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Index > Protein center > RNH1(Gene name) > Human
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  • RNH1 (Gene name),
  • Ribonuclease inhibitor (Protein name ),  RINI_HUMAN from NCBI database.
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  • General Annotation
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  • Antigen Annotation
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  • Predicted Eptitope
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  • Vaild Sequence
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  • Gene name:
    RNH1(PRI;RNH);
    Protein name:
    Ribonuclease inhibitor;
    Alternative:
    Ribonuclease/angiogenin inhibitor 1(RAI);Placental ribonuclease inhibitor(Placental RNase inhibitor);
    Organism:
    Human (Homo sapiens). 
    General Annotation
    Sub Unit:
    Forms high-affinity heterodimers with RNASE1, ANG and RNASE2.
    Function:
    Ribonuclease inhibitor which inhibits RNASE1, RNASE2 and ANG. May play role in redox homeostasis.
    Subcellular Location:
    Cytoplasm
    Protein Attributes:
    Sequence length:
    461
    Sequence:
    50:
    MSLDIQSLDI | QCEELSDARW | AELLPLLQQC | QVVRLDDCGL | TEARCKDISS | 
    100:
    ALRVNPALAE | LNLRSNELGD | VGVHCVLQGL | QTPSCKIQKL | SLQNCCLTGA | 
    150:
    GCGVLSSTLR | TLPTLQELHL | SDNLLGDAGL | QLLCEGLLDP | QCRLEKLQLE | 
    200:
    YCSLSAASCE | PLASVLRAKP | DFKELTVSNN | DINEAGVRVL | CQGLKDSPCQ | 
    250:
    LEALKLESCG | VTSDNCRDLC | GIVASKASLR | ELALGSNKLG | DVGMAELCPG | 
    300:
    LLHPSSRLRT | LWIWECGITA | KGCGDLCRVL | RAKESLKELS | LAGNELGDEG | 
    350:
    ARLLCETLLE | PGCQLESLWV | KSCSFTAACC | SHFSSVLAQN | RFLLELQISN | 
    400:
    NRLEDAGVRE | LCQGLGQPGS | VLRVLWLADC | DVSDSSCSSL | AATLLANHSL | 
    450:
    RELDLSNNCL | GDAGILQLVE | SVRQPGCLLE | QLVLYDIYWS | EEMEDRLQAL | 
    461:
    EKDKPSLRVI | S
    3D Structure:
    N/A
    Predicted Eptitope:
    Please Sign in.
    EIAab Sequence  Vaild Sequence:
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    Related Databases
    MIM:
    UniGene:
    SMR:
    String:
    KEGG:
    Pfam:
    Uniprot:
     
    FOR
    ELISA Kit for Human Ribonuclease inhibitor
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    ELISA Kit for Human Ribonuclease inhibitor
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    ELISA Kit for Human Ribonuclease inhibitor
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    ELISA Kit for Human Ribonuclease inhibitor
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    CLIA Kit for Human Ribonuclease inhibitor
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    CLIA Kit for Human Ribonuclease inhibitor
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    CLIA Kit for Human Ribonuclease inhibitor
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    U1444m
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    CLIA Kit for Human Ribonuclease inhibitor
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    Polyclonal Antibody for Human Ribonuclease inhibitor
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    P1444Rb-r
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    Packing:
    40ug/0.2ml
    Polyclonal Antibody for Human Ribonuclease inhibitor
    Polyclonal Antibody for Human Ribonuclease inhibitor
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    P1444Rb-h
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    Polyclonal Antibody for Human Ribonuclease inhibitor
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    P1444Rb-m
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    Packing:
    40ug/0.2ml
    Monoclonal Antibody for Human Ribonuclease inhibitor
    Monoclonal Antibody for Human Ribonuclease inhibitor
    Monoclonal Antibody for Human Ribonuclease inhibitor
    Monoclonal Antibody for Human Ribonuclease inhibitor
    Protein for Human Ribonuclease inhibitor
    Protein for Human Ribonuclease inhibitor
    Protein for Human Ribonuclease inhibitor
    Protein for Human Ribonuclease inhibitor

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    References
    1. 1.
      "Primary structure of human placental ribonuclease inhibitor."
      Lee F.S. , Fox E.A. , Zhou H.-M. , Strydom D.J. , Vallee B.L.
      Biochemistry27:8545-8553(1988) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [MRNA];PROTEIN SEQUENCE OF 20-28; 35-44; 47-62; 65-72; 87-130; 147-181; 189-200; 206-226; 231-235; 239-268; 272-276; 288-295; 297-299; 303-316; 353-364; 374-394; 402-412; 424-449 AND 453-461;OXIDATION STATE OF THE CYSTEINES
      tissue: Placenta.
    2. 2.
      "The primary structure of human ribonuclease/angiogenin inhibitor (RAI) discloses a novel highly diversified protein superfamily with a common repetitive module."
      Schneider R. , Schneider-Scherzer E. , Thurnher M. , Auer B. , Schweiger M.
      EMBO J.7:4151-4156(1988) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [MRNA];PROTEIN SEQUENCE OF 444-462
    3. 3.
      "Expression of a human ribonuclease inhibitor variant in Escherichia coli and silkworm insect cell (Bombyx mori)."
      Huang G.H. , Yang G.Z. , Chen J.Y. , Wu X.F.
      Sheng Wu Hua Xue Yu Sheng Wu Wu Li Xue Bao35:960-963(2003) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [MRNA];FUNCTION
    4. 4.
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA]
      tissue: Testis.
