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Index > Protein center > TRIM21(Gene name) > Bovine
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  • TRIM21 (Gene name),
  • E3 ubiquitin-protein ligase TRIM21 (Protein name ),  RO52_BOVIN from NCBI database.
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  • General Annotation
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  • Antigen Annotation
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  • Predicted Eptitope
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  • Vaild Sequence
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  • Gene name:
    TRIM21;
    Protein name:
    E3 ubiquitin-protein ligase TRIM21;
    Alternative:
    52 kDa ribonucleoprotein autoantigen Ro/SS-A;52 kDa Ro protein;Sjoegren syndrome type A antigen(SS-A);Ro(SS-A);Tripartite motif-containing protein 21;
    Organism:
    Bovine (Bos taurus). 
    General Annotation
    Sub Unit:
    Interacts (via C-terminus) with IRF8 (via C-terminus). Component of a SCF(SKP2)-like complex containing CUL1, SKP1, TRIM21 and SKP2. Interacts with CALR, CUL1, FBXW11, HSPA5, IKBKB, IRF3, SKP1 and VCP. Interacts with SKP2; the interaction with SKP2 does not depend on an intact F-box domain. Interacts (via N-terminus and C-terminus) with DCP2 (via N-terminus and C-terminus).
    Function:
    E3 ubiquitin-protein ligase whose activity is dependent on E2 enzymes, UBE2D1, UBE2D2, UBE2E1 and UBE2E2. Forms a ubiquitin ligase complex in cooperation with the E2 UBE2D2 that is used not only for the ubiquitination of USP4 and IKBKB but also for its self-ubiquitination. Component of cullin-RING-based SCF (SKP1-CUL1-F-box protein) E3 ubiquitin-protein ligase complexes such as SCF(SKP2)-like complexes. A TRIM21-containing SCF(SKP2)-like complex is shown to mediate ubiquitination of CDKN1B ('Thr-187' phosphorylated-form), thereby promoting its degradation by the proteasome. Monoubiquitinates IKBKB that will negatively regulates Tax-induced NF-kappa-B signaling. Negatively regulates IFN-beta production post-pathogen recognition by polyubiquitin-mediated degradation of IRF3. Mediates the ubiquitin-mediated proteasomal degradation of IgG1 heavy chain, which is linked to the VCP-mediated ER-associated degradation (ERAD) pathway. Promotes IRF8 ubiquitination, which enhanced the ability of IRF8 to stimulate cytokine genes transcription in macrophages. Plays a role in the regulation of the cell cycle progression. Enhances the decapping activity of DCP2. Exists as a ribonucleoprotein particle present in all mammalian cells studied and composed of a single polypeptide and one of four small RNA molecules. At least two isoforms are present in nucleated and red blood cells, and tissue specific differences in RO/SSA proteins have been identified. The common feature of these proteins is their ability to bind HY RNAs.2.
    Subcellular Location:
    Cytoplasm Nucleus Cytoplasm P-body Enters the nucleus upon exposure to nitric oxide. Localizes to small dot- or rod-like structures in the cytoplasm, called cytoplasmic bodies (P-body) that are located underneath the plasma membrane and also diffusely in the cytoplasm and are highly motil in cells. Cytoplasmic bodies are located along the microtubules and do not share the same cytoplasmic bodies with TRIM5. Colocalizes with DCP2 in P-body.
