RNASE2 ELISA Kit for Human(Homo sapiens) | EIAab.comRNASE2 ELISA Kit for Human(Homo sapiens)

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Index > Protein center > RNASE2(Gene name) > Human

RNASE2 (Gene name),

Non-secretory ribonuclease (Protein name ), RNAS2_HUMAN from NCBI database.

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General Annotation

Antigen Annotation

Predicted Eptitope

Vaild Sequence

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Gene name:

RNASE2(EDN;RNS2);

Protein name:

Non-secretory ribonuclease;

Alternative:

RNase UpI-2;Eosinophil-derived neurotoxin;Ribonuclease US;Ribonuclease 2(RNase 2);

Organism:

Human (Homo sapiens).

General Annotation

Sub Unit:

Interacts with and forms a tight 1:1 complex with RNH1. Dimerization of two such complexes may occur.

Function:

This is a non-secretory ribonuclease. It is a pyrimidine specific nuclease with a slight preference for U. Cytotoxin and helminthotoxin. Selectively chemotactic for dendritic cells. Possesses a wide variety of biological activities.

Subcellular Location:

Lysosome Cytoplasmic granule Matrix of eosinophil's large specific granule.

Protein Attributes:

Sequence length:

161

Sequence:

50:

100:

150:

161:

PVVPVHLDRI | I

3D Structure:

N/A

Predicted Eptitope:

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Vaild Sequence:

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Related Databases

STRING:

9606.ENSP00000303276

String:

P10153

KEGG:

hsa:6036

MIM:

131410

SMR:

P10153

UniGene:

Hs.728

Pfam:

PF00074

Uniprot:

P10153

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ELISA Kit for Human Non-secretory ribonuclease

Cat.:

E0765h

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96T

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ELISA Kit for Human Non-secretory ribonuclease

MSDS:

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ELISA Kit for Human Non-secretory ribonuclease

Cat.:

E0765m

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Manual:

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96T

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CLIA Kit for Human Non-secretory ribonuclease

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CLIA Kit for Human Non-secretory ribonuclease

Cat.:

U0765m

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Packing:

96T

CLIA Kit for Human Non-secretory ribonuclease

Cat.:

U0765h

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Packing:

96T

Polyclonal Antibody for Human Non-secretory ribonuclease

Cat.:

P0765Rb-m

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40ug/0.2ml

Polyclonal Antibody for Human Non-secretory ribonuclease

Cat.:

P0765Rb-h

Price:

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Packing:

40ug/0.2ml

Polyclonal Antibody for Human Non-secretory ribonuclease

Monoclonal Antibody for Human Non-secretory ribonuclease

Protein for Human Non-secretory ribonuclease

R&D Technical Data

For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.

Precision

For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.

Recovery

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Linearity

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References

1.

"Sequence of human eosinophil-derived neurotoxin cDNA: identity of deduced amino acid sequence with human nonsecretory ribonucleases."
Hamann K.J. , Barker R.L. , Loegering D.A. , Pease L.R. , Gleich G.J.
Gene83:161-167(1989) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [MRNA]
2.

"Eosinophil cationic protein cDNA. Comparison with other toxic cationic proteins and ribonucleases."
Barker R.L. , Loegering D.A. , Ten R.M. , Hamann K.J. , Pease L.R. , Gleich G.J.
J. Immunol.143:952-955(1989) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [MRNA]
3.

"Molecular cloning of the human eosinophil-derived neurotoxin: a member of the ribonuclease gene family."
Rosenberg H.F. , Tenen D.G. , Ackerman S.J.
Proc. Natl. Acad. Sci. U.S.A.86:4460-4464(1989) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [MRNA]
4.

"Structure and chromosome localization of the human eosinophil-derived neurotoxin and eosinophil cationic protein genes: evidence for intronless coding sequences in the ribonuclease gene superfamily."
Hamann K.J. , Ten R.M. , Loegering D.A. , Jenkins R.B. , Heise M.T. , Schad C.R. , Pease L.R. , Gleich G.J. , Barker R.L.
Genomics7:535-546(1990) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA]
5.

"Sequence variation at two eosinophil-associated ribonuclease loci in humans."
Zhang J. , Rosenberg H.F.
Genetics156:1949-1958(2000) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA];VARIANT ASN-156
6.

Simonsen C.C. , Kennedy J. , Comstock L. , Ashton N. , McGrogan M.
Submitted (1990-10) to the EMBL/GenBank/DDBJ databases

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA / MRNA]
tissue: Colon.
tissue: Leukemia.
7.

"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
The MGC Project Team
Genome Res.14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA]
8.

"Amino acid sequence of the nonsecretory ribonuclease of human urine."
Beintema J.J. , Hofsteenge J. , Iwama M. , Morita T. , Ohgi K. , Irie M. , Sugiyama R.H. , Schieven G.L. , Dekker C.A. , Glitz D.G.
Biochemistry27:4530-4538(1988) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: PROTEIN SEQUENCE OF 28-161
9.

"Biochemical and functional similarities between human eosinophil-derived neurotoxin and eosinophil cationic protein: homology with ribonuclease."
Gleich G.J. , Loegering D.A. , Bell M.P. , Checkel J.L. , Ackerman S.J. , McKean D.J.
Proc. Natl. Acad. Sci. U.S.A.83:3146-3150(1986) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: PROTEIN SEQUENCE OF 28-82;FUNCTION
10.

"Purification and properties of bovine kidney ribonucleases."
Niwata Y. , Ohgi K. , Sanda A. , Takizawa Y. , Irie M.
J. Biochem.97:923-934(1985) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: PROTEIN SEQUENCE OF 28-55
11.

"Purification and characterization of a ribonuclease from human liver."
Sorrentino S. , Tucker G.K. , Glitz D.G.
J. Biol. Chem.263:16125-16131(1988) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: PROTEIN SEQUENCE OF 28-53
tissue: Liver.
12.

"Characterization of a unique nonsecretory ribonuclease from urine of pregnant women."
Sakakibara R. , Hashida K. , Kitahara T. , Ishiguro M.
J. Biochem.111:325-330(1992) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: PROTEIN SEQUENCE OF 24-43
tissue: Urine.
13.

"Characterisation of UGP and its relationship with beta-core fragment."
Kardana A. , Bagshawe K.D. , Coles B. , Read D. , Taylor M.
Br. J. Cancer67:686-692(1993) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: PROTEIN SEQUENCE OF 28-45
tissue: Urine.
14.

"New type of linkage between a carbohydrate and a protein: C-glycosylation of a specific tryptophan residue in human RNase Us."
Hofsteenge J. , Mueller D.R. , de Beer T. , Loeffler A. , Richter W.J. , Vliegenthart J.F.G.
Biochemistry33:13524-13530(1994) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: GLYCOSYLATION AT TRP-34
15.

"The hexopyranosyl residue that is C-glycosidically linked to the side chain of tryptophan-7 in human RNase Us is alpha-mannopyranose."
de Beer T. , Vliegenthart J.F.G. , Loeffler A. , Hofsteenge J.
Biochemistry34:11785-11789(1995) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: STRUCTURE OF C-GLYCOSYLATED GROUP
16.

"Recognition signal for C-mannosylation of Trp-7 in RNase 2 consists of sequence Trp-x-x-Trp."
Krieg J. , Hartmann S. , Vicentini A. , Glasner W. , Hess D. , Hofsteenge J.
Mol. Biol. Cell9:301-309(1998) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: GLYCOSYLATION AT TRP-34
17.

"Mutational analysis of the complex of human RNase inhibitor and human eosinophil-derived neurotoxin (RNase 2)."
Teufel D.P. , Kao R.Y. , Acharya K.R. , Shapiro R.
Biochemistry42:1451-1459(2003) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: FUNCTION;INTERACTION WITH RNH1
18.

"Eosinophil-derived neurotoxin (EDN), an antimicrobial protein with chemotactic activities for dendritic cells."
Yang D. , Rosenberg H.F. , Chen Q. , Dyer K.D. , Kurosaka K. , Oppenheim J.J.
Blood102:3396-3403(2003) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: INVOLVEMENT IN CHEMOTAXIS
19.

"Post-translational tyrosine nitration of eosinophil granule toxins mediated by eosinophil peroxidase."
Ulrich M. , Petre A. , Youhnovski N. , Proemm F. , Schirle M. , Schumm M. , Pero R.S. , Doyle A. , Checkel J. , Kita H. , Thiyagarajan N. , Acharya K.R. , Schmid-Grendelmeier P. , Simon H.-U. , Schwarz H. , Tsutsui M. , Shimokawa H. , Bellon G. , more...
J. Biol. Chem.283:28629-28640(2008) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NITRATION AT TYR-60
20.

"X-ray crystallographic structure of recombinant eosinophil-derived neurotoxin at 1.83-A resolution."
Mosimann S.C. , Newton D.L. , Youle R.J. , James M.N.G.
J. Mol. Biol.260:540-552(1996) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: X-RAY CRYSTALLOGRAPHY (1.83 ANGSTROMS)
21.

"Mapping the ribonucleolytic active site of eosinophil-derived neurotoxin (EDN). High resolution crystal structures of EDN complexes with adenylic nucleotide inhibitors."
Leonidas D.D. , Boix E. , Prill R. , Suzuki M. , Turton R. , Minson K. , Swaminathan G.J. , Youle R.J. , Acharya K.R.
J. Biol. Chem.276:15009-15017(2001) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: X-RAY CRYSTALLOGRAPHY (1.6 ANGSTROMS)
22.

"Molecular recognition of human eosinophil-derived neurotoxin (RNase 2) by placental ribonuclease inhibitor."
Iyer S. , Holloway D.E. , Kumar K. , Shapiro R. , Acharya K.R.
J. Mol. Biol.347:637-655(2005) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: X-RAY CRYSTALLOGRAPHY (1.99 ANGSTROMS) OF 28-161 IN COMPLEX WITH RNH1;SUBUNIT
23.

"Crystal structures of eosinophil-derived neurotoxin (EDN) in complex with the inhibitors 5'-ATP, Ap3A, Ap4A, and Ap5A."
Baker M.D. , Holloway D.E. , Swaminathan G.J. , Acharya K.R.
Biochemistry45:416-426(2006) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: X-RAY CRYSTALLOGRAPHY (0.98 ANGSTROMS) OF 28-161 IN COMPLEX WITH ADP AND ATP

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