RSAD2 ELISA Kit for Human(Homo sapiens) | EIAab.comRSAD2 ELISA Kit for Human(Homo sapiens)

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RSAD2 (Gene name),

Radical S-adenosyl methionine domain-containing protein 2 (Protein name ), RSAD2_HUMAN from NCBI database.

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General Annotation

Antigen Annotation

Predicted Eptitope

Vaild Sequence

Related Databases

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Gene name:

RSAD2(CIG5);

Protein name:

Radical S-adenosyl methionine domain-containing protein 2;

Alternative:

Viperin;Cytomegalovirus-induced gene 5 protein;Virus inhibitory protein, endoplasmic reticulum-associated, interferon-inducible;

Organism:

Human (Homo sapiens).

General Annotation

Sub Unit:

Interacts with FPPS.

Function:

Involved in antiviral defense. May impair virus budding by disrupting lipid rafts at the plasma membrane, a feature which is essential for the budding process of many viruses. Acts through binding with and inactivating FPPS, an enzyme involved in synthesis of cholesterol, farnesylated and geranylated proteins, ubiquinones dolichol and heme. Plays a major role in the cell antiviral state induced by type I and type II interferon. Displays antiviral effect against HIV-1 virus, hepatitis C virus, human cytomegalovirus, and aphaviruses, but not vesiculovirus.

Subcellular Location:

Endoplasmic reticulum membrane Peripheral membrane protein Cytoplasmic side Golgi apparatus Probably associates with the cytosolic side of the endoplasmic reticulum. Infection with human cytomegalovirus (HCMV) causes relocation to the Golgi apparatus and to cytoplasmic vacuoles which also contain HCMV proteins glycoprotein B and pp28.

Protein Attributes:

Sequence length:

361

Sequence:

50:

100:

150:

200:

250:

300:

350:

361:

IWSKADLKLD | W

3D Structure:

N/A

Predicted Eptitope:

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Vaild Sequence:

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Related Databases

STRING:

9606.ENSP00000371471

String:

Q8WXG1

MIM:

607810

UniGene:

Hs.17518

KEGG:

hsa:91543

Pfam:

PF04055

Uniprot:

Q8WXG1

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ELISA Kit for Human Radical S-adenosyl methionine domain-containing protein 2

Cat.:

E3787h

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96T

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ELISA Kit for Human Radical S-adenosyl methionine domain-containing protein 2

Cat.:

E3787m

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96T

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ELISA Kit for Human Radical S-adenosyl methionine domain-containing protein 2

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E3787r

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Packing:

96T

ELISA Kit for Human Radical S-adenosyl methionine domain-containing protein 2

Cat.:

E3787b

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96T

ELISA Kit for Human Radical S-adenosyl methionine domain-containing protein 2

Cat.:

E3787p

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96T

CLIA Kit for Human Radical S-adenosyl methionine domain-containing protein 2

Cat.:

U3787r

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Packing:

96T

CLIA Kit for Human Radical S-adenosyl methionine domain-containing protein 2

Cat.:

U3787m

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MSDS:

Please sign in first.

Packing:

96T

CLIA Kit for Human Radical S-adenosyl methionine domain-containing protein 2

Cat.:

U3787h

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Manual:

Looking for manual.

MSDS:

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Packing:

96T

Range:

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CLIA Kit for Human Radical S-adenosyl methionine domain-containing protein 2

Cat.:

U3787b

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MSDS:

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Packing:

96T

CLIA Kit for Human Radical S-adenosyl methionine domain-containing protein 2

Cat.:

U3787p

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96T

Polyclonal Antibody for Human Radical S-adenosyl methionine domain-containing protein 2

Cat.:

P3787Rb-m

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40ug/0.2ml

Polyclonal Antibody for Human Radical S-adenosyl methionine domain-containing protein 2

Cat.:

P3787Rb-h

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Packing:

40ug/0.2ml

Polyclonal Antibody for Human Radical S-adenosyl methionine domain-containing protein 2

Monoclonal Antibody for Human Radical S-adenosyl methionine domain-containing protein 2

Protein for Human Radical S-adenosyl methionine domain-containing protein 2

R&D Technical Data

For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.

Precision

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Recovery

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Linearity

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References

1.

"Use of differential display analysis to assess the effect of human cytomegalovirus infection on the accumulation of cellular RNAs: induction of interferon-responsive RNAs."
Zhu H. , Cong J.-P. , Shenk T.
Proc. Natl. Acad. Sci. U.S.A.94:13985-13990(1997) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [MRNA];INDUCTION
tissue: Foreskin fibroblast.
2.

"Viperin (cig5), an IFN-inducible antiviral protein directly induced by human cytomegalovirus."
Chin K.-C. , Cresswell P.
Proc. Natl. Acad. Sci. U.S.A.98:15125-15130(2001) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [MRNA];FUNCTION;SUBCELLULAR LOCATION;INDUCTION
tissue: Macrophage.
3.

"Generation and annotation of the DNA sequences of human chromosomes 2 and 4."
Hillier L.W. , Graves T.A. , Fulton R.S. , Fulton L.A. , Pepin K.H. , Minx P. , Wagner-McPherson C. , Layman D. , Wylie K. , Sekhon M. , Becker M.C. , Fewell G.A. , Delehaunty K.D. , Miner T.L. , Nash W.E. , Kremitzki C. , Oddy L. , Du H. , more...
Nature434:724-731(2005) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]
4.

