Gene name:
ARHGAP21(ARHGAP10;KIAA1424);
Protein name:
Rho GTPase-activating protein 21;
Alternative:
Rho-type GTPase-activating protein 21;Rho GTPase-activating protein 10;
Organism:
Human (Homo sapiens).
General Annotation
Sub Unit:
Interacts with GTP-bound ARF1 and ARF6. Interacts with CTNNA1.
Function:
Functions as a GTPase-activating protein (GAP) for RHOA and CDC42. Downstream partner of ARF1 which may control Golgi apparatus structure and function. Also required for CTNNA1 recruitment to adherens junctions.
Subcellular Location:
Golgi apparatus membrane
Peripheral membrane protein
Cell junction
Cytoplasmic vesicle membrane
Peripheral membrane protein
Cytoplasm
cytoskeleton
Localization to the Golgi is dependent on interaction with GTP-bound ARF1.
Protein Attributes:
50:
MATRRTGLSE | GDGDKLKACE | VSKNKDGKEQ | SETVSLSEDE | TFSWPGPKTV |
100:
TLKRTSQGFG | FTLRHFIVYP | PESAIQFSYK | DEENGNRGGK | QRNRLEPMDT |
150:
IFVKQVKEGG | PAFEAGLCTG | DRIIKVNGES | VIGKTYSQVI | ALIQNSDTTL |
200:
ELSVMPKDED | ILQVLQFTKD | VTALAYSQDA | YLKGNEAYSG | NARNIPEPPP |
250:
ICYPWLPSAP | SAMAQPVEIS | PPDSSLSKQQ | TSTPVLTQPG | RAYRMEIQVP |
300:
PSPTDVAKSN | TAVCVCNESV | RTVIVPSEKV | VDLLSNRNNH | TGPSHRTEEV |
350:
RYGVSEQTSL | KTVSRTTSPP | LSIPTTHLIH | QPAGSRSLEP | SGILLKSGNY |
400:
SGHSDGISSS | RSQAVEAPSV | SVNHYSPNSH | QHIDWKNYKT | YKEYIDNRRL |
450:
HIGCRTIQER | LDSLRAASQS | TTDYNQVVPN | RTTLQGRRRS | TSHDRVPQSV |
500:
QIRQRSVSQE | RLEDSVLMKY | CPRSASQGAL | TSPSVSFSNH | RTRSWDYIEG |
550:
QDETLENVNS | GTPIPDSNGE | KKQTYKWSGF | TEQDDRRGIC | ERPRQQEIHK |
600:
SFRGSNFTVA | PSVVNSDNRR | MSGRGVGSVS | QFKKIPPDLK | TLQSNRNFQT |
650:
TCGMSLPRGI | SQDRSPLVKV | RSNSLKAPST | HVTKPSFSQK | SFVSIKDQRP |
700:
VNHLHQNSLL | NQQTWVRTDS | APDQQVETGK | SPSLSGASAK | PAPQSSENAG |
750:
TSDLELPVSQ | RNQDLSLQEA | ETEQSDTLDN | KEAVILREKP | PSGRQTPQPL |
800:
RHQSYILAVN | DQETGSDTTC | WLPNDARREV | HIKRMEERKA | SSTSPPGDSL |
850:
ASIPFIDEPT | SPSIDHDIAH | IPASAVISAS | TSQVPSIATV | PPCLTTSAPL |
900:
IRRQLSHDHE | SVGPPSLDAQ | PNSKTERSKS | YDEGLDDYRE | DAKLSFKHVS |
950:
SLKGIKIADS | QKSSEDSGSR | KDSSSEVFSD | AAKEGWLHFR | PLVTDKGKRV |
1000:
GGSIRPWKQM | YVVLRGHSLY | LYKDKREQTT | PSEEEQPISV | NACLIDISYS |
1050:
ETKRKNVFRL | TTSDCECLFQ | AEDRDDMLAW | IKTIQESSNL | NEEDTGVTNR |
1100:
DLISRRIKEY | NNLMSKAEQL | PKTPRQSLSI | RQTLLGAKSE | PKTQSPHSPK |
1150:
EESERKLLSK | DDTSPPKDKG | TWRKGIPSIM | RKTFEKKPTA | TGTFGVRLDD |
1200:
CPPAHTNRYI | PLIVDICCKL | VEERGLEYTG | IYRVPGNNAA | ISSMQEELNK |
1250:
GMADIDIQDD | KWRDLNVISS | LLKSFFRKLP | EPLFTNDKYA | DFIEANRKED |
1300:
PLDRLKTLKR | LIHDLPEHHY | ETLKFLSAHL | KTVAENSEKN | KMEPRNLAIV |
1350:
FGPTLVRTSE | DNMTHMVTHM | PDQYKIVETL | IQHHDWFFTE | EGAEEPLTTV |
1400:
QEESTVDSQP | VPNIDHLLTN | IGRTGVSPGD | VSDSATSDST | KSKGSWGSGK |
1450:
DQYSRELLVS | SIFAAASRKR | KKPKEKAQPS | SSEDELDNVF | FKKENVEQCH |
1500:
NDTKEESKKE | SETLGRKQKI | IIAKENSTRK | DPSTTKDEKI | SLGKESTPSE |
1550:
EPSPPHNSKH | NKSPTLSCRF | AILKESPRSL | LAQKSSHLEE | TGSDSGTLLS |
1600:
TSSQASLARF | SMKKSTSPET | KHSEFLANVS | TITSDYSTTS | SATYLTSLDS |
1650:
SRLSPEVQSV | AESKGDEADD | ERSELISEGR | PVETDSESEF | PVFPTALTSE |
1700:
RLFRGKLQEV | TKSSRRNSEG | SELSCTEGSL | TSSLDSRRQL | FSSHKLIECD |
1750:
TLSRKKSARF | KSDSGSLGDA | KNEKEAPSLT | KVFDVMKKGK | STGSLLTPTR |
1800:
GESEKQEPTW | KTKIADRLKL | RPRAPADDMF | GVGNHKVNAE | TAKRKSIRRR |
1850:
HTLGGHRDAT | EISVLNFWKV | HEQSGERESE | LSAVNRLKPK | CSAQDLSISD |
1900:
WLARERLRTS | TSDLSRGEIG | DPQTENPSTR | EIATTDTPLS | LHCNTGSSSS |
1950:
TLASTNRPLL | SIPPQSPDQI | NGESFQNVSK | NASSAANAQP | HKLSETPGSK |
Vaild Sequence:
Related Databases
Uniprot: