1198 (ISOFORM 1)
    3. 3.
      "Complete sequencing and characterization of 21,243 full-length human cDNAs."
      Ota T. , Suzuki Y. , Nishikawa T. , Otsuki T. , Sugiyama T. , Irie R. , Wakamatsu A. , Hayashi K. , Sato H. , Nagai K. , Kimura K. , Makita H. , Sekine M. , Obayashi M. , Nishi T. , Shibahara T. , Tanaka T. , Ishii S. , more...
      Nat. Genet.36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORMS 1; 3; 5 AND 9)
      tissue: Amygdala.
      tissue: Testis.
    4. 4.
      "Human PDZ-RGS3."
      Chatterjee T.K. , Fisher R.A.
      Submitted (2001-12) to the EMBL/GenBank/DDBJ databases
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA] (ISOFORM 4)
    5. 5.
      "cDNA clones of human proteins involved in signal transduction sequenced by the Guthrie cDNA resource center (www.cdna.org)."
      Puhl H.L. III , Ikeda S.R. , Aronstam R.S.
      Submitted (2004-03) to the EMBL/GenBank/DDBJ databases
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORMS 1 AND 2)
      tissue: Brain.
    6. 6.
      "DNA sequence and analysis of human chromosome 9."
      Humphray S.J. , Oliver K. , Hunt A.R. , Plumb R.W. , Loveland J.E. , Howe K.L. , Andrews T.D. , Searle S. , Hunt S.E. , Scott C.E. , Jones M.C. , Ainscough R. , Almeida J.P. , Ambrose K.D. , Ashwell R.I.S. , Babbage A.K. , Babbage S. , Bagguley C.L. , more...
      Nature429:369-374(2004) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]
    7. 7.
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]
    8. 8.
      "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
      The MGC Project Team
      Genome Res.14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 4);PARTIAL NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 7)
      tissue: Brain.
      tissue: Kidney.
    9. 9.
      "RGS3 inhibits G protein-mediated signaling via translocation to the membrane and binding to Galpha11."
      Dulin N.O. , Sorokin A. , Reed E. , Elliott S. , Kehrl J.H. , Dunn M.J.
      Mol. Cell. Biol.19:714-723(1999) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: FUNCTION;INTERACTION WITH GNA11 AND GNA13;SUBCELLULAR LOCATION
    10. 10.
      "Regulator of G protein signaling RGS3T is localized to the nucleus and induces apoptosis."
      Dulin N.O. , Pratt P. , Tiruppathi C. , Niu J. , Voyno-Yasenetskaya T. , Dunn M.J.
      J. Biol. Chem.275:21317-21323(2000) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: FUNCTION;SUBCELLULAR LOCATION
    11. 11.
      "Regulator of G-protein signaling 3 (RGS3) inhibits G-beta1/gamma2-induced inositol phosphate production, mitogen-activated protein kinase activation, and Akt activation."
      Shi C.-S. , Lee S.B. , Sinnarajah S. , Dessauer C.W. , Rhee S.G. , Kehrl J.H.
      J. Biol. Chem.276:24293-24300(2001) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: FUNCTION;INTERACTION WITH HETERODIMERIC GNB1-GNG2;SUBCELLULAR LOCATION
    12. 12.
      "Identification and Herc5-mediated ISGylation of novel target proteins."
      Takeuchi T. , Inoue S. , Yokosawa H.
      Biochem. Biophys. Res. Commun.348:473-477(2006) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: ISGYLATION
    13. 13.
      "Toward a global characterization of the phosphoproteome in prostate cancer cells: identification of phosphoproteins in the LNCaP cell line."
      Giorgianni F. , Zhao Y. , Desiderio D.M. , Beranova-Giorgianni S.
      Electrophoresis28:2027-2034(2007) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS]
      tissue: Prostate cancer.
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