Mural R.J. , Istrail S. , Sutton G.G. , Florea L. , Halpern A.L. , Mobarry C.M. , Lippert R. , Walenz B. , Shatkay H. , Dew I. , Miller J.R. , Flanigan M.J. , Edwards N.J. , Bolanos R. , Fasulo D. , Halldorsson B.V. , Hannenhalli S. , Turner R. , more...
Submitted (2005-09) to the EMBL/GenBank/DDBJ databases

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]
5.

"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
The MGC Project Team
Genome Res.14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA];VARIANT ARG-42
tissue: Prostate.
6.

"The antiviral cytomegalovirus inducible gene 5/viperin is expressed in atherosclerosis and regulated by proinflammatory agents."
Olofsson P.S. , Jatta K. , Waagsaeter D. , Gredmark S. , Hedin U. , Paulsson-Berne G. , Soederberg-Naucler C. , Hansson G.K. , Sirsjoe A.
Arterioscler. Thromb. Vasc. Biol.25:E113-E116(2005) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: UP-REGULATION IN ATHEROSCLEROSIS
7.

"Analysis of ISG expression in chronic hepatitis C identifies viperin as a potential antiviral effector."
Helbig K.J. , Lau D.T.-Y. , Semendric L. , Harley H.A.J. , Beard M.R.
Hepatology42:702-710(2005) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: FUNCTION;INDUCTION
8.

"Yellow fever virus strains Asibi and 17D-204 infect human umbilical cord endothelial cells and induce novel changes in gene expression."
Khaiboullina S.F. , Rizvanov A.A. , Holbrook M.R. , St Jeor S.
Virology342:167-176(2005) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: INDUCTION
9.

"Toll-like receptor-dependent and -independent viperin gene expression and counter-regulation by PRDI-binding factor-1/BLIMP1."
Severa M. , Coccia E.M. , Fitzgerald K.A.
J. Biol. Chem.281:26188-26195(2006) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: INDUCTION
10.

"TLR3 ligation activates an antiviral response in human fetal astrocytes: a role for viperin/cig5."
Rivieccio M.A. , Suh H.-S. , Zhao Y. , Zhao M.-L. , Chin K.-C. , Lee S.C. , Brosnan C.F.
J. Immunol.177:4735-4741(2006) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: FUNCTION;SUBCELLULAR LOCATION
11.

"Identification and characterization of interferon-induced proteins that inhibit alphavirus replication."
Zhang Y. , Burke C.W. , Ryman K.D. , Klimstra W.B.
J. Virol.81:11246-11255(2007) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: FUNCTION
12.

"The interferon-inducible protein viperin inhibits influenza virus release by perturbing lipid rafts."
Wang X. , Hinson E.R. , Cresswell P.
Cell Host Microbe2:96-105(2007) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: INTERACTION WITH FPPS
13.

"Influenza virus not cRAFTy enough to dodge viperin."
Waheed A.A. , Freed E.O.
Cell Host Microbe2:71-72(2007) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: FUNCTION
14.

"The N-terminal amphipathic alpha-helix of viperin mediates localization to the cytosolic face of the endoplasmic reticulum and inhibits protein secretion."
Hinson E.R. , Cresswell P.
J. Biol. Chem.284:4705-4712(2009) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: FUNCTION;SUBCELLULAR LOCATION;SUBUNIT
15.

"The antiviral protein viperin is a radical SAM enzyme."
Duschene K.S. , Broderick J.B.
FEBS Lett.584:1263-1267(2010) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: COFACTOR
16.

"Human cytomegalovirus directly induces the antiviral protein viperin to enhance infectivity."
Seo J.Y. , Yaneva R. , Hinson E.R. , Cresswell P.
Science332:1093-1097(2011) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: INTERACTION WITH HHV-5 PROTEIN UL37 AND HADHB;SUBCELLULAR LOCATION
17.

"Viperin inhibits hepatitis C virus replication by interfering with binding of NS5A to host protein hVAP-33."
Wang S. , Wu X. , Pan T. , Song W. , Wang Y. , Zhang F. , Yuan Z.
J. Gen. Virol.93:83-92(2012) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: INTERACTION WITH VAPA
18.

"The presence of the iron-sulfur motif is important for the conformational stability of the antiviral protein, Viperin."
Haldar S. , Paul S. , Joshi N. , Dasgupta A. , Chattopadhyay K.
PLoS ONE7:E31797-E31797(2012) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: COFACTOR;MUTAGENESIS OF CYS-83; CYS-87 AND CYS-90
19.

"Viperin: a multifunctional, interferon-inducible protein that regulates virus replication."
Seo J.Y. , Yaneva R. , Cresswell P.
Cell Host Microbe10:534-539(2011) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: REVIEW
20.

"The interferon inducible gene: Viperin."
Fitzgerald K.A.
J. Interferon Cytokine Res.31:131-135(2011) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: REVIEW
21.

"Viperin, a key player in the antiviral response."
Mattijssen S. , Pruijn G.J.
Microbes Infect.14:419-426(2012) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: REVIEW
22.

"Structural characterization reveals that viperin is a radical S-adenosyl-L-methionine (SAM) enzyme."
Shaveta G. , Shi J. , Chow V.T. , Song J.
Biochem. Biophys. Res. Commun.391:1390-1395(2010) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: STRUCTURE BY NMR OF 45-361;IDENTIFICATION BY MASS SPECTROMETRY;COFACTOR

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