    Protein Attributes:
    Sequence length:
    469
    Sequence:
    50:
    MASAVPLTMM | WEEVTCSICL | DPMVEPMSIE | CGHSFCQECI | SEVGKEGGSV | 
    100:
    CPVCRRHFLL | QNLRPNRQVA | NMVDNLRKIS | QGAKESPHGE | LCVVHREKIH | 
    150:
    LFCEEDGKAL | CWVCSQSQKH | RDHPMVPIEE | AAQEYQEKLQ | VALNKLRHKQ | 
    200:
    ELAEKLELDI | AMKKASWKGK | VEAHKLRIHE | EFVRQKNFLA | EEEQKQLQKL | 
    250:
    EEEERQQLRT | LGDTEARLAQ | QIQALQELIA | ELERRRRGSA | LELLQEVKSV | 
    300:
    LERSESWNLK | ELDVASTDLR | NVFYVPGIKK | MLRTCGVHIT | LDPQTANPWL | 
    350:
    ILSENRRQVR | LANTRQEVPE | NEERFDSYPM | VLGAQRFDSG | KVYWEVDVTG | 
    400:
    KEAWDLGVCR | DNVRRKGQFL | LNSDTGFWII | WLWNKQKYEA | GTCPQTPLHL | 
    450:
    QVPPNRIGIF | LDYEASTVSF | YNITDHASLI | YTFSECAFAG | PLRPFFNPGF | 
    469:
    NDRGTNSAPL | ILCPLKTGW
    3D Structure:
    N/A
    Predicted Eptitope:
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    EIAab Sequence  Vaild Sequence:
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    Related Databases
    Pfam:
    UniGene:
    Pfam:
    SMR:
    UniGene:
    Uniprot:
     
    FOR
    ELISA Kit for Bovine E3 ubiquitin-protein ligase TRIM21
    Cat.:
    E0290h
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    MSDS:
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    Packing:
    96T
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    ELISA Kit for Bovine E3 ubiquitin-protein ligase TRIM21
    Cat.:
    E0290b
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    MSDS:
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    Packing:
    96T
    ELISA Kit for Bovine E3 ubiquitin-protein ligase TRIM21
    Cat.:
    E0290m
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    MSDS:
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    Packing:
    96T
    CLIA Kit for Bovine E3 ubiquitin-protein ligase TRIM21
    Cat.:
    U0290b
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    MSDS:
    Please sign in first.
    Packing:
    96T
    CLIA Kit for Bovine E3 ubiquitin-protein ligase TRIM21
    Cat.:
    U0290m
    Price:
    Please sign in first.
    MSDS:
    Please sign in first.
    Packing:
    96T
    CLIA Kit for Bovine E3 ubiquitin-protein ligase TRIM21
    Cat.:
    U0290h
    Price:
    Please sign in first.
    MSDS:
    Please sign in first.
    Packing:
    96T
    Polyclonal Antibody for Bovine E3 ubiquitin-protein ligase TRIM21
    Cat.:
    P0290Rb-m
    Price:
    Please sign in first.
    Packing:
    40ug/0.2ml
    Polyclonal Antibody for Bovine E3 ubiquitin-protein ligase TRIM21
    Polyclonal Antibody for Bovine E3 ubiquitin-protein ligase TRIM21
    Cat.:
    P0290Rb-h
    Price:
    Please sign in first.
    Packing:
    40ug/0.2ml
    Monoclonal Antibody for Bovine E3 ubiquitin-protein ligase TRIM21
    Monoclonal Antibody for Bovine E3 ubiquitin-protein ligase TRIM21
    Monoclonal Antibody for Bovine E3 ubiquitin-protein ligase TRIM21
    Protein for Bovine E3 ubiquitin-protein ligase TRIM21
    Protein for Bovine E3 ubiquitin-protein ligase TRIM21
    Protein for Bovine E3 ubiquitin-protein ligase TRIM21

    R&D Technical Data
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    Precision
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    Recovery
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    Linearity
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    References
    1. 1.
      "The Ro52/SS-A autoantigen has elevated expression at the brain microvasculature."
      Shusta E.V. , Li J.Y. , Boado R.J. , Pardridge W.M.
      NeuroReport14:1861-1865(2003) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [MRNA]
    2. 2.
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA]
    3. 3.
      NIH - Mammalian Gene Collection (MGC) project
      Submitted (2006-09) to the EMBL/GenBank/DDBJ databases
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA]
      strain: Hereford.
      tissue: Hippocampus.
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