    5. 5.
      "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
      The MGC Project Team
      Genome Res.14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA]
      tissue: Brain.
      tissue: Colon.
      tissue: Lymph.
      tissue: Ovary.
    6. 6.
      "Purification and characterization of human brain ribonuclease inhibitor."
      Nadano D. , Yasuda T. , Takeshita H. , Uchide K. , Kishi K.
      Arch. Biochem. Biophys.312:421-428(1994) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: PROTEIN SEQUENCE OF 2-14
      tissue: Brain.
    7. 7.
      "Characterisation of a tryptic peptide from human placental ribonuclease inhibitor which inhibits ribonuclease activity."
      Crevel-Thieffry I. , Cotterill S. , Schuller E.
      Biochim. Biophys. Acta1122:107-112(1992) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: PROTEIN SEQUENCE OF 174-195 AND 288-302;INTERACTION WITH RNASE1
    8. 8.
      "Site-specific mutagenesis reveals differences in the structural bases for tight binding of RNase inhibitor to angiogenin and RNase A."
      Chen C.Z. , Shapiro R.
      Proc. Natl. Acad. Sci. U.S.A.94:1761-1766(1997) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: MUTAGENESIS OF SER-461;INTERACTION WITH ANG AND RNASE1
    9. 9.
      "Superadditive and subadditive effects of 'hot spot' mutations within the interfaces of placental ribonuclease inhibitor with angiogenin and ribonuclease A."
      Chen C.Z. , Shapiro R.
      Biochemistry38:9273-9285(1999) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: MUTAGENESIS OF 435-TYR-ASP-436;INTERACTION WITH ANG AND RNASE1
    10. 10.
      "Mutational analysis of the complex of human RNase inhibitor and human eosinophil-derived neurotoxin (RNase 2)."
      Teufel D.P. , Kao R.Y. , Acharya K.R. , Shapiro R.
      Biochemistry42:1451-1459(2003) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: FUNCTION;MUTAGENESIS OF TRP-262; TRP-264; TRP-319; 435-TYR-ASP-436 AND SER-461;INTERACTION WITH RNASE2
    11. 11.
      "The cytosolic ribonuclease inhibitor contributes to intracellular redox homeostasis."
      Monti D.M. , Montesano Gesualdi N. , Matousek J. , Esposito F. , D'Alessio G.
      FEBS Lett.581:930-934(2007) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: FUNCTION
    12. 12.
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT THR-82;IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS]
      tissue: Cervix carcinoma.
    13. 13.
      "Quantitative phosphoproteomic analysis of T cell receptor signaling reveals system-wide modulation of protein-protein interactions."
      Mayya V. , Lundgren D.H. , Hwang S.-I. , Rezaul K. , Wu L. , Eng J.K. , Rodionov V. , Han D.K.
      Sci. Signal.2:RA46-RA46(2009) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-91;IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS]
      tissue: Leukemic T-cell.
    14. 14.
      "Quantitative phosphoproteomics reveals widespread full phosphorylation site occupancy during mitosis."
      Olsen J.V. , Vermeulen M. , Santamaria A. , Kumar C. , Miller M.L. , Jensen L.J. , Gnad F. , Cox J. , Jensen T.S. , Nigg E.A. , Brunak S. , Mann M.
      Sci. Signal.3:RA3-RA3(2010) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS]
      tissue: Cervix carcinoma.
    15. 15.
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS]
    16. 16.
      "Comparative large-scale characterisation of plant vs. mammal proteins reveals similar and idiosyncratic N-alpha acetylation features."
      Bienvenut W.V. , Sumpton D. , Martinez A. , Lilla S. , Espagne C. , Meinnel T. , Giglione C.
      Mol. Cell. Proteomics11:M111.015131-M111.015131(2012) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: ACETYLATION [LARGE SCALE ANALYSIS] AT SER-2;IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS];CLEAVAGE OF INITIATOR METHIONINE [LARGE SCALE ANALYSIS]
    17. 17.
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: ACETYLATION [LARGE SCALE ANALYSIS] AT SER-2;IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS]
    18. 18.
      "Molecular recognition of human angiogenin by placental ribonuclease inhibitor -- an X-ray crystallographic study at 2.0-A resolution."
      Papageorgiou A.C. , Shapiro R. , Acharya K.R.
      EMBO J.16:5162-5177(1997) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: X-RAY CRYSTALLOGRAPHY (2.0 ANGSTROMS) OF 2-461 IN COMPLEX WITH ANG;INTERACTION WITH ANG;DOMAIN
    19. 19.
      "Molecular recognition of human eosinophil-derived neurotoxin (RNase 2) by placental ribonuclease inhibitor."
      Iyer S. , Holloway D.E. , Kumar K. , Shapiro R. , Acharya K.R.
      J. Mol. Biol.347:637-655(2005) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: X-RAY CRYSTALLOGRAPHY (2.0 ANGSTROMS) OF 2-461 IN COMPLEX WITH RNASE2;DOMAIN;INTERACTION WITH RNASE2;MUTAGENESIS OF TRP-376 AND ARG-458
    20. 20.
      "Inhibition of human pancreatic ribonuclease by the human ribonuclease inhibitor protein."
      Johnson R.J. , McCoy J.G. , Bingman C.A. , Phillips G.N. Jr. , Raines R.T.
      J. Mol. Biol.368:434-449(2007) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: X-RAY CRYSTALLOGRAPHY (1.95 ANGSTROMS) IN COMPLEX WITH RNASE1;DOMAIN;INTERACTION WITH RNASE1
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