Protein name:
Regulator of G-protein signaling 3 (RGP3;RGS3) ;
Alternative:
Organism:
Human (Homo sapiens).
General Annotation
Sub Unit:
Binds EFNB1 and EFNB2 (By similarity). Binds the GNB1-GNG2 heterodimer.
Function:
Down-regulates signaling from heterotrimeric G-proteins by increasing the GTPase activity of the alpha subunits, thereby driving them into their inactive GDP-bound form. Down-regulates G-protein-mediated release of inositol phosphates and activation of MAP kinases.
Subcellular Location:
Cytoplasm
Nucleus
Cell membrane
Peripheral membrane protein
Long isoforms are cytoplasmic and associated with the plasma membrane. Short isoforms are nuclear.
Protein Attributes:
50:
MPVIPALWEV | EMGRSQGQEI | ETILANRSHS | DSTPLPNFLS | GSHRPECCTC |
100:
RLLTASGAQD | SLPFGRRLYS | GPWRSCEEVC | HVSVLSVLST | SCGLSLSLPI |
150:
FPGWMEWLSP | DIALPRRDEW | TQTSPARKRI | THAKVQGAGQ | LRLSIDAQDR |
200:
VLLLHIIEGK | GLISKQPGTC | DPYVKISLIP | EDSRLRHQKT | QTVPDCRDPA |
250:
FHEHFFFPVQ | EEDDQKRLLV | TVWNRASQSR | QSGLIGCMSF | GVKSLLTPDK |
300:
EISGWYYLLG | EHLGRTKHLK | VARRRLRPLR | DPLLRMPGGG | DTENGKKLKI |
350:
TIPRGKDGFG | FTICCDSPVR | VQAVDSGGPA | ERAGLQQLDT | VLQLNERPVE |
400:
HWKCVELAHE | IRSCPSEIIL | LVWRMVPQVK | PGPDGGVLRR | ASCKSTHDLQ |
450:
SPPNKREKNC | THGVQARPEQ | RHSCHLVCDS | SDGLLLGGWE | RYTEVAKRGG |
500:
QHTLPALSRA | TAPTDPNYII | LAPLNPGSQL | LRPVYQEDTI | PEESGSPSKG |
550:
KSYTGLGKKS | RLMKTVQTMK | GHGNYQNCPV | VRPHATHSSY | GTYVTLAPKV |
600:
LVFPVFVQPL | DLCNPARTLL | LSEELLLYEG | RNKAAEVTLF | AYSDLLLFTK |
650:
EDEPGRCDVL | RNPLYLQSVK | LQEGSSEDLK | FCVLYLAEKA | ECLFTLEAHS |
700:
QEQKKRVCWC | LSENIAKQQQ | LAASPPDSKM | FETEADEKRE | MALEEGKGPG |
750:
AEDSPPSKEP | SPGQELPPGQ | DLPPNKDSPS | GQEPAPSQEP | LSSKDSATSE |
800:
GSPPGPDAPP | SKDVPPCQEP | PPAQDLSPCQ | DLPAGQEPLP | HQDPLLTKDL |
850:
PAIQESPTRD | LPPCQDLPPS | QVSLPAKALT | EDTMSSGDLL | AATGDPPAAP |
900:
RPAFVIPEVR | LDSTYSQKAG | AEQGCSGDEE | DAEEAEEVEE | GEEGEEDEDE |
950:
DTSDDNYGER | SEAKRSSMIE | TGQGAEGGLS | LRVQNSLRRR | THSEGSLLQE |
1000:
PRGPCFASDT | TLHCSDGEGA | ASTWGMPSPS | TLKKELGRNG | GSMHHLSLFF |
1050:
TGHRKMSGAD | TVGDDDEASR | KRKSKNLAKD | MKNKLGIFRR | RNESPGAPPA |
1100:
GKADKMMKSF | KPTSEEALKW | GESLEKLLVH | KYGLAVFQAF | LRTEFSEENL |
1150:
EFWLACEDFK | KVKSQSKMAS | KAKKIFAEYI | AIQACKEVNL | DSYTREHTKD |
1198:
NLQSVTRGCF | DLAQKRIFGL | MEKDSYPRFL | RSDLYLDLIN | QKKMSPPL
Vaild Sequence:
Related Databases
Uniprot:
ELISA Kit
CLIA Kit
Polyclonal Antibody
Monoclonal Antibody
Protein
FOR
Mouse
Human
Rat
Polyclonal Antibody for Human RGP3
Polyclonal Antibody for Human RGP3
Polyclonal Antibody for Human RGP3
Monoclonal Antibody for Human RGP3
Monoclonal Antibody for Human RGP3
Monoclonal Antibody for Human RGP3
R&D Technical Data
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Precision
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Recovery
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Linearity
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References
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[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s)
Cited for : NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1);FUNCTION
2.
[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s)
Cited for : NUCLEOTIDE SEQUENCE [MRNA] (ISOFORMS 4; 6 AND 8);NUCLEOTIDE SEQUENCE [MRNA] OF 105-1198 (ISOFORM 1)
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Nat. Genet.36:40-45(2004)
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Europe PMC ]
[
Abstract ]
[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s)
Cited for : NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORMS 1; 3; 5 AND 9)
tissue :
Amygdala .
tissue :
Testis .
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[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s)
Cited for : NUCLEOTIDE SEQUENCE [GENOMIC DNA] (ISOFORM 4)
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[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s)
Cited for : NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORMS 1 AND 2)
tissue :
Brain .
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Nature429:369-374(2004)
[
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[
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[
Abstract ]
[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s)
Cited for : NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]
7.
Mural R.J.
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Submitted (2005-07) to the EMBL/GenBank/DDBJ databases
[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s)
Cited for : NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]
8.
[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s)
Cited for : NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 4);PARTIAL NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 7)
tissue :
Brain .
tissue :
Kidney .
9.
[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s)
Cited for : FUNCTION;INTERACTION WITH GNA11 AND GNA13;SUBCELLULAR LOCATION
10.
[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s)
Cited for : FUNCTION;SUBCELLULAR LOCATION
11.
[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s)
Cited for : FUNCTION;INTERACTION WITH HETERODIMERIC GNB1-GNG2;SUBCELLULAR LOCATION
12.
[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s)
Cited for : ISGYLATION
13.
[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s)
Cited for : IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS]
tissue :
Prostate cancer .